Inflammatory Markers and Risk of Type 2 Diabetes
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OBJECTIVE: There has been growing evidence that inflammatory markers play a role in the development of type 2 diabetes. We aimed to systematically review prospective studies on the associations of elevated levels of interleukin-6 (IL-6) and C-reactive protein (CRP) with increased risk of type 2 diabetes by conducting a meta-analysis. RESEARCH DESIGN AND METHODS: A systematic search of the PubMed, EMBASE, ISI Web of Knowledge, and Cochrane Library databases up until 10 February 2012 was conducted to retrieve prospective studies matched to search terms. We used generalized least-squares trend estimation to assess dose-response relationships. The summary risk estimates were pooled using either fixed-effects or random-effects models to incorporate between-study variation. RESULTS: The meta-analysis, including 10 prospective studies, with a total of 19,709 participants and 4,480 cases, detected a significant dose-response association of IL-6 levels with type 2 diabetes risk (relative risk [RR] 1.31 [95% CI 1.17–1.46]). For CRP, the meta-analysis involving 22 cohorts, with a total of 40,735 participants and 5,753 cases, showed that elevated CRP levels were significantly associated with increased risk of type 2 diabetes (1.26 [1.16–1.37]), with the absence of publication bias. Sensitivity and subgroup analyses further supported the associations. CONCLUSIONS: This meta-analysis provides further evidence that elevated levels of IL-6 and CRP are significantly associated with increased risk of type 2 diabetes.
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Prospective studies indicate that raised concentrations of IL-6 and CRP in the circulation are associated with increased risk of future T2DM.
“Prospective studies indicate that raised concentrations of IL-6 and CRP in the circulation are associated with increased risk of future T2DM 42.”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [42]
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- Authors
- Wang, X., Bao, W., Liu, J., OuYang, Y.-Y., Wang, D., Rong, S., Xiao, X., Shan, Z.-L., Zhang, Y., Yao, P., & Liu, L.-G.
- Affiliations
- Shandong University (CN)
- Huazhong University of Science and Technology (CN)
- Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2012-12-11
- Volume
- 36
- Issue
- 1
- Pages
- 166-175
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3526249
- OpenAlex
- W2136759091
- Cited by
- 820
- References
- 43
- Citations by year
- 2026: 28 · 2025: 63 · 2024: 79 · 2023: 68 · 2022: 68 · 2021: 72 · 2020: 100 · 2019: 78 · 2018: 61 · 2017: 66 · 2016: 48 · 2015: 45 · 2014: 32 · 2013: 11 · 2012: 1
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- type 2 diabetes, interleukin-6, C-reactive protein, inflammatory markers, diabetes risk, dose-response relationship, inflammation
- MeSH terms
- C-Reactive Protein, Diabetes Mellitus, Type 2, Humans, Risk Factors, Biomarkers, Interleukin-6
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