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Cited by 320Liver Disease Diagnosis and TreatmentPhysical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans

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Perseghin, Gianluca, Lattuada, Guido, De Cobelli, Francesco, Ragogna, Francesca, Ntali, Georgia, Esposito, Antonio, Belloni, Elena, Canu, Tamara, Terruzzi, Ileana, Scifo, Paola, Del Maschio, Alessandro, Luzi, Livio·2007·Diabetes Care
DOI 10.2337/dc06-2032
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Abstract

OBJECTIVE: Fatty liver may be involved in the pathogenesis of type 2 diabetes. Physical exercise is a tool to improve insulin sensitivity, but little is known about its effect on intrahepatic fat (IHF) content. The purpose of this study was to examine the association of habitual physical activity, insulin resistance, and adiponectin with IHF content. RESEARCH DESIGN AND METHODS: Participants were 191 (77 female and 114 male) apparently healthy, nonalcoholic individuals (aged 19-62 years; BMI 17.0-35.5 kg/m2). IHF content was assessed in a quantitative fashion and noninvasively as a continuous variable by means of 1H magnetic resonance spectroscopy (MRS), and habitual physical activity was assessed by means of a questionnaire. Fatty liver was defined as IHF content of >5% wet weight, and insulin sensitivity was estimated using the computer homeostasis model assessment (HOMA)-2 indexes. RESULTS: A reduced prevalence of fatty liver in the quartile of the most physically active individuals (25, 11, 25, and 2% in quartile 1, 2, 3, and 4, respectively; chi2 = 15.63; P = 0.001) was found along with an inverse correlation between the physical activity index and the IHF content when plotted as continuous variables (Pearson's r = -0.27; P < 0.000). This association was not attenuated when adjusted for age, sex, BMI, HOMA-2, and adiponectin (partial correlation r = -0.25; P < 0.001). CONCLUSIONS: This study demonstrated that a higher level of habitual physical activity is associated with a lower IHF content and suggested that this relationship may be due to the effect of exercise per se.

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Authors
Perseghin, G., Lattuada, G., De Cobelli, F., Ragogna, F., Ntali, G., Esposito, A., Belloni, E., Canu, T., Terruzzi, I., Scifo, P., Del Maschio, A., & Luzi, L.
Affiliations
  • University of Milan (IT)
  • IRCCS Ospedale San Raffaele (IT)
  • Unit of Clinical Spectroscopy, San Raffaele Scientific Institute, Milan, Italy
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2007-03-01
Volume
30
Issue
3
Pages
683-688
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc06-2032
OpenAlex
W2075760095
Cited by
320
References
28
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 15 · 2018: 68 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 16 · 2013: 16 · 2012: 18
FWCI
18.57
Type
journal article
Language
en
Open access
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Funders
Harokopio University
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
physical activity behavior, intrahepatic fat, hepatic steatosis, insulin resistance, adiponectin, type 2 diabetes, physical activity, 1H magnetic resonance spectroscopy
MeSH terms
Adipose Tissue, Adult, Blood Pressure, Fatty Liver, Female, Humans, Liver, Male, Middle Aged, Physical Fitness, Reference Values, Exercise, Prevalence

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