Amelioration of Hypoglycemia Via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats
Open accessAbstract
Selective antagonism of somatostatin receptor type 2 (SSTR2) normalizes glucagon and corticosterone responses to hypoglycemic clamp in diabetic rats. The purpose of this study was to determine whether SSTR2 antagonism (SSTR2a) ameliorates hypoglycemia in response to overinsulinization in diabetic rats previously exposed to recurrent hypoglycemia. Streptozotocin diabetic rats (n = 19), previously subjected to five hypoglycemia events over 3 days, received an insulin bolus (10 units/kg i.v.) plus insulin infusion (50 mU/kg/min i.v.) until hypoglycemia ensued (≤3.9 mmol/L) (experimental day 1 [Expt-D1]). The next day (Expt-D2), rats were allocated to receive either placebo treatment (n = 7) or SSTR2a infusion (3,000 nmol/kg/min i.v., n = 12) 60 min prior to the same insulin regimen. On Expt-D1, all rats developed hypoglycemia by ∼90 min, while on Expt-D2, hypoglycemia was attenuated with SSTR2a treatment (nadir = 3.7 ± 0.3 vs. 2.7 ± 0.3 mmol/L in SSTR2a and controls, P < 0.01). Glucagon response to hypoglycemia on Expt-D2 deteriorated by 20-fold in the placebo group (P < 0.001) but improved in the SSTR2a group (threefold increase in area under the curve [AUC], P < 0.001). Corticosterone response deteriorated in the placebo-treated rats on Expt-D2 but increased twofold in the SSTR2a group. Catecholamine responses were not affected by SSTR2a. Thus, SSTR2 antagonism after recurrent hypoglycemia improves the glucagon and corticosterone responses and largely ameliorates insulin-induced hypoglycemia in diabetic rats.
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In rats with chemically induced or autoimmune diabetes, counter-regulatory glucagon secretion can be restored by SSTR antagonists.
“In rats with chemically induced or autoimmune diabetes, counter-regulatory glucagon secretion can be restored by SSTR antagonists4–7”
From Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes (2024) · cites this paper as [4]
The Abstract reports that SSTR2 antagonism improved the glucagon response to hypoglycemia in streptozotocin-diabetic rats, and Research Design and Methods identifies streptozotocin injection as the means of inducing diabetes. The paper does not report an autoimmune-diabetes rat group. Its Discussion also says the response after recurrent hypoglycemia was not fully restored, so “restored” overstates this study’s finding. (LLM, conf=0.88)
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Cites
Somatostatin and Its Receptor Family
Patel, Y. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0183 · Cited by 1,648 · see citing works
Defining and Reporting Hypoglycemia in Diabetes
American Diabetes Association Workgroup on Hypoglycemia (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1245 · Cited by 1,146 · see citing works
The barrier of hypoglycemia in diabetes
Cryer, P. E. (2008) · Diabetes · doi:10.2337/db08-1084 · Cited by 725 · see citing works
Dagogo-Jack, S. E., Craft, S., & Cryer, P. E. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116302 · Cited by 471 · see citing works
Role of Glucagon, Catecholamines, and Growth Hormone in Human Glucose Counterregulation
Rizza, R. A., Cryer, P. E., & Gerich, J. E. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109464 · Cited by 421 · cited 2× · see citing works
“17 increase (45), resulting in the consequent inhibition of adrenomedullary epinephrine secretion from the adrenal medulla.”
Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes
Cryer, P. E. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3592 · Cited by 402 · see citing works
Fanelli, C. G., Epifano, L., Rambotti, A. M., Pampanelli, S., Di Vincenzo, A., Modarelli, F., Lepore, M., Annibale, B., Ciofetta, M., Bottini, P., et al. (1993) · Diabetes · doi:10.2337/diab.42.11.1683 · Cited by 398 · see citing works
Raynor, K., Murphy, W. A., Coy, D. H., Taylor, J. E., Moreau, J. P., Yasuda, K., Bell, G. I., & Reisine, T. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13664-x · Cited by 280 · see citing works
Self-citationTissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat
Bruno, J. F., Xu, Y., Song, J., & Berelowitz, M. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243278 · Cited by 261 · see citing works
Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.
Orci, L., Baetens, D., Rufener, C., AMHERDT, M., Ravazzola, M., Studer, P., MALAISSE-LAGAE, F., & Unger, R. H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1338 · Cited by 254 · see citing works
A Survey of Cognitive Functioning at Different Glucose Levels in Diabetic Persons
Holmes, C. S., Hayford, J. T., González, J. L., & Weydert, J. A. (1983) · Diabetes Care · doi:10.2337/diacare.6.2.180 · Cited by 216 · see citing works
Hypoglycemia in Type 1 Diabetes Mellitus
Cryer, P. E. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.05.003 · Cited by 205 · see citing works
Hypoglycemia: Still The Limiting Factor in the Glycemic Management of Diabetes
Cryer, P. E. (2008) · Endocrine Practice · doi:10.4158/ep.14.6.750 · Cited by 182 · see citing works
SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
Kailey, B., van de Bunt, M., Cheley, S., Johnson, P. R., MacDonald, P. E., Gloyn, A. L., Rorsman, P., & Braun, M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00207.2012 · Cited by 164 · see citing works
Hypoglycemia-Associated Autonomic Failure in Insulin-Dependent Diabetes Mellitus
Cryer, P. E. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60827-3 · Cited by 162 · see citing works
Singh, V., Brendel, M., Zacharias, S., Mergler, S., Jahr, H., Wiedenmann, B., Bretzel, R., Plöckinger, U., & Strowski, M. (2007) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2006-1578 · Cited by 142 · see citing works
Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis
Strowski, M. Z., Köhler, M. G., Chen, H. Y., Trumbauer, M. E., Li, Z., Szalkowski, D., Gopal-Truter, S., Fisher, J. K., Schaeffer, J. M., Blake, A. D., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2001-0035 · Cited by 129 · see citing works
Ovalle, F., Fanelli, C. G., Paramore, D. S., Hershey, T., Craft, S., & Cryer, P. E. (1998) · Diabetes · doi:10.2337/diabetes.47.9.1472 · Cited by 117 · see citing works
Intra-Islet Somatostatin Regulates Glucagon Release via Type 2 Somatostatin Receptors in Rats
Cejvan, K., Coy, D. H., & Efendic, S. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1176 · Cited by 110 · see citing works
Self-citationDay, R. W., Dong, W., Panetta, R., Kraicer, J., Greenwood, M. T., & Patel, Y. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588263 · Cited by 110 · see citing works
Somatostatin and Somatostatin Receptors
Kumar, U., & Grant, M. P. (2009) · Results and problems in cell differentiation · doi:10.1007/400_2009_29 · Cited by 101 · see citing works
Further defects in counterregulatory responses induced by recurrent hypoglycemia in IDDM.
Davis, M. R., Mellman, M., & Shamoon, H. (1992) · Diabetes · doi:10.2337/diab.41.10.1335 · Cited by 98 · see citing works
Fritsche, A., Stefan, N., Häring, H., Gerich, J., & Stumvoll, M. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_1-200105010-00009 · Cited by 98 · see citing works
Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 1 – molecular pathways
Çakır, M., Dorota Dworakowska, B., & Grossman, A. B. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01125.x · Cited by 93 · see citing works
Highly Potent Cyclic Disulfide Antagonists of Somatostatin
Hocart, S. J., Jain, R., Murphy, W. A., Taylor, J. E., & Coy, D. H. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm9806289 · Cited by 85 · see citing works
Self-citationBeaudet, A., Greenspun, D., Raelson, J., & Tannenbaum, G. S. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00486-o · Cited by 85 · see citing works
Lingenfelser, T., Renn, W., Sommerwerck, U., Jung, M. F., Buettner, U. W., Zaiser-Kaschel, H., Kaschel, R., Eggstein, M., & Jakober, B. (1993) · Diabetes · doi:10.2337/diab.42.4.610 · Cited by 80 · see citing works
Yue, J. T. Y., Burdett, E., Coy, D. H., Giacca, A., Efendic, S., & Vranic, M. (2012) · Diabetes · doi:10.2337/db11-0690 · Cited by 75 · see citing works
Self-citationDavis, S. N., Mann, S., Briscoe, V. J., Ertl, A. C., & Tate, D. B. (2009) · Diabetes · doi:10.2337/db08-1230 · Cited by 74 · see citing works
Powell, A. M., Sherwin, R. S., & Shulman, G. I. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116883 · Cited by 73 · see citing works
Impaired Counterregulation of Hypoglycemia in Insulin-dependent Diabetes Mellitus
Kleinbaum, J., & Shamoon, H. (1983) · Diabetes · doi:10.2337/diab.32.6.493 · Cited by 52 · see citing works
Jones, C. W., Reynolds, W. A., & Hoganson, G. E. (1980) · Diabetes · doi:10.2337/diab.29.7.536 · Cited by 46 · see citing works
Cognitive function testing in studies of acute hypoglycaemia: rights and wrongs?
Amiel, S. A. (1998) · Diabetologia · doi:10.1007/s001250050973 · Cited by 42 · see citing works
Maturation of Secretory Granules
Kögel, T., & Gerdes, H. (2009) · Results and problems in cell differentiation · doi:10.1007/400_2009_31 · Cited by 36 · see citing works
Inouye, K., Shum, K. K., Chan, O. T. M., Mathoo, J., Matthews, S. G., & Vranić, M. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00480.2001 · Cited by 36 · see citing works
Brubaker, P. L., SO, D. C. Y., & Drucker, D. J. (1989) · Endocrinology · doi:10.1210/endo-124-6-3003 · Cited by 35 · see citing works
Somatostatin enhances insulin-stimulated glucose uptake in the perfused human forearm.
Møller, N., Bagger, J. P., Schmitz, O., Jørgensen, J. O. L., Ovesen, P., Møller, J. K., Alberti, K. G. M. M., & Ørskov, H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.6.7775624 · Cited by 35 · see citing works
Powell, A. M., & Sherwin, R. S. (1993) · Cited by 34 · see citing works
(1996) · PubMed · Cited by 32 · see citing works
Inouye, K., Chan, O. T. M., Yue, J. T. Y., Matthews, S. G., & Vranić, M. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00389.2004 · Cited by 24 · see citing works
Self-citationRastogi, K. S., Lickley, L. A., JOKAY, M., Efendić, S., & Vranić, M. (1990) · Endocrinology · doi:10.1210/endo-126-2-1096 · Cited by 24 · see citing works
IMMUNOREACTIVE SOMATOSTATIN IN HUMAN PANCREATIC SECRETION
Ertan, A., Taminato, T., Akdamar, K., Ryan, J., Agrawal, N. M., Schally, A. V., & Arimura, A. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-3-589 · Cited by 23 · see citing works
Inouye, K., Yue, J. T. Y., Chan, O. T. M., Kim, T., Akirav, E. M., Park, E., Riddell, M. C., Burdett, E., Matthews, S. G., & Vranić, M. (2006) · Endocrinology · doi:10.1210/en.2005-1040 · Cited by 21 · see citing works
Self-citationO’Carroll, A. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305100107 · Cited by 13 · see citing works
Skare, S., Dahl‐Jørgensen, K., Hanssen, K. F., & Norman, N. (1985) · European Journal of Endocrinology · doi:10.1530/acta.0.1090517 · Cited by 11 · see citing works
Recent Advances in the Prevention of Hypoglycemia in Type 1 Diabetes
Realsen, J., & Chase, H. P. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0150 · Cited by 10 · see citing works
Pancreatic immunoreactive somatostatin and diabetes mellitus
Ertan, A., Arimura, A., Akdamar, K., Shibata, T., Groot, K., Luciano, M. G., Mather, F. J., Değertekin, H., Agrawal, N. M., & Ryan, J. (1984) · Digestive Diseases and Sciences · doi:10.1007/bf01347295 · Cited by 10 · see citing works
Madsbad, S., Hilsted, J., Krarup, T., Tronier, B., & Sestoft, L. (1983) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1983.tb00741.x · Cited by 10 · see citing works
Peng, M., Conforti, L., & Millhorn, D. E. (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm.1.5.841 · Cited by 6 · see citing works
Navascués, I., Gil, J., Pascau, C., Senen, D., & Serrano‐Ríos, M. (1988) · Hormone and Metabolic Research · doi:10.1055/s-2007-1010938 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419 · see citing works
Islet α cells and glucagon--critical regulators of energy homeostasis
Campbell, J. E., & Drucker, D. J. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.51 · Cited by 266 · see citing works
The somatostatin-secreting pancreatic δ-cell in health and disease
Rorsman, P., & Huising, M. O. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0020-6 · Cited by 259 · see citing works
Paracrine regulation of insulin secretion
Huising, M. O. (2020) · Diabetologia · doi:10.1007/s00125-020-05213-5 · Cited by 108 · see citing works
The past, present, and future physiology and pharmacology of glucagon
Capozzi, M. E., D’Alessio, D. A., & Campbell, J. E. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.10.001 · Cited by 110 · see citing works
Glucagon secretion and signaling in the development of diabetes
Gaisano, H. Y., MacDonald, P. E., & Vranić, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00349 · Cited by 75 · see citing works
Karimian, N., Qin, T., Liang, T., Osundiji, M., Huang, Y., Teich, T., Riddell, M. C., Cattral, M. S., Coy, D. H., Vranic, M., et al. (2013) · Diabetes · doi:10.2337/db13-0164 · Cited by 66 · see citing works
Self-citationMoser, O., Yardley, J. E., & Bracken, R. M. (2018) · Nutrients · doi:10.3390/nu10010093 · Cited by 62 · see citing works
Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets
Svendsen, B., & Holst, J. J. (2020) · Diabetologia · doi:10.1007/s00125-020-05288-0 · Cited by 54 · see citing works
Xu, S. F. S., Andersen, D. B., Izarzugaza, J. M. G., Kuhre, R. E., & Holst, J. J. (2020) · Acta Physiologica · doi:10.1111/apha.13464 · Cited by 42 · see citing works
Krentz, N. A. J., Shea, L. D., Huising, M. O., & Shaw, J. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00170-4 · Cited by 37 · see citing works
δ-Cells: The Neighborhood Watch in the Islet Community
Gao, R., Yang, T., & Zhang, Q. (2021) · Biology · doi:10.3390/biology10020074 · Cited by 34 · see citing works
Hill, T. G., Gao, R., Benrick, A., Kothegala, L., Rorsman, N., Santos, C., Acreman, S., Briant, L. J., Dou, H., Gandasi, N. R., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01139-z · Cited by 30 · see citing works
“In rats with chemically induced or autoimmune diabetes, counter-regulatory glucagon secretion can be restored by SSTR antagonists 4–7 but both the underlying cellular mechanism and whether it can be extended to humans remain unestablished.”
GhavamiNejad, A., Lu, B., Samarikhalaj, M., Liu, J. F., Mirzaie, S., Pereira, S., Zhou, L., Giacca, A., & Wu, X. Y. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00944-3 · Cited by 27 · see citing works
Intercellular Communication in the Islet of Langerhans in Health and Disease
Ng, X. W., Chung, Y. H., & Piston, D. W. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200026 · Cited by 39 · see citing works
Hill, T. G., & Hill, D. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074070 · Cited by 20 · see citing works
Huang, H., Bader, T., & Jin, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165867 · Cited by 19 · see citing works
Farhat, R., Aiken, J., D'Souza, N. C., Appadurai, D., Hull, G., Simonson, E., Liggins, R. T., Riddell, M. C., & Chan, O. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14652 · Cited by 19 · see citing works
Self-citationMonnerat, G., Sonoda, M. T., Guerra, B., Manso, G., Ferreira, A. C. F., Silva, D. L. S. G., Coutinho, D. C. O., Carneiro‐Ramos, M. S., Rodrigues, D. C., Cabral-da-Silva, M. C., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.12.013 · Cited by 19 · see citing works
Gap junction coupling and islet delta-cell function in health and disease.
Miranda, C., Begum, M., Vergari, E., & Briant, L. (2021) · Peptides · doi:10.1016/j.peptides.2021.170704 · Cited by 18 · see citing works
Leclair, E., Liggins, R., Peckett, A. J., Teich, T., Coy, D. H., Vranić, M., & Riddell, M. C. (2016) · Diabetologia · doi:10.1007/s00125-016-3953-0 · Cited by 16 · see citing works
Self-citationα-cell electrophysiology and the regulation of glucagon secretion
Gao, R., Acreman, S., Ma, J., Abdulkader, F., Wendt, A., & Zhang, Q. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0295 · Cited by 21 · see citing works
Directed differentiation of pancreatic δ cells from human pluripotent stem cells
Chen, L., Wang, N., Zhang, T., Zhang, F., Zhang, W. K., Meng, H., Chen, J., Liao, Z., Xu, X., Ma, Z., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50611-7 · Cited by 15 · see citing works
Managing Severe Hypoglycaemia in Patients with Diabetes: Current Challenges and Emerging Therapies
Demirbilek, H., Vurallı, D., Haris, B., & Hussain, K. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s313837 · Cited by 15 · see citing works
Hoffman, E. G., D’Souza, N. C., Liggins, R. T., & Riddell, M. C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1295639 · Cited by 13 · see citing works
Self-citationRöthe, J., Kraft, R., Ricken, A. M., Kaczmarek, I., Matz‐Soja, M., Winter, K., Dietzsch, A. N., Buchold, J., Ludwig, M., Liebscher, I., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05783-9 · Cited by 13 · see citing works
Can somatostatin antagonism prevent hypoglycaemia during exercise in type 1 diabetes?
Taleb, N., & RABASA-LHORET, R. P. R. (2016) · Diabetologia · doi:10.1007/s00125-016-3978-4 · Cited by 12 · see citing works
Hoffman, E. G., Jahangiriesmaili, M., Mandel, E. R., Greenberg, C., Aiken, J., D’Souza, N. C., Pasieka, A., Teich, T., Chan, O., Liggins, R., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab189 · Cited by 11 · see citing works
Self-citationIntercellular Communication in the Islet of Langerhans in Health and Disease
Ng, X.-W., Yong, H.-C., & Piston, D. W. (2021) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2021.tb00177.x · Cited by 27 · see citing works
Glucagon – the new ‘insulin’ in the pathophysiology of diabetes
Farhy, L. S., & McCall, A. L. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000192 · Cited by 10 · see citing works
McCarthy, O. M., Schmidt, S., Christensen, M. B., Bain, S. C., Nørgaard, K., & Bracken, R. M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.981723 · Cited by 10 · see citing works
Islet delta-cell architecture is remodelled in the human pancreas during type 1 diabetes
Tegehall, A., Korsgren, O., Ingvast, S., Gasparyan, G., Granlund, L., & Lundberg, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-04471-w · Cited by 9 · see citing works
Yang, M., Mandal, K., Södergren, M., Dumral, Ö., Winroth, L., & Tengholm, A. (2025) · Acta Physiologica · doi:10.1111/apha.14268 · Cited by 7 · see citing works
Hoffman, E. G., D’Souza, N. C., Aiken, J., ATHERLEY, S. C., Liggins, R., & Riddell, M. C. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15002 · Cited by 7 · see citing works
Self-citationFarhat, R., Vliet, E. D. S. V., Su, G., Neely, L., Benally, T., & Chan, O. T. M. (2021) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.226 · Cited by 5 · see citing works
Imaging and therapy of hSSTR2-transfected tumors using radiolabeled somatostatin analogs
Wang, Z., Ma, W., Wang, J., Deng, J., Yuan, M., Zhao, M., Jia, L., Yang, W., Zhang, R., Qin, W., et al. (2013) · Tumor Biology · doi:10.1007/s13277-013-0796-x · Cited by 5 · see citing works
D’Souza, N. C., Aiken, J., Hoffman, E. G., ATHERLEY, S. C., Champsi, S., ALEALI, N., Shakeri, D., El-Zahed, M., Akbarian, N., Nejad-Mansouri, M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1302015 · Cited by 4 · see citing works
Self-citationA bright future for glucagon and alpha cell biology
Panzer, J. K., & Caicedo, A. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0315 · Cited by 4 · see citing works
A differentiation protocol for generating pancreatic delta cells from human pluripotent stem cells
Zhang, T., Wang, N., Liao, Z., Chen, J., Meng, H., Lin, H., Xu, T., Chen, L., Zhu, L., & Liu, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1490040 · Cited by 3 · see citing works
Li, Z., Wu, X., Kang, Q., Ren, Q., Zhang, Y., Zhang, Y., Jin, Q., Wong, F. S., & Li, M. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00193.2025 · Cited by 2 · see citing works
Glucagon and the Glucagon-Like Peptides
Drucker, D. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00034-2 · Cited by 2 · see citing works
Somatostatin Analogues Use in Other than Endocrine Tumor Indications
Gilis‐Januszewska, A., Trofimiuk–Müldner, M., Jabrocka‐Hybel, A., & Pach, D. (2015) · Wiley eBooks · doi:10.1002/9781119031659.ch18
Dr. Mladen Vranic—A Legend in Diabetes Research: 1930–2019
Cherrington, A. D., & Rashid, S. (2020) · Diabetes Care · doi:10.2337/dci20-0010
Nielsen, S. W., Gilliam‐Vigh, H., Jorsal, T., Wahlgren, C. D., Vestergaard, M. B., Forman, J. L., Pedersen, J., Poulsen, S. S., Vilsbøll, T., Gasbjerg, L. S., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf648
Enhanced crosstalk between α- and δ-cells promotes recurrent hypoglycaemia
(2026) · Nature Metabolism · doi:10.1038/s42255-025-01423-6
- Authors
- Yue, J. T. Y., Riddell, M. C., Burdett, E., Coy, D. H., Efendic, S., & Vranic, M.
- Affiliations
- University of Toronto (CA)
- York University (CA)
- Tulane University (US)
- Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
- Department of Physiology, University of Toronto, Toronto, Ontario, Canada
- Corresponding author
- Riddell, Michael C.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2013-06-14
- Volume
- 62
- Issue
- 7
- Pages
- 2215-2222
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3712070
- OpenAlex
- W2164739927
- Cited by
- 45
- References
- 51
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 5 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 4 · 2013: 3 · 2012: 1
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- somatostatin receptor 2, recurrent hypoglycemia, insulin-induced hypoglycemia, glucagon response, streptozotocin-induced diabetes, catecholamine response
- MeSH terms
- Animals, Blood Glucose, Body Weight, Catecholamines, Diabetes Mellitus, Experimental, Eating, Glucagon, Hypoglycemia, Insulin, Peptides, Cyclic, Receptors, Somatostatin, Rats
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