CoChat
Sign Up
Cited by 643Vitamin D Research StudiesNutrition and Health StudiesBone health and osteoporosis research

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Nondiabetic Adults

Pittas, Anastassios G., Harris, Susan S., Stark, Paul C., Dawson-Hughes, Bess·2007·Diabetes Care
DOI 10.2337/dc06-1994
Open this paper in CoChat — free account

Abstract

OBJECTIVE: We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years. RESEARCH DESIGN AND METHODS: A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700 IU vitamin D(3) or placebos daily for 3 years in a double-blind, randomized, controlled trial designed for bone-related outcomes. In a post hoc analysis, fasting plasma glucose (FPG), insulin sensitivity (estimated by homeostasis model assessment of insulin resistance [HOMA-IR]), plasma C-reactive protein, and interleukin-6, were measured at baseline and 3 years. RESULTS: The effects of combined calcium-vitamin D supplementation on 3-year change in FPG depended on baseline FPG (P = 0.02 for interaction). Therefore, we conducted analyses separately in participants with normal fasting glucose (NFG) (FPG <5.6 mmol/l, n = 222) and impaired fasting glucose (IFG) (FPG 5.6-6.9 mmol/l, n = 92) at baseline. Among participants with IFG at baseline, those who took combined calcium-vitamin D supplements had a lower rise in FPG at 3 years compared with those on placebo (0.02 mmol/l [0.4 mg/dl] vs. 0.34 mmol/l [6.1 mg/dl], respectively, P = 0.042) and a lower increase in HOMA-IR (0.05 vs. 0.91, P = 0.031). In the NFG subgroup, there was no difference in the change in FPG or HOMA-IR between the two treatment arms. There were no differences in C-reactive protein or interleukin-6 between the two treatment arms in either subgroup. CONCLUSIONS: In healthy, older adults with IFG, supplementation with calcium and vitamin D may attenuate increases in glycemia and insulin resistance that occur over time. However, our findings should be considered hypothesis generating and need to be confirmed in randomized trials specifically designed for the outcomes of interest.

Overview

Integrity signals

Registry

Crossref · 10.2337/dc06-1994

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 58 references

Research works printed but not linked: 1

  1. Food and Nutrient Board IoM: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC, National Academy Press, 1997

Cited by

Sorted by citations

Items 401–500 of 641

Related

See all

Metadata

Authors
Pittas, A. G., Harris, S. S., Stark, P. C., & Dawson-Hughes, B.
Affiliations
  • Tufts Medical Center (US)
  • Tufts University (US)
  • Department of Endocrinology, Diabetes, and Metabolism, Tufts–New England Medical Center, Boston, Massachusetts
ORCID
Pittas, Anastassios G.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2007-04-01
Volume
30
Issue
4
Pages
980-986
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc06-1994
OpenAlex
W2129327282
Cited by
643
References
58
Citations by year
2026: 9 · 2025: 6 · 2024: 12 · 2023: 12 · 2022: 13 · 2021: 26 · 2020: 17 · 2019: 23 · 2018: 35 · 2017: 48 · 2016: 48 · 2015: 39 · 2014: 60 · 2013: 52 · 2012: 55
FWCI
30.44
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (K23 DK 61506, R01DK076092, K23DK061506)
  • National Center for Research Resources (M01 RR-00054, M01RR000054)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
calcium supplementation, vitamin D supplementation, calcium citrate, vitamin D3, blood glucose, fasting blood glucose, insulin resistance, HOMA-IR, impaired fasting glucose, inflammation, C-reactive protein, interleukin-6, older adults, non-diabetic adults
MeSH terms
Aged, Blood Glucose, Body Weight, Calcium, Dietary, Female, Humans, Hyperglycemia, Inflammation, Insulin, Male, Reference Values, Vitamin D, Biomarkers, Body Mass Index, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review