Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism
Open accessAbstract
PURPOSE OF REVIEW: Glucokinase regulator (GCKR) encodes glucokinase regulatory protein (GKRP), a hepatocyte-specific inhibitor of the glucose-metabolizing enzyme glucokinase (GCK). Genome-wide association studies have identified a common coding variant within GCKR associated with multiple metabolic traits. This review focuses on recent insights into the critical role of GKRP in hepatic glucose metabolism that have stemmed from the study of human genetics. This knowledge has improved our understanding of glucose and lipid physiology and informed the development of targeted molecular therapeutics for diabetes. RECENT FINDINGS: Rare GCKR variants have effects on GKRP expression, localization, and activity. These variants are collectively associated with hypertriglyceridaemia but are not causal. Crystal structures of GKRP and the GCK-GKRP complex have been solved, providing greater insight into the molecular interactions between these proteins. Finally, small molecules have been identified that directly bind GKRP and reduce blood glucose levels in rodent models of diabetes. SUMMARY: GCKR variants across the allelic spectrum have effects on glucose and lipid homeostasis. Functional analysis has highlighted numerous molecular mechanisms for GKRP dysfunction. Hepatocyte-specific GCK activation via small molecule GKRP inhibition may be a new avenue for type 2 diabetes treatment, particularly considering evidence indicating GKRP loss-of-function alone does not cause hypertriglyceridaemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The liver/lipid cluster includes loci GCKR, PNPLA3, and TM6SF2, which functional experiments have shown to relate to liver lipid metabolism.
“The liver/lipid cluster includes loci GCKR, PNPLA3, and TM6SF2, which have been shown through functional experiments to relate to liver lipid metabolism (24–31).”
From Increased genetic risk for β-cell failure is associated with β-cell function decline in people with prediabetes (2024) · cites this paper as [28]
The Conclusion (page not provided) links GCKR’s gene product, GKRP, to hepatic triglyceride metabolism and reports functional analyses of its activity. The paper does not establish the claimed liver/lipid cluster or address PNPLA3 and TM6SF2, so it supports only the GCKR portion of the sentence. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487 · see citing works
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · cited 5× · see citing works
“The first human genetic evidence of a role for GCKR in lipid metabolism was the association of a more than 400 kb genomic region, encompassing GCKR, with plasma triglyceride levels in Europeans via GWAS [7].”
BackgroundInfluentialNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works
Self-citationNewly identified loci that influence lipid concentrations and risk of coronary artery disease
Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585 · see citing works
Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N. P., Rieder, M. J., Cooper, G. M., Roos, C., Voight, B. F., Havulinna, A. S., et al. (2008) · Nature Genetics · doi:10.1038/ng.75 · Cited by 1,386 · see citing works
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364 · see citing works
Human metabolic individuality in biomedical and pharmaceutical research
CARDIoGRAM, Suhre, K., Shin, S.-Y., Petersen, A.-K., Mohney, R. P., Meredith, D., Wägele, B., Altmaier, E., Deloukas, P., Erdmann, J., et al. (2011) · Nature · doi:10.1038/nature10354 · Cited by 1,017 · see citing works
Speliotes, E. K., Yerges-Armstrong, L. M., Wu, J., Hernaez, R., Kim, L. J., Palmer, C. D., Gudnason, V., Eiriksdottir, G., Garcia, M. E., Launer, L. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001324 · Cited by 984 · see citing works
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Aulchenko, Y. S., Janssens, A. C. J. W., Albert Hofman, D., Isaacs, A. J., Sijbrands, E. J. G., Witteman, J. C. M., van Duijn, C. M., Ripatti, S., Lindqvist, I., Perola, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.269 · Cited by 846 · see citing works
Scott, R. A., Lagou, V., Welch, R., Wheeler, E., Montasser, M. E., Luan, J., Mägi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., et al. (2012) · Nature Genetics · doi:10.1038/ng.2385 · Cited by 817 · see citing works
New loci associated with kidney function and chronic kidney disease
Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., et al. (2010) · Nature Genetics · doi:10.1038/ng.568 · Cited by 801 · see citing works
Kolz, M., Johnson, T., Sanna, S., Teumer, A., Vitart, V., Perola, M., Mangino, M., Albrecht, E., Wallace, C., Farrall, M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000504 · Cited by 659 · see citing works
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Saxena, R., the MAGIC investigators, Hivert, M., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia‐Naji, N., Dupuis, J., et al. (2010) · Nature Genetics · doi:10.1038/ng.521 · Cited by 621 · see citing works
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
Kettunen, J., Tukiainen, T., Sarin, A.-P., Ortega-Alonso, A., Tikkanen, E., Lyytikäinen, L.-P., Kangas, A. J., Soininen, P., Würtz, P., Silander, K., et al. (2012) · Nature Genetics · doi:10.1038/ng.1073 · Cited by 553 · see citing works
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers, J. C., Study, D. G. R. A. M.-A. (., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Hólm, H., Sanna, S., Kavousi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.970 · Cited by 546 · see citing works
Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
Grimsby, J. S., Sarabu, R., Corbett, W. L., Haynes, N.-E., Bizzarro, F. T., Coffey, J. W., Guertin, K. R., Hilliard, D. W., Kester, R. F., Mahaney, P. E., et al. (2003) · Science · doi:10.1126/science.1084073 · Cited by 526 · see citing works
Genome-wide association study of hematological and biochemical traits in a Japanese population
Kamatani, Y., Matsuda, K., Okada, Y., Kubo, M., Hosono, N., Daigo, Y., Nakamura, Y., & Kamatani, N. (2010) · Nature Genetics · doi:10.1038/ng.531 · Cited by 501 · see citing works
The Disposal of an Oral Glucose Load in Healthy Subjects: A Quantitative Study
Ferrannini, E., Bjorkman, O., Reichard, G. A., Pilo, A., Olsson, M., Wahren, J., & DeFronzo, R. A. (1985) · Diabetes · doi:10.2337/diab.34.6.580 · Cited by 439 · see citing works
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Johansen, C. T., Wang, J., Lanktree, M. B., Cao, H., McIntyre, A. D., Ban, M. R., Martins, R. A., Kennedy, B. A., Hassell, R. G., Visser, M. E., et al. (2010) · Nature Genetics · doi:10.1038/ng.628 · Cited by 437 · see citing works
Lemaître, R. N., Tanaka, T., Tang, W., Manichaikul, A. W., Foy, M., Kabagambe, E. K., Nettleton, J. A., King, I. B., Weng, L.-C. C., Bhattacharya, S., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002193 · Cited by 412 · see citing works
New gene functions in megakaryopoiesis and platelet formation
Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic‐Canic, J., Elling, U., Goodall, A. H., Labrune, Y., et al. (2011) · Nature · doi:10.1038/nature10659 · Cited by 404 · see citing works
Assessing the potential of glucokinase activators in diabetes therapy
Matschinsky, F. M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2850 · Cited by 402 · see citing works
Beer, N. L., Tribble, N. D., McCulloch, L. J., Roos, C., Johnson, P. R. V., Orho-Melander, M., & Gloyn, A. L. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp357 · Cited by 401 · see citing works
Self-citationRegulation of Hepatic Glucose Uptake and Storage In Vivo
Moore, M. C., Coate, K. C., Winnick, J. J., An, Z., & Cherrington, A. D. (2012) · Advances in Nutrition · doi:10.3945/an.112.002089 · Cited by 351 · see citing works
Ridker, P. M., Paré, G., Parker, A. N., Zee, R. Y. L., Danik, J. S., Buring, J. E., Kwiatkowski, D. J., Cook, N. R., Miletich, J. P., & Chasman, D. I. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.03.015 · Cited by 342 · see citing works
Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.01.009 · Cited by 309 · see citing works
Orho‐Melander, M., Melander, O., Guiducci, C., Pérez‐Martínez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M. J., Hall, J. L., Abecasis, G. R., et al. (2008) · Diabetes · doi:10.2337/db08-0516 · Cited by 301 · see citing works
Meininger, G. E., Scott, R. S., Alba, M., Shentu, Y., Luo, E., Amin, H., Davies, M. J., Kaufman, K. D., & Goldstein, B. J. (2011) · Diabetes Care · doi:10.2337/dc11-1200 · Cited by 212 · see citing works
Lange, L. A., Hu, Y., Zhang, H., Xue, C., Schmidt, E. M., Tang, Z.-Z., Bizon, C., Lange, E. M., Smith, J. D., Turner, E. H., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.01.010 · Cited by 209 · see citing works
SCHAFTINGEN, E. V. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14538.x · Cited by 195 · see citing works
Vaxillaire, M., Cavalcanti-Proença, C., Dechaume, A., Tichet, J., Marre, M., Balkau, B., Froguel, P., & for the DESIR Study Group (2008) · Diabetes · doi:10.2337/db07-1807 · Cited by 191 · see citing works
Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome
Nica, A. C., Ongen, H., Irminger, J.-C., Bosco, D., Berney, T., Antonarakis, S. E., Halban, P. A., & Dermitzakis, E. T. (2013) · Genome Research · doi:10.1101/gr.150706.112 · Cited by 189 · see citing works
O’Seaghdha, C. M., Wu, H., Yang, Q., Kapur, K., Guessous, I., Zuber, A. M., Köttgen, A., Stoudmann, C., Teumer, A., Kutalik, Z., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003796 · Cited by 181 · see citing works
Sparsø, T., Andersen, G., Nielsen, T., Burgdorf, K. S., Gjesing, A. P., Nielsen, A. L., Albrechtsen, A., Rasmussen, S. S., Jørgensen, T., Borch‐Johnsen, K., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0865-z · Cited by 171 · see citing works
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers, J. C., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Hólm, H., Sanna, S., Kavousi, M., Baumeister, S. E., et al. (2011) · Archive ouverte UNIGE (University of Geneva) · doi:10.5451/unibas-ep81762 · Cited by 169 · see citing works
Farrelly, D., Brown, K. S., Tieman, A., Ren, J., Lira, S. A., Hagan, D. L., Gregg, R. E., Mookhtiar, K. A., & Hariharan, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14511 · Cited by 153 · see citing works
Agius, L., Peak, M., Newgard, C. B., Gómèz‐Foix, A. M., & Guinovart, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30479 · Cited by 149 · see citing works
Pleiotropic genes for metabolic syndrome and inflammation
Kraja, A. T., Chasman, D. I., North, K. E., Reiner, A. P., Yanek, L. R., Kilpeläinen, T. O., Smith, J. A., Dehghan, A., Dupuis, J., Johnson, A. D., et al. (2014) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2014.04.007 · Cited by 147 · see citing works
Glucokinase Regulatory Protein May Interact With Glucokinase in the Hepatocyte Nucleus
Brown, K. S., Kalinowski, S. S., Megill, J. R., Durham, S. K., & Mookhtiar, K. A. (1997) · Diabetes · doi:10.2337/diab.46.2.179 · Cited by 145 · see citing works
Characterization of Glucokinase Regulatory Protein-deficient Mice
Grimsby, J. S., Coffey, J. W., Dvorozniak, M. T., Magram, J., Li, G., Matschinsky, F. M., Shiota, C., Kaur, S., Magnuson, M. A., & Grippo, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7826 · Cited by 133 · see citing works
Reiner, A. P., Beleza, S. S., Franceschini, N., Auer, P. L., Robinson, J. G., Kooperberg, C. L., Peters, U., & Tang, H. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.07.023 · Cited by 127 · see citing works
Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men
Mahendran, Y., Vangipurapu, J., Cederberg, H., Stančáková, A., Pihlajamäki, J., Soininen, P., Kangas, A. J., Paananen, J., Civelek, M., Saleem, N. K., et al. (2013) · Diabetes · doi:10.2337/db12-1363 · Cited by 122 · see citing works
Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk
Rees, M. G., Wincovitch, S., Schultz, J., Waterstradt, R., Beer, N. L., Baltrusch, S., Collins, F. S., & Gloyn, A. L. (2011) · Diabetologia · doi:10.1007/s00125-011-2348-5 · Cited by 103 · see citing works
Self-citationJohansen, C. T., Wang, J., Lanktree, M. B., McIntyre, A. D., Ban, M. R., Martins, R. A., Kennedy, B. A., Hassell, R. G., Visser, M. E., Schwartz, S. M., et al. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.226365 · Cited by 97 · see citing works
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
Lloyd, D. J., Jean, D. J. S., Kurzeja, R. J. M., Wahl, R. C., Michelsen, K., Cupples, R. L., Chen, M., Wu, J. W. Y., Sivits, G. N., Helmering, J., et al. (2013) · Nature · doi:10.1038/nature12724 · Cited by 95 · see citing works
Choi, J. M., Seo, M., Kyeong, H., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300457110 · Cited by 91 · see citing works
Competitive inhibition of liver glucokinase by its regulatory protein
Vandercammen, A., & SCHAFTINGEN, E. V. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16217.x · Cited by 89 · see citing works
Characterization of Glucokinase-binding Protein Epitopes by a Phage-displayed Peptide Library
Baltrusch, S., Lenzen, S., Okar, D. A., Lange, A. J., & Tiedge, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105470200 · Cited by 84 · see citing works
Johnson, D., Shepherd, R. M., Gill, D., Gorman, T., Smith, D. M., & Dunne, M. (2007) · Diabetes · doi:10.2337/db07-0026 · Cited by 80 · see citing works
Ceuninck, F. D., Kargar, C., Ilic, C., Caliez, A., Rolin, J., Umbdenstock, T., Vinson, C., Combettes, M., Fanti, B. A. D., Harley, E. A., et al. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02184.x · Cited by 74 · see citing works
Evidence for Glucokinase Translocation by Glucose in Rat Hepatocytes
Toyoda, Y., Miwa, I., Kamiya, M., Ogiso, S., Nonogaki, T., Aoki, S., & Okuda, J. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2452 · Cited by 74 · see citing works
Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation
Detheux, M., Vandercammen, A., & SCHAFTINGEN, E. V. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16218.x · Cited by 71 · see citing works
Veiga‐da‐Cunha, M., & SCHAFTINGEN, E. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105984200 · Cited by 71 · see citing works
Agius, L., Peak, M., & SCHAFTINGEN, E. V. (1995) · Biochemical Journal · doi:10.1042/bj3090711 · Cited by 70 · see citing works
Pleiotropic Effects of Lipid Genes on Plasma Glucose, HbA1c, and HOMA-IR Levels
Li, N., van der Sijde, M. R., LifeLines Cohort Study Group, Bakker, S. J. L., Dullaart, R. P. F., van der Harst, P., Gansevoort, R. T., Elbers, C. C., Wijmenga, C., Snieder, H., et al. (2014) · Diabetes · doi:10.2337/db13-1800 · Cited by 70 · see citing works
Tam, C. H. T., Ronald, C. W., So, W. Y., Wang, Y., Lam, V. K. L., Germer, S., Martin, M., Chan, J. C. N., & Ng, M. C. Y. (2008) · Diabetes · doi:10.2337/db08-1277 · Cited by 61 · see citing works
Amino Acid Conservation in Animal Glucokinases
Veiga‐da‐Cunha, M., Courtois, S. J., Michel, A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6292 · Cited by 59 · see citing works
Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein
Beck, T., & Miller, B. G. (2013) · Biochemistry · doi:10.1021/bi400838t · Cited by 57 · see citing works
Nishimura, N., Norman, M. H., Liu, L., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5000497 · Cited by 57 · see citing works
Mari, A., Wahren, J., DeFronzo, R. A., & Ferrannini, E. (1994) · Metabolism · doi:10.1016/0026-0495(94)90038-8 · Cited by 55 · see citing works
Rees, M. G., Ng, D., Ruppert, S. L., Turner, C., Beer, N. L., Swift, A. J., Morken, M. A., Below, J. E., Blech, I., Mullikin, J. C., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46425 · Cited by 48 · see citing works
Self-citationNissim, I., Horyn, O., Nissim, I. B., Daikhin, Y., Wehrli, S. L., Yudkoff, M., & Matschinsky, F. M. (2012) · Biochemical Journal · doi:10.1042/bj20120163 · Cited by 46 · see citing works
Anderka, O., Boyken, J., Aschenbach, U., Batzer, A., Boscheinen, O., & Schmoll, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805434200 · Cited by 46 · see citing works
Crystal Structure of Glucokinase Regulatory Protein
Pautsch, A., Stadler, N., Löhle, A., Rist, W., Berg, A., Glocker, L., Nar, H., Reinert, D. J., Lenter, M., Heckel, A., et al. (2013) · Biochemistry · doi:10.1021/bi4000782 · Cited by 44 · see citing works
Baltrusch, S., Francini, F., Lenzen, S., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2829 · Cited by 43 · see citing works
Effect of mutations on the sensitivity of human beta-cell glucokinase to liver regulatory protein
Veiga‐da‐Cunha, M., Xu, L. Z., Lee, Y. H., et al. (1996) · Diabetologia · doi:10.1007/bf02658503 · Cited by 41 · see citing works
Vandercammen, A., Detheux, M., & SCHAFTINGEN, E. V. (1992) · Biochemical Journal · doi:10.1042/bj2860253 · Cited by 38 · see citing works
Differences in regulatory properties between human and rat glucokinase regulatory protein
Brocklehurst, K. J., Davies, R. A., & Agius, L. (2004) · Biochemical Journal · doi:10.1042/bj20031414 · Cited by 33 · see citing works
Ashton, K. S., Andrews, K. L., Bryan, M. C., Chen, J., Chen, K., Chen, M., Chmait, S., Croghan, M. D., Cupples, R. L., Fotsch, C. H., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm4016735 · Cited by 33 · see citing works
Small molecular glucokinase activators: has another new anti‐diabetic therapeutic lost favour?
Rees, M. G., & Gloyn, A. L. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02201.x · Cited by 29 · see citing works
Self-citationToyoda, Y., Miwa, I., Kamiya, M., et al. (1995) · Histochemistry and Cell Biology · doi:10.1007/bf01464473 · Cited by 27 · see citing works
Zelent, B., Raimondo, A., Barrett, A., Buettger, C. W., Chen, P., Gloyn, A. L., & Matschinsky, F. M. (2014) · Biochemical Journal · doi:10.1042/bj20131363 · Cited by 27 · see citing works
Self-citationRees, M. G., Raimondo, A., Wang, J., Ban, M. R., Davis, M. I., Barrett, A., Ranft, J., Jagdhuhn, D., Waterstradt, R., Baltrusch, S., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu269 · Cited by 26 · see citing works
Self-citationJean, D. J. S., Ashton, K. S., Bartberger, M. D., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm4016747 · Cited by 26 · see citing works
Veiga‐da‐Cunha, M., Sokolova, T. N., Opperdoes, F. R., et al. (2009) · Biochemical Journal · doi:10.1042/bj20090986 · Cited by 22 · see citing works
Shin, S., Petersen, A.-K., Wahl, S., Zhai, G., Römisch‐Margl, W., Small, K. S., Döring, A., Kato, B. S., Peters, A., Grundberg, E., et al. (2014) · Genome Medicine · doi:10.1186/gm542 · Cited by 18 · see citing works
Bourbonais, F., Chen, J., Huang, C., et al. (2011) · Biochemical Journal · doi:10.1042/bj20110721 · Cited by 12 · see citing works
Hong, F., Norman, M. H., Ashton, K. S., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5001979 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [1]Gloyn AL Odili S Buettger C Matschinsky FM Magnuson MA Glucokinase and the regulation of blood sugar Glucokinase and glycaemic disease: from basics to novel therapeutics 2004 92 109 Karger Basel
Cited by
Sorted by citations
Udler, M. S., Kim, J., von Grotthuss, M., Bonàs-Guarch, S., Cole, J. B., Chiou, J., ISGC, C. D. A. O. B. O. M. A. T., Boehnke, M., Laakso, M., Atzmon, G., et al. (2018) · PLOS Medicine · doi:10.1371/journal.pmed.1002654 · Cited by 542 · see citing works
Adeva-Andany, M. M., González-Lucán, M., Donapetry-García, C., Fernández-Fernández, C., & Ameneiros-Rodríguez, E. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.02.001 · Cited by 504 · see citing works
Clarke, T.-K., Adams, M. J., Davies, G., Howard, D. M., Hall, L. S., Padmanabhan, S., Murray, A. D., Smith, B. H., Campbell, A., Hayward, C., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.153 · Cited by 440 · see citing works
Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans
Pafili, K., & Roden, M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101122 · Cited by 330 · see citing works
Carlsson, B., Lindén, D., Brolén, G., Liljeblad, M., Bjursell, M., Romeo, S., & Loomba, R. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15738 · Cited by 169 · see citing works
Billings, L. K., Jablonski, K. A., Pan, Q., Florez, J. C., Franks, P. W., Goldberg, R. B., Hivert, M.-F., Kahn, S. E., Knowler, W. C., Lee, C. G., et al. (2024) · Diabetes · doi:10.2337/db23-0761 · Cited by 11 · see citing works
- Authors
- Raimondo, A., Rees, M. G., & Gloyn, A. L.
- Affiliations
- Broad Institute (US)
- Churchill Hospital (GB)
- Corresponding author
- Gloyn, Anna L.
- Venue
- Current Opinion in Lipidology
- Published
- 2015-04
- Volume
- 26
- Issue
- 2
- Pages
- 88-95
- ISSN
- 0957-9672 (ISSN-L)
- PMC
- PMC4422901
- OpenAlex
- W2072399907
- Cited by
- 118
- References
- 78
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 15 · 2023: 3 · 2022: 14 · 2021: 11 · 2020: 12 · 2019: 15 · 2018: 13 · 2017: 11 · 2016: 4 · 2015: 3
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Current Opinion in Lipidology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (095101, 095101/Z/10/Z, 090532)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- GCKR, glucokinase, hepatic glucose metabolism, hypertriglyceridemia, type 2 diabetes, small molecule drugs, glucose and lipid homeostasis, loss of function
- MeSH terms
- Animals, Carrier Proteins, Diabetes Mellitus, Enzyme Inhibitors, Glucose, Homeostasis, Humans, Triglycerides, Mutation, Missense, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
