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Cited by 46Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsNeurological Disease Mechanisms and Treatments

White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes

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Gao, Shudan, Chen, Yaojing, Sang, Feng, Yang, Yiru, Xia, Jianan, Li, Xin, Zhang, Junying, Chen, Kewei +1 more·2019·Diabetes
DOI 10.2337/db19-0233PMC PMC6804632
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Abstract

Patients with type 2 diabetes mellitus (T2DM) have a considerably high risk of developing dementia, especially for those with mild cognitive impairment (MCI). The investigation of the microstructural change of white matter (WM) between T2DM with amnesic MCI (T2DM-aMCI) and T2DM with normal cognition (T2DM-NC) and their relationships to cognitive performances can help to understand the brain variations in T2DM-related amnesic cognitive impairment. In the current study, 36 T2DM-aMCI patients, 40 T2DM-NC patients, and 40 healthy control (HC) individuals underwent diffusion tensor image and T1-weighted MRI scans and comprehensive cognition assessments. All of these cognitive functions exhibited intergroup ranking differences in patients. The T2DM-NC patients and HC individuals did not reveal any significant differences in WM integrity. The T2DM-aMCI patients showed disrupted integrity in multiple WM tracts compared with HC and T2DM-NC. Specifically, the damaged WM integrity of the right inferior fronto-occipital fasciculus and the right inferior longitudinal fasciculus exhibited significant correlations with episodic memory and attention function impairment in T2DM patients. Furthermore, cognitive impairment-related WM microstructural damage was associated with the degeneration of cortex connected to the affected WM tract. These findings indicate that degeneration exists extensively in WM tracts in T2DM-aMCI, whereas no brain WM damage is evident in T2DM-NC.

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  • 80% of Alzheimer's disease patients also exhibit symptoms of type 2 diabetes mellitus or abnormal glucose and insulin levels.

    “80% of AD patients also exhibit symptoms of T2DM or abnormal glucose and insulin levels (S. Gao et al., 2019).”

    From AD-Like Neuropsychiatric Dysfunction in a Mice Model Induced by a Combination of High-Fat Diet and Intraperitoneal Injection of Streptozotocin (2024) · cites this paper as S. Gao et al., 2019

    The Introduction reports an association between T2DM and dementia, but gives no estimate of diabetes or abnormal glucose and insulin levels among patients with Alzheimer’s disease. Its 90–95% figure refers to the proportion of diabetes cases that are T2DM, not the claimed 80% of Alzheimer’s patients. Searches for the 80% figure and abnormal glucose or insulin levels in Alzheimer’s patients found no supporting passage in our copy. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Gao, S., Chen, Y., Sang, F., Yang, Y., Xia, J., Li, X., Zhang, J., Chen, K., & Zhang, Z.
Affiliations
  • Beijing Normal University (CN)
  • Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, People’s Republic of China
  • Banner Alzheimer’s Institute (US)
Corresponding author
Zhang, Zhanjun
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2019-08-22
Volume
68
Issue
11
Pages
2085-2094
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db19-0233
PMC
PMC6804632
OpenAlex
W2969897589
Cited by
46
References
3
Citations by year
2026: 5 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 2
FWCI
3.31
Type
journal article
Language
en
Open access
Licence
www.diabetesjournals.org/content/license (vor, 60 d)
Locations
  • Diabetes (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31700997)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
type 2 diabetes, mild cognitive impairment, white matter microstructure, white matter integrity, diffusion tensor imaging, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, episodic memory, attention, dementia risk, cortical degeneration
MeSH terms
Aged, Cognition, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Diabetes Complications, Diffusion Tensor Imaging, White Matter

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