The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes
Abstract
C-reactive protein (CRP) has been shown to be associated with type 2 diabetes, but whether CRP has a causal role is not yet clear. We examined the association in the Rotterdam Study, a population-based prospective cohort study. The association of baseline serum CRP and incident diabetes during follow-up was investigated, and a meta-analysis was conducted on the BMI-adjusted relation of CRP and diabetes. Furthermore, the association of CRP haplotypes with serum CRP and risk of diabetes was assessed. The age- and sex-adjusted hazard ratio for diabetes was 1.41 (95% CI 1.29–1.54) per 1 SD increase in natural logarithm of CRP, and it was 1.88, 2.16, and 2.83 for the second, third, and fourth quartiles of CRP, respectively, compared with the first quartile. The risk estimates attenuated but remained statistically significant after additional adjustment for obesity indexes, which agreed with the results of the meta-analysis. The most common genetic haplotype was associated with a significantly lower CRP level compared with the three other haplotypes. The risk of diabetes was significantly higher in the haplotype with the highest serum CRP level compared with the most common haplotype (OR 1.45, 95% CI 1.08–1.96). These findings support the hypothesis that serum CRP enhances the development of diabetes.
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Citations
Cites
Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women
Hu, F. B., Meigs, J. B., Li, T. Y., Rifai, N., & Manson, J. E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.693 · Cited by 788 · cited 3×
“However, some studies found that obesity does not explain the association of CRP with diabetes completely, suggesting an independent role for CRP in the development of diabetes (1,5,9).”
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Cited by
Inflammatory Markers and Risk of Type 2 Diabetes
Wang, X., Bao, W., Liu, J., OuYang, Y.-Y., Wang, D., Rong, S., Xiao, X., Shan, Z.-L., Zhang, Y., Yao, P., et al. (2013) · Diabetes Care · doi:10.2337/dc12-0702 · Cited by 820
Liu, C., Feng, X., Li, Q., Wang, Y., Li, Q., & Hua, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.028 · Cited by 470
Jones, M. L., Martoni, C. J., & Prakash, S. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.126 · Cited by 277
Young, H. A., & Benton, D. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000383 · Cited by 249
The Rotterdam Study: 2010 objectives and design update
Hofman, A., Breteler, M. M. B., van Duijn, C. M., Janssen, H. L. A., Krestin, G. P., Kuipers, E. J., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., et al. (2009) · European Journal of Epidemiology · doi:10.1007/s10654-009-9386-z · Cited by 244
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Metadata
- Authors
- Dehghan, A., Kardys, I., de Maat, M. P. M., Uitterlinden, A. G., Sijbrands, E. J. G., Bootsma, A. H., Stijnen, T., Hofman, A., Schram, M. T., & Witteman, J. C. M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2007-03-01
- Volume
- 56
- Issue
- 3
- Pages
- 872-878
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2111803150
- Cited by
- 257
- References
- 1
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dehghan, A., Kardys, I., de Maat, M. P. M., Uitterlinden, A. G., Sijbrands, E. J. G., Bootsma, A. H., Stijnen, T., Hofman, A., Schram, M. T., & Witteman, J. C. M. (2007). Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes. Diabetes. https://doi.org/10.2337/db06-0922
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