The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
Open accessAbstract
Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its biological activities through the IL-1 type I receptor (IL-1RI). The body weights of IL-1RI−/− mice of both sexes started to deviate from those of wild-type mice at 5–6 months of age and were 20% higher at 9 months of age. Visceral and subcutaneous fat mass, measured by dual-energy X-ray absorptiometry and magnetic resonance imaging, was markedly (1.5- to 2.5-fold) increased. Lean body mass and crown-rump length were also slightly (11 and 5%, respectively) increased, as was serum IGF-I. Obese IL-1RI−/− mice were insulin resistant, as evidenced by hyperinsulinemia, decreased glucose tolerance, and insulin sensitivity. To elucidate the mechanisms for the development of obesity, young preobese IL-1RI−/− mice were investigated. They showed decreased suppression of body weight and food intake in response to systemic leptin treatment. The decreased leptin responsiveness was even more pronounced in older obese animals. Moreover, spontaneous locomotor activity and fat utilization, as measured by respiratory quotient, were decreased in preobese IL-1RI−/− mice. In conclusion, lack of IL-1RI–mediated biological activity causes mature-onset obesity. This obese phenotype is preceded by decreased leptin sensitivity, fat utilization, and locomotor activity.
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Interleukin-6-deficient mice develop mature-onset obesity
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Self-citationRole of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans
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Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance
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Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798
Mechanisms of insulin resistance in obesity
Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 532
Vascular endothelial growth factor B controls endothelial fatty acid uptake
Hagberg, C. E., Falkevall, A., Wang, X., Larsson, E., Huusko, J., Nilsson, I., van Meeteren, L. A., Samen, E., Lu, L., Vanwildemeersch, M., et al. (2010) · Nature · doi:10.1038/nature08945 · Cited by 512
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
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Metadata
- Authors
- García, M. C., Wernstedt, I., Berndtsson, A., Enge, M., Bell, M., Hultgren, O., Horn, M., Ahrén, B., Enerback, S., Ohlsson, C., Wallenius, V., & Jansson, J.-O.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-05-01
- Volume
- 55
- Issue
- 5
- Pages
- 1205-1213
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120522574
- Cited by
- 175
- References
- 7
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- García, M. C., Wernstedt, I., Berndtsson, A., Enge, M., Bell, M., Hultgren, O., Horn, M., Ahrén, B., Enerback, S., Ohlsson, C., Wallenius, V., & Jansson, J.-O. (2006). Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice. Diabetes. https://doi.org/10.2337/db05-1304
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