Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes

Billings, Liana K.; Jablonski, Kathleen A.; Pan, Qing; Florez, Jose C.; Franks, Paul W.; Goldberg, Ronald B.; Hivert, Marie-France; Kahn, Steven E.; Knowler, William C.; Lee, Christine G.; Merino, Jordi; Huerta-Chagoya, Alicia; Mercader, Josep M.; Raghavan, Sridharan; Shi, Zhuqing; Srinivasan, Shylaja; Xu, Jianfeng; Udler, Miriam S.

doi:10.2337/db23-0761

Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes

Partitioned polygenic scores (pPS) have been developed to capture pathophysiologic processes underlying type 2 diabetes (T2D). We investigated the association of T2D pPS with diabetes-related traits and T2D incidence in the Diabetes Prevention Program. We generated five T2D pPS (β-cell, proinsuli…