The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.
Open accessAbstract
OBJECTIVE: Chronic diabetic foot ulcers are a source of major concern for both patients and health care systems. The aim of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) in the management of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS: The Hyperbaric Oxygen Therapy in Diabetics with Chronic Foot Ulcers (HODFU) study was a randomized, single-center, double-blinded, placebo-controlled clinical trial. The outcomes for the group receiving HBOT were compared with those of the group receiving treatment with hyperbaric air. Treatments were given in a multi-place hyperbaric chamber for 85-min daily (session duration 95 min), five days a week for eight weeks (40 treatment sessions). The study was performed in an ambulatory setting. RESULTS: Ninety-four patients with Wagner grade 2, 3, or 4 ulcers, which had been present for >3 months, were studied. In the intention-to-treat analysis, complete healing of the index ulcer was achieved in 37 patients at 1-year of follow-up: 25/48 (52%) in the HBOT group and 12/42 (29%) in the placebo group (P = 0.03). In a sub-analysis of those patients completing >35 HBOT sessions, healing of the index ulcer occurred in 23/38 (61%) in the HBOT group and 10/37 (27%) in the placebo group (P = 0.009). The frequency of adverse events was low. CONCLUSIONS: The HODFU study showed that adjunctive treatment with HBOT facilitates healing of chronic foot ulcers in selected patients with diabetes.
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“Dressing selection Based on wound characteristics, ie, location, inflammation, and amount of exudate Promote a moist environment conducive to tissue growth and epithelial migration.63,64”
From Diabetic Foot Ulcers: A Review (2023) · cites this paper as [63]
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Cites
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“Two of these ulcers were classified as Wagner grade 4 and two were classified as grade 3 ulcers (20).”
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“D iabetic foot ulcers are a common and serious complication of diabetes (1,2).”
BackgroundHyperbaric oxygen therapy for chronic wounds
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“In contrast to our findings, some studies have shown the beneficial effect of HBOT in preventing amputations (8,21,23).”
BackgroundResultAbidia, A., Laden, G., Kuhan, G., Johnson, B., Wilkinson, A. R., Renwick, P., Masson, E. A., & McCollum, P. T. (2003) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2002.1911 · Cited by 367 · cited 1×
“(17) in 2003 suggested the benefit of HBOT, but the study was small and included only patients with Wagner grade 1 and 2 ulcers.”
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“Furthermore, loss of mobility poses a great burden on the patient and the health care system (3).”
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TREATMENT OF ACUTE AND CHRONIC FOOT WOUNDS IN PATIENTS WITH DIABETES. REVIEW OF PUBLISHED STUDIES
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Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers
Duarte, V., Ivo, C., Veríssimo, D., & Marcelino, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-06346-5_16
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Hyperbaric oxygen in the artificial intelligence era: integration and innovation
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Hyperbaric Oxygen Therapy and Mild Hyperbaric Oxygen Therapy Are Not Synonymous: A Narrative Review
Morningstar, M. W., & Strauchman, M. N. (2026) · Medical Sciences · doi:10.3390/medsci14030360
“The Hyperbaric Oxygen Therapy in Diabetics with Chronic Foot Ulcers (HODFU) trial further reinforced these findings, demonstrating improved complete healing rates at one year [43].”
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Supersaturated Oxygen Therapy for Wound Healing
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A Narrative Review of Local Therapies in Diabetic Foot Ulcers: Promises, Limitations and Unmet Needs
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Metadata
- Authors
- Löndahl, M., Katzman, P., Nilsson, A., & Hammarlund, C.
- Affiliations
- Lund University (SE)
- Department of Internal Medicine, Ängelholm Hospital, Ängelholm, Sweden;
- Helsingborgs lasarett (SE)
- Corresponding author
- Löndahl, Magnus
- ORCID
- Löndahl, Magnus
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2010-05-01
- Volume
- 33
- Issue
- 5
- Pages
- 998-1003
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2858204
- OpenAlex
- W2143723758
- Cited by
- 441
- References
- 28
- Citations by year
- 2026: 22 · 2025: 28 · 2024: 25 · 2023: 20 · 2022: 16 · 2021: 31 · 2020: 33 · 2019: 25 · 2018: 31 · 2017: 26 · 2016: 26 · 2015: 28 · 2014: 22 · 2013: 45 · 2012: 29
- FWCI
- 25.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- hyperbaric oxygen therapy, chronic diabetic foot ulcers, wound healing, hyperbaric air, Wagner grade, adjunctive therapy, diabetes mellitus, adverse events
- MeSH terms
- Adult, Aged, Aged, 80 and over, Air, Amputation, Surgical, Chronic Disease, Female, Follow-Up Studies, Humans, Hyperbaric Oxygenation, Male, Middle Aged, Placebos, Wound Healing, Treatment Outcome, Diabetic Foot
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