Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion
Open accessAbstract
Excessive glucocorticoid exposure has been shown to be deleterious for pancreatic β-cell function and insulin release. However, glucocorticoids at physiological levels are essential for many homeostatic processes, including glycemic control. We show that corticosterone and cortisol and their less active precursors 11-dehydrocorticosterone (11-DHC) and cortisone suppress voltage-dependent Ca2+ channel function and Ca2+ fluxes in rodent as well as in human β-cells. However, insulin secretion, maximal ATP/ADP responses to glucose, and β-cell identity were all unaffected. Further examination revealed the upregulation of parallel amplifying cAMP signals and an increase in the number of membrane-docked insulin secretory granules. Effects of 11-DHC could be prevented by lipotoxicity and were associated with paracrine regulation of glucocorticoid activity because global deletion of 11β-hydroxysteroid dehydrogenase type 1 normalized Ca2+ and cAMP responses. Thus, we have identified an enzymatically amplified feedback loop whereby glucocorticoids boost cAMP to maintain insulin secretion in the face of perturbed ionic signals. Failure of this protective mechanism may contribute to diabetes in states of glucocorticoid excess, such as Cushing syndrome, which are associated with frank dyslipidemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cortisol modulates insulin secretion in pancreatic beta cells.
“by modulating insulin secretion in pancreatic beta cells ( 36-39 ),”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [37]
The Results section (‘Glucocorticoids Do Not Affect Insulin Secretory Responses’) reports that cortisol treatment did not change insulin secretion in primary human islets. The Discussion explains that glucocorticoids alter β-cell signaling, but compensatory cAMP signaling preserves insulin secretory output rather than changing it. (LLM, conf=0.85)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredHypercortisolism induced by chronic stress, Cushing's syndrome, or medication is a known risk factor for the development of diabetes.
“For instance, hypercortisolism induced by chronic stress, Cushing’s syndrome, or medication is a known risk factor for the development of diabetes.”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [82]
The passage indexed under Abstract (page unavailable) says glucocorticoid excess, including Cushing syndrome, is prodiabetic because it causes glucose intolerance and insulin resistance. It also describes insulin resistance after systemic glucocorticoid administration, but does not specifically address medication use or chronic stress as causes of hypercortisolism. (LLM, conf=0.84)
Experimental — accuracy not yet measuredGlucocorticoid effects on beta cell function depend on the dose, potency, duration of exposure, cellular context, and susceptibility of the cell line.
“These arise because glucocorticoid effects depend on the dose, potency, and duration of exposure of the steroid used, the cellular context (e.g., in vivo vs. in vitro ) and the susceptibility of the cell line ( 37 ).”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [37]
The introductory passage in our copy (page unavailable) says that effects on insulin secretion vary with steroid potency, concentration, and treatment duration. The Discussion also contrasts isolated-islet and in vivo administration and notes differences between islets from obese and wild-type mice. These passages support the dose, duration, and cellular-context points, but do not establish susceptibility of a particular cell line. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Segerstolpe, Å., Palasantza, A., Eliasson, P., Andersson, E.-M., Andréasson, A.-C., Sun, X., Picelli, S., Sabirsh, A., Clausen, M., Bjursell, M. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.020 · Cited by 1,550 · see citing works
Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201 · see citing works
Kotelevtsev, Y. V., Holmes, M. C., Burchell, A. N., Houston, P., Schmoll, D., Jamieson, P. M., Best, R., Brown, R., Edwards, C. R. W., Seckl, J. R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14924 · Cited by 858 · see citing works
Glucocorticoids and insulin resistance: old hormones, new targets
ANDREWS, R. C., & WALKER, B. R. (1999) · Clinical Science · doi:10.1042/cs0960513 · Cited by 731 · see citing works
Seckl, J. R., & Walker, B. R. (2001) · Endocrinology · doi:10.1210/endo.142.4.8114 · Cited by 714 · see citing works
Inactivation of specific β cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65390 · Cited by 520 · see citing works
Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase
Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J., & Nagata, Y. (2004) · Structure · doi:10.1016/j.str.2004.02.005 · Cited by 502 · see citing works
A genetically encoded fluorescent reporter of ATP:ADP ratio
Berg, J., Hung, Y. P., & Yellen, G. (2009) · Nature Methods · doi:10.1038/nmeth.1288 · Cited by 481 · see citing works
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J.-I., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707054104 · Cited by 425 · see citing works
Lambillotte, C., Gilon, P., & Henquin, J. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119175 · Cited by 419 · see citing works
Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells
Ämmälä, C., Ashcroft, F. M., & Rorsman, P. (1993) · Nature · doi:10.1038/363356a0 · Cited by 377 · see citing works
Regulation and organization of adenylyl cyclases and cAMP
COOPER, D. M. F. (2003) · Biochemical Journal · doi:10.1042/bj20031061 · Cited by 356 · see citing works
Pancreatic β-cell identity, glucose sensing and the control of insulin secretion.
Rutter, G., Pullen, T., Hodson, D., & Martinez-Sánchez, A. (2015) · Biochemical Journal · doi:10.1042/bj20141384 · Cited by 344 · see citing works
Self-citationPancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.
Delaunay, F., Khan, A. R., Cintra, A., Davani, B., Ling, Z. C., Andersson, A., Östenson, C., Gustafsson, J.-Α., Efendić, S., & Okret, S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119743 · Cited by 331 · see citing works
Regulation of ATP production by mitochondrial Ca2+
Tarasov, A. I., Griffiths, E. J., & Rutter, G. A. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.03.003 · Cited by 319 · see citing works
Self-citationCell physiology of cAMP sensor Epac
Holz, G. G., Kang, G., Harbeck, M. C., Roe, M. W., & Chepurny, O. G. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.119644 · Cited by 275 · see citing works
11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess
Morgan, S., McCabe, E. L., Gathercole, L., Hassan-Smith, Z. K., Larner, D. P., Bujalska, I. J., Stewart, P. M., Tomlinson, J., & Lavery, G. G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323681111 · Cited by 273 · see citing works
Self-citationGlucocorticoids and insulin resistance: old hormones, new targets
Andrews, R. C., & Walker, B. R. (1999) · Clinical Science · doi:10.1042/cs19980388 · Cited by 266 · see citing works
Lipotoxicity disrupts incretin-regulated human β cell connectivity
Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W.-H., Bugliani, M., Marchetti, P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68459 · Cited by 210 · see citing works
Self-citationInterplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line
Landa, L. R., Harbeck, M. C., Kaihara, K. A., Chepurny, O. G., Kitiphongspattana, K., Graf, O., Nikolaev, V. O., Lohse, M. J., Holz, G. G., & Roe, M. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505657200 · Cited by 201 · see citing works
Glucose-Induced Cyclic AMP Oscillations Regulate Pulsatile Insulin Secretion
Dyachok, O., Idevall-Hagren, O., Sågetorp, J., Tian, G., Wuttke, A., Arrieumerlou, C., Akusjärvi, G., Gylfe, E., & Tengholm, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.003 · Cited by 193 · see citing works
Pathophysiology of Dyslipidemia in Cushing’s Syndrome
Arnaldi, G., Scandali, V. M., Trementino, L., Cardinaletti, M., Appolloni, G., & Boscaro, M. (2010) · Neuroendocrinology · doi:10.1159/000314213 · Cited by 189 · see citing works
Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes.
Ogawa, A., Johnson, J. H., Ohneda, M., McAllister, C. T., Inman, L., Alam, T., & Unger, R. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115886 · Cited by 159 · see citing works
Gremlich, S., Roduit, R., & Thorens, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3216 · Cited by 155 · see citing works
Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells
Piccand, J., Strasser, P., Hodson, D. J., Meunier, A., Ye, T., Keime, C., Birling, M., Rutter, G. A., & Gradwohl, G. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.033 · Cited by 153 · see citing works
Self-citationADCY5 Couples Glucose to Insulin Secretion in Human Islets
Hodson, D. J., Mitchell, R. K., Marselli, L., Pullen, T. J., Gimeno Brias, S., Semplici, F., Everett, K. L., Cooper, D. M. F., Bugliani, M., Marchetti, P., et al. (2014) · Diabetes · doi:10.2337/db13-1607 · Cited by 147 · see citing works
Self-citationStamateris, R. E., Sharma, R. B., Hollern, D. A., & Alonso, L. C. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00040.2013 · Cited by 138 · see citing works
Dissecting the role of glucocorticoids on pancreas development.
Gésina, E., Tronche, F., Herrera, P., Duchêne, B., Tales, W., Czernichow, P., & Bréant, B. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2322 · Cited by 124 · see citing works
Lyon, J., Fox, J. E. M., Spigelman, A., Kim, R., Smith, N., O'Gorman, D., Kin, T., Shapiro, A. M. J., Rajotte, R., & Macdonald, P. (2016) · Endocrinology · doi:10.1210/en.2015-1562 · Cited by 120 · see citing works
Davani, B., Khan, A., Hult, M., Mårtensson, E., Okret, S., Efendić, S., Jörnvall, H., & Oppermann, U. C. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000600200 · Cited by 112 · see citing works
Glucocorticoids suppress β-cell development and induce hepatic metaplasia in embryonic pancreas
Shen, C., Seckl, J. R., Slack, J. M. W., & Tosh, D. (2003) · Biochemical Journal · doi:10.1042/bj20030140 · Cited by 99 · see citing works
Li, J., Shuai, H., Gylfe, E., & Tengholm, A. (2013) · Diabetologia · doi:10.1007/s00125-013-2894-0 · Cited by 93 · see citing works
Weight Loss Increases 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in Human Adipose Tissue
Tomlinson, J., Moore, J. S., Clark, P. M. S., Holder, G., Shakespeare, L., & Stewart, P. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031376 · Cited by 90 · see citing works
Crosstalk between the cAMP and Inositol Trisphosphate-Signalling Pathways in Pancreatic β-Cells
Liu, Y., Grapengiesser, E., Gylfe, E., & Hellman, B. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0458 · Cited by 88 · see citing works
Kitaguchi, T., Oya, M., Wada, Y., Tsuboi, T., & Miyawaki, A. (2013) · Biochemical Journal · doi:10.1042/bj20121022 · Cited by 88 · see citing works
cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells
Idevall‐Hagren, O., Barg, S., Gylfe, E., & Tengholm, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095992 · Cited by 84 · see citing works
Zhu, L., Almaça, J., Dadi, P., Hong, H., Sakamoto, W., Rossi, M., Lee, R. J., Vierra, N., Lu, H.-Y., Cui, Y.-H., et al. (2017) · Nature Communications · doi:10.1038/ncomms14295 · Cited by 82 · see citing works
Self-citationRafacho, A., Marroquí, L., Taboga, S. R., Abrantes, J. L. F., Silveira, L. R., Boschero, A. C., Carneiro, E. M., Bosqueiro, J. R., Nadal, A., & Quesada, I. (2010) · Endocrinology · doi:10.1210/en.2009-0704 · Cited by 80 · see citing works
Kaihara, K. A., Dickson, L. M., Jacobson, D. A., Tamarina, N., Roe, M. W., Philipson, L. H., & Wicksteed, B. (2013) · Diabetes · doi:10.2337/db12-1013 · Cited by 80 · see citing works
Self-citationDetimary, P., Gilon, P., Nenquin, M., & Henquin, J. C. (1994) · Biochemical Journal · doi:10.1042/bj2970455 · Cited by 75 · see citing works
Jacobson, D. A., Mendez, F., Thompson, M., Torres, J., Cochet, O., & Philipson, L. H. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190207 · Cited by 73 · see citing works
Self-citationSwali, A., Walker, E. A., Lavery, G. G., Tomlinson, J., & Stewart, P. M. (2008) · Diabetologia · doi:10.1007/s00125-008-1137-2 · Cited by 63 · see citing works
Self-citationIncretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans
Hodson, D. J., Tarasov, A. I., Brias, S. G., Mitchell, R. K., Johnston, N. R., Haghollahi, S., Cane, M. C., Bugliani, M., Marchetti, P., Bosco, D., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1038 · Cited by 62 · see citing works
Self-citationPullen, T. J., Huising, M. O., & Rutter, G. A. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00041 · Cited by 57 · see citing works
Self-citationPlasma membrane depolarization as a determinant of the first phase of insulin secretion
Hatlapatka, K., Willenborg, M., & Rustenbeck, I. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90981.2008 · Cited by 50 · see citing works
Tian, G., Sol, E.-R. M., Xu, Y., Shuai, H., & Tengholm, A. (2014) · Diabetes · doi:10.2337/db14-1036 · Cited by 43 · see citing works
Turban, S., Liu, X., Ramage, L. E., Webster, S. P., Walker, B. R., Dunbar, D. R., Mullins, J. J., Seckl, J. R., & Morton, N. M. (2012) · Diabetes · doi:10.2337/db11-1054 · Cited by 31 · see citing works
Ortsäter, H., Alberts, P., Berglund, U. W., Engblom, L. O. M., Abrahmsén, L., & Bergsten, P. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.525 · Cited by 30 · see citing works
Koizumi, M., & Yada, T. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0462 · Cited by 27 · see citing works
Biomarkers of hypothalamic–pituitary–adrenal axis activity in mice lacking 11β-HSD1 and H6PDH
Abrahams, L., Semjonous, N. M., Guest, P., Zielinska, A. E., Hughes, B. A., Lavery, G. G., & Stewart, P. M. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0178 · Cited by 14 · see citing works
Self-citationChowdhury, S., Grimm, L., Gong, Y. J. K., Wang, B., Li, B., Srikant, C. B., Gao, Z., & Liu, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136656 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The multiple roles of life stress in metabolic disorders
Mika Kivimaki, B., Bartolomucci, A., & Kawachi, I. I. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00746-8 · Cited by 329 · see citing works
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271 · see citing works
Glucocorticoid Metabolism in Obesity and Following Weight Loss
Akalestou, E., Genser, L., & Rutter, G. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00059 · Cited by 129 · see citing works
Self-citationSteroid-induced hyperglycemia: An underdiagnosed problem or clinical inertia? A narrative review
Bonaventura, A., & Montecucco, F. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.006 · Cited by 108 · see citing works
Wang, Q., Xu, J., Li, X., Liu, Z., Han, Y., Xu, X., Li, X., Tang, Y., Liu, Y., Tao, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28918 · Cited by 106 · see citing works
Mathematical Modelling of Endocrine Systems
Zavala, E., Wedgwood, K. C. A., Voliotis, M., Tabak, J., Spiga, F., Lightman, S. L., & Tsaneva-Atanasova, K. (2019) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.01.008 · Cited by 81 · see citing works
Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
Diz-Chaves, Y., Herrera-Pérez, S., González-Matías, L. C., Lamas, J. A., & Mallo, F. (2020) · Nutrients · doi:10.3390/nu12113304 · Cited by 84 · see citing works
Cancer Biology and Prevention in Diabetes
Srivastava, S. P., & Goodwin, J. E. (2020) · Cells · doi:10.3390/cells9061380 · Cited by 72 · see citing works
Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?
Mayayo‐Peralta, I., Zwart, W. T., & Preković, S. (2021) · Endocrine Related Cancer · doi:10.1530/erc-20-0489 · Cited by 63 · see citing works
Wu, T., Shao, Y., Li, X., Wu, T., Yu, L. K., Liang, J. H., Zhang, Y., Wang, J., Sun, T., Zhu, Y., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2200625 · Cited by 64 · see citing works
Zhang, Y., Wang, M., Xu, X. M., Liu, Y., & Xiao, C. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28838 · Cited by 40 · see citing works
Perinatal programming of metabolic diseases: The role of glucocorticoids
Facchi, J. C., de Lima, T. A. L., de Oliveira, L. R., Costermani, H. D. O., Miranda, G. D. S., & de Oliveira, J. C. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154047 · Cited by 37 · see citing works
Glucose metabolism in Cushing's syndrome
Sharma, A. R., & Vella, A. V. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000537 · Cited by 39 · see citing works
Aylward, A., Okino, M.-L., Benaglio, P., Chiou, J., Beebe, E., Padilla, J. A., Diep, S., & Gaulton, K. J. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009531 · Cited by 31 · see citing works
Williams, H., Howell, C. R., Chemaitilly, W., Wilson, C. L., Karol, S. E., Nolan, V. G., Smeltzer, M. P., Green, D. M., Ehrhardt, M. J., Mulrooney, D. A., et al. (2019) · Cancer · doi:10.1002/cncr.32596 · Cited by 29 · see citing works
Martín, A. S., Arce‐Molina, R., Aburto, C., Baeza‐Lehnert, F., Barros, L. F., Contreras‐Baeza, Y., Pinilla, A., Ruminot, I., Rauseo, D., & Sandoval, P. Y. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.012 · Cited by 28 · see citing works
Qin, R., Lin, D., Zhang, L., Xiao, F., & Guo, L. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28969 · Cited by 27 · see citing works
Maternal hypothyroidism in mice influences glucose metabolism in adult offspring
Kemkem, Y., Nasteska, D., de Bray, A., Bargi‐Souza, P., Garcia, R. A. P., Guillou, A., Mollard, P., Hodson, D. J., & Schaeffer, M. (2020) · Diabetologia · doi:10.1007/s00125-020-05172-x · Cited by 26 · see citing works
Self-citationTholen, S., Patel, R., Agas, A., Kovary, K. M., Rabiee, A., Nicholls, H. T., Bielczyk-Maczyńska, E., Yang, W., Kraemer, F. B., & Teruel, M. N. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111018 · Cited by 24 · see citing works
Mifepristone Improves Adipose Tissue Insulin Sensitivity in Insulin Resistant Individuals
Gubbi, S., Muniyappa, R., Sharma, S. T., Grewal, S., McGlotten, R., & Nieman, L. K. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab046 · Cited by 23 · see citing works
Song, H., Wang, M., & Xin, T. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28945 · Cited by 19 · see citing works
Ma, C., Fan, L., Wang, J., Hao, L., & He, J. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-01008-9 · Cited by 19 · see citing works
Lu, K., Liu, X., & Guo, W. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28935 · Cited by 17 · see citing works
Delangre, E., Liu, J., Tolu, S., Maouche, K., Armanet, M., Cattan, P., Pommier, G., Bailbé, D., & Movassat, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04419-8 · Cited by 15 · see citing works
Dalle, S., & Abderrahmani, A. (2024) · Cells · doi:10.3390/cells13151244 · Cited by 14 · see citing works
Meal Timing and Glycemic Control during Pregnancy—Is There a Link?
Zhu, S., Surampudi, P. N., Field, N. T., & Chondronikola, M. (2021) · Nutrients · doi:10.3390/nu13103379 · Cited by 13 · see citing works
Gojda, J., Koudelková, K., Ouřadová, A., Lang, A., Krbcová, M., Gvozdeva, A., Šebo, V., Slagmolen, L., Potočková, J., Tůma, P., et al. (2023) · Nutrition and Diabetes · doi:10.1038/s41387-023-00241-7 · Cited by 13 · see citing works
Wang, Y., Chen, H., Li, Y., Hao, H., Liu, J., Chen, Y., Meng, J., Zhang, S., Gu, W., Lyu, Z., et al. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2023.12.006 · Cited by 12 · see citing works
Henriquez, A. R., Snow, S. J., Schladweiler, M. C. J., Miller, C. N., & Kodavanti, U. P. (2020) · Inhalation Toxicology · doi:10.1080/08958378.2020.1759736 · Cited by 12 · see citing works
Wang, H., Duan, A., Zhang, J., Wang, Q., Xing, Y., Qin, Z. S., Liu, Z., & Yang, J. (2021) · Communications Biology · doi:10.1038/s42003-021-02209-8 · Cited by 11 · see citing works
Henquin, J. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154821 · Cited by 12 · see citing works
Karagiannopoulos, A., Westholm, E., Ofori, J. K., Cowan, E., Esguerra, J. L. S., & Eliasson, L. (2023) · iScience · doi:10.1016/j.isci.2023.106555 · Cited by 10 · see citing works
Snow, S. J., Henriquez, A. R., Fisher, A., Vallanat, B., House, J. S., Schladweiler, M. C. J., Wood, C. E., & Kodavanti, U. P. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115427 · Cited by 10 · see citing works
4-Phenylbutyric acid protects islet β cell against cellular damage induced by glucocorticoids
Zhou, X., Xu, Y., Gu, Y., & Sun, M. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06211-5 · Cited by 9 · see citing works
Sensitivity of the Neuroendocrine Stress Axis in Metabolic Diseases
Cozma, D., Siatra, P., Bornstein, S. R., & Steenblock, C. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2201-6641 · Cited by 9 · see citing works
Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease
Zavala, E., Gil-Gómez, C. A., Wedgwood, K. C. A., Burgess, R., Tsaneva-Atanasova, K., & Herrera-Valdez, M. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.27.968354 · Cited by 8 · see citing works
Glucocorticoid therapy is a risk factor for cardiovascular diseases
Dzherieva, I. S., Волкова, Н. И., Davidenko, I. Y., Reshetnikov, I., Brovkina, S. S., Avakova, S. M., & Tishchenko, Y. V. (2022) · Medical Herald of the South of Russia · doi:10.21886/2219-8075-2022-13-3-93-106 · Cited by 8 · see citing works
Zhao, Q., Zhou, J., Pan, Y., Ju, H., Zhū, L., Liu, Y., & Zhang, Y. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01566-w · Cited by 8 · see citing works
Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes
Perna‐Barrull, D., Gieras, A., Rodríguez-Fernández, S., Tolosa, E., & Vives‐Pi, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00540 · Cited by 8 · see citing works
Messika, A., Toledano, Y., Hadar, E., Tauman, R., Froy, O., & Shamir, R. (2024) · Nutrients · doi:10.3390/nu17010157 · Cited by 7 · see citing works
Brix, J. M., Tura, A., Herz, C. T., Feder, A., Krzizek, E.-C., Parzer, V., Pacini, G., & Ludvik, B. H. (2021) · Obesity Facts · doi:10.1159/000517766 · Cited by 6 · see citing works
Adrenal Glands, Pineal Gland, and the Circadian Rhythm: Structure and Physiology
Al-Suhaimi, E. A., & Khan, F. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-9016-7_7 · Cited by 6 · see citing works
Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective
Huey, J., Keutler, K., & Schultz, C. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.07.023 · Cited by 5 · see citing works
Salimi, M., Eskandari, F., Khodagholi, F., Abdollahifar, M., Hedayati, M., Zardooz, H., & Keyhanmanesh, . (2022) · HORMONES · doi:10.1007/s42000-022-00383-w · Cited by 4 · see citing works
Glucocorticoid-Induced Hyperinsulinism in a Preterm Neonate with Inherited ABCC8 Variant
Motte‐Signoret, E., Saint‐Martin, C., Bellanné‐Chantelot, C., Portha, B., & Boileau, P. (2022) · Metabolites · doi:10.3390/metabo12090847 · Cited by 4 · see citing works
Nutrient and non-nutrient regulators of insulin secretion
Kolic, J., Assaf, N., & Johnson, J. D. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-026-01281-6 · Cited by 3 · see citing works
Mathias, P. C. D. F., Rodrigues, A. M. D., Lisboa, P. C., Miranda, R. A., Malta, A., Ribeiro, T. A., Barella, L. F., Miranda, G. D. S., de Lima, T. A. L., Gomes, R. M., et al. (2024) · Biology · doi:10.3390/biology13121036 · Cited by 3 · see citing works
Wang, B., Yang, Y., Yuan, H., & Li, X. (2021) · International Journal of Endocrinology · doi:10.1155/2021/9536730 · Cited by 3 · see citing works
Tijani, O. K., Moreno-Lopez, M., Louvet, I., Acosta-Montalvo, A., Coddeville, A., Gmyr, V., Kerr-Conte, J., Pattou, F. N., Vantyghem, M., Saponaro, C., et al. (2024) · Annales d Endocrinologie · doi:10.1016/j.ando.2024.101676 · Cited by 3 · see citing works
Li, S., Zhang, S., Rensen, P. C. N., Meijer, O. C., Kooijman, S., & Kroon, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123080 · Cited by 2 · see citing works
Glucocorticoids: novel agents to stimulate beta-cell neogenesis?
Russell, M. A., & Leete, P. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.03.25 · Cited by 2 · see citing works
Mathematical Modeling of the Endocrine System
Bulgakova, S. V., Romanchuk, N., & Treneva, E. V. (2022) · Bulletin of Science and Practice · doi:10.33619/2414-2948/76/16 · Cited by 1 · see citing works
Antevska, A., Long, C. C., Dupuy, S. D., Collier, J. J., Karlstad, M. D., & Do, T. D. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00668 · Cited by 2 · see citing works
Sarriyah, J. F., Alghamdi, A., Al-Otaibi, N. M., Abdulrahman, B. B., & Aljaed, K. M. (2024) · Cureus · doi:10.7759/cureus.54430 · Cited by 1 · see citing works
Akbib, S., Stichelmans, J., Stangé, G. M., Ling, Z., Assefa, Z., & Hellemans, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212210 · Cited by 1 · see citing works
Endocrine Regulation of the Pancreas by Insulin-like Growth Factors
Liu, J., Kaddour, N., Xega, V., & Gao, Z. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00016-8 · Cited by 1 · see citing works
Knowledge and Applications of the Nurses: the Application of Corticosteroid
Boyraz, S., & KÖK, A. (2022) · Hemşirelik Bilimi Dergisi · doi:10.54189/hbd.1116552
Methylprednisolone Protects Human Pancreatic Beta Cells From Inflammation-induced Damage
Paz-Barba, M., Peters, I., de Graaf, N., Carlotti, F., & de Koning, E. J. P. (2025) · Transplantation Direct · doi:10.1097/txd.0000000000001770
Pancreatic HB9 protein expression is affected by long-term high-fat diet in female rat dams
Karbaschi, R., Salimi, M., & Zardooz, H. (2025) · Economy of Tajikistan · doi:10.61882/phypha.29.3.284
Delangre, E. (2021) · theses.fr (ABES) · doi:10.70675/622d48edz59dcz427ez85c9z9da5f8129e84
Xu, Q.-Y., Zhang, J., Wan, X., Ling, W., Yang, J.-C., & Yan, L. (2026) · Military Medical Research · doi:10.1016/j.mmr.2026.100037
- Authors
- Fine, N. H. F., Doig, C. L., Elhassan, Y. S., Vierra, N. C., Marchetti, P., Bugliani, M., Nano, R., Piemonti, L., Rutter, G. A., Jacobson, D. A., Lavery, G. G., & Hodson, D. J.
- Affiliations
- University of Birmingham (GB)
- Vanderbilt University (US)
- University of Pisa (IT)
- IRCCS Ospedale San Raffaele (IT)
- Imperial College London (GB)
- University of Nottingham (GB)
- Corresponding author
- Hodson, David J.
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2017-12-04
- Volume
- 67
- Issue
- 2
- Pages
- 278-290
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC5780059
- OpenAlex
- W2773672092
- Cited by
- 61
- References
- 50
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 11 · 2018: 1
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Spiral (Imperial College London) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- National Institutes of Health (R01-DK-097392)
- American Diabetes Association (1-17-IBS-024)
- JDRF (1-RSC-2014-90-I-X)
- Wellcome Trust (WT098424AIA)
- Medical Research Council (MR/J0003042/1)
- Biological and Biotechnology Research Council (BB/J015873/1)
- Diabetes UK (11/0004210, MR/N00275X/1, 104612/Z/14/Z, 12/0004431)
- European Foundation for the Study of Diabetes ((EFSD)/Novo Nordisk Rising Star Fellowship)
- European Research Council (715884)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, pancreatic beta cells, insulin secretion, corticosterone, cortisol, 11-dehydrocorticosterone, cortisone, voltage-gated calcium channels, calcium flux, cAMP signaling, insulin secretory granules, 11β-hydroxysteroid dehydrogenase type 1, lipotoxicity, Cushing's syndrome, dyslipidemia
- MeSH terms
- Insulin Secretion, Cyclic AMP, Animals, Cell Differentiation, Corticosterone, Cortisone, Glucocorticoids, Glucose, Humans, Hydrocortisone, Insulin, Kinetics, Mice, Inbred Strains, Calcium Channels, Biomarkers, Mice, Knockout, Calcium Signaling, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Tissue Culture Techniques, Insulin-Secreting Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
