CoChat
Sign Up
Cited by 423Diabetes Management and ResearchDiabetes and associated disordersDiabetes Treatment and Management

The DOI matches its Crossref record, with a small difference in title or year; 23 of the 23 references it cites were found in a registry or an index.

Long-Term Complications and Mortality in Young-Onset Diabetes

Open access
Constantino, Maria I., Molyneaux, Lynda, Limacher-Gisler, Franziska, Al-Saeed, Abdulghani, Luo, Connie, Wu, Ted, Twigg, Stephen M., Yue, Dennis K., Wong, Jencia·2013·Diabetes Care
DOI 10.2337/dc12-2455PMC PMC3836093
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVE: To evaluate long-term clinical outcomes and survival in young-onset type 2 diabetes (T2DM) compared with type 1 diabetes (T1DM) with a similar age of onset. RESEARCH DESIGN AND METHODS: Records from the Royal Prince Alfred Hospital Diabetes Clinical Database, established in 1986, were matched with the Australian National Death Index to establish mortality outcomes for all subjects until June 2011. Clinical and mortality outcomes in 354 patients with T2DM, age of onset between 15 and 30 years (T2DM15–30), were compared with T1DM in several ways but primarily with 470 patients with T1DM with a similar age of onset (T1DM15–30) to minimize the confounding effect of age on outcome. RESULTS: For a median observation period of 21.4 (interquartile range 14–30.7) and 23.4 (15.7–32.4) years for the T2DM and T1DM cohorts, respectively, 71 of 824 patients (8.6%) died. A significant mortality excess was noted in T2DM15–30 (11 vs. 6.8%, P = 0.03), with an increased hazard for death (hazard ratio 2.0 [95% CI 1.2–3.2], P = 0.003). Death for T2DM15–30 occurred after a significantly shorter disease duration (26.9 [18.1–36.0] vs. 36.5 [24.4–45.4] years, P = 0.01) and at a relatively young age. There were more cardiovascular deaths in T2DM15–30 (50 vs. 30%, P < 0.05). Despite equivalent glycemic control and shorter disease duration, the prevalence of albuminuria and less favorable cardiovascular risk factors were greater in the T2DM15–30 cohort, even soon after diabetes onset. Neuropathy scores and macrovascular complications were also increased in T2DM15–30 (P < 0.0001). CONCLUSIONS: Young-onset T2DM is the more lethal phenotype of diabetes and is associated with a greater mortality, more diabetes complications, and unfavorable cardiovascular disease risk factors when compared with T1DM.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2337/dc12-2455

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 A: Kaplan-Meier survival curve for T2DM15–30 (n = 357) and T1DM15–30 (n = 470) patients. B: Kaplan-Meier survival curve for T2DM15–30 and all T1DM (age of onset <30 years) (n = 870) patients.
Figure 1 A: Kaplan-Meier survival curve for T2DM15–30 (n = 357) and T1DM15–30 (n = 470) patients. B: Kaplan-Meier survival curve for T2DM15–30 and all T1DM (age of onset <30 years) (n = 870) patients.CC BY-NC-ND · PubMed Central
Figure 2 Kaplan-Meier curve for cardiovascular deaths.
Figure 2 Kaplan-Meier curve for cardiovascular deaths.CC BY-NC-ND · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 23 references

Cited by

Sorted by citations

Items 401–423 of 423

Related

See all

Metadata

Authors
Constantino, M. I., Molyneaux, L., Limacher-Gisler, F., Al-Saeed, A., Luo, C., Wu, T., Twigg, S. M., Yue, D. K., & Wong, J.
Affiliations
  • The University of Sydney (AU)
  • Diabetes Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia;
  • Royal Prince Alfred Hospital (AU)
Corresponding author
Constantino, Maria I.
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2013-11-13
Volume
36
Issue
12
Pages
3863-3869
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc12-2455
PMC
PMC3836093
OpenAlex
W2112954588
Semantic Scholar
305edc35a7998be9c33ffe827fe4d3a51d64470f
Cited by
423
References
23
Citations by year
2026: 17 · 2025: 22 · 2024: 43 · 2023: 30 · 2022: 34 · 2021: 48 · 2020: 39 · 2019: 38 · 2018: 30 · 2017: 29 · 2016: 31 · 2015: 34 · 2014: 24 · 2013: 3
FWCI
24.38
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Diabetes Care (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • University of Sydney
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
youth-onset type 2 diabetes, type 1 diabetes, mortality, cardiovascular mortality, albuminuria, diabetic nephropathy, diabetic neuropathy, macrovascular complications, disease duration, cardiovascular risk factors, late complications
MeSH terms
Adolescent, Adult, Cardiovascular Diseases, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Forecasting, Humans, Male, Middle Aged, New South Wales, Retrospective Studies, Risk Factors, Incidence, Prevalence, Survival Rate, Diabetes Complications, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review