Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial
Abstract
Background/objectives The percentage of hypercholesterolemic individuals not reaching their LDL-cholesterol (LDL-C) goal remains high and additional therapeutic strategies should be evaluated. The objective of this study was to evaluate the cholesterol-lowering efficacy and mechanism of action of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 capsules in hypercholesterolemic adults.Subjects/methods A total of 127 subjects completed a randomized, double-blind, placebo-controlled, parallel-arm, multicenter study. Subjects were randomized to consume L. reuteri NCIMB 30242 capsules or placebo capsules over a 9-week intervention period. The primary outcome was LDL-C relative to placebo at the study end point.Results L. reuteri NCIMB 30242 capsules reduced LDL-C by 11.64% (P<0.001), total cholesterol by 9.14%, (P<0.001), non-HDL-cholesterol (non-HDL-C) by 11.30% (P < 0.001) and apoB-100 by 8.41% (P = 0.002) relative to placebo. The ratios of LDL-C/HDL-cholesterol (HDL-C) and apoB-100/apoA-1 were reduced by 13.39% (P = 0.006) and 9.00% (P = 0.026), respectively, relative to placebo. Triglycerides and HDL-C were unchanged. High-sensitivity C-reactive protein and fibrinogen were reduced by 1.05 mg/l (P = 0.005) and 14.25% (P = 0.004) relative to placebo, respectively. Mean plasma deconjugated bile acids were increased by 1.00 nmol/l (P=0.025) relative to placebo, whereas plasma campesterol, sitosterol and stigmasterol were decreased by 41.5%, 34.2% and 40.7%, respectively.Conclusions The present results suggest that the deconjugation of intraluminal bile acids results in reduced absorption of non-cholesterol sterols and indicate that L. reuteri NCIMB 30242 capsules may be useful as an adjunctive therapy for treating hypercholesterolemia.
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In two well powered, randomised, placebo-controlled and double-blinded studies, ingestion of a bile salt-hydrolysing Lactobacillus reuteri strain significantly lowered total and LDL-cholesterol in hypercholesterolaemic individuals.
“In two well powered, randomised, placebo-controlled and double-blinded studies, they demonstrated that ingestion of this strain significantly lowered total and low density lipoprotein (LDL)-cholesterol.”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [19]
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- Authors
- Jones, M. L., Martoni, C. J., & Prakash, S.
- Affiliations
- McGill University (CA)
- Université du Québec à Montréal (CA)
- Corresponding author
- Prakash, S
- Venue
- European Journal of Clinical Nutrition
- Published
- 2012-09-19
- Volume
- 66
- Issue
- 11
- Pages
- 1234-1241
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2007288537
- Cited by
- 277
- References
- 64
- Citations by year
- 2026: 17 · 2025: 8 · 2024: 21 · 2023: 21 · 2022: 22 · 2021: 21 · 2020: 24 · 2019: 21 · 2018: 30 · 2017: 20 · 2016: 17 · 2015: 26 · 2014: 17 · 2013: 10 · 2012: 2
- FWCI
- 27.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- bile salt hydrolase, hypercholesterolemia, LDL cholesterol lowering, non-cholesterol sterols, campesterol, sitosterol, stigmasterol, apolipoprotein B-100, HDL cholesterol
- MeSH terms
- Adult, Bile Acids and Salts, C-Reactive Protein, Cholesterol, Double-Blind Method, Female, Fibrinogen, Humans, Hypercholesterolemia, Intestinal Absorption, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Phytosterols, Sitosterols, Stigmasterol, Apolipoprotein A-I, Limosilactobacillus reuteri, Apolipoprotein B-100
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