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Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
Open accessAbstract
Metformin is a widely used antidiabetic drug that exerts cardiovascular protective effects in patients with diabetes. How metformin protects against diabetes-related cardiovascular diseases remains poorly understood. Here, we show that metformin abated the progression of diabetes-accelerated atherosclerosis by inhibiting mitochondrial fission in endothelial cells. Metformin treatments markedly reduced mitochondrial fragmentation, mitigated mitochondrial-derived superoxide release, improved endothelial-dependent vasodilation, inhibited vascular inflammation, and suppressed atherosclerotic lesions in streptozotocin (STZ)-induced diabetic ApoE−/− mice. In high glucose–exposed endothelial cells, metformin treatment and adenoviral overexpression of constitutively active AMPK downregulated mitochondrial superoxide, lowered levels of dynamin-related protein (Drp1) and its translocation into mitochondria, and prevented mitochondrial fragmentation. In contrast, AMPK-α2 deficiency abolished the effects of metformin on Drp1 expression, oxidative stress, and atherosclerosis in diabetic ApoE−/−/AMPK-α2−/− mice, indicating that metformin exerts an antiatherosclerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission. Consistently, mitochondrial division inhibitor 1, a potent and selective Drp1 inhibitor, reduced mitochondrial fragmentation, attenuated oxidative stress, ameliorated endothelial dysfunction, inhibited inflammation, and suppressed atherosclerosis in diabetic mice. These findings show that metformin attenuated the development of atherosclerosis by reducing Drp1-mediated mitochondrial fission in an AMPK-dependent manner. Suppression of mitochondrial fission may be a therapeutic approach for treating macrovascular complications in patients with diabetes.
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“In diabetes, mitochondrial dysfunction induces and aggravates macrovascular complications [218,219].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [218]
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“Wang et al., reported that treatment of streptozotocin (STZ)-induced diabetic mice with metformin (300 mg/kg/day) in their drinking water for 4 weeks suppressed mitochondrial fission through inhibition of dynamin-related protein (Drp1) via an AMPK-dependent process and enhanced mitochondrial fusion (186).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [186]
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Cites
2 retracted
Wang, S., Xu, J. C., Song, P., Viollet, B., & Zou, M. (2009) · Diabetes · doi:10.2337/db09-0267 · Cited by 137
RetractedHypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes
Zhou, J., Wang, Q., Ding, Y., & Zou, M. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0213 · Cited by 17
RetractedReport of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,325
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600
Mitochondrial fusion and fission in cell life and death
Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002 · cited 1×
“Recent work has highlighted the importance of mitochondrial dynamics, particularly mitochondrial fusion and fission, in mitochondrial homeostasis (6).”
BackgroundYu, T., Robotham, J. L., & Yoon, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511154103 · Cited by 1,246
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Toyama, E. Q., Herzig, S., Courchet, J., Lewis, T. L., Losón, O. C., Hellberg, K., Young, N. P., Chen, H., Polleux, F., Chan, D. C., et al. (2016) · Science · doi:10.1126/science.aab4138 · Cited by 1,085
Redox Homeostasis and Mitochondrial Dynamics
Willems, P. H. G. M., Rossignol, R., Dieteren, C. E. J., Murphy, M. P., & Koopman, W. J. H. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.006 · Cited by 876
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–370 of 370
Ning, M., Li, Y., Chen, Z., Han, P., Tang, X., Zhang, Y., & Gao, L. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12985 · Cited by 3
Song, G., Zhang, Y., Jiang, Y., Zhang, H., Gu, W., Xu, X., Yao, J., & Chen, Z. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1119181 · Cited by 3
Wu, Y., Li, Q., Zhu, Y., Zhou, Y., Liu, L., & Li, T. (2023) · Advanced Biology · doi:10.1002/adbi.202300024 · Cited by 3
Dysregulation of Mitochondrial Homeostasis in Cardiovascular Diseases
Patil, R., Wang, H., Kazaleh, M., Ailawadi, G., & Salmon, M. (2025) · Pharmaceuticals · doi:10.3390/ph18010112 · Cited by 4
Naumova, N., Koliada, A. K., Kuzub, N., & Vaiserman, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00012-6 · Cited by 3
Thadeus, M. S., Fauziah, C., Bahar, M., & Nugraha, Y. (2021) · SULUH Jurnal Abdimas · doi:10.35814/suluh.v2i2.1802 · Cited by 3
Dubayee, M. A., Alshahrani, A. S., Aljada, D., Zhra, M., Alotaibi, A., Ababtain, I., Alnaim, M., Alahmari, A. M., Aljarallah, A., Elahi, M. A., et al. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s300048 · Cited by 3
Sun, S., Chen, Q., Wu, B., Huang, Q., & Maimaitijiang, A. (2022) · Computational Intelligence and Neuroscience · doi:10.1155/2022/2685648 · Cited by 3
RetractedNolden, K. A., Kakarla, M., Egner, J. M., Wang, J., Harwig, M. C., Puppala, V. K., Hofeld, B. C., Arnold, L. A., Trykall, D. Z., Peterson, F. C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.16.385054 · Cited by 3
Panusatid, C., Soiyangsuk, R., Tanadjindarat, M., & Peerapittayamongkol, C. (2025) · FEBS Open Bio · doi:10.1002/2211-5463.70165 · Cited by 2
Endothelial mitochondrial homeostasis in the development and progression of atherosclerosis
Remex, N. S., Miah, M. S., Islam, T., Aishwarya, R., Sinha, M. H., Dhar, P., Dhaou, C. B., Orr, A. W., & Bhuiyan, M. S. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1813122 · Cited by 2
Zou, M., & Wu, S. (2021) · Cardiology Discovery · doi:10.1097/cd9.0000000000000009 · Cited by 2
Self-citationMetabolic Regulation of Mitochondrial Dynamics and Cardiac Function
Rudokas, M. W., Cacheux, M., & Akar, F. G. (2022) · Springer eBooks · doi:10.1007/978-3-031-08309-9_6 · Cited by 2
Kp, Z., & Furmanova, O. V. (2018) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.14.2.2018.130564 · Cited by 3
Han, W.-M., Chen, X.-C., Wang, Y., & Li, G. (2020) · doi:10.21203/rs.3.rs-30047/v1 · Cited by 2
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Pourteymour, S., Fan, J., Mahji, R. K., Guo, S., Huang, Z., Liu, Y., Sun, X., Winter, H., Bäcklund, A., Skenteris, N. T., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2057017/v1 · Cited by 2
Yıldız, E., Ayvat, P. U., Şahin, A. S., Pişkin, M., & Soner, B. (2022) · Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences · doi:10.26650/jarhs2022-1105948 · Cited by 1
Liu, M., Wang, L., Wang, L., Yang, T., Xiang, F., Lu, J., Chen, S., Li, H., He, Y., Wang, W., et al. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.153102 · Cited by 1
Guo, Q., Huang, G., Li, W., Ma, Y., Liu, H., Liu, Z., Zhu, L., Ma, L., Zhou, Q., & Zhao, S. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02784-5 · Cited by 1
Ma, R., Liu, J., Yang, S., Chen, G., Ren, J., Zhang, C., Chen, X., Zhao, Y. S., Zhang, J., Yin, C., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158171 · Cited by 1
Temp, J., Strässler, E. T., Freitag, J., Wu, H., Haritonow, N., Landmesser, U., Podzniakova, S., & Barcena, M. L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1903774 · Cited by 1
Li, Y., Zhang, X., Yang, S., Bai, X., Li, X., Hu, L., Sun, C., Cao, Y., Li, T., Yuan, Y., et al. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.08.037 · Cited by 1
Othman, N. S., Aminuddin, A., Hamid, A. A., Abidin, S. Z., Syafruddin, S. E., Ahmad, M. F., Jaffar, F. H. F., Basri, N. A. O., & Ugusman, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177556 · Cited by 1
Li, T., He, M., Li, Z., Wang, D., Xu, Y., Wu, W., & Yan, Y. (2019) · Europe PMC (PubMed Central) · doi:10.12122/j.issn.1673-4254.2019.11.14 · Cited by 1
Zhu, H., Cheng, X., & Fan, Q. (2020) · Endokrynologia Polska · doi:10.5603/ep.a2020.0051 · Cited by 1
Sukhorukov, V. S., Baranich, T. I., Egorova, A. V., Fedorova, E. N., Андреевна, С. К., Алексеевич, Х. Д., & Krapivkin, A. I. (2024) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2024-69-2-12-18 · Cited by 1
Роль імунної системи у механізмі терапевтичної дії метформіну у хворих на цукровий діабет 2-го типу
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Popov, L. (2018) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.1000334 · Cited by 1
Lal, J. C., Zhou, Y., Gore-Panter, S. R., Rennison, J. H., Barnard, J., Wagoner, D. R. V., Cheng, F., & Chung, M. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.17.460826 · Cited by 1
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Faizal, M., & Khan, A. A. (2018) · International Journal of Neurology Research · doi:10.17554/j.issn.2313-5611.2018.04.73
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Eagles, L. (2018) · Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton)
Gorb, Y. G., Strona, V. I., & Komir, I. (2020) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs05.02.018
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Day, E. A. (2020) · MacSphere (McMaster University) · doi:10.71548/25269
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Forbes, T., & George, S. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa227
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Fernández-Álvarez, A. J., Thomas, M. G., Pascual, M. L., Habif, M., Pimentel, J., Corbat, A. A., Pessoa, J., Spina, P. E. L., Boscaglia, L., Plessis, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.31.223099
Faruq, F., Ahsan, S. A., Mahmood, M., Mandal, M., Siddiki, K., Mostofa, A. G., Islam, M. A., Akand, A. I., Saha, S. K., & Parvin, T. (2021) · University Heart Journal · doi:10.3329/uhj.v17i2.54366
Ye, Y., Wang, X., Zhenqing, Y., Xu, Q., & Zhang, B. (2021) · Journal of Biomaterials and Tissue Engineering · doi:10.1166/jbt.2021.2763
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Su, Y., Lu, S., Ren, K., Wang, M., Hou, C., Liu, X., Zhao, S., & Liu, X. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3990740
Fontana, L. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732061632.793538504
Lal, J. C., Mao, C., Zhou, Y., Gore-Panter, S. R., Rennison, J. H., Lovano, B. S., Castel, L., Shin, J., Gillinov, A. M., Smith, J. D., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4102637
Ultrasonic characteristics and influencing factors of atherosclerosis in diabetic patients.
Zhao, Y., Lin, S., Chen, K., Chen, D., & Lai, J. (2022) · PubMed Central
Zhu, Z., Meng, W., & Liu, S. (2022) · Journal of Biomaterials and Tissue Engineering · doi:10.1166/jbt.2022.3211
New pharmacotherapeutic aspects associated with the use of Metformin
Tanushevska, I., Grozdanova, A., Nestorovska, A. K., Naumovska, Z., Dimkovski, A., Mihajloska, E., & Sterjev, Z. (2022) · Macedonian Pharmaceutical Bulletin · doi:10.33320/maced.pharm.bull.2022.68.03.237
Sokolova, A. M., PUSHKAREV, V. V., SOKOLOVA, L. K., Pushkarev, V. M., & Tronko, M. D. (2024) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.20.3.2024.1391
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He, S., Li, P. A., He, J., Wang, Z., Liang, X., He, Z., Jia, S., & Ma, W. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s524020
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Liu, F., Xu, C., Bai, Y., & Yuan, Y. (2025) · Open Medicine · doi:10.1515/med-2025-1262
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Chekuri, A. K. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.11.036
Su, Z.-D.-Z., Li, C.-Q., Wang, H.-W., Zheng, M.-M., & Chen, Q.-W. (2024) · Figshare · doi:10.6084/m9.figshare.26600992
Xiang, X., Pang, H., Ma, T., Du, F., Li, L., Huang, J., Ma, L., & Qiu, L. (2021) · Figshare · doi:10.6084/m9.figshare.14431748
Su, Z.-D.-Z., Li, C.-Q., Wang, H.-W., Zheng, M.-M., & Chen, Q.-W. (2024) · Figshare · doi:10.6084/m9.figshare.26600998
Su, Z.-D.-Z., Li, C.-Q., Wang, H.-W., Zheng, M.-M., & Chen, Q.-W. (2024) · Figshare · doi:10.6084/m9.figshare.26600995
Jiang, H., Song, D., Zhou, X., Chen, F., Yu, Q., Ren, L., Dai, Q., & Zeng, M. (2023) · Figshare · doi:10.6084/m9.figshare.24630334
Su, Z.-D.-Z., Li, C.-Q., Wang, H.-W., Zheng, M.-M., & Chen, Q.-W. (2024) · Figshare · doi:10.6084/m9.figshare.26601001
富田, 一., Tomita, I., 菅原, 翔., 大澤, 紀., 山原, 康., 山原, 真., Takeda, N., 金崎, 雅., 扇田, 久., 荒木, 信., et al. (2020) · Institutional Repositories DataBase (IRDB)
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Becker, P. (2022) · theses.fr (ABES) · doi:10.70675/0bff8b92z95b0z44daz8f52z9e5d3eec2879
Li, W., Liu, J., Fu, X., Liu, Y., Xu, Y., Fang, X., Guo, Q., & Liu, Q. (2026) · Archives of Pharmacal Research · doi:10.1007/s12272-026-01614-z
Liang, R., Lin, P., Yin, D., Wei, P., & Kang, Z. (2026) · Free Radical Research · doi:10.1080/10715762.2026.2665462
Luo, J., Wei, C., Sun, L., Liu, H., Mi, Y., An, Q., Yang, C., Yu, X., Yu, Z., & Ge, H. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113157
Lu, H., Mu, Q., Wang, B., Chen, Y., Zeng, B., Gu, L., & Zhao, W. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114724
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Sud, N. (2026) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2026.162007
Mireles, J. A. G., Espinoza, E. A. R., Loera‐Castañeda, V., Hurtado, L. P. C., Font, A. E. G., Avila, J. C. G., Fierro, I. V., Lares-Asseff, I., Muñoz, C. M., Villa, G. V., et al. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060577
Cheng, S.-A., & Lim, J. H. (2026) · Life · doi:10.3390/life16071135
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An, S., Sun, W., Shi, L., Chen, H., & Mo, Z. (2026) · Molecular Medicine Reports · doi:10.3892/mmr.2026.13987
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Zhang, Q., Chen, Y., Wang, D., Pereira, S., & Kurtyk, M. J. B. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1951400
Metadata
- Authors
- Wang, Q., Zhang, M., Torres, G., Wu, S., Ouyang, C., Xie, Z., & Zou, M.-H.
- Affiliations
- Georgia State University (US)
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Xie, Zhonglin
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2016-10-13
- Volume
- 66
- Issue
- 1
- Pages
- 193-205
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC5204316
- OpenAlex
- W2531934030
- Cited by
- 370
- References
- 55
- Citations by year
- 2026: 21 · 2025: 34 · 2024: 30 · 2023: 38 · 2022: 53 · 2021: 56 · 2020: 43 · 2019: 40 · 2018: 35 · 2017: 18 · 2016: 1
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung and Blood Institute (HL-128014, HL-132500, HL-079584, HL-080499, HL-089920, HL-110488)
- National Institute on Aging (AG-047776)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- metformin, mitochondrial fission, Drp1, AMPK, endothelial cells, mitochondrial superoxide, oxidative stress, endothelial dysfunction, vascular inflammation, ApoE-deficient mice, streptozotocin-induced diabetes, macrovascular complications
- MeSH terms
- Animals, Apolipoproteins E, Diabetes Mellitus, Experimental, Glucose, Humans, Male, Metformin, Superoxides, Reactive Oxygen Species, Mice, Knockout, Oxidative Stress, Dynamins, Atherosclerosis, Mice, Human Umbilical Vein Endothelial Cells, Mitochondrial Dynamics
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