Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

Diagnosis and Classification of Diabetes Mellitus

American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

Neuropathological alterations in Alzheimer disease

Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · see citing works

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208 · see citing works

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185 · see citing works

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · cited 2× · see citing works

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

Diagnosis and classification of diabetes mellitus

American Diabetes Association (2009) · Diabetes Care · doi:10.2337/dc09-s062 · Cited by 1,817 · see citing works

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works

Insulin Receptor Signaling in Normal and Insulin-Resistant StatesPreprint

Boucher, J., Kleinridders, A., & Kahn, C. R. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009191 · Cited by 1,473 · see citing works

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E., Frosch, M., Eckman, C., Tanzi, R., Selkoe, D., & Guénette, S. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0230450100 · Cited by 1,361 · see citing works

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207 · see citing works

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Spires-Jones, T. L., & Hyman, B. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.004 · Cited by 1,201 · see citing works

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,186 · see citing works

Alzheimer’s disease is type 3 diabetes—Evidence reviewed

de la Monte, S. M., & Wands, J. R. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200619 · Cited by 1,158 · see citing works

Tau in Alzheimer Disease and Related Tauopathies

Iqbal, K., Liu, F., Gong, C., & Grundke, I. (2010) · Current Alzheimer Research · doi:10.2174/156720510793611592 · Cited by 1,122 · see citing works

Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Spilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., Richardson, A., Strong, R., & Galvan, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009979 · Cited by 1,033 · see citing works

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.014 · Cited by 1,004 · see citing works

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

Mucke, L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006338 · Cited by 1,000 · see citing works

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975 · see citing works

Adult mouse astrocytes degrade amyloid-β in vitro and in situ

Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., Silverstein, S. C., & Husemann, J. (2003) · Nature Medicine · doi:10.1038/nm838 · Cited by 909 · see citing works

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

Rubio-Perez, J. M., & Morillas-Ruiz, J. M. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/756357 · Cited by 841 · see citing works

Autophagy, amyloidogenesis and Alzheimer disease

Nixon, R. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.019265 · Cited by 749 · see citing works

The acetylation of tau inhibits its function and promotes pathological tau aggregation

Cohen, T. J., Guo, J. L., Hurtado, D. E., Kwong, L. K., Mills, I. P., Trojanowski, J. Q., & Lee, V. M. Y. (2011) · Nature Communications · doi:10.1038/ncomms1255 · Cited by 724 · see citing works

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease

Busche, M. A., Chen, X., Henning, H. A., Reichwald, J., Staufenbiel, M., Sakmann, B., & Konnerth, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206171109 · Cited by 715 · see citing works

Current and future treatments for Alzheimer's disease

Yiannopoulou, K. G., & Papageorgiou, S. G. (2013) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285612461679 · Cited by 677 · see citing works

Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

Li, S., Jin, M., Koeglsperger, T., Shepardson, N. E., Shankar, G. M., & Selkoe, D. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0203-11.2011 · Cited by 664 · see citing works

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., Viola, K. L., Zhao, W.-Q., Ferreira, S. T., & Klein, W. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809158106 · Cited by 657 · cited 2× · see citing works

Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M. Y., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5215-08.2009 · Cited by 648 · see citing works

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

Felice, F. G. D., & Ferreira, S. T. (2014) · Diabetes · doi:10.2337/db13-1954 · Cited by 647 · see citing works

Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

Ho, L., Qin, W., Pompl, P., Xiang, Z.-M., Wang, J., Zhao, Z., Peng, Y., Cambareri, G., Rocher, A., Mobbs, C., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0978fje · Cited by 646 · see citing works

Endoplasmic Reticulum Stress and Type 2 Diabetes

Back, S. H., & Kaufman, R. J. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-072909-095555 · Cited by 621 · see citing works

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

Deane, R., Singh, I., Sagare, A. P., Bell, R. D., Ross, N. T., LaRue, B., Love, R., Perry, S., Paquette, N., Deane, R. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58642 · Cited by 619 · see citing works

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

Haataja, L., Gurlo, T., Huang, C. J., & Butler, P. C. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0037 · Cited by 612 · see citing works

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

Chiang, S.-H., Baumann, C. A., Kanzaki, M., Thurmond, D. C., Watson, R. T., Neudauer, C. L., Macara, I. G., Pessin, J. E., & Saltiel, A. R. (2001) · Nature · doi:10.1038/35073608 · Cited by 611 · see citing works

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

Yuzwa, S. A., Shan, X., Macauley, M. S., Clark, T., Skorobogatko, Y., Vosseller, K., & Vocadlo, D. J. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.797 · Cited by 611 · see citing works

Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone

Watson, G. S., Cholerton, B. A., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Fishel, M. A., Kulstad, J. J., Green, P. S., Cook, D. G., et al. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.11.950 · Cited by 607 · see citing works

The role of insulin receptor signaling in the brain

Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604 · see citing works

Amyloid oligomers: formation and toxicity of Aβ oligomers

Sakono, M., & Zako, T. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07568.x · Cited by 602 · see citing works

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

Mosconi, L., Pupi, A., & de Leon, M. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 599 · see citing works

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

Maphis, N., Xu, G., Kokiko-Cochran, O. N., Jiang, S., Cardona, A., Ransohoff, R. M., Lamb, B. T., & Bhaskar, K. (2015) · Brain · doi:10.1093/brain/awv081 · Cited by 595 · see citing works

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

Kaneto, H., Katakami, N., Matsuhisa, M., & Matsuoka, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/453892 · Cited by 578 · see citing works

Epidemiology and risk factors of dementia

van der Flier, W. M. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.082867 · Cited by 550 · see citing works

Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Qiu, W. Q., & Folstein, M. F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.004 · Cited by 538 · see citing works

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D., & Münch, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.016 · Cited by 524 · see citing works

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

Kadavath, H., Hofele, R. V., Biernat, J., Kumar, S., Tepper, K., Urlaub, H., Mandelkow, E., & Zweckstetter, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504081112 · Cited by 524 · see citing works

Alzheimer's disease: synaptic dysfunction and Aβ

Shankar, G. M., & Walsh, D. M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-48 · Cited by 522 · see citing works

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes

Takeda, S., Sato, N., Uchio‐Yamada, K., Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., & Morishita, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000645107 · Cited by 506 · see citing works

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., & Ruiz-Albusac, J. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00161 · Cited by 502 · see citing works

Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

Gasparini, L., Gouras, G. K., Wang, R., Gross, R. S., Beal, M. F., Greengard, P., & Xu, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02561.2001 · Cited by 493 · see citing works

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

Schubert, M., Brazil, D. P., Burks, D. J., Kushner, J. A., Ye, J., Flint, C. L., Farhang-Fallah, J., Dikkes, P., Warot, X. M., Rio, C., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07084.2003 · Cited by 488 · see citing works

The role of tau in neurodegeneration

Gendron, T. F., & Petrucelli, L. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-13 · Cited by 478 · see citing works

Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein

Balducci, C., Beeg, M., Stravalaci, M., Bastone, A., Sclip, A., Biasini, E., Tapella, L., Colombo, L., Manzoni, C., Borsello, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911829107 · Cited by 466 · see citing works

Alzheimer's disease: Aβ, tau and synaptic dysfunction

LaFerla, F. M., & Oddo, S. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.02.009 · Cited by 461 · see citing works

Microtubules and microtubule-associated proteins

Mandelkow, E., & Mandelkow, E.-M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80047-6 · Cited by 458 · see citing works

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

Jay, T. R., Hirsch, A. M., Broihier, M. L., Miller, C. M., Neilson, L. E., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2110-16.2016 · Cited by 457 · see citing works

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

Tai, H., Serrano‐Pozo, A., Hashimoto, T., Frosch, M. P., Spires‐Jones, T. L., & Hyman, B. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.033 · Cited by 456 · see citing works

Astrocytes in Alzheimer's Disease

Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 453 · see citing works

Microglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism

Koenigsknecht-Talboo, J., & Landreth, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-04.2004 · Cited by 444 · see citing works

c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade

Lee, Y. H., Giraud, J., Davis, R. J., & White, M. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208359200 · Cited by 441 · see citing works

Tau phosphorylation: physiological and pathological consequences

Stoothoff, W. H., & Johnson, G. V. W. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.017 · Cited by 439 · see citing works

Post-translational modifications of tau protein in Alzheimer’s disease

Gong, C.-X., Liu, F., Grundke-Iqbal, I., & Iqbal, K. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-004-0221-0 · Cited by 437 · see citing works

Synapses and Alzheimer's Disease

Sheng, M., Sabatini, B. L., & Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005777 · Cited by 436 · see citing works

Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes

Romeo, G. R., Liu, W.-H., Asnaghi, V., Kern, T. S., & Lorenzi, M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2241 · Cited by 413 · see citing works

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

Peraldi, P., Hotamisligil, G. S., Buurman, W. A., White, M. F., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13018 · Cited by 412 · see citing works

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

Moore, E. M., Mander, A. G., Ames, D. J., Kotowicz, M. A., Carne, R. P., Brodaty, H., Woodward, M., Boundy, K. L., Ellis, K. A., Bush, A. I., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0229 · Cited by 405 · see citing works

Insulin Resistance and Type 2 Diabetes

Taylor, R. (2012) · Diabetes · doi:10.2337/db12-0073 · Cited by 394 · see citing works

Antidiabetic drug metformin (Glucophage ^R ) increases biogenesis of Alzheimer's amyloid peptides via up-regulating <i>BACE1</i> transcription

Chen, Y., Zhou, K., Wang, R., Liu, Y., Kwak, Y.-D., Ma, T., Thompson, R. C., Zhao, Y., Smith, L., Gasparini, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807991106 · Cited by 390 · see citing works

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

Ferreira, S. T., Lourenco, M. V., Oliveira, M. M., & De Felice, F. G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00191 · Cited by 373 · see citing works

BACE1: The β-Secretase Enzyme in Alzheimer's Disease

Vassar, R. J. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:105 · Cited by 369 · see citing works

Contribution of Alzheimer disease to mortality in the United States

James, B. D., Leurgans, S. E., Hebert, L. E., Scherr, P. A., Yaffe, K. S., & Bennett, D. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000240 · Cited by 364 · see citing works

<scp>mTOR</scp> regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López‐Aranda, M. F., Silva, A. J., & Oddo, S. (2013) · Aging Cell · doi:10.1111/acel.12057 · Cited by 362 · see citing works

Autophagy in human type 2 diabetes pancreatic beta cells

Masini, M., Bugliani, M., Lupi, R., Guerra, S. D., Boggi, U., Filipponi, F., Marselli, L., Masiello, P., & Marchetti, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1347-2 · Cited by 360 · see citing works

Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease

Wang, J.-Z., Grundke-Iqbal, I., & Iqbal, K. (1996) · Nature Medicine · doi:10.1038/nm0896-871 · Cited by 360 · see citing works

GSK3 and tau: Two convergence points in Alzheimer’s disease

Hernandez, F., Lucas, J. J., & Avila, J. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-129025 · Cited by 359 · see citing works

Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome

Kim, B., & Feldman, E. L. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.3 · Cited by 357 · see citing works

Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.

(1997) · Europe PMC (PubMed Central) · Cited by 354 · see citing works

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

Zhao, W., & Townsend, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 353 · see citing works

Loss‐of‐function presenilin mutations in Alzheimer disease

Strooper, B. D. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400897 · Cited by 351 · see citing works

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Doens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348 · see citing works

Microglia Function in Alzheimer’s Disease

Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 347 · see citing works

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

Schaeffer, V., Lavenir, I., Ozcelik, S., Tolnay, M., Winkler, D. T., & Goedert, M. (2012) · Brain · doi:10.1093/brain/aws143 · Cited by 343 · see citing works

Neuronal autophagy and neurodegenerative diseases

Son, J., Shim, J., Kim, K.-H., Ha, J., & Han, J.-Y. (2012) · Experimental and Molecular Medicine · doi:10.3858/emm.2012.44.2.031 · Cited by 342 · see citing works

Role for neuronal insulin resistance in neurodegenerative diseases

Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Alber, J., Galldiks, N., Kustermann, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308724101 · Cited by 339 · see citing works

How does brain insulin resistance develop in Alzheimer's disease?

De Felice, F. G., Lourenco, M. V., & Ferreira, S. T. (2014) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2013.12.004 · Cited by 337 · see citing works

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Schmitz, T. W., Spreng, R. N., Initiative, T. A. D. N., Weiner, M. W., Aisen, P. S. S., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowki, J. Q., Toga, A. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13249 · Cited by 335 · see citing works

Autophagy and neurodegeneration

Frake, R. A., Ricketts, T., Menzies, F. M., & Rubinsztein, D. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73944 · Cited by 332 · see citing works

Molecular Basis of Familial and Sporadic Alzheimer's Disease

Dorszewska, J., Prendecki, M., Oczkowska, A., Dezor, M., & Kozubski, W. P. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160314150501 · Cited by 329 · see citing works

Extended results of the Alzheimer's disease anti‐inflammatory prevention trial

Breitner, J. C. S., Baker, L. D., Montine, T. J., Meinert, C. L., Lyketsos, C. G., Ashe, K. H., Brandt, J., Craft, S., Evans, D. A., Green, R. C., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.12.014 · Cited by 327 · see citing works

Elucidating the Role of TREM2 in Alzheimer’s Disease

Ulrich, J. D., Ulland, T. K., Colonna, M., & Holtzman, D. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.042 · Cited by 325 · see citing works

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

Jo, C., Gundemir, S., Pritchard, S., Jin, Y. N., Rahman, I., & Johnson, G. V. W. (2014) · Nature Communications · doi:10.1038/ncomms4496 · Cited by 323 · see citing works

The role of protein glycosylation in Alzheimer disease

Schedin‐Weiss, S., Winblad, B. G., & Tjernberg, L. O. (2013) · FEBS Journal · doi:10.1111/febs.12590 · Cited by 316 · see citing works

Type 2 diabetes mellitus and Alzheimer’s disease

Barbagallo, M. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i6.889 · Cited by 313 · see citing works

The role of mammalian target of rapamycin (mTOR) in insulin signaling

Yoon, M.-S. (2017) · Nutrients · doi:10.3390/nu9111176 · Cited by 300 · see citing works

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Bemiller, S. M., McCray, T. J., Allan, K., Formica, S. V., Xu, G., Wilson, G., Kokiko-Cochran, O. N., Crish, S. D., Lasagna-Reeves, C. A., Ransohoff, R. M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0216-6 · Cited by 299 · see citing works

Type 2 diabetes mellitus and biomarkers of neurodegeneration

Moran, C., Beare, R. J., Phan, T. G., Bruce, D. G., Callisaya, M. L., & Srikanth, V. K. (2015) · Neurology · doi:10.1212/wnl.0000000000001982 · Cited by 298 · see citing works

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

Li, X., Leng, S. X., & Song, D. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s74042 · Cited by 294 · see citing works

Role of NF-κB in the pathogenesis of diabetes and its associated complications

Patel, S., & Santani, D. D. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70111-2 · Cited by 291 · see citing works

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

Luchsinger, J. A., Perez, T., Chang, H., Mehta, P., Steffener, J., Pradabhan, G., Ichise, M., Manly, J., Devanand, D. P., & Bagiella, E. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150493 · Cited by 285 · see citing works

Insulin modulates hippocampal activity‐dependent synaptic plasticity in a <i>N</i>‐methyl‐<scp>d</scp>‐aspartate receptor and phosphatidyl‐inositol‐3‐kinase‐dependent manner

Van Der Heide, L. P., Kamal, A., Artola, A., Gispen, W. H., & Ramakers, G. M. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03269.x · Cited by 278 · see citing works

The Emerging Link between O-GlcNAc and Alzheimer Disease

Zhu, Y., Shan, X., Yuzwa, S. A., & Vocadlo, D. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.601351 · Cited by 267 · see citing works

Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study

Huang, C., Chung, C., Leu, H., Lin, L., Chiu, C.-C., Hsu, C., Chiang, C.-H., Huang, P., Chen, T., Lin, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087095 · Cited by 266 · see citing works

GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

Mudher, A., Shepherd, D., Newman, T. A., Mildren, P., Jukes, J. P., Squire, A., Mears, A., Berg, S., MacKay, D., Asuni, A. A., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001483 · Cited by 265 · see citing works

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy

Zotova, E., Nicoll, J. A. R., Kalaria, R. N., Holmes, C., & Boche, D. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt24 · Cited by 257 · see citing works

Genome-wide association studies in Alzheimer’s disease

Bertram, L., & Tanzi, R. E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp406 · Cited by 257 · see citing works

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo

Žilka, N., Filipčík, P., Koson, P., Fialová, Ľ., Škrabana, R., Žilková, M., Rolkova, G., Kontseková, E., & Novák, M. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.05.029 · Cited by 254 · see citing works

Diabetes and Alzheimer’s disease crosstalk

Baglietto‐Vargas, D., Shi, J. J., Yaeger, D. M., Ager, R. R., & LaFerla, F. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.005 · Cited by 254 · see citing works

Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans

Fröjdö, S., Vidal, H., & Pirola, L. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.019 · Cited by 242 · see citing works

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

Kim, B., Backus, C., Oh, S., Hayes, J. M., & Feldman, E. L. (2009) · Endocrinology · doi:10.1210/en.2009-0695 · Cited by 241 · see citing works

Insulin Dysfunction InducesIn VivoTau Hyperphosphorylation through Distinct Mechanisms

Planel, E., Tatebayashi, Y., Miyasaka, T., Liu, L., Wang, L., Herman, M., Yu, W. H., Luchsinger, J. A., Wadzinski, B. E., Duff, K., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3949-07.2007 · Cited by 238 · see citing works

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and <i>Drosophila</i> Genetic Models of Epilepsy

Holth, J. K., Bomben, V. C., Reed, J. G., Inoue, T., Younkin, L., Younkin, S. G., Pautler, R. G., Botas, J., & Noebels, J. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3191-12.2013 · Cited by 238 · see citing works

Evidence for impaired amyloid β clearance in Alzheimer's disease

Wildsmith, K. R., Holley, M. M., Savage, J. C., Skerrett, R., & Landreth, G. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt187 · Cited by 235 · see citing works

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works

High-fat diet-induced memory impairment in triple-transgenic Alzheimer’s disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.

Knight, E. M., Martins, I. V. A., Gümüsgöz, S., Allan, S. M., & Lawrence, C. B. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.010 · Cited by 232 · see citing works

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

Yarchoan, M. M., & Arnold, S. E. (2014) · Diabetes · doi:10.2337/db14-0287 · Cited by 228 · see citing works

The roles of inflammation and immune mechanisms in Alzheimer's disease

Eldik, L. J. V., Carrillo, M. C., Cole, P. E., Feuerbach, D., Greenberg, B., Hendrix, J. A., Kennedy, M. E., Kozauer, N., Margolin, R. A., Molinuevo, J. L., et al. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.05.001 · Cited by 226 · see citing works

Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

Ozcelik, S., Fraser, G., Castets, P., Schaeffer, V., Skachokova, Z., Breu, K., Clavaguera, F., Sinnreich, M., Kappos, L., Goedert, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062459 · Cited by 226 · see citing works

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

Matos, M., Augusto, E., Oliveira, C. R., & Agostinho, P. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.022 · Cited by 223 · see citing works

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

Mullins, R. J., Diehl, T. C., Chia, C. W., & Kapogiannis, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00118 · Cited by 213 · see citing works

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

Macauley, S. L., Stanley, M., Caesar, E. E., Yamada, S. A., Raichle, M. E., Perez, R., Mahan, T. E., Sutphen, C. L., & Holtzman, D. M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79742 · Cited by 211 · see citing works

Association of type 2 diabetes with brain atrophy and cognitive impairment

Roberts, R. O., Knopman, D. S., Przybelski, S. A., Mielke, M. M., Kantarci, K., Preboske, G. M., Senjem, M. L., Pankratz, V. S., Geda, Y. E., Boeve, B. F., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000269 · Cited by 211 · see citing works

Atypical, non-standard functions of the microtubule associated Tau protein

Sotiropoulos, I., Galas, M., Silva, J. M., Skoulakis, E. M. C., Wegmann, S., Maina, M. B., Blum, D. L., Sayas, C. L., Mandelkow, E., Mandelkow�, E., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0489-6 · Cited by 207 · see citing works

Tau deletion promotes brain insulin resistance

Marciniak, E., Leboucher, A., Caron, E., Ahmed, T., Tailleux, A., Dumont, J., Issad, T., Gerhardt, E., Pagesy, P., Vileno, M., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161731 · Cited by 205 · see citing works

A role for tau at the synapse in Alzheimer’s disease pathogenesis

Pooler, A. M., Noble, W., & Hanger, D. P. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.018 · Cited by 203 · see citing works

Tau phosphorylation affects its axonal transport and degradation

Rodríguez-Martín, T., Cuchillo‐Ibáñez, I., Noble, W. J., Nyenya, F., Anderton, B. H., & Hanger, D. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.015 · Cited by 200 · see citing works

Autophagic/lysosomal dysfunction in Alzheimer’s disease

Orr, M. E., & Oddo, S. (2013) · Alzheimer's Research &amp; Therapy · doi:10.1186/alzrt217 · Cited by 199 · see citing works

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

Stanley, M., Macauley, S. L., & Holtzman, D. M. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160493 · Cited by 199 · see citing works

Alzheimer’s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

Sekar, S., McDonald, J., Cuyugan, L., Aldrich, J., Kurdoglu, A., Adkins, J., Serrano, G., Beach, T. G., Craig, D. W., Valla, J., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.027 · Cited by 199 · see citing works

Brain glucose transporters, O‐GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06320.x · Cited by 193 · see citing works

mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions

Showkat, M., Beigh, M. A., & Andrabi, K. I. (2014) · Molecular Biology International · doi:10.1155/2014/686984 · Cited by 191 · see citing works

Islet amyloid polypeptide and type 2 diabetes.

Marzban, L., Park, K., & Verchere, C. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00004-4 · Cited by 191 · see citing works

Amyloid precursor protein (APP) regulates synaptic structure and function

Tyan, S.-H., Shih, A. Y.-J., Walsh, J. J., Maruyama, H., Sarsoza, F., Ku, L., Eggert, S., Hof, P. R., Koo, E. H., & Dickstein, D. L. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.07.009 · Cited by 191 · see citing works

Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

Goure, W. F., Krafft, G. A., Jerecic, J., & Hefti, F. (2014) · Alzheimer's Research &amp; Therapy · doi:10.1186/alzrt272 · Cited by 190 · see citing works

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Ke, Y. D., Delerue, F., Gladbach, A., Götz, J., & Ittner, L. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007917 · Cited by 189 · see citing works

Association of TNF-α with insulin resistance in type 2 diabetes mellitus

Swaroop, J. J., Rajarajeswari, D., & Naidu, J. N. (2012) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.93435 · Cited by 189 · see citing works

A pivotal role of GSK-3 in synaptic plasticity

Bradley, C. A., Peineau, S., Taghibiglou, C., Nicolas, C. S., Whitcomb, D. J., Bortolotto, Z. A., Kaang, B., Cho, K., Wang, Y. T., & Collingridge, G. L. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00013 · Cited by 189 · see citing works

Type 2 diabetes as a risk factor for cognitive impairment: current insights

Umegaki, H. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s48926 · Cited by 180 · see citing works

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

Gaspar, J. M., Baptista, F. I., Macedo, M. P., & Ambrósio, A. F. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00240 · Cited by 179 · see citing works

Glycation exacerbates the neuronal toxicity of β-amyloid

Li, X.-H., Du, L.-L., Cheng, X.-S., Jiang, X., Zhang, Y., Lv, B.-L., Liu, R., Wang, J.-Z., & Zhou, X.-W. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.180 · Cited by 178 · see citing works

Dissociation of tau toxicity and phosphorylation: role of GSK-3β, MARK and Cdk5 in a Drosophila model

Chatterjee, S., Sang, T.-K., Lawless, G. M., & Jackson, G. R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn326 · Cited by 178 · see citing works

Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk

Barron, H., Hafizi, S., Andreazza, A. C., & Mizrahi, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030651 · Cited by 176 · see citing works

PET amyloid-beta imaging in preclinical Alzheimer's disease

Vlassenko, A. G., Benzinger, T. L. S., & Morris, J. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.005 · Cited by 173 · see citing works

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

Puzzo, D., Piacentini, R., Fá, M., Gulisano, W., Li Puma, D. D., Staniszewski, A., Zhang, H., Tropea, M. R., Cocco, S., Palmeri, A., et al. (2017) · eLife · doi:10.7554/elife.26991 · Cited by 172 · see citing works

Intranasal Insulin to Improve Memory Function in Humans

Benedict, C., Hallschmid, M., Schultes, B., Jan Born, A., & Kern, W. (2007) · Neuroendocrinology · doi:10.1159/000106378 · Cited by 171 · see citing works

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Inoue, K., Rispoli, J., Kaphzan, H., Klann, E., Chen, E. I., Kim, J., Komatsu, M., & Abeliovich, A. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-48 · Cited by 168 · see citing works

Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons

Janning, D., Igaev, M., Sündermann, F., Brühmann, J., Beutel, O., Heinisch, J. J., Bakota, L., Piehler, J., Junge, W., & Brandt, R. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1099 · Cited by 168 · see citing works

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease

Guerrero-Muñoz, M. J., Gerson, J., & Castillo-Carranza, D. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00464 · Cited by 168 · see citing works

Molecular Structure of a Fibrillar Alzheimer's Aβ Fragment

Serpell, L. C., Blake, C., & Fraser, P. E. (2000) · Biochemistry · doi:10.1021/bi000637v · Cited by 153 · see citing works

The Risk of Dementia among Persons with Diabetes Mellitus: A Population‐Based Cohort Studya

Leibson, C. L., Rocca, W. A., Hanson, V., CHA, R., Kokmen, E., O’Brien, P. C., & Palumbo, P. J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48496.x · Cited by 152 · see citing works

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

Zhao, R., Hu, W., Tsai, J., Li, W., & Gan, W.-B. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0188-6 · Cited by 151 · see citing works

Accumulation of Aspartic Acid 421 - and Glutamic Acid 391 -Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

Basurto‐Islas, G., Luna‐Muñoz, J., Guillozet-Bongaarts, A. L., Binder, L. I., Mena, R., & García‐Sierra, F. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31817275c7 · Cited by 150 · see citing works

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet

Molina, J., Rodriguez-Diaz, R., Fachado, A., Jacques-Silva, M. C., Berggren, P.-O., & Caicedo, A. (2014) · Diabetes · doi:10.2337/db13-1371 · Cited by 149 · see citing works

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

Reddy, P. H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.06.012 · Cited by 147 · see citing works

A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

Dolan, P. J., & Johnson, G. V. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110940 · Cited by 147 · see citing works

A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration

Karsten, S. L., Sang, T.-K., Gehman, L. T., Chatterjee, S., Liu, J., Lawless, G. M., Sengupta, S., Berry, R. W., Pomakian, J., Oh, H. S., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.019 · Cited by 147 · see citing works

Paradoxical Upregulation of Glutamatergic Presynaptic Boutons during Mild Cognitive Impairment

Bell, K. F. S., Bennett, D. A., & Cuello, A. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3269-07.2007 · Cited by 145 · see citing works

Alzheimer’s disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

Carvalho, C., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.05.001 · Cited by 145 · see citing works

NSAIDs and incident Alzheimer’s disease. The Rotterdam study

In ’t Veld, B. A., Launer, L. J., Hoes, A. W., Ott, A., Hofman, A., Breteler, M. M. B., & Stricker, B. H. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00096-7 · Cited by 145 · see citing works

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila

Zhang, W., Thompson, B. J., Hietakangas, V., & Cohen, S. M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002429 · Cited by 144 · see citing works

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy–Lysosome System in a γ-Secretase-Independent Manner

Neely, K. M., Green, K. N., & LaFerla, F. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5156-10.2010 · Cited by 141 · see citing works

Brain Insulin Resistance in Alzheimer's Disease and its Potential Treatment with GLP-1 Analogs

Talbot, K. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.13.73 · Cited by 139 · see citing works

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

Ávila, J., Wandosell, F. G., & Hernández, F. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.40 · Cited by 135 · see citing works

Type 2 Diabetes and Late-Onset Alzheimer’s Disease

Cheng, D., Noble, J. M., Tang, M. ‐., Schupf, N., Mayeux, R. P., & Luchsinger, J. A. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000324134 · Cited by 134 · see citing works

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

Smet‐Nocca, C., Broncel, M., Wieruszeski, J., Tokarski, C., Hanoulle, X., Leroy, A., Landrieu, I., Rolando, C. H., Lippens, G. M., & Hackenberger, C. P. R. (2011) · Molecular BioSystems · doi:10.1039/c0mb00337a · Cited by 133 · see citing works

Acetylation: a new key to unlock tau’s role in neurodegeneration

Cook, C. N., Stankowski, J. N., Carlomagno, Y., Stetler, C. T., & Petrucelli, L. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt259 · Cited by 133 · see citing works

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease

Son, S. M., Cha, M.-Y., Choi, H., Kang, S., Choi, H., Lee, M., Park, S. A., & Mook‐Jung, I. (2016) · Autophagy · doi:10.1080/15548627.2016.1159375 · Cited by 129 · see citing works

Rosiglitazone and Pioglitazone for the Treatment of Alzheimer's Disease

Miller, B. W., Willett, K. C., & Desilets, A. R. (2011) · Annals of Pharmacotherapy · doi:10.1345/aph.1q238 · Cited by 128 · see citing works

Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid-β, Wild-Type Tau, and R406W Tau

Tackenberg, C., & Brandt, R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3590-09.2009 · Cited by 127 · see citing works

Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

Irwin, D. J., Cohen, T. J., Grossman, M., Arnold, S. E., McCarty-Wood, E., Van Deerlin, V. M., Lee, V. M.-Y., & Trojanowski, J. Q. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.04.025 · Cited by 125 · see citing works

Synaptic alterations in the rTg4510 mouse model of tauopathy

Kopeikina, K. J., Polydoro, M., Tai, H., Yaeger, E., Carlson, G. A., Pitstick, R., Hyman, B. T., & Spires‐Jones, T. L. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23234 · Cited by 125 · see citing works

Neuropathology of dementia in a large cohort of patients with Parkinson's disease

Horvath, J. E., Herrmann, F. R., Burkhard, P. R., Bouras, C., & Kövari, E. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.05.010 · Cited by 124 · see citing works

Genome-wide Association Studies in Alzheimer’s Disease: A Review

Tosto, G., & Reitz, C. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0381-0 · Cited by 124 · see citing works

Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains

Esparza, T. J., Wildburger, N. C., Jiang, H., Gangolli, M., Cairns, N. J., Bateman, R. J., & Brody, D. L. (2016) · Scientific Reports · doi:10.1038/srep38187 · Cited by 124 · see citing works

Physiological and Pathological Changes in Glucose Regulate Brain Akt and Glycogen Synthase Kinase-3

Clodfelder‐Miller, B., Sarno, P. D., Zmijewska, A. A., Song, L., & Jope, R. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508824200 · Cited by 123 · see citing works

An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

Jaeschke, A., Czech, M. P., & Davis, R. J. (2004) · Genes &amp; Development · doi:10.1101/gad.1216504 · Cited by 121 · see citing works

Tau Phosphorylation by GSK3 in Different Conditions

Ávila, J., León‐Espinosa, G., García, E., García‐Escudero, V., Hernández, F., & DeFelipe, J. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/578373 · Cited by 119 · see citing works

Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival?

Lee, J.-A. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.1.1 · Cited by 119 · see citing works

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

Uranga, R. M., Katz, S., & Salvador, G. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457622 · Cited by 118 · see citing works

Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-β Exposure

Moreira, P. I., Santos, M. S., Moreno, A. M., Seiça, R., & Oliveira, C. R. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1449 · Cited by 117 · see citing works

TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists

Blagosklonny, M. V. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.506 · Cited by 116 · see citing works

Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer’s disease

Choi, B.-R., Cho, W.-H., Kim, J., Lee, H. J., Chung, C., Jeon, W. K., & Han, J.-S. (2014) · Experimental &amp; Molecular Medicine · doi:10.1038/emm.2013.147 · Cited by 111 · see citing works

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

Trzeciakiewicz, H., Tseng, J., Wander, C. M., Madden, V. J., Tripathy, A., Yuan, C., & Cohen, T. J. (2017) · Scientific Reports · doi:10.1038/srep44102 · Cited by 110 · see citing works

Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases

Lee, E. J., & Park, J. H. (2013) · Genomics & Informatics · doi:10.5808/gi.2013.11.4.224 · Cited by 109 · see citing works

Atg7 in development and disease: panacea or Pandora’s Box?

Xiong, J. (2015) · Protein & Cell · doi:10.1007/s13238-015-0195-8 · Cited by 109 · see citing works

The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding

Beckett, L. A., Donohue, M., Wang, C., Aisen, P. S. S., Harvey, D. J., Saito, N. H., & Initiative, A. D. N. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.05.004 · Cited by 106 · see citing works

CD33 in Alzheimer's Disease

Jiang, T., Yu, J., Hu, N., Tan, M., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8536-1 · Cited by 106 · see citing works

Degradative organelles containing mislocalized α- and β-synuclein proliferate in presenilin-1 null neurons

Wilson, C., Murphy, D. D., Giasson, B. I., Zhang, B., Trojanowski, J. Q., & Lee, V. M. ‐. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403061 · Cited by 106 · see citing works

Expression Profiles of Cytokines in the Brains of Alzheimer's Disease (AD) Patients Compared to the Brains of Non-Demented Patients with and without Increasing AD Pathology

Morimoto, K., Horio, J., Satoh, H., Sue, L. I., Beach, T. G., Arita, S., Tooyama, I., & Konishi, Y. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101815 · Cited by 105 · see citing works

Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease

Wes, P. D., Easton, A. E., Corradi, J., Barten, D. M., Devidze, N., DeCarr, L. B., Truong, A. B., He, A., Barrezueta, N. X., Polson, C. T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106050 · Cited by 105 · see citing works

Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells

Quan, W., Lim, Y.-M., & Lee, M. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.2.030 · Cited by 105 · see citing works

Fyn-Tau-Amyloid: A Toxic Triad

Haass, C., & Mandelkow�, E. (2010) · Cell · doi:10.1016/j.cell.2010.07.032 · Cited by 104 · see citing works

The role of autophagy in pancreatic β-cell and diabetes

Fujitani, Y., Kawamori, R., & Watada, H. (2009) · Autophagy · doi:10.4161/auto.5.2.7656 · Cited by 103 · see citing works

Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi

Nilsson, P., Sekiguchi, M., Akagi, T., Izumi, S., Komori, T., Hui, K. K., Sörgjerd, K. M., Tanaka, M., Saito, T., Iwata, N., et al. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.10.011 · Cited by 100 · see citing works

The potential role of tau protein O-glycosylation in Alzheimer's disease

Robertson, L. A., Moya, K. L., & Breen, K. C. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6505 · Cited by 99 · see citing works

Amyloid Beta in Aging and Alzheimer’s Disease

Sehar, U., Rawat, P., Reddy, A. P., Kopel, J. J., & Reddy, P. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112924 · Cited by 385 · see citing works

Degradation of proteins by PROTACs and other strategies

Wang, Y., Jiang, X., Feng, F., Liu, W., & Sun, H. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.001 · Cited by 335 · see citing works

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Fernández-Calle, R., Konings, S. C., Frontiñán-Rubio, J., García-Revilla, J., Camprubí-Ferrer, L., Svensson, M., Martinson, I., Boza-Serrano, A., Venero, J. L., Nielsen, H. M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00566-4 · Cited by 278 · see citing works

The Impact of Disease Comorbidities in Alzheimer’s Disease

Santiago, J. A., & Potashkin, J. A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.631770 · Cited by 259 · see citing works

Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia

Lima, J. E. B. F., Moreira, N. C. S., & Sakamoto-Hojo, E. T. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2021.503437 · Cited by 203 · see citing works

Glucose, glycolysis, and neurodegenerative diseases

Tang, B. L. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29682 · Cited by 196 · see citing works

Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease

Martins, T. S., Trindade, D., Vaz, M., Campelo, I., Almeida, M., Trigo, G., Silva, O. A. B. D. C. E., & Henriques, A. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15112 · Cited by 174 · see citing works

Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies

Singh, A. P., Shadangi, S., Gupta, P. K., & Rana, S. (2025) · Comprehensive physiology · doi:10.1002/cph4.70003 · Cited by 183 · see citing works

Insulin action in the brain regulates both central and peripheral functions

Agrawal, R., Reno, C. M., Sharma, S., CHRISTENSEN, C. G., Huang, Y., & Fisher, S. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00642.2020 · Cited by 144 · see citing works

Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications

Yan, L., Vaghari‐Tabari, M., Malakoti, F., Moein, S., Qujeq, D., Yousefi, B., & Asemi, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2067825 · Cited by 133 · see citing works

Amyloid-beta and tau protein beyond Alzheimer’s disease

Abyadeh, M., Gupta, V., Paulo, J. A., Mahmoudabad, A. G., Shadfar, S., Mirshahvaladi, S., Gupta, V. B., Nguyen, C. T. O., Finkelstein, D. I., You, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386406 · Cited by 121 · see citing works

Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain

Xie, J., Gonzalez‐Carter, D., Tockary, T. A., Nakamura, N., Xue, Y., Nakakido, M., Akiba, H., Dirisala, A., Liu, X., Toh, K., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b09991 · Cited by 116 · see citing works

Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions

Kumar, V., Kim, S.-H., & Bishayee, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179540 · Cited by 115 · see citing works

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

López-Gambero, A. J., Sanjuan, C., Serrano-Castro, P. J., Suárez, J., & de Fonseca, F. R. (2020) · Biomedicines · doi:10.3390/biomedicines8090295 · Cited by 110 · see citing works

Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes

Gąsecka, A., Siwik, D., Gajewska, M., Jaguszewski, M. J., Mazurek, T., Filipiak, K. J., Postula, M. A., & Eyileten, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092807 · Cited by 103 · see citing works

EEG spectral power abnormalities and their relationship with cognitive dysfunction in patients with Alzheimer's disease and type 2 diabetes

Benwell, C., Davila-Pérez, P., Fried, P. J., Jones, R. N., Travison, T. G., Santarnecchi, E., Pascual‐Leone, Á., & Shafi, M. M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.004 · Cited by 100 · see citing works

Alzheimer’s disease as type 3 diabetes: understanding the link and implications

Kciuk, M., Kruczkowska, W., Gałęziewska, J., Wanke, K., Kałuzińska-Kołat, Ż., Aleksandrowicz, M., & Kontek, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211955 · Cited by 98 · see citing works

Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms

Zheng, H., Zhu, H., Liu, X., Huang, X., Huang, A., & Huang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.750382 · Cited by 100 · see citing works

Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis

Athanasaki, A., Melanis, K., Tsantzali, I., Stefanou, M., Ntymenou, S., Paraskevas, S. G., Κalamatianos, T., Boutati, E. I., Lambadiari, V., Voumvourakis, K. I., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10040778 · Cited by 99 · see citing works

Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

Krohn, L., Heilbron, K., Blauwendraat, C., Reynolds, R. H., Yu, E., Senkevich, K. A., Rudakou, U., Estiar, M. A., Gustavsson, E. K., Brolin, K. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34732-5 · Cited by 101 · see citing works

Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease

Zheng, M., & Wang, P. (2021) · 3 Biotech · doi:10.1007/s13205-021-02738-3 · Cited by 98 · see citing works

Type 2 Diabetes Mellitus Increases the Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

Hayden, M. R. (2019) · Brain Sciences · doi:10.3390/brainsci9100262 · Cited by 90 · see citing works

Cognitive disorder and dementia in type 2 diabetes mellitus

Ortíz, G. G., Huerta, M., González-Usigli, H., Torres-Sánchez, E. D., Delgado-Lara, D. L. C., Pacheco-Moisés, F. P., Mireles-Ramírez, M. A., Torres-Mendoza, B. M., Moreno-Cih, R. I., & Velázquez-Brizuela, I. E. (2022) · World Journal of Diabetes · doi:10.4239/wjd.v13.i4.319 · Cited by 90 · see citing works

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

Komleva, Y. K., Chernykh, A., Lopatina, O. L., Gorina, Y. V., Lokteva, I., Salmina, A. B., & Gollasch, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.618395 · Cited by 79 · see citing works

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease

Pradeepkiran, J. A., Baig, J., Islam, M. A., Kshirsagar, S., & Reddy, P. H. (2024) · Aging and Disease · doi:10.14336/ad.2024.0286 · Cited by 81 · see citing works

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

Abdalla, M. M. I. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v15.i7.1430 · Cited by 82 · see citing works

A Network-Based Bioinformatics Approach to Identify Molecular Biomarkers for Type 2 Diabetes that Are Linked to the Progression of Neurological Diseases

Rahman, M. H., Peng, S., Hu, X., Chen, C., Rahman, M. R., Uddin, S., Quinn, J. M. W., & Moni, M. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17031035 · Cited by 75 · see citing works

Anticancer, anti-diabetic, antimicrobial activity of zinc oxide nanoparticles: A comparative analysis

Chandrasekaran, S., Anusuya, S., & Anbazhagan, V. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133139 · Cited by 75 · see citing works

Insulin and Its Key Role for Mitochondrial Function/Dysfunction and Quality Control: A Shared Link between Dysmetabolism and Neurodegeneration

Galizzi, G., & Carlo, M. D. (2022) · Biology · doi:10.3390/biology11060943 · Cited by 76 · see citing works

Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease

Blanco, K., Salcidua, S., Orellana, P., Sauma-Pérez, T., León, T., Steinmetz, L. C. L., Ibañez, A., Duran-Aniotz, C., & de la Cruz, R. (2023) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-023-01304-8 · Cited by 73 · see citing works

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Yang, A. J. T., Bagit, A., & MacPherson, R. E. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094628 · Cited by 75 · see citing works

Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models

Carranza-Naval, M. J., Vargas-Soria, M., Hierro‐Bujalance, C., Baena‐Nieto, G., Garcı́a-Alloza, M., Infante‐Garcia, C., & del Marco, À. (2021) · Biomolecules · doi:10.3390/biom11020262 · Cited by 73 · see citing works

Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus

Sim, A. Y., Barua, S., Kim, J. Y., Lee, Y.-H., & Lee, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.708547 · Cited by 62 · see citing works

Aberrant energy metabolism in Alzheimer’s disease

Yu, L., Jin, J., Xu, Y., & Zhu, X. (2022) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2022-0024 · Cited by 66 · see citing works

Associations Between Diabetes Mellitus and Neurodegenerative Diseases

Szablewski, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020542 · Cited by 74 · see citing works

Reassessment of Pioglitazone for Alzheimer’s Disease

Saunders, A. M., Burns, D. K., & Gottschalk, W. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.666958 · Cited by 67 · see citing works

A Comprehensive Review of Neuronal Changes in Diabetics

Luna, R., Manjunatha, R. T., Bollu, B., Jhaveri, S., Avanthika, C., Reddy, N., Saha, T., & Gandhi, F. R. (2021) · Cureus · doi:10.7759/cureus.19142 · Cited by 70 · see citing works

Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations

Krishaa, L., Ng, T. K. S., Wee, H. N., & Ching, J. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111787 · Cited by 60 · see citing works

Statins and cognition: Modifying factors and possible underlying mechanisms

Jamshidnejad-Tosaramandani, T., Kashanian, S., Al-Sabri, M. H., Kročianová, D., Clemensson, L. E., Gentreau, M., & Schiöth, H. B. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.968039 · Cited by 59 · see citing works

Circulating miRNAs as a Predictive Biomarker of the Progression from Prediabetes to Diabetes: Outcomes of a 5-Year Prospective Observational Study

Sidorkiewicz, I., Niemira, M., Maliszewska, K., Erol, A., Bielska, A., Szalkowska, A., Adamska-Patruno, E., Szczerbiński, Ł., Górska, M., & Kretowski, A. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072184 · Cited by 57 · see citing works

Mechanistic insights and emerging therapeutic stratagems for Alzheimer’s disease

Rajendran, K., & Krishnan, U. M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102309 · Cited by 58 · see citing works

Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

Sharma, N. K., Tramutola, A., Lanzillotta, C., Arena, A., Blarzino, C., Cassano, T., Butterfield, D. A., Domenico, F. D., Marzia Perluigi, A., & Barone, E. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.003 · Cited by 57 · see citing works

Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer’s Disease and Type 2 Diabetes

Carranza-Naval, M. J., del Marco, À., Hierro‐Bujalance, C., Alves-Martínez, P., Infante‐Garcia, C., Vargas-Soria, M., Herrera, M., Barba-Cordoba, B., Atienza‐Navarro, I., Lubián‐López, S. P., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.741923 · Cited by 54 · see citing works

Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

Kacířová, M., Zmeškalová, A., Kořínková, L., Železná, B., Kuneš, J., & Maletı́nská, L. (2020) · Clinical Science · doi:10.1042/cs20191313 · Cited by 53 · see citing works

Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?

Lundqvist, M., Almby, K. E., Abrahamsson, N., & Eriksson, J. W. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00457 · Cited by 49 · see citing works

White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes

Gao, S., Chen, Y., Sang, F., Yang, Y., Xia, J., Li, X., Zhang, J., Chen, K., & Zhang, Z. (2019) · Diabetes · doi:10.2337/db19-0233 · Cited by 46 · see citing works

A neural signature of metabolic syndrome

Kotkowski, E., Price, L. R., Franklin, C. G., Salazar, M., Woolsey, M. D., DeFronzo, R. A., Blangero, J., Glahn, D. C., & Fox, P. T. (2019) · Human Brain Mapping · doi:10.1002/hbm.24617 · Cited by 48 · see citing works

Overview of Metformin and Neurodegeneration: A Comprehensive Review

Kruczkowska, W., Gałęziewska, J., Buczek, P., Płuciennik, E., Kciuk, M., & Śliwińska, A. (2025) · Pharmaceuticals · doi:10.3390/ph18040486 · Cited by 50 · see citing works

Crucial players in Alzheimer’s disease and diabetes mellitus: Friends or foes?

Kubis-Kubiak, A., Rorbach-Dolata, A., & Piwowar, A. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.008 · Cited by 46 · see citing works

Dysfunction of the neurovascular unit in diabetes-related neurodegeneration

Yan, C., Zhou, Y., Chen, Q., Luo, Y., Zhang, J. H., Huang, H., & Shao, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110656 · Cited by 44 · see citing works

Iron and Ferroptosis More than a Suspect: Beyond the Most Common Mechanisms of Neurodegeneration for New Therapeutic Approaches to Cognitive Decline and Dementia

Cerasuolo, M., Meo, I. D., Auriemma, M. C., Trojsi, F., Maiorino, M. I., Cirillo, M., Esposito, F., Polito, R., Colangelo, A. M., Paolisso, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119637 · Cited by 47 · see citing works

A Tale of Two Diseases: Exploring Mechanisms Linking Diabetes Mellitus with Alzheimer’s Disease

Lynn, J., Park, M., Ogunwale, C., & Acquaah-Mensah, G. K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210612 · Cited by 42 · see citing works

Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases

Jeong, N., Jung, J., & Tabassum, R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265543 · Cited by 40 · see citing works

The Expression of Insulin in the Central Nervous System: What Have We Learned So Far?

Dakic, T. B., Jevdjovic, T. V., Lakic, I. V., Ružičić, A., Jasnic, N. I., Djurasevic, S. F., Djordjevic, J. D., & Vujovic, P. Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076586 · Cited by 39 · see citing works

Role of liraglutide in Alzheimer’s disease pathology

Vargas-Soria, M., Carranza-Naval, M. J., del Marco, À., & Garcı́a-Alloza, M. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00853-0 · Cited by 37 · see citing works

A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials

Gonzales, M. M., Krishnamurthy, S., Garbarino, V. R., Daeihagh, A. S., Gillispie, G. J., Deep, G., Craft, S., & Orr, M. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111589 · Cited by 37 · see citing works

Association between the Use of Dipeptidyl Peptidase 4 Inhibitors and the Risk of Dementia among Patients with Type 2 Diabetes in Taiwan

Chen, K.-C., Chung, C., Lu, C., Tzeng, N., Lee, C.-H., Su, S., Kuo, F.-C., Liu, J., Hsieh, C., & Chien, W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030660 · Cited by 36 · see citing works

Emerging Pathophysiological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: An Old Wine in a New Bottle

Patel, V. N., Chorawala, M. R., Shah, M. B., Shah, K. C., Dave, B. P., Shah, M. P., & Patel, T. M. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220021 · Cited by 36 · see citing works

Amyloid-β and heart failure in Alzheimer’s disease: the new vistas

Al-kuraishy, H., Sulaiman, G., Mohammed, H. A., Mohammed, S. G., Al-Gareeb, A., Albuhadily, A. K., Dawood, R. A., Ali, A. A., & Abu-Alghayth, M. H. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1494101 · Cited by 43 · see citing works

A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse

López-Gambero, A. J., Rosell‐Valle, C., Vera, D. M., Navarro, J. A., Vargas, A., Rivera, P., Sanjuan, C., de Fonseca, F. R., & Suárez, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105365 · Cited by 35 · see citing works

Potential roles of branched-chain amino acids in neurodegeneration

Yoo, H.-S., Shanmugalingam, U., & Smith, P. D. (2022) · Nutrition · doi:10.1016/j.nut.2022.111762 · Cited by 36 · see citing works

The Brain AT2R—a Potential Target for Therapy in Alzheimer’s Disease and Vascular Cognitive Impairment: a Comprehensive Review of Clinical and Experimental Therapeutics

Ahmed, H. A., & Ishrat, T. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01964-9 · Cited by 33 · see citing works

Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders

McDonald, T. S., Lerskiatiphanich, T., Woodruff, T. M., McCombe, P., & Lee, J. D. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221135061 · Cited by 35 · see citing works

Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link

Brzecka, A., Madetko‐Alster, N., Nikolenko, V. N., Ashraf, G. M., Ejma, M., Leszek, J., Daroszewski, C., Sarul, K., Михалева, Л. М., Somasundaram, S. G., et al. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200309101750 · Cited by 34 · see citing works

Metformin/Donepezil combination modulates brain antioxidant status and hippocampal endoplasmic reticulum stress in type 2 diabetic rats

Obafemi, T. O., Olasehinde, O. R., Olaoye, O. A., Jaiyesimi, K. F., Adewumi, F. D., Adewale, O. B., & Afolabi, B. A. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00541-0 · Cited by 32 · see citing works

Glucose metabolism in the brain: An update

Nimgampalle, M., Chakravarthy, H., & Devanathan, V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821406-0.00008-4 · Cited by 32 · see citing works

Metformin in the Prevention of Alzheimer's Disease and Alzheimer's Disease Related Dementias

Tahmi, M., & Luchsinger, J. A. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.113 · Cited by 31 · see citing works

Brain insulin resistance and Alzheimer’s disease: a systematic review

Andrade, L. J. D. O., de Oliveira, L. M., Bittencourt, A. M. V., Lourenço, L. G. D. C., & de Oliveira, G. C. M. (2024) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2023-0032 · Cited by 32 · see citing works

Comorbidity-based framework for Alzheimer’s disease classification using graph neural networks

Abuhantash, F., Hantash, M. K. A., & Shehhi, A. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-72321-2 · Cited by 31 · see citing works

Diabetes mellitus type 2 as an underlying, comorbid or consequent state of mental disorders

Borovčanin, M., Vesić, K., Petrović, I., Jovanović, I., & Mijailović, N. R. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i5.481 · Cited by 30 · see citing works

Prioritizing target-disease associations with novel safety and efficacy scoring methods

Failli, M., Paananen, J., & Fortino, V. (2019) · Scientific Reports · doi:10.1038/s41598-019-46293-7 · Cited by 30 · see citing works

The Interplay between Diabetes and Alzheimer’s Disease—In the Hunt for Biomarkers

Kubis-Kubiak, A., Dyba, A. J., & Piwowar, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082744 · Cited by 30 · see citing works

MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced Alzheimer's like rat model

Bazrgar, M., Khodabakhsh, P., Dargahi, L., Mohagheghi, F., & Ahmadiani, A. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111812 · Cited by 31 · see citing works

Current understandings and perspectives of petroleum hydrocarbons in Alzheimer’s disease and Parkinson’s disease: a global concern

Rajendran, R., Raghavan, R. P., Al-Sehemi, A. G., Uddin, M. S., Aleya, L., & Mathew, B. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-17931-3 · Cited by 29 · see citing works

Novel therapeutic mechanism of action of metformin and its nanoformulation in Alzheimer's disease and role of AKT/ERK/GSK pathway

Kumar, H., Chakrabarti, A., Sarma, P., Modi, M., Banerjee, D., Radotra, B. D., Bhatia, A., & Medhi, B. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106348 · Cited by 32 · see citing works

Alzheimer’s Disease: From Amyloid to Autoimmune Hypothesis

Arshavsky, Y. I. (2020) · The Neuroscientist · doi:10.1177/1073858420908189 · Cited by 28 · see citing works

The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity

Lorenzo, P. I., Vázquez, E. M., López–Noriega, L., Fuente-Martín, E., Mellado‐Gil, J. M., Franco, J. M., Cobo‐Vuilleumier, N., Guerrero-Martinez, J. A., Romero‐Zerbo, S., Pérez-Cabello, J. A., et al. (2021) · Theranostics · doi:10.7150/thno.57237 · Cited by 27 · see citing works

Alzheimer’s Disease Treatment: The Search for a Breakthrough

Reiss, A. B., Muhieddine, D., Jacob, B., Mesbah, M., Pinkhasov, A., Gomolin, I. H., Stecker, M. M., Wısnıewskı, T., & Leon, J. D. (2023) · Medicina · doi:10.3390/medicina59061084 · Cited by 29 · see citing works

Signalling Pathways Implicated in Alzheimer′s Disease Neurodegeneration in Individuals with and without Down Syndrome

Martínez‐Cué, C., & Rueda, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186906 · Cited by 26 · see citing works

Verapamil Prevents Development of Cognitive Impairment in an Aged Mouse Model of Sporadic Alzheimer’s Disease

Ahmed, H. A., Ismael, S., Mirzahosseini, G., & Ishrat, T. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02350-9 · Cited by 27 · see citing works

Effects of antidiabetic agents on Alzheimer’s disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin

Ali, S. K., & Ali, R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271138 · Cited by 27 · see citing works

Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease

Confettura, A. D., Cuboni, E., Ammar, M. R., Jia, S., Gomes, G. M., Yuanxiang, P., Raman, R., Li, T., Grochowska, K. M., Ahrends, R., et al. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-021-00277-8 · Cited by 25 · see citing works

Emerging Therapeutic Promise of Ketogenic Diet to Attenuate Neuropathological Alterations in Alzheimer’s Disease

Uddin, M. S., Kabir, M. T., Tewari, D., Mamun, A. A., Barreto, G. E., BUNGAU, S. G., Bin-Jumah, M. N., Abdel‐Daim, M. M., & Ashraf, G. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02065-3 · Cited by 27 · see citing works

Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury—a Review

McGlennon, T. W., Buchwald, J. N., Pories, W. J., Yu, F., Roberts, A. J., Ahnfeldt, E. P., Menon, R., & Buchwald, H. (2020) · Obesity Surgery · doi:10.1007/s11695-020-05065-3 · Cited by 25 · see citing works

Alleviative Effect of Alpha-Lipoic Acid on Cognitive Impairment in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats

Ko, C., Xu, J., Lo, Y.-M. M., Tu, R.-S., Wu, J. S., Huang, W., & Shen, S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.774477 · Cited by 25 · see citing works

The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome

Kim, J., Park, J.-H., Shah, K., Mitchell, S. J., Cho, K., & Hoe, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.754123 · Cited by 24 · see citing works

Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats

Ghosh, R., Sil, S., Gupta, P., & Ghosh, T. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00588-1 · Cited by 24 · see citing works

Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease

Arnold, M., Büyüközkan, M., Doraiswamy, P. M., Nho, K. T., Wu, T., Gudnason, V. G., Launer, L. J., Wang‐Sattler, R., Adamski, J., Initiative, T. A. D. N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57032-0 · Cited by 24 · see citing works

Brain insulin responsiveness is linked to age and peripheral insulin sensitivity

Wagner, L., Veit, R., Kübler, C., Fritsche, A., Häring, H., Birkenfeld, A. L., Heni, M., Preissl, H., & Kullmann, S. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15094 · Cited by 22 · see citing works

Chronic stress and Alzheimer's disease

Mohammadi, S., Zandi, M., Kataj, P. D., & Karimi‐Zandi, L. (2021) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2216 · Cited by 22 · see citing works

PEGylated Polymer–Lipid Hybrid Nanoparticles to Enhance In Vivo Exposure and Uptake of Repaglinide in Brain Cells to Treat Diabetes-Linked Neurodegenerative Disorders

Wadhwa, G., Krishna, K. V., Dubey, S. K., & Taliyan, R. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.2c05272 · Cited by 22 · see citing works

The fusion of multi-omics profile and multimodal EEG data contributes to the personalized diagnostic strategy for neurocognitive disorders

Han, Y., Zeng, X., Hua, L., Quan, X., Chen, Y., Zhou, M., Chuang, Y. C., Li, Y., Wang, S., Shen, X., et al. (2024) · Microbiome · doi:10.1186/s40168-023-01717-5 · Cited by 22 · see citing works

Levels of serum S100B are associated with cognitive dysfunction in patients with type 2 diabetes

Yu, H., Li, H., Liu, X., Du, X., & Deng, B. (2020) · Aging · doi:10.18632/aging.102873 · Cited by 21 · see citing works

Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals

Kozma, M., Mészáros, Á., Nyúl-Tóth, Á., Molnár, K., Costea, L., Hernádi, Z., Fazakas, C., Farkas, A. E., Wilhelm, I., & Krizbai, I. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116122 · Cited by 21 · see citing works

Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPARγ-dependent activation of PGC-1α/GLUT4 signalling in APP/PS1 transgenic mice

Li, Z., Zhang, Y., Zheng, Y., Liu, W., Zhang, X., Li, W., Zhang, D., Cai, Q., Wang, S., Meng, X., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108685 · Cited by 19 · see citing works

The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice.

Dekeryte, R., Franklin, Z., Hull, C., Croce, L., Kamli-Salino, S., Helk, O., Hoffmann, P. A., Yang, Z.-X., Riedel, G., Delibegović, M., et al. (2021) · Biochimica et Biophysica Acta - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166149 · Cited by 17 · see citing works

GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysisPreprint

Ball, R. L., Bogue, M. A., Liang, H., Srivastava, A., Ashbrook, D. G., Lamoureux, A., Gerring, M. W., Hatoum, A. S., Kim, M. J., He, H., et al. (2024) · Genome Research · doi:10.1101/gr.278157.123 · Cited by 18 · see citing works

Understanding the Insulin-Degrading Enzyme: A New Look at Alzheimer’s Disease and Aβ Plaque Management

Cerasuolo, M., Auriemma, M. C., Meo, I. D., Lenti, C., Papa, M., Paolisso, G., & Rizzo, M. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146693 · Cited by 18 · see citing works

Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical/noncanonical Wnt/β-catenin signaling

Muneeb, M., Mansou, S. M., Saleh, S., & Mohammed, R. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277457 · Cited by 19 · see citing works

Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning

Yuan, X., Yan, F., Gao, L., Ma, Q., & Wang, J. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14260 · Cited by 18 · see citing works

Type 3 diabetes (Alzheimer's disease): new insight for promising therapeutic avenues

Candasamy, M., Elhassan, S. A. M., Bhattamisra, S. K., Hua, W. Y., Sern, L. M., Busthamin, N. A. B., Ilni, N. B. M., Shun, N. S., Baohong, L., Ya, N. S., et al. (2020) · Panminerva Medica · doi:10.23736/s0031-0808.20.03879-3 · Cited by 23 · see citing works

Insulin Signaling Abnormality and Insulin Resistance A Common Pathogenic Mechanism Between Type 2 Diabetes Mellitus and Alzheimer's Disease

Xinru, R., Xiang, L., Niu, Y., Qiumin, Q., & Ma, L. (2026) · Journal of Diabetes Research Review & Reports · doi:10.47363/jdrr/2026(8)2117

Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes

Michailidis, M., Moraitou, D., Tata, D. A., Kalinderi, K., Papamitsou, T., & Papaliagkas, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052687 · Cited by 330 · see citing works

The Common Pathophysiologic Mechanism in Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Resistance

Boonen, R. A. C. M. (2014) · Utrecht University Repository (Utrecht University)

Type 2 diabetes mellitus in the pathophysiology of Alzheimer's disease

de Nazareth, A. M. (2017) · Dementia & Neuropsychologia · doi:10.1590/1980-57642016dn11-020002 · Cited by 60 · see citing works