The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Development of the Human Pancreas From Foregut to Endocrine Commitment
Open accessAbstract
Knowledge of human pancreas development underpins our interpretation and exploitation of human pluripotent stem cell (PSC) differentiation toward a β-cell fate. However, almost no information exists on the early events of human pancreatic specification in the distal foregut, bud formation, and early development. Here, we have studied the expression profiles of key lineage-specific markers to understand differentiation and morphogenetic events during human pancreas development. The notochord was adjacent to the dorsal foregut endoderm during the fourth week of development before pancreatic duodenal homeobox-1 detection. In contrast to the published data from mouse embryos, during human pancreas development, we detected only a single-phase of Neurogenin 3 (NEUROG3) expression and endocrine differentiation from approximately 8 weeks, before which Nirenberg and Kim homeobox 2.2 (NKX2.2) was not observed in the pancreatic progenitor cell population. In addition to revealing a number of disparities in timing between human and mouse development, these data, directly assembled from human tissue, allow combinations of transcription factors to define sequential stages and differentiating pancreatic cell types. The data are anticipated to provide a useful reference point for stem cell researchers looking to differentiate human PSCs in vitro toward the pancreatic β-cell so as to model human development or enable drug discovery and potential cell therapy.
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Induction of Pancreatic Differentiation by Signals from Blood Vessels
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GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
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Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Notochord repression of endodermal Sonic hedgehog permits pancreas development
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Pancreas organogenesis: From bud to plexus to gland
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SOX9 is required for maintenance of the pancreatic progenitor cell pool
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Cited by
Churchill, A. J., Gutiérrez, G. D., Singer, R. A., Lorberbaum, D. S., Fischer, K. A., & Sussel, L. (2017) · eLife · doi:10.7554/elife.20010 · Cited by 1,236
Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro
Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, T., Puri, S., Haataja, L., Cirulli, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591058 · Cited by 591
Zhu, Y., Liu, Q., Zhou, Z., & Ikeda, Y. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0694-z · Cited by 323
Engineering islets from stem cells for advanced therapies of diabetes
Siehler, J., Blöchinger, A. K., Meier, M., & Lickert, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00262-w · Cited by 125
Generation of pancreatic β cells from CD177+ anterior definitive endoderm
Mahaddalkar, P. U., Scheibner, K., Pfluger, S., Ansarullah, Sterr, M., Beckenbauer, J., Irmler, M., Beckers, J., Knöbel, S., & Lickert, H. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0492-5 · Cited by 115
Metadata
- Authors
- Jennings, R. E., Berry, A. A., Kirkwood-Wilson, R., Roberts, N. A., Hearn, T., Salisbury, R. J., Blaylock, J., Piper Hanley, K., & Hanley, N. A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2013-09-17
- Volume
- 62
- Issue
- 10
- Pages
- 3514-3522
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2115389601
- Cited by
- 310
- References
- 42
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jennings, R. E., Berry, A. A., Kirkwood-Wilson, R., Roberts, N. A., Hearn, T., Salisbury, R. J., Blaylock, J., Piper Hanley, K., & Hanley, N. A. (2013). Development of the Human Pancreas From Foregut to Endocrine Commitment. Diabetes. https://doi.org/10.2337/db12-1479
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