The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Streptozotocin‐Induced Diabetic Models in Mice and Rats
Abstract
Streptozotocin (STZ) is an antibiotic that can cause pancreatic β‐cell destruction, so it is widely used experimentally as an agent capable of inducing insulin‐dependent diabetes mellitus (IDDM), also known as type 1 diabetes mellitus (T1DM). This unit describes protocols for the production of insulin deficiency and hyperglycemia in mice and rats, using STZ. These models for diabetes can be employed for assessing the mechanisms of T1DM, screening potential therapies for the treatment of this condition, and evaluation of therapeutic options. Curr. Protoc. Pharmacol. 40:5.47.1‐5.47.14. © 2008 by John Wiley & Sons, Inc.
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Citations
Cites
Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus
Like, A. A., & Rossini, A. A. (1976) · Science · doi:10.1126/science.180605 · Cited by 979
Diabetogenic action of streptozotocin: relationship of dose to metabolic response
Junod, A., Lambert, A. E., Stauffacher, W., & Renold, A. E. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106180 · Cited by 930
Mouse Models of Diabetic Nephropathy
Breyer, M. D., Bo[Combining Diaeresis]ttinger, E., Brosius, F. C., Coffman, T. M., Harris, R. C., Heilig, C. W., & Sharma, K. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080648 · Cited by 467
Kolb, H. (1987) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610030308 · Cited by 259
Light and Electron Microscopy of Lesions in Rats Rendered Diabetic with Streptozotocin
Arison, R. N., Ciaccio, E. I., Glitzer, M. S., Cassaro, J. A., & Pruss, M. P. (1967) · Diabetes · doi:10.2337/diab.16.1.51 · Cited by 245
Studies on Streptozotocin Diabetes
Ganda, O. P., Rossini, A. A., & Like, A. A. (1976) · Diabetes · doi:10.2337/diab.25.7.595 · Cited by 224
Increased atherosclerosis in streptozotocin-induced diabetic mice.
Kunjathoor, V. V., Wilson, D. L., & LeBoeuf, R. C. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118604 · Cited by 182
Characteristics of Learning and Memory in Streptozocin-Induced Diabetic Mice
Flood, J. F., Mooradian, A. D., & Morley, J. E. (1990) · Diabetes · doi:10.2337/diab.39.11.1391 · Cited by 180
Genetic Influence of the Streptozotocin-induced Insulitis and Hyperglycemia
Rossini, A. A., Appel, M. C., Williams, R. M., & Like, A. A. (1977) · Diabetes · doi:10.2337/diab.26.10.916 · Cited by 158
Kolb-Bachofen, V., Epstein, S. E., Kiesel, U., & Kolb, H. (1988) · Diabetes · doi:10.2337/diab.37.1.21 · Cited by 157
Cited by
Goyal, S. N., Reddy, N. M., Patil, K. R., Nakhate, K. T., Ojha, S., Patil, C. R., & Agrawal, Y. O. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.11.032 · Cited by 419
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Cheng, C.-W., Villani, V., Buono, R., Wei, M., Kumar, S., Yilmaz, O. H., Cohen, P., Sneddon, J. B., Perin, L., & Longo, V. D. (2017) · Cell · doi:10.1016/j.cell.2017.01.040 · Cited by 331
Zhang, B., Yang, Y., Yi, J., Zhao, Z., & Ye, R. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12912 · Cited by 253
Geng, J., Wang, L., Zhang, L., Qin, C., Song, Y., Ma, Y., Chen, Y., Chen, S., Wang, Y., Zhang, Z., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00129 · Cited by 123
Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes
Rivera-Yañez, N., Rodriguez-Canales, M., Nieto-Yañez, O., Jimenez-Estrada, M., Ibarra-Barajas, M., Canales-Martinez, M. M., & Rodriguez-Monroy, M. A. (2018) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2018/4360356 · Cited by 83
Metadata
- Authors
- Wu, K. K., & Huan, Y.
- Venue
- Current Protocols in Pharmacology
- Publisher
- Wiley
- Published
- 2008-03
- Volume
- 40
- Issue
- 1
- Pages
- Unit 5.47-Unit 5.47
- ISSN
- 1934-8282 (ISSN-L)
- 1934-8290
- OpenAlex
- W1565468145
- Cited by
- 374
- References
- 17
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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