Connections Between the Gut Microbiome and Metabolic Hormones in Early Pregnancy in Overweight and Obese Women
Abstract
Overweight and obese women are at a higher risk for gestational diabetes mellitus. The gut microbiome could modulate metabolic health and may affect insulin resistance and lipid metabolism. The aim of this study was to reveal relationships between gut microbiome composition and circulating metabolic hormones in overweight and obese pregnant women at 16 weeks' gestation. Fecal microbiota profiles from overweight (n = 29) and obese (n = 41) pregnant women were assessed by 16S rRNA sequencing. Fasting metabolic hormone (insulin, C-peptide, glucagon, incretin, and adipokine) concentrations were measured using multiplex ELISA. Metabolic hormone levels as well as microbiome profiles differed between overweight and obese women. Furthermore, changes in some metabolic hormone levels were correlated with alterations in the relative abundance of specific microbes. Adipokine levels were strongly correlated with Ruminococcaceae and Lachnospiraceae, which are dominant families in energy metabolism. Insulin was positively correlated with the genus Collinsella. Gastrointestinal polypeptide was positively correlated with the genus Coprococcus but negatively with family Ruminococcaceae This study shows novel relationships between gut microbiome composition and the metabolic hormonal environment in overweight and obese pregnant women at 16 weeks' gestation. These results suggest that manipulation of the gut microbiome composition may influence pregnancy metabolism.
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The gut microbiome has been consistently reported to differ between metabolically healthy and obese individuals, including during pregnancy.
“The gut microbiome has been consistently reported to differ between metabolically healthy and obese individuals, including during pregnancy [127].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [127]
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- Authors
- Gomez-Arango, L. F., Barrett, H. L., McIntyre, H. D., Callaway, L. K., Morrison, M., & Dekker Nitert, M.
- Affiliations
- School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
- The University of Queensland (AU)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2016-05-23
- Volume
- 65
- Issue
- 8
- Pages
- 2214-2223
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2400607720
- Cited by
- 287
- References
- 5
- Citations by year
- 2026: 17 · 2025: 29 · 2024: 27 · 2023: 33 · 2022: 37 · 2021: 41 · 2020: 38 · 2019: 26 · 2018: 21 · 2017: 16 · 2016: 2
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Departamento Administrativo de Ciencia, Tecnología e Innovación
- Australian Diabetes Society (Skip Martin Research Fellowship)
- National Health and Medical Research Council (1028575)
- Royal Brisbane and Women’s Hospital Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, metabolic hormones, early pregnancy, maternal obesity, overweight, gestational diabetes mellitus, insulin resistance, adipokines, Ruminococcaceae, Lachnospiraceae, Collinsella, Coprococcus, fecal microbiota
- MeSH terms
- Gastrointestinal Microbiome, Adult, Blood Glucose, C-Peptide, Energy Metabolism, Enzyme-Linked Immunosorbent Assay, Female, Gestational Age, Humans, Insulin, Obesity, Pregnancy, RNA, Ribosomal, 16S, Ruminococcus, Overweight, Adipokines
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