Women With Mitochondrial Haplogroup N9a Are Protected Against Metabolic Syndrome
Open accessAbstract
To identify mitochondrial haplogroups that confer resistance against or susceptibility to metabolic syndrome, we performed a large-scale association study on 1,337 unrelated Japanese individuals, including 871 subjects with metabolic syndrome and 466 control subjects. Metabolic syndrome was diagnosed according to modified National Cholesterol Education Program Adult Treatment Panel III guidelines, using the cutoff point for obesity as a BMI of ≥25 kg/m2 instead of waist circumference. The genotypes for 25 polymorphisms in the coding region of the mitochondrial genome were determined, and the haplotypes were classified into 10 major haplogroups, i.e., F, B, A, N9a, M7a, M7b, G1, G2, D5, and D4. Multivariate logistic regression analysis revealed that the haplogroup N9a was significantly associated with resistance against metabolic syndrome in women with an odds ratio (OR) of 0.21 (95% CI 0.07–0.58, P = 0.0042). Women with haplogroups G1 and D5 tended to be resistant against metabolic syndrome with an OR of 0.22 (0.06–0.68, P = 0.0129) for G1 and with an OR of 0.32 (0.10–0.96, P = 0.0469) for D5, respectively. These results indicate that mitochondrial haplogroup N9a may be a protective factor against metabolic syndrome in Japanese women.
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Variations in mtDNA have been linked to higher risk for metabolic disorders.
“Interestingly, mtDNA polymorphisms have been associated with an increased risk of metabolic diseases.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [128]
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- Authors
- Tanaka, M., Fuku, N., Nishigaki, Y., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yoko, K., Ito, M., Nozawa, Y., & Yamada, Y.
- Affiliations
- Tokyo Metropolitan Institute of Gerontology (JP)
- Gifu Prefectural General Medical Center (JP)
- Gifu Prefectural Tajimi Hospital (JP)
- Gifu International Institute of Biotechnology, Kakamigahara, Japan
- Mie University (JP)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2007-02-01
- Volume
- 56
- Issue
- 2
- Pages
- 518-521
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2157585816
- Cited by
- 75
- References
- 27
- Citations by year
- 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15200051)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- metabolic syndrome, mitochondrial DNA, sex differences, Japanese women, genetic susceptibility, obesity, protective genetic factor
- MeSH terms
- Aged, Female, Haplotypes, Humans, Immunity, Innate, Japan, Middle Aged, Mitochondria, Multivariate Analysis, Logistic Models, Odds Ratio, Metabolic Syndrome
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