Hypoglycemia in Type 1 Diabetes Mellitus

Cryer, Philip E.

doi:10.1016/j.ecl.2010.05.003

Cited by 205Diabetes Management and ResearchDiabetes and associated disordersDiabetes Treatment and Management

Hypoglycemia in Type 1 Diabetes Mellitus

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Cryer, Philip E.·2010·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2010.05.003PMC PMC2923455

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Abstract

Iatrogenic hypoglycemia, typically the result of the interplay of therapeutic hyperinsulinemia and compromised defenses resulting in hypoglycemia-associated autonomic failure (HAAF) in diabetes, is a problem for people with type 1 diabetes mellitus (T1DM). It causes recurrent morbidity is sometimes fatal, leads to recurrent hypoglycemia, and precludes euglycemia over a lifetime of T1DM. Risk factors include those that result in relative or absolute insulin excess and those indicative of HAAF in diabetes. Elimination of hypoglycemia from the lives of people with T1DM will likely be accomplished by new treatment methods that provide plasma glucose-regulated insulin replacement or secretion.

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People with type 1 diabetes, particularly those with concomitant chronic kidney disease, are at higher risk of hypoglycemia.
“People with type 1 diabetes, particularly those with concomitant chronic kidney disease, are at higher risk of hypoglycemia, which should be avoided by careful insulin and carbohydrate matching (129).”
From The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2021) · cites this paper as [129]
The Conventional Risk Factors section identifies reduced insulin clearance in renal failure as a hypoglycemia risk factor, and the Summary of Recommendations advises matching insulin action to glucose availability to avoid hypoglycemia. The paper does not extend the renal-failure finding to all chronic kidney disease, so the claim's broader CKD qualifier is not fully supported. No page numbers are available in our copy. (LLM, conf=0.84)
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Hypoglycemia risk reduction in type 1 diabetes
Cryer, P. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-18599 · Cited by 29 · see citing works
Self-citation
Hypoglycemia in Patients with Type 1 Diabetes: Epidemiology, Pathogenesis, and Prevention
Awoniyi, O., Rehman, R., & Dagogo-Jack, S. E. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0411-y · Cited by 53 · see citing works
Exercise-Related Hypoglycemia-Associated Autonomic Failure in Diabetes
Cryer, P. E. (2009) · Diabetes · doi:10.2337/db09-0834 · Cited by 28 · see citing works
Self-citation
Are Gender Differences in the Responses to Hypoglycemia Relevant to Iatrogenic Hypoglycemia in Type 1 Diabetes?
Cryer, P. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6659 · Cited by 7 · see citing works
Self-citation
NAVIGATING THE CHALLENGES OF HYPOGLYCEMIA IN TYPE 1 DIABETES: A COMPREHENSIVE REVIEW
Devendra, N., Adlekha, S., & Shah, D. K. (2024) · INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH · doi:10.36106/ijsr/6100510

Authors: Cryer, P. E.
Affiliations: Barnes-Jewish Hospital (US)
Corresponding author: Cryer, Philip E.
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2010-09
Volume: 39
Issue: 3
Pages: 641-654
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2010.05.003
PMC: PMC2923455
OpenAlex: W2009090185
Cited by: 205
References: 68
Citations by year: 2026: 16 · 2025: 20 · 2024: 11 · 2023: 12 · 2022: 12 · 2021: 21 · 2020: 14 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 9 · 2013: 16 · 2012: 11
FWCI: 1.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p60dk020579-35, UL1TR000448)
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK027085, P60-DK20579, R37-DK27085, T32 DK07120, P60-DK-020579, P30DK020579, T32DK007120)
National Center for Research Resources (UL1-RR-24992, M01-RR00036, UL1RR024992, M01RR000036)
NIH Clinical Center
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: hypoglycemia, type 1 diabetes, hypoglycemia-associated autonomic failure, iatrogenic hypoglycemia, hyperinsulinemia, insulin excess, hypoglycemia risk factors, insulin secretion
MeSH terms: Blood Glucose, Diabetes Mellitus, Type 1, Humans, Hypoglycemia, Models, Biological, Risk Factors

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Hypoglycemia in Type 1 Diabetes Mellitus

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