Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity—a preliminary report
Open accessAbstract
The objective was to explore if and how the microbiota changed in polycystic ovary syndrome (PCOS) women compared with healthy women. Eight obese PCOS (PO group), 10 nonobese PCOS (PN group), and nine healthy normal weight women (control) (C group) were enrolled. Insulin (INS), testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), and dehydroepiandrosterone (DHEA) were detected with radioimmunoassay. Antimullerian hormone (AMH), fasting glucose, and hemoglobin A1c (HbA1c) were determined by a chemiluminescence immunoassay, glucose oxidase method, and HPLC, respectively. Gut microbiota composition was evaluated by PCR. Alpha diversity was assessed using Chao1 and the Shannon index. PCOS women showed significantly higher T, LH, and LH/FSH and lower FSH levels than the C group (p < 0.05). The AMH level was significantly higher in the PO than in the PN group (p < 0.05). The PO group presented a significantly higher fasting INS level and HMOA-IR scores than the other groups, lower observed SVs and alpha diversity than the C group, higher beta diversity than the PN group (p < 0.05), and decreased abundances of genera (mainly butyrate producers). Regression analysis showed that decreased abundances of several genera were correlated with higher circulating T and impaired glucose metabolism. PCOS is associated with changes in the gut microbiota composition. Obesity has a driving role in the development of dysbiotic gut microbiota in PCOS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Testosterone levels were inversely correlated with co-abundance groups containing operational taxonomic units belonging to Alistipes, Akkermansia, Coprococcus, Collinsella, and Ruminococcus genera.
“Furthermore, an inverse correlation was found between testosterone levels and CAGs which contained operational taxonomic units (OTU) belonging to the genera Alistipes, Akkermansia, Coprococcus, Collinsella and Ruminococcus.(27)”
From Association Between Sex Hormone Levels and Gut Microbiota Composition and Diversity—A Systematic Review (2022) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y. Y., Wang, X., Fu, H., Xue, X., Lu, C., Ma, J., et al. (2018) · Science · doi:10.1126/science.aao5774 · Cited by 2,304 · see citing works
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025 · see citing works
Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603 · see citing works
Regional variation limits applications of healthy gut microbiome reference ranges and disease models
He, Y., Wu, W., Zheng, H.-M., Li, P., McDonald, D., Sheng, H.-F., Chen, M.-X., Chen, Z.-H., Ji, G.-Y., Zheng, Z.-D.-X., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0164-x · Cited by 894 · see citing works
The gut microbiota and obesity: from correlation to causality
Zhao, L. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3089 · Cited by 847 · see citing works
High-fat diet alters gut microbiota physiology in mice
Daniel, H., Gholami, A. M., Berry, D., Desmarchelier, C., Hahne, H., Loh, G., Mondot, S., Lepage, P., Rothballer, M., Walker, A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2013.155 · Cited by 680 · see citing works
Dewailly, D., Robin, G., Peigné, M., Decanter, C., Pigny, P., & Catteau-Jonard, S. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw027 · Cited by 537 · see citing works
Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism
Torres, P. J., Siakowska, M., Banaszewska, B., Pawelczyk, L., Duleba, A. J., Kelley, S. T., & Thackray, V. G. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02153 · Cited by 399 · see citing works
Dysbiosis of Gut Microbiota Associated with Clinical Parameters in Polycystic Ovary Syndrome
Liu, R., Zhang, C., Shi, Y., Zhang, F., Li, L., Wang, X., Ling, Y., Fu, H., Dong, W., Shen, J., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00324 · Cited by 372 · see citing works
Association between polycystic ovary syndrome and gut microbiota
Guo, Y., Qi, Y., Yang, X., Zhao, L., Wen, S., Liu, Y., & Tang, L. (2016) · PLOS ONE · doi:10.1371/journal.pone.0153196 · Cited by 350 · see citing works
Lauritsen, M. P., Bentzen, J. G., Pinborg, A., Loft, A., Forman, J. L., Thuesen, L. L., Cohen, A., Hougaard, D. M., & Nyboe Andersen, A. (2014) · Human Reproduction · doi:10.1093/humrep/det469 · Cited by 334 · see citing works
Gut microbiota and the polycystic ovary syndrome: influence of sex, sex hormones, and obesity
Insenser, M., Murri, M., del Campo, R., Martínez-García, M. Á., Fernández-Durán, E., & Escobar-Morreale, H. F. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02799 · Cited by 312 · see citing works
Takagi, T., Naito, Y., Inoüe, R., Kashiwagi, S., Uchiyama, K., Mizushima, K., Tsuchiya, S., Dohi, O., Yoshida, N., Kamada, K., et al. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1488-5 · Cited by 310 · see citing works
Gomez-Arango, L. F., Barrett, H. L., McIntyre, H. D., Callaway, L. K., Morrison, M., & Dekker Nitert, M. (2016) · Diabetes · doi:10.2337/db16-0278 · Cited by 287 · see citing works
van den Munckhof, I., Kurilshikov, A., ter Horst, R., Riksen, N. P., Joosten, L. A. B., Zhernakova, A., Fu, J., Keating, S. T., Netea, M. G., Graaf, J. D., et al. (2018) · Obesity Reviews · doi:10.1111/obr.12750 · Cited by 275 · see citing works
Beyond fertility: polycystic ovary syndrome and long-term health
Cooney, L. G., & Dokras, A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.08.021 · Cited by 270 · see citing works
Kaliannan, K., Robertson, R. C., Murphy, K., Stanton, C., Kang, C., Wang, B., Hao, L., Bhan, A. K., & Kang, J. X. (2018) · Microbiome · doi:10.1186/s40168-018-0587-0 · Cited by 263 · see citing works
Behçet's syndrome patients exhibit specific microbiome signature
Consolandi, C., Turroni, S., Emmi, G., Severgnini, M., Fiori, J., Peano, C., Biagi, E., Grassi, A., Rampelli, S., Silvestri, E., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.009 · Cited by 242 · see citing works
The gut microbiome is altered in a letrozole-induced mouse model of polycystic ovary syndrome
Kelley, S. T., Skarra, D. V., Rivera, A. J., & Thackray, V. G. (2016) · PLOS ONE · doi:10.1371/journal.pone.0146509 · Cited by 205 · see citing works
New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins
Walters, K. A., Gilchrist, R. B., Ledger, W. L., Teede, H. J., Handelsman, D. J., & Campbell, R. E. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.08.005 · Cited by 186 · see citing works
High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction
Rastmanesh, R. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.10.002 · Cited by 178 · see citing works
Chen, C., You, L., Huang, Q., Fu, X., Zhang, B., Liu, R., & Li, C. (2018) · Food & Function · doi:10.1039/c7fo01346a · Cited by 167 · see citing works
Long term effect of gut microbiota transfer on diabetes development
Peng, J., Narasimhan, S., Marchesi, J. R., Benson, A. K., Wong, F. S., & Li, W. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.03.005 · Cited by 157 · see citing works
Bajaj, J. S., Kakiyama, G., Savidge, T., Takei, H., Kassam, Z., Fagan, A., Gavis, E. A., Pandak, W. M., Nittono, H., Hylemon, P. B., et al. (2018) · Hepatology · doi:10.1002/hep.30037 · Cited by 147 · see citing works
The microbiome and hepatobiliary-pancreatic cancers
Mima, K., Nakagawa, S., Sawayama, H., Ishimoto, T., Imai, K., Iwatsuki, M., Hashimoto, D., Baba, Y., Yamashita, Y., Yoshida, N., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.05.001 · Cited by 133 · see citing works
Pterostilbene‐induced changes in gut microbiota composition in relation to obesity
Etxeberría, U., Hijona, E., Aguirre, L., Milagro, F. I., Bujanda, L., Rimando, A. M., Martínez, J. A., & Portillo, M. P. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500906 · Cited by 131 · see citing works
Huang, C., Chen, J., Wang, J., Zhou, H. J., Lu, Y., Lou, L., Zheng, J., Tian, L., Wang, X., Cao, Z., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00776 · Cited by 121 · see citing works
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
Tye, H., Yu, C., Simms, L. A., de Zoete, M. R., Kim, M. L., Zakrzewski, M., Penington, J. S., Harapas, C. R., Souza-Fonseca-Guimarães, F., Wockner, L. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06125-0 · Cited by 111 · see citing works
Chiu, C.-M., Huang, W.-C., Weng, S.-L., Tseng, H., Liang, C., Wang, W.-C., Yang, T., Yang, T.-L., Weng, C.-T., Chang, T., et al. (2014) · BioMed Research International · doi:10.1155/2014/906168 · Cited by 107 · see citing works
Is there a role for gut microbiota in type 1 diabetes pathogenesis?
Bibbò, S., Dore, M. P., Pes, G. M., Delitala, G., & Delitala, A. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1222449 · Cited by 107 · see citing works
Fangmann, D., Theismann, E., Türk, K., Schulte, D. M., Relling, I., Hartmann, K., Keppler, J. K., Knipp, J.-R., Rehman, A., Heinsen, F., et al. (2017) · Diabetes Care · doi:10.2337/dc17-1967 · Cited by 104 · see citing works
Kisuse, J., La-ongkham, O., Nakphaichit, M., Therdtatha, P., Momoda, R., Tanaka, M., Fukuda, S., Popluechai, S., Kespechara, K., Sonomoto, K., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01345 · Cited by 100 · see citing works
Pedrogo, D. A. M., Jensen, M. D., Dyke, C. T. V., Murray, J. A., Woods, J. A., Chen, J., Kashyap, P., & Nehra, V. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.02.019 · Cited by 97 · see citing works
Butts, S. F., Seifer, D. B., Koelper, N., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00750 · Cited by 75 · see citing works
Huazano-García, A., Shin, H., & López, M. G. (2017) · Nutrients · doi:10.3390/nu9090821 · Cited by 67 · see citing works
Sheng, T., Zhao, L., Gao, L., Liu, W., Cui, M.-H., Guo, Z., Ma, X., Ho, S., & Wang, A. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0585-z · Cited by 66 · see citing works
A study of the correlation between obesity and intestinal flora in school-age children
Gao, X., Jia, R., Xie, L., Kuang, L., Feng, L., & Wan, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-32730-6 · Cited by 60 · see citing works
Foroozanfard, F., Samimi, M., Almadani, K. H., & Sehat, M. (2017) · Electronic physician · doi:10.19082/5969 · Cited by 26 · see citing works
Nouri, M., Aghadavod, E., Khani, S., Jamilian, M., Siavashani, M. A., Ahmadi, S., & Asemi, Z. (2016) · Clinical Endocrinology · doi:10.1111/cen.13098 · Cited by 23 · see citing works
Dovrolis, N., Drygiannakis, I., Filidou, E., Kandilogiannakis, L., Arvanitidis, K. I., Tentes, I. K., Kolios, G. C., & Valatas, V. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy328 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
d’Afflitto, M., Upadhyaya, A., Green, A., & Peiris, M. (2022) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001676 · Cited by 142 · see citing works
- Authors
- Liang, Y., Ming, Q., Liang, J., Zhang, Y., Zhang, H., & Shen, T.
- Affiliations
- Zhongda Hospital Southeast University (CN)
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 2020-11
- Volume
- 98
- Issue
- 11
- Pages
- 803-809
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W3010742978
- Cited by
- 95
- References
- 43
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 23 · 2023: 12 · 2022: 15 · 2021: 18 · 2020: 4
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Canadian Journal of Physiology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- polycystic ovary syndrome, gut microbiota, dysbiosis, obesity, anti-Müllerian hormone, insulin resistance, testosterone, luteinizing hormone, follicle-stimulating hormone, butyrate-producing bacteria, alpha diversity, beta diversity, glucose metabolism
- MeSH terms
- Gastrointestinal Microbiome, Adult, Blood Glucose, Fasting, Female, Humans, Insulin, Obesity, Polycystic Ovary Syndrome, Testosterone, Body Mass Index, Case-Control Studies, Young Adult, Healthy Volunteers, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
