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Cited by 33Celiac Disease Research and ManagementDiabetes and associated disordersThyroid Disorders and Treatments

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Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study

Kurien, Matthew, Mollazadegan, Kaziwe, Sanders, David S., Ludvigsson, Jonas F.·2016·Diabetes Care
DOI 10.2337/dc15-2117
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Abstract

Objective Both type 1 diabetes (T1D) and celiac disease (CD) have been linked to autoimmune thyroid disease (ATD). We examined if individuals with both T1D and CD were at a higher risk of ATD than those with only T1D. Research design and methods This study was a nationwide population-based cohort study. We defined T1D as having an inpatient or a hospital-based outpatient diagnosis of T1D at age ≤30 years in the Swedish National Patient Register between 1964 and 2009. Data on CD were obtained through small intestinal biopsy reports showing villous atrophy (Marsh histopathology grade III) between 1969 and 2008 at any of the 28 pathology departments in Sweden. ATD included hyperthyreosis and hypothyreosis, defined according to the Swedish National Patient Register. We identified 947 individuals with T1D and biopsy-verified CD. These were matched to 4,584 control subjects with T1D but no CD diagnosis. Cox regression then estimated the risk of ATD. Results Among T1D, CD was a risk factor for later ATD. During follow-up, 90 T1D+CD patients developed ATD (expected n = 54). Adjusting for sex, age, and calendar period, this corresponded to a hazard ratio (HR) of 1.67 (95% CI 1.32-2.11; P Conclusions Among patients with T1D, CD is a risk factor for the later development of ATD.

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  • Patients with both celiac disease and type 1 diabetes have an increased risk of thyroid pathology compared to isolated type 1 diabetes or isolated celiac disease.

    “Data on long-term follow-up of patients with both diseases show that they have an increased risk of thyroid pathology compared to isolated T1D (124) or to isolated CD (128)”

    From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [124]

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Metadata

Authors
Kurien, M., Mollazadegan, K., Sanders, D. S., & Ludvigsson, J. F.
Affiliations
  • Royal Hallamshire Hospital (GB)
  • Karolinska Institutet (SE)
  • Örebro University (SE)
Corresponding author
Ludvigsson, Jonas F.
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2015-12-17
Volume
39
Issue
3
Pages
371-375
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc15-2117
OpenAlex
W2197747162
Cited by
33
References
0
Citations by year
2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 4
FWCI
3.81
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute for Health and Care Research (CL-2014-04-501)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords
celiac disease, type 1 diabetes, autoimmune thyroid disease, hypothyroidism, hyperthyroidism, villous atrophy, comorbidities, risk factors
MeSH terms
Adolescent, Adult, Aged, Celiac Disease, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Male, Middle Aged, Risk Factors, Sweden, Thyroid Diseases, Cohort Studies, Comorbidity, Young Adult

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