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Genetic Influence of the Streptozotocin-induced Insulitis and Hyperglycemia
Abstract
Multiple injections of subdiabetogenic doses of streptozotodn (SZ) to CD-I male mice produce a diabetic syndrome that includes a cell-mediated immune reaction against the pancreatic islet. The importance of the host genetic background in the pathogenesis of this model of diabetes was studied by comparing various inbred strains of mice. Of eight strains of mice studied, only C57BL/KsJ developed insulitis and hyperglycemie comparable to that observed in CD-I mice. In two mouse strains (DBA/2J and BALB/cJ) having an haplotype similar to the C57BL/KsJ, only mild insulitis and glucose intolerance were observed. These data suggest that major histocompatibility complex genes, as presently defined, cannot be the only determinant of the severity of hyperglycemia and insulitis in this model.
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Cited by
Mouse Models of Diabetic Nephropathy
Brosius, F. C., Alpers, C. E., Bottinger, E. P., Breyer, M. D., Coffman, T. M., Gurley, S. B., Harris, R. C., Kakoki, M., Kretzler, M., Leiter, E. H., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009070721 · Cited by 895
Streptozotocin‐Induced Diabetic Models in Mice and Rats
Furman, B. L. (2021) · Current Protocols · doi:10.1002/cpz1.78 · Cited by 874
Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis
Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P. A., & Drucker, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209423200 · Cited by 589
The Ins2AkitaMouse as a Model of Early Retinal Complications in Diabetes
Barber, A. J., Antonetti, D. A., Kern, T. S., Reiter, C. E. N., Soans, R. S., Krady, J. K., Levison, S. W., Gardner, T. W., & Bronson, S. K. (2005) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.04-1340 · Cited by 472
Streptozotocin‐Induced Diabetic Models in Mice and Rats
Wu, K. K., & Huan, Y. (2008) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0547s40 · Cited by 374
Metadata
- Authors
- Rossini, A. A., Appel, M. C., Williams, R. M., & Like, A. A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1977-10-01
- Volume
- 26
- Issue
- 10
- Pages
- 916-920
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1974089457
- Cited by
- 158
- References
- 0
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Genetic Influence of the Streptozotocin-induced Insulitis and Hyperglycemia. https://app.cochat.ai/papers/10.2337/diab.26.10.916
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- Rossini, A. A., Appel, M. C., Williams, R. M., & Like, A. A. (1977). Genetic Influence of the Streptozotocin-induced Insulitis and Hyperglycemia. Diabetes. https://doi.org/10.2337/diab.26.10.916
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