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Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans
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OBJECTIVE: Fatty liver may be involved in the pathogenesis of type 2 diabetes. Physical exercise is a tool to improve insulin sensitivity, but little is known about its effect on intrahepatic fat (IHF) content. The purpose of this study was to examine the association of habitual physical activity, insulin resistance, and adiponectin with IHF content. RESEARCH DESIGN AND METHODS: Participants were 191 (77 female and 114 male) apparently healthy, nonalcoholic individuals (aged 19-62 years; BMI 17.0-35.5 kg/m2). IHF content was assessed in a quantitative fashion and noninvasively as a continuous variable by means of 1H magnetic resonance spectroscopy (MRS), and habitual physical activity was assessed by means of a questionnaire. Fatty liver was defined as IHF content of >5% wet weight, and insulin sensitivity was estimated using the computer homeostasis model assessment (HOMA)-2 indexes. RESULTS: A reduced prevalence of fatty liver in the quartile of the most physically active individuals (25, 11, 25, and 2% in quartile 1, 2, 3, and 4, respectively; chi2 = 15.63; P = 0.001) was found along with an inverse correlation between the physical activity index and the IHF content when plotted as continuous variables (Pearson's r = -0.27; P < 0.000). This association was not attenuated when adjusted for age, sex, BMI, HOMA-2, and adiponectin (partial correlation r = -0.25; P < 0.001). CONCLUSIONS: This study demonstrated that a higher level of habitual physical activity is associated with a lower IHF content and suggested that this relationship may be due to the effect of exercise per se.
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“A second study reported a low level of habitual physical activity was associated with higher intrahepatic fat content in healthy, nonalcoholic males and females ages 19–62 (407).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [407]
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Cites
Use and Abuse of HOMA Modeling
Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114
A short questionnaire for the measurement of habitual physical activity in epidemiological studies
Baecke, J. A. H., BUREMA, J., & Frijters, J. E. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.936 · Cited by 3,950
Diet, lifestyle, and the risk of type 2 diabetes mellitus in women.
Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G., Liu, S., Solomon, C. G., & Willett, W. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010492 · Cited by 2,901
Nonalcoholic Fatty Liver Disease
Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G., & Melchionda, N. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1844 · Cited by 2,581
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
Neuschwander‐Tetri, B. A., & Caldwell, S. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50193 · Cited by 2,166
Szczepaniak, L. S., Nurenberg, P., Leonard, D. S., Browning, J. D., Reingold, J. S., Grundy, S. M., Hobbs, H. H., & Dobbins, R. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00064.2004 · Cited by 1,573
Association of nonalcoholic fatty liver disease with insulin resistance
Marchesini, G., Brizi, M., Morselli‐Labate, A. M., Bianchi, G. P., Bugianesi, E., McCullough, A. J., Forlani, G., & Melchionda, N. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00271-5 · Cited by 1,570
Lewis, G. F., Carpentier, A. C., Adeli, K., & Giacca, A. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0461 · Cited by 1,370
Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911
Vozarova, B., Stefan, N., Lindsay, R. S., Saremi, A., Pratley, R. E., Bogardus, C., & Tataranni, P. A. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1889 · Cited by 717
Cited by
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Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575
Treatment of NAFLD with diet, physical activity and exercise
Romero-Gómez, M., Zelber-Sagi, S., & Trenell, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.016 · Cited by 1,347
A position statement on NAFLD/NASH based on the EASL 2009 special conference
Ratziu, V., Bellentani, S., Cortez‐Pinto, H., Day, C., & Marchesini, G. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.04.008 · Cited by 1,083
Identification and characterization of metabolically benign obesity in humans
Stefan, N. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1609 · Cited by 1,049
Kotronen, A., & Yki‐Järvinen, H. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147538 · Cited by 793
Musso, G., Cassader, M., Rosina, F., & Gambino, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2446-4 · Cited by 661
Johnson, N. A., Sachinwalla, T., Walton, D. W., Smith, K., Armstrong, A., Thompson, M. W., & George, J. (2009) · Hepatology · doi:10.1002/hep.23129 · Cited by 631
Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Keating, S. E., Hackett, D. A., George, J., & Johnson, N. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.02.023 · Cited by 548
Causes and Metabolic Consequences of Fatty Liver
Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 536
Hallsworth, K., Fattakhova, G., Hollingsworth, K. G., Thoma, C., Moore, S., Taylor, R., Day, C. P., & Trenell, M. I. (2011) · Gut · doi:10.1136/gut.2011.242073 · Cited by 529
Taylor, R. (2013) · Diabetes Care · doi:10.2337/dc12-1805 · Cited by 485
Gastaldelli, A., Kozàkovà, M., Højlund, K., Flyvbjerg, A., Favuzzi, A. M. R., Mitrakou, A., & Balkau, B. (2009) · Hepatology · doi:10.1002/hep.22845 · Cited by 381
Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause
Taylor, R. (2008) · Diabetologia · doi:10.1007/s00125-008-1116-7 · Cited by 352
Non-alcoholic fatty liver disease and the metabolic syndrome: An update
Rector, R. S., Thyfault, J. P., Wei, Y., & Ibdah, J. A. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.185 · Cited by 337
Nonalcoholic Fatty Liver Disease Review: Diagnosis, Treatment, and Outcomes
Ahmed, A., Wong, R. J., & Harrison, S. A. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.07.029 · Cited by 336
Rector, R. S., Thyfault, J. P., Morris, R. T., Laye, M. J., Borengasser, S. J., Booth, F. W., & Ibdah, J. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00428.2007 · Cited by 321
Pathogenesis and Prevention of Hepatic Steatosis.
Nassir, F., Rector, R. S., Hammoud, G. M., & Ibdah, J. A. (2015) · PubMed Central · Cited by 317
Independent effects of physical activity in patients with nonalcoholic fatty liver disease #
St. George, A., Bauman, A., Johnston, A., Farrell, G., Chey, T., & George, J. (2009) · Hepatology · doi:10.1002/hep.22940 · Cited by 318
Current treatment paradigms and emerging therapies for NAFLD/NASH
Raza, S. (2020) · Frontiers in bioscience · doi:10.2741/4892 · Cited by 329
Ghouri, N., Preiss, D., & Sattar, N. A. (2010) · Hepatology · doi:10.1002/hep.23789 · Cited by 302
Role of leisure-time physical activity in nonalcoholic fatty liver disease: A population-based study
Zelber-Sagi, S., Nitzan-Kaluski, D., Goldsmith, R., Webb, M., Zvibel, I., Goldiner, I., Blendis, L., Halpern, Z., & Oren, R. (2008) · Hepatology · doi:10.1002/hep.22525 · Cited by 296
Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies
Bergouignan, A., Rudwill, F., Simon, C., & Blanc, S. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00698.2011 · Cited by 293
Kantartzis, K., Thamer, C., Peter, A., Machann, J., Schick, F., Schraml, C., Konigsrainer, A., Konigsrainer, I., Krober, S., Niess, A., et al. (2009) · Gut · doi:10.1136/gut.2008.151977 · Cited by 273
KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease
Kang, S. H., Lee, H. W., Yoo, J., Cho, Y., Kim, S. U., Lee, T. H., Jang, B. K., Ahn, S. B., Ahn, S. B., Kim, H., et al. (2021) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2021.0178 · Cited by 276
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Torres, D. M., Williams, C. D., & Harrison, S. A. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.03.011 · Cited by 275
Lifestyle modification in NAFLD/NASH: Facts and figures
Hallsworth, K., & Adams, L. A. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.10.008 · Cited by 281
Non-alcoholic fatty liver disease: A patient guideline
Francque, S. M., Marchesini, G., Kautz, A., Walmsley, M., Dorner, R., Lazarus, J. V., Zelber-Sagi, S., Hallsworth, K., Busetto, L., Frühbeck, G., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100322 · Cited by 264
van der Heijden, G., Wang, Z., Chu, Z. D., Sauer, P. J. J., Haymond, M. W., Rodríguez, L. M., & Sunehag, A. L. (2009) · Obesity · doi:10.1038/oby.2009.274 · Cited by 259
Koehler, E. M., Schouten, J. N. L., Hansen, B. E., van Rooij, F. J. A., Albert Hofman, D., Stricker, B. H. C., & Janssen, H. L. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.028 · Cited by 261
Perseghin, G., Lattuada, G., COBELLI, F. D., Esposito, A., Belloni, E., Ntali, G., Ragogna, F., Canu, T., Scifo, P., Maschio, A. D., et al. (2007) · Hepatology · doi:10.1002/hep.21983 · Cited by 213
Self-citationNon-alcoholic fatty liver disease: pathophysiological concepts and treatment options
Grander, C., Grabherr, F., & Tilg, H. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad095 · Cited by 236
Non‐alcoholic fatty liver disease from pathogenesis to management: an update
Musso, G., Gambino, R., & Cassader, M. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00657.x · Cited by 200
Exercise and the Regulation of Hepatic Metabolism
Trefts, E., Williams, A. S., & Wasserman, D. H. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.010 · Cited by 201
Shah, K., Stufflebam, A., Hilton, T. N., Sinacore, D. R., Klein, S., & Villareal, D. T. (2009) · Obesity · doi:10.1038/oby.2009.126 · Cited by 194
Guiu, B., Petit, J., Loffroy, R., Salem, D. B., Aho, S., Masson, D., Hillon, P., Krause, D., & Cercueil, J. (2008) · Radiology · doi:10.1148/radiol.2493080217 · Cited by 192
Recent Epidemiology and Risk Factors of Nonalcoholic Fatty Liver Disease
Huh, Y., Cho, Y. J., & Nam, G. E. (2022) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes22021 · Cited by 192
Whole body fat: Content and distribution
Thomas, E. L., Fitzpatrick, J. A., Malik, S., Taylor-Robinson, S. D., & Bell, J. D. (2013) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2013.04.001 · Cited by 177
Rector, R. S., Uptergrove, G. M., Morris, E. M., Borengasser, S. J., Laughlin, M. H., Booth, F. W., Thyfault, J. P., & Ibdah, J. A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00510.2010 · Cited by 153
Health‐related fitness and physical activity in patients with nonalcoholic fatty liver disease†‡
Krasnoff, J. B., Painter, P. L., Wallace, J. P., Bass, N. M., & Merriman, R. B. (2008) · Hepatology · doi:10.1002/hep.22137 · Cited by 148
Oh, S., So, R., Shida, T., Matsuo, T., Kim, B., Akiyama, K., Isobe, T., Okamoto, Y., Tanaka, K., & Shoda, J. (2017) · Scientific Reports · doi:10.1038/srep43029 · Cited by 146
Fitness Versus Fatness: Moving Beyond Weight Loss in Nonalcoholic Fatty Liver Disease
Johnson, N. A., & George, J. (2010) · Hepatology · doi:10.1002/hep.23711 · Cited by 146
Zelber‐Sagi, S., Godos, J., & Salomone, F. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16638830 · Cited by 141
Role of diet and lifestyle changes in nonalcoholic fatty liver disease.
Nseir, W., Hellou, E., & Assy, N. (2014) · PubMed Central · doi:10.3748/wjg.v20.i28.9338 · Cited by 147
Yahoo, N., Dudek, M., Knolle, P. A., & Heikenwälder, M. F. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.033 · Cited by 147
Cuthbertson, D. J., Shojaee-Moradie, F., Sprung, V. S., Jones, H., Pugh, C. J. A., Richardson, P., Kemp, G. J., Barrett, M., Jackson, N. C., Thomas, E. L., et al. (2016) · Clinical Science · doi:10.1042/cs20150447 · Cited by 138
Exercise therapy in Type 2 diabetes
Praet, S., & van Loon, L. J. C. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0129-0 · Cited by 135
Nutritional therapy for nonalcoholic fatty liver disease
Dongiovanni, P., Lanti, C., Riso, P., & Valenti, L. V. C. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.024 · Cited by 133
Hepatocellular carcinoma and lifestyles
Saran, U., Humar, B., Kolly, P., & Dufour, J. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.028 · Cited by 126
Gelli, C., Tarocchi, M., Abenavoli, L., Renzo, L. D., Galli, A., & LORENZO, A. D. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i17.3150 · Cited by 130
Mouzaki, M., & Allard, J. P. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31824cf51e · Cited by 125
Physical activity and the endocannabinoid system: an overview
Tantimonaco, M., Ceci, R., Sabatini, S., Catani, M. V., Rossi, A., Gasperi, V., & Maccarrone, M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1575-6 · Cited by 112
Rector, R. S., Thyfault, J. P., Laye, M. J., Morris, R. T., Borengasser, S. J., Uptergrove, G. M., Chakravarthy, M. V., Booth, F. W., & Ibdah, J. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156745 · Cited by 110
Exercise Combats Hepatic Steatosis: Potential Mechanisms and Clinical Implications
Thyfault, J. P., & Rector, R. S. (2020) · Diabetes · doi:10.2337/dbi18-0043 · Cited by 112
Hallsworth, K., Thoma, C., Moore, S. A., Plötz, T., Anstee, Q. M., Taylor, R., Day, C. P., & Trenell, M. I. (2014) · Frontline Gastroenterology · doi:10.1136/flgastro-2014-100432 · Cited by 116
Non-alcoholic fatty liver disease: a practical approach to treatment
Dyson, J. K., Anstee, Q. M., & McPherson, S. (2014) · Frontline Gastroenterology · doi:10.1136/flgastro-2013-100404 · Cited by 113
Magkos, F., Fabbrini, E., Mohammed, B. S., Patterson, B. W., & Klein, S. (2010) · Obesity · doi:10.1038/oby.2010.90 · Cited by 97
Hannukainen, J. C., Borra, R., Linderborg, K. M., Kallio, H. P. T., Kišš, J., Saunavaara, V., Kalliokoski, K. K., Kujala, U. M., Kaprio, J. A., Heinonen, O. J., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.07.029 · Cited by 95
Does physical inactivity cause nonalcoholic fatty liver disease?
Rector, R. S., & Thyfault, J. P. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00384.2011 · Cited by 97
Treating NAFLD in OLETF Rats with Vigorous-Intensity Interval Exercise Training
Linden, M. A., Fletcher, J. A., Morris, E. M., Meers, G. M.-E., Laughlin, M. H., Booth, F. W., Sowers, J. R., Ibdah, J. A., Thyfault, J. P., & Rector, R. S. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000430 · Cited by 92
Effects of physical activity upon the liver
Shephard, R. J., & Johnson, N. A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-3031-6 · Cited by 93
Tsekouras, Y. E., Magkos, F., Kellas, Y., Basioukas, K. N., Kavouras, S. A., & Sidossis, L. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90545.2008 · Cited by 88
Management of Autistic Patients in Dental Office: A Clinical Update
Bommangoudar, J. S. (2018) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-1515 · Cited by 94
Current Concepts and Management Approaches in Nonalcoholic Fatty Liver Disease
Attar, B. M., & Thiel, D. H. V. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/481893 · Cited by 85
Riazi, K., Raman, M., Taylor, L., Swain, M. G., & Shaheen, A. A. (2019) · Nutrients · doi:10.3390/nu11122878 · Cited by 87
Scaglioni, F., Ciccia, S., Marino, M., Bedogni, G., & Bellentani, S. (2011) · Digestive Diseases · doi:10.1159/000323886 · Cited by 79
Liu, T.-W., Park, Y.-M., Holscher, H. D., Padilla, J., Scroggins, R. J., Welly, R., Britton, S. L., Koch, L. G., Vieira-Potter, V. J., & Swanson, K. S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136150 · Cited by 78
The Role of Skeletal Muscle in Development of Nonalcoholic Fatty Liver Disease
Moon, J. S., Yoon, J. S., Won, K. C., & Lee, H. W. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.4.278 · Cited by 76
Dudekula, A. B., Rachakonda, V. P., Shaik, B., & Behari, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111808 · Cited by 73
Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
Schuster, D. (2010) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmsott.s7354 · Cited by 99
Is liver fat detrimental to vessels?: intersections in the pathogenesis of NAFLD and atherosclerosis
Loria, P., Lonardo, A., & Targher, G. (2008) · Clinical Science · doi:10.1042/cs20070311 · Cited by 72
Magkos, F. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.02.003 · Cited by 71
Mitochondria and Redox Signaling in Steatohepatitis
Morris, E. M., Rector, R. S., Thyfault, J. P., & Ibdah, J. A. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3795 · Cited by 71
Yang, L., Lin, H., Lin, W., & Xu, X. (2020) · Biology · doi:10.3390/biology9080203 · Cited by 72
Møller, L. F., Stødkilde‐Jørgensen, H., Jensen, F. T., & Jørgensen, J. O. L. (2008) · Clinical Science · doi:10.1042/cs20070217 · Cited by 70
Exercise and diet in the management of nonalcoholic fatty liver disease
Mahady, S. E., & George, J. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.032 · Cited by 73
Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors
Levinger, I., Goodman, C. A., Peake, J. M., GARNHAM, A. P., Hare, D. L., Jerums, G., & Selig, S. E. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02679.x · Cited by 68
Park, S., Hong, S. M., Lee, J. E., & Sung, S. R. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00434.2007 · Cited by 68
Aerobic exercise training in the treatment of non‐alcoholic fatty liver disease related fibrosis
Linden, M. A., Sheldon, R. D., Meers, G. M.-E., Ortinau, L. C., Morris, E. M., Booth, F. W., Kanaley, J. A., Vieira‐Potter, V. J., Sowers, J. R., Ibdah, J. A., et al. (2016) · The Journal of Physiology · doi:10.1113/jp272235 · Cited by 66
The Effect of Lifestyle Changes in Non-Alcoholic Fatty Liver Disease
Centis, E., Marzocchi, R., Domizio, S. D., Ciaravella, M. F., & Marchesini, G. (2010) · Digestive Diseases · doi:10.1159/000282101 · Cited by 69
Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise
Barcelos, R. P., Royes, L. F. F., González‐Gallego, J., & Bresciani, G. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1291942 · Cited by 66
NAFLD/NASH in patients with type 2 diabetes and related treatment options
Radaelli, M. G., Martucci, F., Perra, S., Accornero, S., Castoldi, G., Lattuada, G., Manzoni, G., & Perseghin, G. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0799-3 · Cited by 63
Self-citationPrevention and Treatment of Alzheimer’s Disease: Biological Mechanisms of Exercise
McGurran, H., Glenn, J. M., Madero, E. N., & Bott, N. T. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180958 · Cited by 63
Shi, L., Liu, Z. W., Li, Y., Gong, C., Zhang, H., Li, S., Huang, C. Y., & Li, M. (2012) · PubMed · doi:10.3967/0895-3988.2012.04.002 · Cited by 70
Lifestyle Modification as the Primary Treatment of NASH
Neuschwander‐Tetri, B. A. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.07.006 · Cited by 62
Effects of Therapeutic Lifestyle Program on Ultrasound-diagnosed Nonalcoholic Fatty Liver Disease
Chen, S., Liu, C., Li, S.-R., Huang, H.-T., Tsai, C.-Y., & Jou, H. (2008) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(08)70168-0 · Cited by 60
Li, M., & McDermott, R. A. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.12.004 · Cited by 58
Fat distribution in men of different waist girth, fitness level and exercise habit
O’Donovan, G., Thomas, E. L., McCarthy, J. P., Fitzpatrick, J. A., Durighel, G., Mehta, S., Morin, S. H., Goldstone, A. P., & Bell, J. D. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.189 · Cited by 55
Is visceral fat reduction necessary to favour metabolic changes in the liver?
Finelli, C., & Tarantino, G. (2012) · PubMed · Cited by 52
Perseghin, G., Lattuada, G., COBELLI, F. D., Esposito, A., Belloni, E., Canu, T., Ragogna, F., Scifo, P., Maschio, A. D., & Luzi, L. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0325 · Cited by 53
Self-citationSex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity
McCoin, C. S., Schulze, A. T. V., Allen, J., Fuller, K. N. Z., Xia, Q., Koestler, D. C., Houchen, C. J., Maurer, A., Dorn, G. W., Shankar, K., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00098.2019 · Cited by 51
Exercise and fat accumulation in the human liver
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Panasevich, M. R., Morris, E. M., Chintapalli, S. V., Wankhade, U. D., Shankar, K., Britton, S. L., Koch, L. G., Thyfault, J. P., & Rector, R. S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00065.2016 · Cited by 47
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Hayes, L., Pearce, M. S., Firbank, M., Walker, M., Taylor, R., & Unwin, N. C. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-723 · Cited by 47
Pachori, A., Kambalimath, H. V., Bhambhani, G., & Malhotra, G. (2018) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-1507 · Cited by 47
Metadata
- Authors
- Perseghin, G., Lattuada, G., De Cobelli, F., Ragogna, F., Ntali, G., Esposito, A., Belloni, E., Canu, T., Terruzzi, I., Scifo, P., Del Maschio, A., & Luzi, L.
- Affiliations
- University of Milan (IT)
- IRCCS Ospedale San Raffaele (IT)
- Unit of Clinical Spectroscopy, San Raffaele Scientific Institute, Milan, Italy
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2007-03-01
- Volume
- 30
- Issue
- 3
- Pages
- 683-688
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2075760095
- Cited by
- 320
- References
- 28
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 15 · 2018: 68 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 16 · 2013: 16 · 2012: 18
- FWCI
- 18.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Harokopio University
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- physical activity behavior, intrahepatic fat, hepatic steatosis, insulin resistance, adiponectin, type 2 diabetes, physical activity, 1H magnetic resonance spectroscopy
- MeSH terms
- Adipose Tissue, Adult, Blood Pressure, Fatty Liver, Female, Humans, Liver, Male, Middle Aged, Physical Fitness, Reference Values, Exercise, Prevalence
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