The DOI matches its Crossref record, with a small difference in title or year; 23 of the 23 references it cites were found in a registry or an index.
Long-Term Complications and Mortality in Young-Onset Diabetes
Open accessAbstract
OBJECTIVE: To evaluate long-term clinical outcomes and survival in young-onset type 2 diabetes (T2DM) compared with type 1 diabetes (T1DM) with a similar age of onset. RESEARCH DESIGN AND METHODS: Records from the Royal Prince Alfred Hospital Diabetes Clinical Database, established in 1986, were matched with the Australian National Death Index to establish mortality outcomes for all subjects until June 2011. Clinical and mortality outcomes in 354 patients with T2DM, age of onset between 15 and 30 years (T2DM15–30), were compared with T1DM in several ways but primarily with 470 patients with T1DM with a similar age of onset (T1DM15–30) to minimize the confounding effect of age on outcome. RESULTS: For a median observation period of 21.4 (interquartile range 14–30.7) and 23.4 (15.7–32.4) years for the T2DM and T1DM cohorts, respectively, 71 of 824 patients (8.6%) died. A significant mortality excess was noted in T2DM15–30 (11 vs. 6.8%, P = 0.03), with an increased hazard for death (hazard ratio 2.0 [95% CI 1.2–3.2], P = 0.003). Death for T2DM15–30 occurred after a significantly shorter disease duration (26.9 [18.1–36.0] vs. 36.5 [24.4–45.4] years, P = 0.01) and at a relatively young age. There were more cardiovascular deaths in T2DM15–30 (50 vs. 30%, P < 0.05). Despite equivalent glycemic control and shorter disease duration, the prevalence of albuminuria and less favorable cardiovascular risk factors were greater in the T2DM15–30 cohort, even soon after diabetes onset. Neuropathy scores and macrovascular complications were also increased in T2DM15–30 (P < 0.0001). CONCLUSIONS: Young-onset T2DM is the more lethal phenotype of diabetes and is associated with a greater mortality, more diabetes complications, and unfavorable cardiovascular disease risk factors when compared with T1DM.
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“The rising rates of obesity and T2D in adolescents put these youth at greater risk of CVD as they age [20,21,22].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [20]
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Cites
Stratton, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7258.405 · Cited by 9,059 · cited 1×
“Glycemic exposure was quantified by the calculation of the updated HbA1c, which accounts for the time between visits and the number of measurements (8,9).”
MethodOnset of NIDDM occurs at Least 4–7 yr Before Clinical Diagnosis
Harris, M. I., Klein, R., Welborn, T. A., & Knuiman, M. W. (1992) · Diabetes Care · doi:10.2337/diacare.15.7.815 · Cited by 1,306
Type 2 diabetes among North adolescents: An epidemiologic health perspective
Fagot‐Campagna, A., Pettitt, D. J., Engelgau, M. M., Burrows, N. R., Geiss, L. S., Valdez, R. A., Beckles, G. L., SAADDINE, J. B., Gregg, E. W., Williamson, D. F., et al. (2000) · The Journal of Pediatrics · doi:10.1067/mpd.2000.105141 · Cited by 1,123
A Clinical Trial to Maintain Glycemic Control in Youth with Type 2 Diabetes
TODAY Study Group (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109333 · Cited by 993
Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes
Laing, S. P., Swerdlow, A. J., Slater, S. D., Burden, A. C., Morris, A., Waugh, N. R., Gatling, W., Bingley, P. J., & Patterson, C. C. (2003) · Diabetologia · doi:10.1007/s00125-003-1116-6 · Cited by 724 · cited 1×
“Given that the traditional focus of diabetes in youth has been on T1DM and that established morbidity and mortality data exist for this group (4,5), a comparison was made with T1DM.”
ResultPrevalence of Diabetes Complications in Adolescents With Type 2 Compared With Type 1 Diabetes
Eppens, M. C., Craig, M. E., Cusumano, J. M., Hing, S. J., Chan, A. K. F., Howard, N. J., Silink, M., & Donaghue, K. C. (2006) · Diabetes Care · doi:10.2337/dc05-2470 · Cited by 468
Laing, S. P., Swerdlow, A. J., Slater, S. D., Botha, J. L., Burden, A. C., Waugh, N. R., Smith, A. W. M., Hill, R. D., Bingley, P. J., Patterson, C. C., et al. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00075.x · Cited by 427
Complications in Young Adults With Early-Onset Type 2 Diabetes
Hillier, T. A., & Pedula, K. L. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.2999 · Cited by 395
Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway
Skrivarhaug, T., Bangstad, H.-J., Stene, L. C., Sandvik, L., Hanssen, K. F., & Joner, G. (2006) · Diabetologia · doi:10.1007/s00125-005-0082-6 · Cited by 390 · cited 1×
“Because T1DM itself carries an increased mortality risk, with standardized mortality ratios in the order of 4 (14,15) compared with the general population, the present findings give a disquieting perspective on the longtermmortality risk of T2DM15–30 and a sobering glimpse of the future for patients, such as those in…”
ResultHigh Burden of Kidney Disease in Youth-Onset Type 2 Diabetes
Dart, A. B., Sellers, E. A. C., Martens, P. J., Rigatto, C., Brownell, M. D., & Dean, H. (2012) · Diabetes Care · doi:10.2337/dc11-2312 · Cited by 181 · cited 2×
“(19) examined survival in youth aged 1–18 years with T2DM versus T1DM.”
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European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457
Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., de Ferranti, S., Faiella-Tommasino, J., Forman, D. E., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000625 · Cited by 6,185
Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., de Ferranti, S., Faiella-Tommasino, J., Forman, D. E., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.003 · Cited by 2,691
Chatterjee, S., Khunti, K., & Davies, M. J. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30058-2 · Cited by 2,577
Metadata
- Authors
- Constantino, M. I., Molyneaux, L., Limacher-Gisler, F., Al-Saeed, A., Luo, C., Wu, T., Twigg, S. M., Yue, D. K., & Wong, J.
- Affiliations
- The University of Sydney (AU)
- Diabetes Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia;
- Royal Prince Alfred Hospital (AU)
- Corresponding author
- Constantino, Maria I.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2013-11-13
- Volume
- 36
- Issue
- 12
- Pages
- 3863-3869
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3836093
- OpenAlex
- W2112954588
- Semantic Scholar
- 305edc35a7998be9c33ffe827fe4d3a51d64470f
- Cited by
- 423
- References
- 23
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 43 · 2023: 30 · 2022: 34 · 2021: 48 · 2020: 39 · 2019: 38 · 2018: 30 · 2017: 29 · 2016: 31 · 2015: 34 · 2014: 24 · 2013: 3
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- University of Sydney
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- youth-onset type 2 diabetes, type 1 diabetes, mortality, cardiovascular mortality, albuminuria, diabetic nephropathy, diabetic neuropathy, macrovascular complications, disease duration, cardiovascular risk factors, late complications
- MeSH terms
- Adolescent, Adult, Cardiovascular Diseases, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Forecasting, Humans, Male, Middle Aged, New South Wales, Retrospective Studies, Risk Factors, Incidence, Prevalence, Survival Rate, Diabetes Complications, Young Adult
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