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Cited by 166

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Obesity-Related Upregulation of Monocyte Chemotactic Factors in Adipocytes

Open access
Jiao, Ping, Chen, Qiu, Shah, Suketu, Du, Jing, Tao, Bo, Tzameli, Iphigenia, Yan, Weiqun, Xu, Haiyan·2009·Diabetes
DOI 10.2337/db07-1344
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Abstract

OBJECTIVE—We sought to evaluate the entire picture of all monocyte chemotactic factors that potentially contribute to adipose tissue macrophage accumulation in obesity. RESEARCH DESIGN AND METHODS—Expression and regulation of members in the entire chemokine superfamily were evaluated in adipose tissue and isolated adipocytes of obese versus lean mice. Kinetics of adipose tissue macrophage infiltration was characterized by fluorescence-activated cell sorting. The effects of fatty acids on stimulation of chemokine expression in adipocytes and underlying mechanisms were investigated. RESULTS—Six monocyte chemotactic factors were found to be predominantly upregulated in isolated adipocytes versus stromal vascular cells in obese mice for the first time, although most of them were previously reported to be upregulated in whole adipose tissue. In diet-induced obese mice, adipose tissue enlargement, increase of adipocyte number, and elevation of multiple chemokine expression precede the initiation of macrophage infiltration. Free fatty acids (FFAs) are found to be inducers for upregulating these chemokines in 3T3-L1 adipocytes, and this effect can be partially blunted by reducing Toll-like receptor 4 expression. FFAs induce expression of monocyte chemotactic factors in adipocytes via both transcription-dependent and -independent mechanisms. In contrast to the reported role of JNK as the exclusive mediator of FFA-induced monocyte chemoattractant protein-1 (MCP-1) expression in macrophages, we show a novel role of inhibitor of κB kinase-β (IKKβ) in mediating FFA-induced upregulation of all six chemokines and a role of JNK in FFA-induced upregulation of MCP-1 and MCP-3. CONCLUSIONS—Multiple chemokines derived from adipocytes might contribute to obesity-related WAT macrophage infiltration with FFAs as potential triggers and involvement of both IKKβ and JNK pathways.

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Metadata

Authors
Jiao, P., Chen, Q., Shah, S., Du, J., Tao, B., Tzameli, I., Yan, W., & Xu, H.
Venue
Diabetes
Publisher
American Diabetes Association
Published
2009-01-01
Volume
58
Issue
1
Pages
104-115
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db07-1344
OpenAlex
W2111842746
Cited by
166
References
18
FWCI
6.35
Type
journal article
Language
en
Open access
hybrid

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