Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes

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IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance

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DNA methylation in the pathogenesis of type 2 diabetes in humans

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Body mass index history and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

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Insulin-Like Growth Factor-I Stimulates Both Cell Growth and Lipogenesis during Differentiation of Human Mesenchymal Stem Cells into Adipocytes

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Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women

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Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study

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Probe Lasso: A novel method to rope in differentially methylated regions with 450K DNA methylation data

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Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data

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Gender-Specific Changes in Bone Turnover and Skeletal Architecture in Igfbp-2-Null Mice

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IGFBP-2: The dark horse in metabolism and cancer

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Associations of Adiposity from Childhood into Adulthood with Insulin Resistance and the Insulin-Like Growth Factor System: 65-Year Follow-Up of the Boyd Orr Cohort

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The IGF1 P2 promoter is an epigenetic QTL for circulating IGF1 and human growth

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Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3 in Relation to the Risk of Type 2 Diabetes Mellitus: Results From the EPIC–Potsdam Study

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Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men

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Insulin‐Like Growth Factor (IGF) Binding Protein‐2, Independently of IGF‐1, Induces GLUT‐4 Translocation and Glucose Uptake in 3T3‐L1 Adipocytes

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Epigenetic dysregulation of the IGF system in placenta of newborns exposed to maternal impaired glucose tolerance

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The P2 promoter of the IGF1 gene is a major epigenetic locus for GH responsiveness

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T2DM: Why Epigenetics?

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IGFBP-2 at the interface of growth and metabolism--implications for childhood obesity.

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Expression patterns of insulin-like growth factor system members and their correlations with growth and carcass traits in Landrace and Lantang pigs during postnatal development

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Glucose metabolism and hepatic Igf1 DNA methylation are altered in the offspring of dams fed a low-salt diet during pregnancy

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Trends in insulin resistance: insights into mechanisms and therapeutic strategy

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Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes

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Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

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A knowledge graph to interpret clinical proteomics data

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Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model

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Genetic and epigenetic factors determining NAFLD risk

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Signaling Pathways of the Insulin-like Growth Factor Binding Proteins

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Bacteriophage-mediated manipulation of the gut microbiome – promises and presents limitations

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Epigenetic regulation of insulin action and secretion – role in the pathogenesis of type 2 diabetes

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Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

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Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis

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Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance

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DNA methylation and type 2 diabetes: a systematic review

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Epigenetic contribution to obesity

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Clinical Knowledge Graph Integrates Proteomics Data into Clinical Decision-MakingPreprint

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Associations of plasma proteomics with type 2 diabetes and related traits: results from the longitudinal KORA S4/F4/FF4 Study

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Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes

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Circulating IGFBP‐2: a novel biomarker for incident dementia

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Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1).

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Proteomic Analyses in Diverse Populations Improved Risk Prediction and Identified New Drug Targets for Type 2 Diabetes

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Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis

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Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men

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The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases

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Metabolic syndrome and the plasma proteome: from association to causation

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Differential production of insulin-like growth factor-binding proteins in liver fibrosis progression

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Adiponectin, IGFBP-1 and -2 are independent predictors in forecasting prediabetes and type 2 diabetes

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Biomarker-defined pathways for incident type 2 diabetes and coronary heart disease—a comparison in the MONICA/KORA study

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The impact of circulating IGF-1 and IGFBP-2 on cardiovascular prognosis in patients with acute coronary syndrome

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Circulating IGFBP-2 levels are inversely associated with the incidence of nonalcoholic fatty liver disease: A cohort study

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A Panel of 6 Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA/KORA Study Population

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Low IGF1 and high IGFBP1 predict diabetes onset in prediabetic patients

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Bioinformatics Analysis of Next Generation Sequencing Data Identifies Molecular Biomarkers Associated With Type 2 Diabetes Mellitus

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IGFBP2 secretion by mammary adipocytes limits breast cancer invasion

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Protein Markers of Diabetes Discovered in an African American Cohort

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Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects

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Increased concentrations of myeloperoxidase in serum and serum extracellular vesicles are associated with type 2 diabetes mellitus

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Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes

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Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis

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Skeletal Muscle Gene Expression Signatures of Obese High and Low Responders to Endurance Exercise Training

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Proteome-wide assessment of diabetes mellitus in Qatari identifies IGFBP-2 as a risk factor already with early glycaemic disturbances

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Multi-omics characterization of type 2 diabetes associated genetic variationPreprint

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Incretin-based therapy: a new horizon in diabetes management

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Plasma proteomic profile of abdominal obesity in older adults

Sathyan, S., Milman, S., Ayers, E. I., Gao, T., Verghese, J., & Barzilai, N. (2024) · Obesity · doi:10.1002/oby.24000 · Cited by 9 · see citing works

Neuropathological links between T2DM and LOAD: systematic review and meta-analysis

Lemche, E., Hortobágyi, T., Kiecker, C. M., & Turkheimer, F. (2025) · Physiological Reviews · doi:10.1152/physrev.00040.2024 · Cited by 8 · see citing works

Tissue-specific roles of IGFBP2 in glucose and lipid metabolism in obesity-related metabolic diseases

Song, X., Zhong, W., Zheng, H., Ou, X., Zheng, D., & Li, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1814752 · Cited by 7 · see citing works

Circulating IGF-1 and IGFBP-2 may be biomarkers for risk stratification in patients with acute coronary syndrome: A prospective cohort study

Wang, W., Sun, Y., Mo, D.-G., Li, T., & Yao, H.-C. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.05.030 · Cited by 5 · see citing works

Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain health

Fan, Y., Yuan, J., Han, F., Somekh, J., Mor Peleg, B., Wu, F. L., Jia, Z., Zhu, Y., & Huang, Z. (2025) · Brain · doi:10.1093/brain/awaf057 · Cited by 5 · see citing works

The potential of circulating free DNA of methylated IGFBP as a biomarker for type 2 diabetes Mellitus: A Comprehensive review

Belinda, A., Humardani, F. M., Putra, S. E. D., & Widyadhana, B. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.120104 · Cited by 4 · see citing works

Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women

Mendham, A. E., Micklesfield, L. K., Karpe, F., Kengne, A. P., Chikowore, T., Kufe, C. N., Masemola, M., Crowther, N. J., Norris, S. A., Olsson, T., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05788-1 · Cited by 4 · see citing works

Type-2 diabetes epigenetic biomarkers: present status and future directions for global and Indigenous health

Munns, S., Brown, A. D. H., & Buckberry, S. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1502640 · Cited by 6 · see citing works

Role of inflammatory and Growth factors in diabetes mellitus

Firdous, S. M., & Pal, S. (2024) · Palestinian medical and pharmaceutical journal/Palestinian medical & pharmaceutical journal · doi:10.59049/2790-0231.1153 · Cited by 3 · see citing works

Analysis of key genes and pathways associated with the pathogenesis of Type 2 diabetes mellitusPreprint

Alur, V. C., Raju, V., Vastrad, B. M., Vastrad, C. M., & Kotrashetti, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.12.456106 · Cited by 3 · see citing works

Lycium barbarum polysaccharide regulates serum metabolites in type 2 diabetic patients with the metabolomics-based approach of GC-TOF-MS

Zhu, Z., Sui, J., Cai, H., Zhou, B., Hu, B., Wang, Y., Gong, D., Wang, S., Yang, L., Liao, W., et al. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2024.12.001 · Cited by 2 · see citing works

Circulating epigenetic signatures classifying brain insulin resistance in humans

Kullmann, S., Singh, A., Sehgal, R., Eichelmann, F., Sandforth, L., Wilms, B., Jähnert, M., Peter, A., Meyhöfer, S., Walther, D., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adv7834 · Cited by 2 · see citing works

Is Predisposition to T2D Impacted by Polymorphisms in Genes Involved in Insulin Signaling and Cellular Bioenergetics?

Pati, B., Jastroch, M., & Bal, N. C. (2025) · Acta Physiologica · doi:10.1111/apha.70122 · Cited by 3 · see citing works

A novel method of immunomodulation of endothelial cells using Streptococcus pyogenes and its lysate

Arokiaraj, M. C., & Wilson, J. J. (2021) · European Journal of Clinical and Experimental Medicine · doi:10.15584/ejcem.2021.2.2 · Cited by 2 · see citing works

Biomarker signatures associated with ageing free of major chronic diseases: results from a population-based sample of the EPIC-Potsdam cohort

Reichmann, R., Schulze, M. B., Pischon, T., Weikert, C., & Aleksandrova, K. (2024) · Age and Ageing · doi:10.1093/ageing/afae041 · Cited by 2 · see citing works

IGFBP2 protects against pulmonary fibrosis through inhibiting P21-mediated senescencePreprint

Chin, C., Lee, J., Ravichandran, R., Fleming, T. P., Wheatcroft, S. B., Kearney, M. T., Bremner, R. M., Mohanakumar, T., Flint, D. J., & Sureshbabu, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.21.427684 · Cited by 2 · see citing works

Stratifying high-risk prediabetes clusters using blood-based epigenetic markers

Singh, A., von Schwartzenberg, R. J., Wagner, R., Sandforth, L., Sandforth, A., Jähnert, M., Ganslmeier, M., Kabisch, S., Perakakis, N., Preissl, H. T., et al. (2026) · Biomarker Research · doi:10.1186/s40364-025-00887-8 · Cited by 1 · see citing works

Greater Concentrations of IGF Binding Protein-2 after Bariatric Surgery Compared with Diet

Aneke-Nash, C. S., Borden, S., Werth, E. G., Leskowitz, J., Ramakrishnan, R., Sagredo, J. A., Reid, T. J., Krikhely, A., Bessler, M., Brown, L. M., et al. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf218 · Cited by 1 · see citing works

Dissecting Genetic and Environmental Determinants of Plasma Molecular Signatures and Their Link to Type 2 Diabetes RiskPreprint

Sevilla-González, M. D. R., Wang, N., Hanson, P. A., Bebo, A., Hitchcock, D. S., Hsu, S. C., Westerman, K. E., CROMER, S. J., Barry, V. G., Borns-Weil, Y., et al. (2025) · medRxiv · doi:10.1101/2025.11.26.25341007 · Cited by 1 · see citing works

Niedriger IGFBP-2-Spiegel deutet auf erhöhtes Diabetesrisiko hin

DZD (2019) · Info Diabetologie · doi:10.1007/s15034-019-1455-0

10 Jahre DZD

Niesing, B. (2019) · Diabetes aktuell · doi:10.1055/a-0873-5656

The short-term high fat diet-induced increase in %5-methylcytosine expression in peripheral blood T lymphocytes, is attenuated by low-dose aspirinPreprint

Mutize, T., Dludla, P. V., Mkandla, Z., & Nkambule, B. B. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/825125

Additional file 2 of Metabolic syndrome and the plasma proteome: from association to causation

Elhadad, M. A., Wilson, R., Zaghlool, S. B., Huth, C., Gieger, C., Grallert, H., Graumann, J., Rathmann, W., Köenig, W., Sinner, M. F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14634053

Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomesPreprint

Huang, Z. (2024) · medRxiv · doi:10.1101/2024.05.07.24306979

Insulin-like growth factor (IGF) and Insulin-like growth factor binding proteins (IGFBP) as predictors of type 2 diabetes risk in obese adults

Maurya, P., Yang, J., Barnes, A. E., Yanek, L. R., Becker, L. C., Everett, A. D., & Vaidya, D. M. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01753-y

Additional file 1 of DNA methylation and type 2 diabetes: a systematic review

Nadiger, N., Veed, J. K., Chinya Nataraj, P., & Mukhopadhyay, A. (2024) · Figshare · doi:10.6084/m9.figshare.25844447

Additional file 2 of DNA methylation and type 2 diabetes: a systematic review

Nadiger, N., Veed, J. K., Chinya Nataraj, P., & Mukhopadhyay, A. (2024) · Figshare · doi:10.6084/m9.figshare.25844547

Additional file 1 of Metabolic syndrome and the plasma proteome: from association to causation

Elhadad, M. A., Wilson, R., Zaghlool, S. B., Huth, C., Gieger, C., Grallert, H., Graumann, J., Rathmann, W., Koenig, W., Sinner, M. F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14634050

Additional file 1 of Biomarker-defined pathways for incident type 2 diabetes and coronary heart disease—a comparison in the MONICA/KORA study

Huth, C., Bauer, A., Zierer, A., Sudduth-Klinger, J., Meisinger, C., Roden, M., Peters, A., Koenig, W., Herder, C., & Thorand, B. (2020) · Figshare · doi:10.6084/m9.figshare.11978466

Epigenome-wide mediation analysis identified Cytosine-phosphate-Guanine sites linking environmental factors with diabetes indicators

Wan-Yu, L. (2025) · Epigenomics · doi:10.1080/17501911.2025.2606041

Diagnostic model and identification of IGFBP2 as an aging-related biomarker and therapeutic target for systemic sclerosis-associated interstitial lung disease through integrated bioinformatics and machine learning approaches

Li, Y., Du, Y., Lv, J., Liu, D., Huang, L., Wang, Q., Zhuo, J., Yu, Q., Jiang, X., Chen, J., et al. (2026) · International Journal of Surgery · doi:10.1097/js9.0000000000004351

Multi-omic signatures of genetic mechanisms inform on type 2 diabetes biology and patient heterogeneityPreprint

Sevilla-González, M. D. R., Martinez-Munoz, A. M., Hanson, P. A., Hsu, S. C., Wang, X., Smith, K., Chen, Z., Szczerbiński, Ł., Kaur, V., Taylor, K. D., et al. (2026) · medRxiv · doi:10.64898/2026.04.17.26351136

Association of the phase angle with type 2 diabetes and related traits: results from two prospective KORA studies

Ai, F., Huemer, M., Rathmann, W., Roden, M., Herder, C., Zeller, T., Köenig, W., Nano, J., Drey, M., Peters, A., et al. (2026) · Nutrition and Diabetes · doi:10.1038/s41387-026-00425-x

Rewiring the tumor microenvironment: IGFBP2 at the Nexus of remodeling and therapy resistance?

Das, P., Conley, S. M., Panja, P., Bhattacharya, R., & Mukherjee, P. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189672

Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk

Wang, Z., Su, C., Lu, J., Hasebe, M., Mejía‐García, A., Tsao, H. M., Hu, J., Lu, T., & Zhou, S. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03363-1

Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men

Gu, T., Gu, H., Hilding, A., Sjöholm, L. K., Östenson, C., Ekström, T., & Brismar, K. (2013) · Clinical Epigenetics · doi:10.1186/1868-7083-5-21 · Cited by 49 · see citing works

Niedriger IGFBP-2-Spiegel deutet auf erhöhtes Diabetesrisiko hin

DZD (2019) · Info Diabetologie · doi:10.1007/s15034-019-1455-0

Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk

Zhou, J., ZouShicheng, H., Liu, G., & Xu, L. L. (2012)

Insulin-like Growth Factor 2 Binding Protein 2 Gene Polymorphism in Egyptian Patients with Type 2 Diabetes

Hajar, M. A., Sabek, N. A., Elkazaz, A. Y., Hassan, F., & Eldeib, A. (2018) · Egyptian Journal of Biochemistry and Molecular Biology · doi:10.21608/ejb.2018.19873 · Cited by 5 · see citing works

IGF2BP2 and obesity interaction analysis for type 2 diabetes mellitus in Chinese Han population

Wu, H., Liu, N., YANG, Z. K., Tao, X., Du, Y., Wang, X., Lü, B., Zhang, Z., Hu, R., & Wen, J. (2014) · European journal of medical research · doi:10.1186/2047-783x-19-40 · Cited by 19 · see citing works