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Cited by 364Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes Management and Education

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Effects of Continuous Glucose Monitoring on Metrics of Glycemic Control in Diabetes: A Systematic Review With Meta-analysis of Randomized Controlled Trials

Maiorino, Maria Ida, Signoriello, Simona, Maio, Antonietta, Chiodini, Paolo, Bellastella, Giuseppe, Scappaticcio, Lorenzo, Longo, Miriam, Giugliano, Dario, Esposito, Katherine·2020·Diabetes Care
DOI 10.2337/dc19-1459
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Abstract

Background Continuous glucose monitoring (CGM) provides important information to aid in achieving glycemic targets in people with diabetes. Purpose We performed a meta-analysis of randomized controlled trials (RCTs) comparing CGM with usual care for parameters of glycemic control in both type 1 and type 2 diabetes. Data sources Many electronic databases were searched for articles published from inception until 30 June 2019. Study selection We selected RCTs that assessed both changes in HbA 1c and time in target range (TIR), together with time below range (TBR), time above range (TAR), and glucose variability expressed as coefficient of variation (CV). Data extraction Data were extracted from each trial by two investigators. Data synthesis All results were analyzed by a random effects model to calculate the weighted mean difference (WMD) with the 95% CI. We identified 15 RCTs, lasting 12-36 weeks and involving 2,461 patients. Compared with the usual care (overall data), CGM was associated with modest reduction in HbA 1c (WMD -0.17%, 95% CI -0.29 to -0.06, I 2 = 96.2%), increase in TIR (WMD 70.74 min, 95% CI 46.73-94.76, I 2 = 66.3%), and lower TAR, TBR, and CV, with heterogeneity between studies. The increase in TIR was significant and robust independently of diabetes type, method of insulin delivery, and reason for CGM use. In preplanned subgroup analyses, real-time CGM led to the higher improvement in mean HbA 1c (WMD -0.23%, 95% CI -0.36 to -0.10, P P Limitations Heterogene…

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Metadata

Authors
Maiorino, M. I., Signoriello, S., Maio, A., Chiodini, P., Bellastella, G., Scappaticcio, L., Longo, M., Giugliano, D., & Esposito, K.
Affiliations
University of Campania "Luigi Vanvitelli" (IT)
Corresponding author
Maiorino, Maria Ida
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2020-04-13
Volume
43
Issue
5
Pages
1146-1156
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc19-1459
OpenAlex
W3017384252
Cited by
364
References
45
Citations by year
2026: 45 · 2025: 76 · 2024: 75 · 2023: 59 · 2022: 53 · 2021: 37 · 2020: 19
FWCI
6.45
Type
journal article
Language
en
Open access
closed
Licence
www.diabetesjournals.org/content/license (vor, 7 d)
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords
continuous glucose monitoring, glycemic control, HbA1c, time in range, time below range, time above range, glycemic variability, coefficient of variation, type 1 diabetes, type 2 diabetes, sensor-augmented pump, flash glucose monitoring, real-time CGM, usual care comparison, insulin delivery method, hypoglycemia, hyperglycemia
MeSH terms
Glycemic Control, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Male, Time Factors, Blood Glucose Self-Monitoring, Randomized Controlled Trials as Topic, Databases, Factual, Outcome Assessment, Health Care, Benchmarking

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