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Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.
Open accessAbstract
OBJECTIVE: Chronic diabetic foot ulcers are a source of major concern for both patients and health care systems. The aim of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) in the management of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS: The Hyperbaric Oxygen Therapy in Diabetics with Chronic Foot Ulcers (HODFU) study was a randomized, single-center, double-blinded, placebo-controlled clinical trial. The outcomes for the group receiving HBOT were compared with those of the group receiving treatment with hyperbaric air. Treatments were given in a multi-place hyperbaric chamber for 85-min daily (session duration 95 min), five days a week for eight weeks (40 treatment sessions). The study was performed in an ambulatory setting. RESULTS: Ninety-four patients with Wagner grade 2, 3, or 4 ulcers, which had been present for >3 months, were studied. In the intention-to-treat analysis, complete healing of the index ulcer was achieved in 37 patients at 1-year of follow-up: 25/48 (52%) in the HBOT group and 12/42 (29%) in the placebo group (P = 0.03). In a sub-analysis of those patients completing >35 HBOT sessions, healing of the index ulcer occurred in 23/38 (61%) in the HBOT group and 10/37 (27%) in the placebo group (P = 0.009). The frequency of adverse events was low. CONCLUSIONS: The HODFU study showed that adjunctive treatment with HBOT facilitates healing of chronic foot ulcers in selected patients with diabetes.
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“Dressing selection Based on wound characteristics, ie, location, inflammation, and amount of exudate Promote a moist environment conducive to tissue growth and epithelial migration.63,64”
From Diabetic Foot Ulcers: A Review (2023) · cites this paper as [63]
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“The majority of studies [16,18] have demonstrated an inverse correlation between HbA1C levels and the rate of healing in diabetic wounds.”
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“shorter follow-up times between our and their (Swedish) study (6).”
BackgroundMethodInfluentialComparative efficacy of gas therapy for diabetic foot ulcers using network meta-analysis
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Republication of “The Evaluation and Treatment of Diabetic Foot Ulcers and Diabetic Foot Infections”
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“In general, we find more sessions completed means better healing, however, a range of sessions has been used in practice.(4,9,22) Being able to tailor treatment based on measurable criteria throughout a patient's course would make”
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Metadata
- Authors
- Löndahl, M., Katzman, P., Nilsson, A., & Hammarlund, C.
- Affiliations
- Lund University (SE)
- Department of Internal Medicine, Ängelholm Hospital, Ängelholm, Sweden;
- Helsingborgs lasarett (SE)
- Corresponding author
- Löndahl, Magnus
- ORCID
- Löndahl, Magnus
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2010-05-01
- Volume
- 33
- Issue
- 5
- Pages
- 998-1003
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2858204
- OpenAlex
- W2143723758
- Cited by
- 441
- References
- 28
- Citations by year
- 2026: 22 · 2025: 28 · 2024: 25 · 2023: 20 · 2022: 16 · 2021: 31 · 2020: 33 · 2019: 25 · 2018: 31 · 2017: 26 · 2016: 26 · 2015: 28 · 2014: 22 · 2013: 45 · 2012: 29
- FWCI
- 25.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- hyperbaric oxygen therapy, chronic diabetic foot ulcers, wound healing, hyperbaric air, Wagner grade, adjunctive therapy, diabetes mellitus, adverse events
- MeSH terms
- Adult, Aged, Aged, 80 and over, Air, Amputation, Surgical, Chronic Disease, Female, Follow-Up Studies, Humans, Hyperbaric Oxygenation, Male, Middle Aged, Placebos, Wound Healing, Treatment Outcome, Diabetic Foot
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