Caffeine increases ambulatory glucose and postprandial responses in coffee drinkers with type 2 diabetes
Abstract
R ecent laboratory studies demon-strated that caffeine exaggeratesglucose and insulin responses to standardized carbohydrate loads in habit-ual coffee drinkers who have type 2 dia-betes (1–3). Similar postprandial effects in everyday life could disrupt clinical ef-forts to maintain glucose control in pa-tients with type 2 diabetes. The aim of this study was to examine the effects of a mod-erate dose of caffeine on glucose levels and postprandial glucose responses in free-living coffee drinkers with type 2 di-abetes. We specifically predicted that caf-feine administration would increase glucose concentrations during the day and exaggerate the glucose increases that followed meals when habitual coffee drinkers with type 2 diabetes were mon-itored during everyday life.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In elderly participants, training significantly reduced inflammatory markers without changes in BMI or body fat.
“Several training interventions have not produced changes in basal IL-6 or CRP concentrations (213 -218) , while significant reductions in inflammatory markers have been observed following training without changes in BMI or body fat in elderly participants (219,220) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [220]
Cites
Thong, F. S. L., & Graham, T. E. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01229.2001 · Cited by 123 · see citing works
Robinson, L. E., Savani, S., Battram, D. S., McLaren, D. H., Sathasivam, P., & Graham, T. E. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2528 · Cited by 116 · see citing works
Efficacy and Reliability of the Continuous Glucose Monitoring System
Gross, T. M., & Mastrototaro, J. J. (2000) · Diabetes Technology & Therapeutics · doi:10.1089/15209150050214087 · Cited by 108 · see citing works
Caffeine Impairs Glucose Metabolism in Type 2 Diabetes
Lane, J. D., Barkauskas, C. E., Surwit, R. S., & Feinglos, M. N. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.2047 · Cited by 95 · see citing works
Han, D. H., Hansen, P. A., Nolte, L. A., & Holloszy, J. O. (1998) · Diabetes · doi:10.2337/diabetes.47.11.1671 · Cited by 92 · see citing works
Tissue‐specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats
Crist, G. H., Xu, B., LaNoue, K. F., & Lang, C. H. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.13.1301 · Cited by 70 · see citing works
Lane, J. D., Hwang, A. L., Feinglos, M. N., & Surwit, R. S. (2007) · Endocrine Practice · doi:10.4158/ep.13.3.239 · Cited by 32 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
The impact of coffee on health
Cano-Marquina, A., Tarín, J. J., & Cano, A. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.02.002 · Cited by 332 · see citing works
Glade, M. J. (2010) · Nutrition · doi:10.1016/j.nut.2010.08.004 · Cited by 307 · see citing works
Caffeine Consumption through Coffee: Content in the Beverage, Metabolism, Health Benefits and Risks
DePaula, J., & Farah, A. (2019) · Beverages · doi:10.3390/beverages5020037 · Cited by 240 · see citing works
Polyphenols in Cocoa and Cocoa Products: Is There a Link between Antioxidant Properties and Health?
Jalil, A. M. M., & Ismail, A. (2008) · Molecules · doi:10.3390/molecules13092190 · Cited by 206 · see citing works
Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer
van Dam, R. M. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-120 · Cited by 161 · see citing works
Effects of coffee on type 2 diabetes mellitus
Akash, M. S. H., Rehman, K., & Chen, S. (2013) · Nutrition · doi:10.1016/j.nut.2013.11.020 · Cited by 152 · see citing works
Halaby, M., Hibma, J. C., He, J., & Yang, D. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.04.011 · Cited by 132 · see citing works
Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity
INSERM, U., & Fromenty, B. (2017) · Journal of Clinical and Translational Research · doi:10.18053/jctres.03.2017s1.006 · Cited by 124 · see citing works
Acute Effects of Coffee on Endothelial Function in Healthy Subjects
Buscemi, S., Verga, S., Batsis, J. A., Donatelli, M., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., & Cerasola, G. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.9 · Cited by 110 · see citing works
Role of coffee in modulation of diabetes risk
Natella, F., & Scaccini, C. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00470.x · Cited by 94 · see citing works
Ohnaka, K., Ikeda, M., Maki, T., Okada, T., Shimazoe, T., Adachi, M., Nomura, M., Takayanagi, R., & Kono, S. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/207426 · Cited by 79 · see citing works
Coffee and Lower Risk of Type 2 Diabetes: Arguments for a Causal Relationship
Kolb, H., Martin, S., & Kempf, K. (2021) · Nutrients · doi:10.3390/nu13041144 · Cited by 86 · see citing works
Zhang, W. L., López‐García, E., Li, T. Y., Hu, F. B., & van Dam, R. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1311-1 · Cited by 76 · see citing works
Zhang, W., López‐García, E., Li, T. Y., Hu, F. B., & van Dam, R. M. (2009) · Diabetes Care · doi:10.2337/dc08-2251 · Cited by 61 · see citing works
Decaffeinated Coffee and Glucose Metabolism in Young Men
Greenberg, J. A., Owen, D. R., & Geliebter, A. (2009) · Diabetes Care · doi:10.2337/dc09-1539 · Cited by 59 · see citing works
Shearer, J., & Graham, T. E. (2014) · Nutrition Reviews · doi:10.1111/nure.12124 · Cited by 60 · see citing works
Solubility improvement of epalrestat by layered structure formation via cocrystallization
Putra, O. D., Umeda, D., Nugraha, Y. P., Furuishi, T., Nagase, H., Fukuzawa, K., Uekusa, H., & Yonemochi, E. (2017) · CrystEngComm · doi:10.1039/c7ce00284j · Cited by 56 · see citing works
Methylxanthines and Human Health: Epidemiological and Experimental Evidence
Beaudoin, M., & Graham, T. E. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_21 · Cited by 54 · see citing works
Tea Consumption May Improve Biomarkers of Insulin Sensitivity and Risk Factors for Diabetes
Stote, K. S., & Baer, D. J. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1584s · Cited by 49 · see citing works
de França, N. A. G., Camargo, M. B. R., Lazaretti-Castro, M., Peters, B. S. E., & Martini, L. A. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.27 · Cited by 49 · see citing works
Caffeine ingestion impairs insulin sensitivity in a dose-dependent manner in both men and women
Beaudoin, M., Allen, B., Mazzetti, G., Sullivan, P. J., & Graham, T. E. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0201 · Cited by 43 · see citing works
Whitehead, N., & White, H. (2013) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12033 · Cited by 41 · see citing works
Iwai, K., Narita, Y., Fukunaga, T., Nakagiri, O., Kamiya, T., Ikeguchi, M., & KIKUCHI, Y. (2012) · Food Science and Technology Research · doi:10.3136/fstr.18.849 · Cited by 41 · see citing works
Krebs, J. D., Parry‐Strong, A., Weatherall, M., Carroll, R. W., & Downie, M. R. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.021 · Cited by 39 · see citing works
Beaudoin, M., Robinson, L. E., & Graham, T. E. (2011) · Journal of Nutrition · doi:10.3945/jn.110.132761 · Cited by 39 · see citing works
Halaby, M., Kastein, B. K., & Yang, D. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.047 · Cited by 36 · see citing works
Caffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes
Eny, K. M., Orchard, T. J., Miller, R. G., Maynard, J., Grant, D. M., Costacou, T., Cleary, P. A., Braffett, B. H., & Paterson, A. D. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2015.0017 · Cited by 33 · see citing works
Caffeine, Diabetes, Cognition, and Dementia
Biessels, G. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091228 · Cited by 32 · see citing works
Ji, Y., Yao, Y., Duan, Y., Zhao, H., Hong, Y., Cai, Z., & Sun, H. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143836 · Cited by 29 · see citing works
Caffeine, Glucose Metabolism, and Type 2 Diabetes
Lane, J. D. (2011) · Journal of Caffeine Research · doi:10.1089/jcr.2010.0007 · Cited by 26 · see citing works
Caffeine and glucose homeostasis during rest and exercise in diabetes mellitus
Zaharieva, D. P., & Riddell, M. C. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0471 · Cited by 25 · see citing works
Fan, H., Xiong, Y., Huang, Y., Li, W., Xu, C., Feng, X., Hua, R., Yang, Y., Wang, Z., Yuan, Z., et al. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.06.013 · Cited by 24 · see citing works
A brief manualized treatment for problematic caffeine use: A randomized control trial.
Evatt, D. P., Juliano, L. M., & Griffiths, R. R. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000064 · Cited by 23 · see citing works
Approaches to Treatment of Pre-Diabetes and Obesity and Promising New Approaches to Type 2 Diabetes
Bloomgarden, Z. T. (2008) · Diabetes Care · doi:10.2337/dc08-zb07 · Cited by 16 · see citing works
Alkaabi, J., Al-Dabbagh, B., Saadi, H., Gariballa, S., & Yasin, J. (2013) · PubMed · doi:10.6133/apjcn.2013.22.4.09 · Cited by 15 · see citing works
Emami, M. R., Khorshidi, M., Zarezadeh, M., Safabakhsh, M., Rezagholizadeh, F., & Alizadeh, S. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.05.003 · Cited by 15 · see citing works
Albar, S. A., Almaghrabi, M. A., Bukhari, R. A., Alghanmi, R. H., Althaiban, M. A., & Yaghmour, K. A. (2021) · Nutrients · doi:10.3390/nu13061960 · Cited by 15 · see citing works
Fernández-Sánchez, J., Trujillo-Colmena, D., Rodríguez-Castaño, A., Pérez, A. M. L., Coso, J. D., Casado, A., & Collado‐Mateo, D. (2024) · Nutrients · doi:10.3390/nu16020207 · Cited by 10 · see citing works
James, J. E. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118771780 · Cited by 10 · see citing works
Timing of caffeine ingestion alters postprandial metabolism in rats
Jarrar, S. F., & Obeid, O. (2013) · Nutrition · doi:10.1016/j.nut.2013.07.015 · Cited by 10 · see citing works
Pilot Study of Caffeine Abstinence for Control of Chronic Glucose in Type 2 Diabetes
Lane, J. D., Lane, A. J., Surwit, R. S., Kuhn, C. M., & Feinglos, M. N. (2012) · Journal of Caffeine Research · doi:10.1089/jcr.2012.0003 · Cited by 9 · see citing works
Yao, H., Li, L., Wang, X., & Wang, Z. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01417-6 · Cited by 7 · see citing works
Kempf, K., & Martin, S. (2010) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-010-1156-x · Cited by 6 · see citing works
Solid Versus Liquid—Satiety Study in Well-Adjusted Lap-Band Patients
Jones, L. V., Jones, K., Hensman, C., Bertuch, R., McGee, T. L., & Dixon, J. B. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0897-z · Cited by 5 · see citing works
James, J. E. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_26 · Cited by 4 · see citing works
The Impact of Knowledge, Att itude, and Peer Influe nce on Adolescent Energy Drink Consumption
Ward, A. (2009) · Cited by 4 · see citing works
The Influence of Acute Caffeine and Coffee Consumption on Glucose Homeostasis
Beaudoin, M., & Graham, T. E. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00053-x · Cited by 4 · see citing works
Li, J., Choudhury, T., Zhang, M., Chen, L., Wen, J., Liu, W., & Chen, P. (2021) · medRxiv · doi:10.1101/2021.03.08.21253114 · Cited by 3 · see citing works
Habtemariam, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102922-0.00021-3 · Cited by 2 · see citing works
Gilglioni, E. H., Ghuidotti, C., Vilela, V., Bataglini, C., Furlan, J., Berti, J., Pedrosa, M., & Godoi, V. (2016) · Physiology International · doi:10.1556/2060.103.2016.3.3 · Cited by 2 · see citing works
Polyphenol-Rich Cocoa and Chocolate: Potential Role in the Prevention of Diabetes
Almoosawi, S., & Al‐Dujaili, E. A. S. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-803-0_24 · Cited by 1 · see citing works
Assessing the Utility of a Brief Abstinence Test for Initiating Caffeine Abstinence
Irons, J. G., Joachim, B. T., Stanley, T. B., Rininger, A. M., & Jarvis, B. P. (2019) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2018.0013 · Cited by 1 · see citing works
Exercise and Nutritional Concerns
Colberg, S. R. (2017) · Contemporary diabetes · doi:10.1007/978-3-319-61013-9_13
Ni'ma, A. S., Sari, G. M., & Prasetyowati, L. (2018) · JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA · doi:10.20473/jfiki.v4i12017.6-12
Bodeker, G. C. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7506-8464-4.00025-4
Physical exercises and fat burners – the easy road to severe consequences?
Shuvalova, N. V., Драндров, Г. Л., Lezhenina, S. V., Вячеславовна, К. А., & Igonin, Y. A. (2020) · BIO Web of Conferences · doi:10.1051/bioconf/20202600049
Nahas, R. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1793-8.00032-7
Pump Therapy Management (Keeping Patients On The Pump)
(2024) · American Diabetes Association eBooks · doi:10.2337/9781580408363.ch06
Primasari, A., Minasari, Fitri, A. R., & Pratama, Y. (2025) · The Open Dentistry Journal · doi:10.2174/0118742106351629250206061143
Yao, H., Li, L., Wang, X., & Wang, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26384552
Grover, M., Eastman, E., Rybka, J., Semet, E., & Zdanowicz, L. (2026) · Research Square · doi:10.21203/rs.3.rs-9003742/v1
- Authors
- Lane, J. D., Feinglos, M. N., & Surwit, R. S.
- Affiliations
- Duke Medical Center (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-02-01
- Volume
- 31
- Issue
- 2
- Pages
- 221-222
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2120733260
- Cited by
- 62
- References
- 7
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 8
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- caffeine, type 2 diabetes, coffee consumption, postprandial blood glucose, glycemic control
- MeSH terms
- Aged, Blood Glucose, Caffeine, Coffee, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Humans, Male, Middle Aged, Cross-Over Studies, Monitoring, Ambulatory, Postprandial Period
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
