The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Correlates of Insulin Injection Omission
Open accessAbstract
OBJECTIVE: The purpose of this study was to assess factors associated with patient frequency of intentionally skipping insulin injections. RESEARCH DESIGN AND METHODS: Data were obtained through an Internet survey of 502 U.S. adults self-identified as taking insulin by injection to treat type 1 or type 2 diabetes. Multiple regression analysis assessed independent associations of various demographic, disease, and injection-specific factors with insulin omission. RESULTS: Intentional insulin omission was reported by more than half of respondents; regular omission was reported by 20%. Significant independent risk factors for insulin omission were younger age, lower income and higher education, type 2 diabetes, not following a healthy diet, taking more daily injections, interference of injections with daily activities, and injection pain and embarrassment. Risk factors differed between type 1 and type 2 diabetic patients, with diet nonadherence more prominent in type 1 diabetes and age, education, income, pain, and embarrassment more prominent in type 2 diabetes. CONCLUSIONS: Whereas most patients did not report regular intentional omission of insulin injections, a substantial number did. Our findings suggest that it is important to identify patients who intentionally omit insulin and be aware of the potential risk factors identified here. For patients who report injection-related problems (interference with daily activities, injection pain, and embarrassment), providers should consider recommending strategies and tools for addressing these problems to increase adherence to prescribed insulin regimens. This could improve clinical outcomes.
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“The present study was the first to investigate the effects of missed basal insulin injections using accurate injection data from a smart insulin pen; previous studies using data from smart insulin pens have primarily focused on missed bolus insulin doses.4,8”
From Smart Pen Exposes Missed Basal Insulin Injections and Reveals the Impact on Glycemic Control in Adults With Type 1 Diabetes (2024) · cites this paper as [8]
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“The present study was the first to investigate the effects of missed basal insulin injections using accurate injection data from a smart insulin pen; previous studies using data from smart insulin pens have primarily focused on missed bolus insulin doses.4,8”
From Smart Pen Exposes Missed Basal Insulin Injections and Reveals the Impact on Glycemic Control in Adults With Type 1 Diabetes (2024) · cites this paper as [8]
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Depression and Diabetes Treatment Nonadherence: A Meta-Analysis
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Self-citationDepression, Self-Care, and Medication Adherence in Type 2 Diabetes
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Impact of Dosage Frequency on Patient Compliance
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Self-citationLee, W. C., Balu, S., Cobden, D., Joshi, A. V., & Pashos, C. L. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.10.004 · Cited by 262
Behavioral and Psychosocial Interventions in Diabetes
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Self-citationLink, B. G., Phelan, J. C., Miech, R., & Westin, E. L. (2008) · Journal of Health and Social Behavior · doi:10.1177/002214650804900106 · Cited by 234
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Self-citationBarriers to Insulin Injection Therapy
Rubin, R. R., Peyrot, M. F., Kruger, D. F., & Travis, L. B. (2009) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721709345773 · Cited by 155
Self-citationSnoek, F. J., Skovlund, S. E., & Pouwer, F. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-69 · Cited by 145
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Development and validation of the insulin treatment satisfaction questionnaire
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Self-citationDiabetes Fear of Injecting and Self-Testing Questionnaire: a psychometric evaluation.
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Research works printed but not linked: 1
- 2008, Centers for Disease Control and Prevention (CDC) National Center for Health Statistics, Division of Health Interview Statistics, data from the National Health Interview Survey
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Peyrot, M., Barnett, A. H., Meneghini, L. F., & Schumm‐Draeger, P. ‐. (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03605.x · Cited by 655
Self-citationIonic liquids for oral insulin delivery
Banerjee, A., Ibsen, K. N., Brown, T. D., Chen, R., Agatemor, C., & Mitragotri, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722338115 · Cited by 379
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
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Micro and nanoscale technologies in oral drug delivery
Ahadian, S., Finbloom, J. A., Mofidfar, M., Diltemiz, S. E., Nasrollahi, F., Davoodi, E., Hosseini, V., Mylonaki, I., Sangabathuni, S., Montazerian, H., et al. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.012 · Cited by 280
Metadata
- Authors
- Peyrot, M., Rubin, R. R., Kruger, D. F., & Travis, L. B.
- Affiliations
- Johns Hopkins University (US)
- Henry Ford Health (US)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Peyrot, Mark
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2010-02-01
- Volume
- 33
- Issue
- 2
- Pages
- 240-245
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2809256
- OpenAlex
- W2103829708
- Cited by
- 407
- References
- 24
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 17 · 2023: 18 · 2022: 18 · 2021: 17 · 2020: 21 · 2019: 30 · 2018: 33 · 2017: 31 · 2016: 38 · 2015: 29 · 2014: 33 · 2013: 37 · 2012: 22
- FWCI
- 22.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Keywords
- insulin omission, insulin injection, type 1 diabetes, type 2 diabetes, insulin adherence, injection pain, socioeconomic factors, age, insulin regimens
- MeSH terms
- Adult, Aged, Behavior, Cardiovascular Diseases, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Ethnicity, Female, Health Surveys, Humans, Hypertension, Hypoglycemic Agents, Income, Insulin, Male, Middle Aged, Perception, Regression Analysis, Risk-Taking, Self Care, Racial Groups
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