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Cited by 55Diabetes and associated disordersDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017

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Liu, Chang, Yuan, Ying-Chao, Guo, Mo-Ning, Xin, Zhong, Chen, Guan-Jie, Bentley, Amy R., Hua, Lin, Zheng, Jian-Peng +2 more·2021·Diabetes Care
DOI 10.2337/dc21-0342PMC PMC8546282

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Abstract

OBJECTIVE: Previous reports of the annual incidence of type 1 diabetes (T1D) in China were conducted using retrospective hospital cases, which may not reflect the reality. This longitudinal study estimated T1D incidence in a Chinese population of 21.7 million from 2007 to 2017. RESEARCH DESIGN AND METHODS: A population-based registry of T1D was performed by the Beijing Municipal Health Commission Information Center. Annual incidence and 95% CIs were calculated by age group and sex. The association of sex with T1D incidence and predicted new cases of T1D were assessed using Poisson regression models. Annual percentage change and average annual percentage of change were assessed using Joinpoint regression. RESULTS: Overall, there were 6,875 individuals who developed T1D from 2007 to 2017 in this population. T1D incidence (/100,000 persons) (95% CI) significantly increased from 2.72 (2.51, 2.93) in 2007 to 3.60 (3.38, 3.78) in 2017 (P < 0.001). The T1D onset peak was in the 10–14-year-old age group. While no significant trend was found in the 0–14- and 15–29-year-old age groups, T1D incidence markedly increased from 1.87 to 3.52 in the ≥30-year-old age group (P < 0.05). The prevalence of diabetic ketoacidosis at diagnosis was highest in the 0–4-year-old age group. We predicted new cases of T1D will increase 1.57-fold over the next decade. CONCLUSIONS: T1D incidence in this large Chinese population is higher than has been reported previously. From 2007 to 2017, although the incidence peak was in the 10–14-year age group, the T1D incidence increased sharply in adults but not in youth.

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  • In China, type 1 diabetes mellitus incidence was 1.49 per 100,000 person-years among those aged ≥75 years, more than four times higher than the 0.37 per 100,000 person-years reported in a separate Chinese study.

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    From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [22]

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Authors
Liu, C., Yuan, Y.-C., Guo, M.-N., Xin, Z., Chen, G.-J., Bentley, A. R., Hua, L., Zheng, J.-P., Ekoru, K., & Yang, J.-K.
Affiliations
  • Beijing Tongren Hospital (CN)
  • Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
  • Beijing Municipal Health Commission Information Center, Beijing, China
  • The Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
  • National Institutes of Health (US)
  • Capital Medical University (CN)
Corresponding author
Yang, Jin-Kui
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2021-08-19
Volume
44
Issue
11
Pages
2503-2509
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc21-0342
PMC
PMC8546282
OpenAlex
W3194518908
Cited by
55
References
4
Citations by year
2026: 9 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 9 · 2021: 2
FWCI
5.08
Type
journal article
Language
en
Open access
Licence
www.diabetesjournals.org/content/license (vor)
Locations
  • Diabetes Care (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81930019)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 1 diabetes, incidence, China, age-specific incidence, sex differences, diabetic ketoacidosis, incidence trends, adult-onset type 1 diabetes, type 1 diabetes in children, population-based registry
MeSH terms
Adolescent, Adult, Child, Child, Preschool, China, Diabetes Mellitus, Type 1, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Retrospective Studies, Incidence, Young Adult

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