Cited by 662Liver Disease Diagnosis and TreatmentDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

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Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)

Kuchay, Mohammad Shafi, Krishan, Sonal, Mishra, Sunil Kumar, Farooqui, Khalid Jamal, Singh, Manish Kumar, Wasir, Jasjeet Singh, Bansal, Beena, Kaur, Parjeet, Jevalikar, Ganesh, Gill, Harmendeep Kaur, Choudhary, Narendra Singh, Mithal, Ambrish·2018·Diabetes Care

DOI 10.2337/dc18-0165

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Abstract

OBJECTIVE Sodium–glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent models. Data regarding the effect of SGLT-2 inhibitors on human liver fat are scarce. This study examined the effect of empagliflozin (an SGLT-2 inhibitor) on liver fat in patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) by using MRI-derived proton density fat fraction (MRI-PDFF). RESEARCH DESIGN AND METHODS Fifty patients with type 2 diabetes and NAFLD were randomly assigned to either the empagliflozin group (standard treatment for type 2 diabetes plus empagliflozin 10 mg daily) or the control group (standard treatment without empagliflozin) for 20 weeks. Change in liver fat was measured by MRI-PDFF. Secondary outcome measures were change in alanine transaminase (ALT), aspartate transaminase (AST), and γ-glutamyl transferase (GGT) levels. RESULTS When included in the standard treatment for type 2 diabetes, empagliflozin was significantly better at reducing liver fat (mean MRI-PDFF difference between the empagliflozin and control groups −4.0%; P < 0.0001). Compared with baseline, significant reduction was found in the end-of-treatment MRI-PDFF for the empagliflozin group (16.2% to 11.3%; P < 0.0001) and a nonsignificant change was found in the control group (16.4% to 15.5%; P = 0.057). The two groups showed a significant difference for change in serum ALT level (P = 0.005) and nonsignificant differences for AST (P = 0.212) and GGT (P = 0.057) levels. CONCLUSIONS When included in the standard treatment for type 2 diabetes, empagliflozin reduces liver fat and improves ALT levels in patients with type 2 diabetes and NAFLD.

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Authors: Kuchay, M. S., Krishan, S., Mishra, S. K., Farooqui, K. J., Singh, M. K., Wasir, J. S., Bansal, B., Kaur, P., Jevalikar, G., Gill, H. K., Choudhary, N. S., & Mithal, A.
Affiliations: Medanta The Medicity (IN)
Corresponding author: Kuchay, Mohammad Shafi
ORCID: Kuchay, Mohammad Shafi
Mishra, Sunil Kumar
Singh, Manish Kumar
Bansal, Beena
Kaur, Parjeet
Jevalikar, Ganesh
Choudhary, Narendra Singh
Mithal, Ambrish
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2018-06-12
Volume: 41
Issue: 8
Pages: 1801-1808
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/dc18-0165
OpenAlex: W2808615577
Cited by: 662
References: 40
Citations by year: 2026: 81 · 2025: 98 · 2024: 73 · 2023: 86 · 2022: 85 · 2021: 78 · 2020: 88 · 2019: 52 · 2018: 18
FWCI: 46.08
Type: journal article
Language: en
Open access: closed
Licence: www.diabetesjournals.org/content/license (vor, 38 d)
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Funders: Endocrine and Diabetes Foundation, India
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: empagliflozin, SGLT2 inhibitors, liver fat, non-alcoholic fatty liver disease, type 2 diabetes, proton density fat fraction, alanine aminotransferase, liver enzymes
MeSH terms: Adipose Tissue, Adult, Alanine Transaminase, Aspartate Aminotransferases, Benzhydryl Compounds, Diabetes Mellitus, Type 2, Female, Glucosides, Humans, Hypoglycemic Agents, Liver, Magnetic Resonance Imaging, Male, Middle Aged, Treatment Outcome, Adiposity, Non-alcoholic Fatty Liver Disease

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Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)

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