The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
Open accessAbstract
OBJECTIVE—Sedentary lifestyle and a western diet promote subacute-chronic inflammation, obesity, and subsequently dysglycemia. The aim of the current study was to evaluate the efficacy of the anti-inflammatory drug salsalate to improve glycemia by reducing systemic inflammation in obese adults at risk for the development of type 2 diabetes. RESEARCH DESIGN AND METHODS—In a double-masked, placebo controlled trial, we evaluated 20 obese nondiabetic adults at baseline and after 1 month of salsalate or placebo. RESULTS—Compared with placebo, salsalate reduced fasting glucose 13% (P < 0.002), glycemic response after an oral glucose challenge 20% (P < 0.004), and glycated albumin 17% (P < 0.0003). Although insulin levels were unchanged, fasting and oral glucose tolerance test C-peptide levels decreased in the salsalate-treated subjects compared with placebo (P < 0.03), consistent with improved insulin sensitivity and a known effect of salicylates to inhibit insulin clearance. Adiponectin increased 57% after salsalate compared with placebo (P < 0.003). Additionally, within the group of salsalate-treated subjects, circulating levels of C-reactive protein were reduced by 34% (P < 0.05). CONCLUSIONS—This proof-of-principle study demonstrates that salsalate reduces glycemia and may improve inflammatory cardiovascular risk indexes in overweight individuals. These data support the hypothesis that subacute-chronic inflammation contributes to the pathogenesis of obesity-related dysglycemia and that targeting inflammation may provide a therapeutic route for diabetes prevention.
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Inflammatory Mechanisms in Obesity
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Type 2 diabetes as an inflammatory disease
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Inflammation in obesity, diabetes, and related disorders
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Metadata
- Authors
- Fleischman, A., Shoelson, S. E., Bernier, R., & Goldfine, A. B.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-02-01
- Volume
- 31
- Issue
- 2
- Pages
- 289-294
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2151672809
- Cited by
- 352
- References
- 14
- FWCI
- 21.68
- Type
- journal article
- Language
- en
- Open access
- green
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