The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies
Open accessAbstract
BACKGROUND: Due to the rapidly increasing availability of metabolomics data in prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes risk is warranted. PURPOSE: To conduct an updated systematic review and meta-analysis of plasma, serum, and urine metabolite markers and incident type 2 diabetes. DATA SOURCES: We searched PubMed and Embase until 6 March 2021. STUDY SELECTION: We selected prospective observational studies where investigators used high-throughput techniques to investigate the relationship between plasma, serum, or urine metabolites and incident type 2 diabetes. DATA EXTRACTION: Baseline metabolites per-SD risk estimates and 95% CIs for incident type 2 diabetes were extracted from all eligible studies. DATA SYNTHESIS: A total of 61 reports with 71,196 participants and 11,771 type 2 diabetes cases/events were included in the updated review. Meta-analysis was performed for 412 metabolites, of which 123 were statistically significantly associated (false discovery rate–corrected P < 0.05) with type 2 diabetes risk. Higher plasma and serum levels of certain amino acids (branched-chain, aromatic, alanine, glutamate, lysine, and methionine), carbohydrates and energy-related metabolites (mannose, trehalose, and pyruvate), acylcarnitines (C4-DC, C4-OH, C5, C5-OH, and C8:1), the majority of glycerolipids (di- and triacylglycerols), (lyso)phosphatidylethanolamines, and ceramides included in meta-analysis were associated with higher risk of type 2 diabetes (hazard ratio 1.07–2.58). Higher levels of glycine, glutamine, betaine, indolepropionate, and (lyso)phosphatidylcholines were associated with lower type 2 diabetes risk (hazard ratio 0.69–0.90). LIMITATIONS: Substantial heterogeneity (I2 > 50%, τ2 > 0.1) was observed for some of the metabolites. CONCLUSIONS: Several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk.
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Diabetes mellitus—Progress and opportunities in the evolving epidemic
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Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology
Wu, Y., Ehlert, B., Metwally, A. A., Perelman, D., Park, H., Brooks, A. W., Abbasi, F., Michael, B., Celli, A., Bejikian, C., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03719-2 · Cited by 48
Metadata
- Authors
- Morze, J., Wittenbecher, C., Schwingshackl, L., Danielewicz, A., Rynkiewicz, A., Hu, F. B., & Guasch-Ferré, M.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2022-03-29
- Volume
- 45
- Issue
- 4
- Pages
- 1013-1024
- ISSN
- 0149-5992 (ISSN-L)
- OpenAlex
- W4225413474
- Cited by
- 298
- References
- 81
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Morze, J., Wittenbecher, C., Schwingshackl, L., Danielewicz, A., Rynkiewicz, A., Hu, F. B., & Guasch-Ferré, M. (2022). Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies. Diabetes Care. https://doi.org/10.2337/dc21-1705
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