Levels of 25-Hydroxyvitamin D3, Biochemical Parameters and Symptoms of Depression and Anxiety in Healthy Individuals
Abstract
Growing evidence support the role of vitamin D in brain function and behavior. This study investigated the relationship between 25-hydroxyvitamin D 3 [25(OH)D 3] levels, biochemical profile and symptoms of depression and anxiety in healthy individuals. Symptoms of depression were assessed by the Beck Depression Inventory (BDI) and anxiety was evaluated with the State-Trait Anxiety Inventory (STAI). Our sample included 36 individuals, mostly women 27(75%), 36.39 ± 9.72 years old, non-smokers 31(86.1%), body mass index of 26.57 ± 3.92 kg/m 2, 27.95 ± 7.50% body fat. Participants were divided into those with 25(OH)D 3 levels lower than 40 ng/mL (mean 28.16 ± 7.07) and equal or higher than 40 ng/mL (mean 53.19 ± 6.32). Those with lower 25(OH)D 3 had higher levels of triacylglycerol, triacylglycerol/high density lipoprotein (HDL) ratio, high glucose and homeostatic model assessment of insulin resistance (HOMA-IR) index. No changes were observed in sociodemographic variables, body composition, inflammatory parameters and cortisol. Additionally, in the groups with low and high 25(OH)D 3 levels, STAI state, STAI trait and BDI scores were not statistically different. Levels of 25(OH)D 3 were inversely and independently associated with glucose and HOMA-IR, but not associated with triacylglycerol, depression and anxiety scores. Lower levels of 25(OH)D 3 were associated with dysfunction in glucose metabolism but not with depression and anxiety in healthy individuals.
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No changes were identified for calcifediol in AD.
“No changes were identified for calcifediol [78].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [78]
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Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
Zorkina, Y., Ushakova, V., Ochneva, A., Tsurina, A., Abramova, O., Savenkova, V., Goncharova, A., Alekseenko, I., Morozova, I., Riabinina, D., et al. (2024) · Metabolites · doi:10.3390/metabo14020080 · Cited by 36 · see citing works
- Authors
- Casseb, G. A. S., Ambrósio, G., Rodrigues, A. L. S., & Kaster, M. P.
- Affiliations
- Universidade Federal de Santa Catarina (BR)
- Corresponding author
- Kaster, Manuella P.
- Venue
- Metabolic Brain Disease
- Published
- 2019-01-02
- Volume
- 34
- Issue
- 2
- Pages
- 527-535
- ISSN
- 0885-7490 (ISSN-L)
- 1573-7365
- OpenAlex
- W2907849946
- Cited by
- 13
- References
- 75
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 4
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Metabolic Brain Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CNPq research fellow (303488/2015-8, 310113/2017-2)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- 25-hydroxyvitamin D3, vitamin D status, depression, anxiety, insulin resistance, HOMA-IR, glucose metabolism, triglycerides, HDL cholesterol, healthy individuals, biomarkers
- MeSH terms
- Adult, Anxiety, Anxiety Disorders, Calcifediol, Depression, Depressive Disorder, Female, Humans, Male, Middle Aged, Vitamin D Deficiency, Vitamins
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