Cited by 203Diabetes Management and ResearchAdvanced Glycation End Products researchAnalytical Chemistry and Chromatography

The DOI matches its Crossref record.

A high‐performance liquid chromatography method for hemoglobin A1c

Davis, J E, Mcdonald, Jay M, Jarett, Leonard·1978·Diabetes

DOI 10.2337/diab.27.2.102

Open this paper in CoChat — free account

Abstract

Hemoglobin A1c (HbA1c) is a glycosylated derivative of hemoglobin and is one of a family of derivatives whose concentrations are elevated in patients with diabetes mellitus. Published methods for the measurement of HbA1c are relatively tedious and require modest amounts of blood. A high-performance liquid chromatographic (HPLC) method for the determination of HbA1c is presented. The method is rapid (20 minutes), precise (coefficient of variation of 5-10 per cent), uses small amounts of sample (3 microliter.), can be automated. A sample preparation technique using filtration was developed that shortened and simplified preparation of venous blood and allowed use of capillary samples. HbA1c was measured by this method in three age-stratified groups of controls and a group of insulin-requiring juvenile diabetics. There was clear separation of HbA1c values between all normals (5.9 +/- 1.3, 5.6 +/- 0.7, 7.1 +/- 0.9 per cent) and the diabetics (12.1 +/- 2.4 per cent). Use of this method can facilitate large-scale clinical investigations and permit biochemical investigations of the metabolism and formation of hemoglobin A1c where small sample sizes are necessary.

Integrity signals

Registry

Crossref · 10.2337/diab.27.2.102

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–192 of 192

Acarbose treatment of non-insulin-dependent diabetes mellitus.
Lardinois, C. K., Greenfield, M. S., Schwartz, H. C., Vreman, H. J., & Reaven, G. M. (1984) · PubMed · Cited by 21
Uncontrolled hypertension is associated with a rapid progression of nephropathy in type 2 diabetic patients with proteinuria and preserved renal function.
Baba, T., Murabayashi, S., Tomiyama, T., et al. (1990) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.161.311 · Cited by 21
Measurement of glycosylated hemoglobins using boronate affinity chromatography.
Herold, D. A., Boyd, J. C., Bruns, D. E., et al. (1984) · PubMed · Cited by 20
The Significance of Screening for Microvascular Diseases in Chinese Community-Based Subjects with Various Metabolic Abnormalities
Pang, C., Jia, L., Hou, X., Gao, X., Liu, W., Bao, Y., & Jia, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097928 · Cited by 20
Renal effects of nicardipine, a calcium antagonist, in hypertensive type 2 (non-insulin-dependent) diabetic patients with and without nephropathy
Baba, T., Tomiyama, T., Murabayashi, S., & Takebe, K. (1990) · European Journal of Clinical Pharmacology · doi:10.1007/bf02336678 · Cited by 20
“performance liquid chromatography [ 21 ] on a cation-exchange minicolumn (Auto AI0 HA-8110, Kyoto Daiichi Kagaku, Kyoto, Japan).”
Method
Influence of Iron Deficiency on HbA1c Levels in Pregnant Women: Comparison with Non-Pregnant Women
Hashimoto, K., & Koga, M. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7020034 · Cited by 19
Abnormal distribution of VLDL subfractions in Type 1 (insulin-dependent) diabetic patients: could plasma lipase activities play a role?
Patti, L., Romanò, G., Marino, L., Annuzzi, G., Mancini, M., Riccardi, G., & Rivellese, A. A. (1993) · Diabetologia · doi:10.1007/bf00400698 · Cited by 18
“HbAic was measured by high pressure liquid chromatography [ 27 ]; normal values in our laboratory are less than 6,7 %.”
Method
Lifestyle factors associated with glycaemic control and body mass index in older adults with diabetes
Grylls, W. K., McKenzie, J. E., Horwath, C. C., & Mann, J. I. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601700 · Cited by 17
“(Davis et al, 1978).”
Best use of the recommended IFCC reference method, material and values in HbA1Canalyses
Penttilä, I., Halonen, T., Punnonen, K. R. A., & Tiikkainen, U. (2005) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510510025809 · Cited by 17
Renal kallikrein in diabetic patients with hypertension accompanied by nephropathy
Baba, T., Murabayashi, S., Ishizaki, T., et al. (1986) · Diabetologia · doi:10.1007/bf02427087 · Cited by 17
“Glycosylated haemoglobin Aac was measured by high-performance liquid chromatography [ 19 ] on a cation-exchange minieolumn (Auto Ale HA-8110, Kyoto Daiichi Kagaku, Kyoto, Japan) (intrassay CV, 2.2%).”
MethodInfluential
Hemoglobin osler: Report of a new family with exercise studies before and after phlebotomy
Butler, W. M., Spratling, L., Kark, J. A., et al. (1982) · American Journal of Hematology · doi:10.1002/ajh.2830130404 · Cited by 16
Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain
López‐Sáez, J. B., Martinez-Rubio, J. A., Alvarez, M. M., et al. (2008) · The Open Clinical Cancer Journal · doi:10.2174/1874189400802010001 · Cited by 16
Sequential vitreous fluorophotometry in diabetes mellitus: a five-year prospective study.
Waltman, S. R. (1984) · PubMed · Cited by 16
Glycemic Control and Adverse Clinical Outcomes in Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus: Results from KNOW-CKD
Heo, G. Y., Koh, H. B., Kim, H. W., Park, J. T., Yoo, T., Kang, S., Kim, J., Kim, S. W., Kim, Y. H., Sung, S. A., et al. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0112 · Cited by 15
“Although HPLC is expensive and requires regular maintenance, it is a rapid, automated, and highly precise method, that delivers high resolution compared to other techniques [36].”
Method
Very low density lipoprotein subfraction abnormalities in IDDM patients: any effect of blood glucose control?
Patti, L., Marino, L., Maffettone, A., Romanò, G., Annuzzi, G., Riccardi, G., & Rivellese, A. A. (1995) · Diabetologia · doi:10.1007/bf00400602 · Cited by 15
Cation-exchange, high-performance liquid chromatographic determination of hemoglobin A1c.
Toren, E. C., Vacik, D. N., & Mockridge, P. B. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)90894-5 · Cited by 14
Label-free electrochemical detection of glycated hemoglobin (HbA1c) and C-reactive protein (CRP) to predict the maturation of coronary heart disease due to diabetes
Grewal, R., Ortega, G. A., Geng, F., Srinivasan, S., & Rajabzadeh, A. R. (2024) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2024.108743 · Cited by 14
Bone mass and bone resorption in postmenopausal women with type 2 diabetes mellitus
Hosoda, H., Fukui, M., Nakayama, I., Asano, M., Kadono, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2008) · Metabolism · doi:10.1016/j.metabol.2008.02.009 · Cited by 13
Adenosine triphosphate release by osmotic shock and hemoglobin A1C in diabetic subjects' erythrocytes
Petruzzi, E., Orlando, C., Pinzani, P., et al. (1994) · Metabolism · doi:10.1016/0026-0495(94)90072-8 · Cited by 13
Plasma Epinephrine Disturbances in Diabetic Subjects during Standing and after Isometric Exercise*
Gustafson, A. B., & Kalkhoff, R. K. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-4-759 · Cited by 13
Glomerular basement membrane changes, HbAIc and urinary excretion of acid glycosaminoglycans in children with diabetes mellitus
Lübec, G., Legenstein, E., Pollak, A. J., et al. (1980) · Clinica Chimica Acta · doi:10.1016/0009-8981(80)90229-6 · Cited by 13
Comparison of single- and split-dose insulin regimens with 24-hour monitoring
Langdon, D. R., James, F. D., & Sperling, M. A. (1981) · The Journal of Pediatrics · doi:10.1016/s0022-3476(81)80006-6 · Cited by 14
An automatic method for determination of glycosylated hemoglobins using low-pressure liquid chromatography
Blouquit, Y., Senan, C., & Rosa, J. (1983) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)84342-x · Cited by 13
Associations between 25-hydroxyvitamin D levels, body composition and metabolic profiles in young women
groups, O. B. O. T. Y. A. S.-D. S., Tabesh, M., Callegari, E. T., Gorelik, A., Garland, S. M., Nankervis, A. J., Subasinghe, A. K., & Wark, J. D. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0086-1 · Cited by 12
“HbA1c was measured by a high-performance liquid chromatography method using phenylboronic acid [19].”
Method
Prevalence of normoalbuminuric renal insufficiency and associated clinical factors in adult onset diabetes
Liyanage, P. L. G. C., Lekamwasam, S., Weerarathna, T. P., et al. (2018) · BMC Nephrology · doi:10.1186/s12882-018-1001-7 · Cited by 12
Direct and Label-Free Determination of Human Glycated Hemoglobin Levels Using Bacteriorhodopsin as the Biosensor Transducer
Lin, Y., Lin, C., Chen, H.-M., Kuo, L.-P., Hsieh, C.-E., Wang, X.-H., Cheng, C.-W., Wu, C.-Y., & Chen, Y.-S. (2020) · Sensors · doi:10.3390/s20247274 · Cited by 12
Inorganic phosphate accelerates hemoglobin A1c synthesis
Kunika, K., Itakura, M., & Yamashita, K. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90048-9 · Cited by 12
Falsely low HbA1c value due to a rare variant of hemoglobin J-Baltimore
Barakat, O., Krishnan, S. T. M., & Dhatariya, K. (2008) · Primary care diabetes · doi:10.1016/j.pcd.2008.05.003 · Cited by 12
Glycemic Control and Bone Age Are Independently Associated With Muscle Capillary Basement Membrane Width in Diabetic Children After Puberty
Rogers, D. G., White, N. H., Santiago, J. V., et al. (1986) · Diabetes Care · doi:10.2337/diacare.9.5.453 · Cited by 12
GLYCOSYLATED HEMOGLOBIN (HbAtc) AND PLASMA LIPOPROTEINS IN JUVENILE ONSET DIABETES MELLITUS
Pollak, A. J., Widhalm, K., Havelec, L., et al. (1980) · Acta Paediatrica · doi:10.1111/j.1651-2227.1980.tb07117.x · Cited by 12
“Body & Brain”: effects of a multicomponent exercise intervention on physical and cognitive function of adults with dementia - study protocol for a quasi-experimental controlled trial
Carvalho, J., Borges‐Machado, F., Barros, D. G. M., Sampaio, A., Marques‐Aleixo, I., Bohn, L., Pizarro, A. I. N., Teixeira, L., Magalhães, J., & Ribeiro, Ó. M. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02104-1 · Cited by 19
Usefulness of glycated albumin for early detection of deterioration of glycemic control state after discharge from educational admission
Murai, J., Soga, S., Saito, H., & Koga, M. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0281 · Cited by 11
The Prevalence of Incipient Tubular Dysfunction, But Not of Glomerular Dysfunction, Is Increased in Patients with Diabetes Onset in Childhood
Kordonouri, O., Kahl, A., Jörres, A., et al. (1999) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(99)00055-0 · Cited by 11
Association of variation range in glycated albumin (GA) with increase but not decrease in plasma glucose: Implication for the mechanism by which GA reflects glycemic excursion
Hashimoto, K., Tanikawa, K., Nishikawa, J., et al. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.12.021 · Cited by 10
Modification of human haemoglobin with glucose 6-phosphate enhances tetramer-dimer subunit dissociation
Valdes, R. (1986) · Biochemical Journal · doi:10.1042/bj2390769 · Cited by 10
Can We Use Plasma Fibronectin Levels as a Marker for Early Diabetic Nephropathy.
Özata, M., Kurt, İ., Azal, Ö., et al. (1995) · Endocrine Journal · doi:10.1507/endocrj.42.301 · Cited by 10
Fast hemoglobins and red blood cell metabolites in citrate phosphate dextrose adenine stored blood.
Zeller, W. P., Eyzaguirre, M., Hannigan, J. J., et al. (1985) · PubMed · Cited by 10
Nocturnal blood pressure elevation is related to adrenomedullary hyperactivity, but not to hyperinsulinemia, in nonobese normoalbuminuric type 1 diabetes
Peters, A., Gromeier, S., Kohlmann, T., Look, D., & Kerner, W. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636259 · Cited by 11
ApoE isoforms, treatment of diabetes and the risk of coronary heart disease
Ehara, H. (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i3.54 · Cited by 9
La HbA1c en el diagnóstico y en el manejo de la diabetes
Campuzano‐Maya, G., & Sierra, G. L. (2010) · Dialnet (Universidad de la Rioja) · Cited by 9
Silica monolithic membrane as separation medium
Hosoya, K., Ogata, T., Watabe, Y., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.09.042 · Cited by 9
The Clinical Value of HbA1‐Determinations
Wålinder, O., Wibell, L. B., & Boström, H. (1980) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1980.tb12858.x · Cited by 9
Exploring anti-diabetic activity of Caryota mitis Lour. through modulation of PPAR- α/γ, GLUT-4, using in-vitro, in-vivo and in-silico approaches
Pattanaik, S. K., Pattanaik, S., Dash, M., Sahoo, S., Ray, A., Jena, S., & Rath, D. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120215 · Cited by 8
Effect of source of dietary fats on serum glucose, insulin, and gastric inhibitory polypeptide responses to mixed test meals in subjects with non-insulin dependent diabetes mellitus.
Lardinois, C. K., Starich, G. H., Mazzaferri, E. L., & DeLett, A. (1988) · Journal of the American College of Nutrition · doi:10.1080/07315724.1988.10720229 · Cited by 8
Effect of group-based nutritional education combined with individual standard care for outpatients with type 2 diabetes: study protocol for a randomized clinical trial {1}
Busanello, A., Menezes, V. M., Koller, O. G., Andreia, Â. V., & de Almeida, J. C. (2025) · Trials · doi:10.1186/s13063-025-08720-1 · Cited by 9
“HbA1c will be determined by high-performance liquid chromatography using the Turbo variant II sys-tem [29], with a reference interval of 4.0 to 6.0%.”
Influential
The narrow therapeutic window of glycated hemoglobin and assay variability
Hosseini, S. S., Bibler, I., & Charles, M. A. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90236-6 · Cited by 7
Role of Chromatography for Monitoring of Breast Cancer Biomarkers
Ali, I., ALOthman, Z. A., Saleem, K., et al. (2011) · Recent Patents on Biomarkerse · doi:10.2174/2210309011101010089 · Cited by 6
Determination of glucitollysine for the quantitation of non-enzymatic glucosylation by ion exchange chromatography and reverse phase liquid chromatography
Schmid, R., Pollak, A. J., Vycudilik, W., et al. (1984) · Clinica Chimica Acta · doi:10.1016/0009-8981(84)90320-6 · Cited by 6
Effects of the treatment with acarbose in elderly overweight type 2 diabetic patients in poor glycemic control with oral hypoglycemic agents or insulin
Sangiorgio, L., Attardo, T. M., Condorelli, L., & Lunetta, M. (2000) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(00)00064-9 · Cited by 6
gamma-Glutamyl-transpeptidase in diabetics: a case control study
Colloredo-Mels, G., Bettale, G., Bellati, G., et al. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90009-5 · Cited by 6
Major decrements in glycated hemoglobin levels between 1978 and 1989 in patients with insulin-dependent diabetes mellitus
Arfken, C. L., Schmidt, L. E., McGill, J. B., White, N. H., & Santiago, J. V. (1996) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(94)00048-4 · Cited by 6
A Novel Capillary Collection Method for Obtaining Current Glycosylated Haemoglobin Levels in Diabetic Children
Shah, A. R., Challener, J., Elsey, T. S., Maguire, G. A., Calvin, J., & Rayman, G. A. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00278.x · Cited by 5
Vascular risk factors in Japanese non-insulin-dependent diabetic patients with microalbuminuria
Kodama, T., Tomiyama, T., Ishizaki, T., et al. (1992) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(92)90015-d · Cited by 5
Cardiovascular and Respiratory Measures in Adults With Early-onset Type 2 Diabetes Mellitus Compared With Matched Controls
Muñoz, P. A., Celermajer, D. S., Gu, Y., Bradley, S., Wong, J., Constantino, M., McLennan, S., Lau, E., Alison, J. A., & Harmer, A. R. (2024) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2024.11.003 · Cited by 5
Gold Nanoparticle-Based Detection of Low Molecular Weight AGEs from In Vitro Glycated Haemoglobin A0 Samples
Madhavan, A. A., Juneja, S., Sen, P., Moulick, R. G., & Bhattacharya, J. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2812-y · Cited by 4
Amiodarone therapy and glucose tolerance ? A prospective trial
Lakhdar, A., FARISH, E., Dunn, F. G., et al. (1988) · European Journal of Clinical Pharmacology · doi:10.1007/bf00615233 · Cited by 4
Role of hepatitis B virus infection in chronic liver disease of diabetic patients: A case-control study
Mels, G. C., Bettale, G., Bellati, G., et al. (1986) · Acta Diabetologica · doi:10.1007/bf02581351 · Cited by 4
A Rapid Microchromatographic Method for Determination of Hemoglobin AI
Wålinder, O. (1980) · Upsala Journal of Medical Sciences · doi:10.3109/03009738009179182 · Cited by 4
Measurement
Cohen, M. P. (1986) · Springer eBooks · doi:10.1007/978-1-4612-4938-2_3 · Cited by 4
Total serum bilirubin levels as mediators of antiatherosclerosis mechanisms with consideration of smoking status
Tani, S., Imatake, K., Suzuki, Y., Yagi, T., & Takahashi, A. (2024) · Tobacco Induced Diseases · doi:10.18332/tid/195378 · Cited by 3
“Glycated hemoglobin A1c levels were measured using high-performance liquid chromatography 23 .”
Accuracy, Patient Acceptance and Clinical Application of Capillary HbA1c Monitoring
Dunning, P., Weberruss, M., & Ward, G. M. (1991) · Diabetic Medicine · doi:10.1111/j.1464-5491.1991.tb01702.x · Cited by 3
HIV Infection Does Not Explain Elevation of Glycated Hemoglobin among Non-Diabetic Patients in Gabon
Perret, J. L., Ngou-Milama, E., Delaporte, É., et al. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.097 · Cited by 3
Glycated haemoglobin (HBA1C): an update on available methods
Ezegbogu, M. O., & Abdulsalam, K. S. (2018) · Bayero Journal of Pure and Applied Sciences · doi:10.4314/bajopas.v11i1.2 · Cited by 3
“Commercial assays to measure HbA1c became available in 1978 (Davis et al., 1978; Beccaria et al., 1978), and the test gained popularity during the 1980s.”
Background
Glycated Hemoglobin and Serum Proteins as Tools for Monitoring
Goldstein, B. J., Jabbour, S. A., & Ahmed, I. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0806 · Cited by 3
Biochemical and histological characterization of chemical-induced diabetes mellitus in the rhesus monkey (Macaca mulatta)
Rosenblum, I., Barbolt, T. A., Billhymer, B., & Coulston, F. (1981) · Ecotoxicology and Environmental Safety · doi:10.1016/0147-6513(81)90026-9 · Cited by 3
Determination of Hemoglobin A1C in Diabetic Patients
Almér, L. ‐., & Jeppsson, J. (1982) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1982.tb07705.x · Cited by 3
Niveles de hemoglobina glucosilada y su correlación con las glucemias de ayuno y postprandial en un grupo de pacientes diabéticos
Amador, L. R., Pérez, J. C. O. S., Faxas, E. B., Valdés, F. F., Rojas, S. B., & Mora, I. (2015) · Acta Médica de Cuba · Cited by 2
Evaluation of HbA1c from CGM traces in an Indian population
Majumdar, S., Kalamkar, S. D., Dudhgaonkar, S., Shelgikar, K. M., Ghaskadbi, S., & Goel, P. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1264072 · Cited by 2
“Therefore, accurate experimental methods (6) have been developed to measure HbA1c levels.”
Method
Enhanced high-performance liquid chromatographic resolution of hemoglobin A1c at low temperatures
Torelli, J. A., Eklund, P., & Levy, E. (1982) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)81763-6 · Cited by 2
Glycated hemoglobin, serum proteins, and other markers as tools for monitoring
Gerber, S. M., Stickle, D. F., Ahmed, I., & Jabbour, S. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch59 · Cited by 2
Hemoglobin A1 in Community Care
Åhrén, B., Bitzén, P. ‐., & Scherstén, B. (1982) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1982.tb07706.x · Cited by 2
Serum fatty acid composition as a marker of eating habits in normal and diabetic subjects
Hasegawa, T., & Oshima, M. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00076-5 · Cited by 2
A healthy lifestyle pattern and mortality risk in patients with type 2 diabetes mellitus: A prospective cohort study in China
Yu, H., Liu, X., Cheng, X., Fan, X., Shen, Y., Liu, K., Wan, Y., Su, J., Yu, Q., Sun, Z., et al. (2025) · Journal of Biomedical Research · doi:10.7555/jbr.39.20250107 · Cited by 1
Development of Mobile‐Phase Buffers and Evaluation of Analytical Performance for HbA1c Assays
Zhang, Y., Zhang, G., Yang, F., & Zou, Z. (2025) · Biomedical Chromatography · doi:10.1002/bmc.70136 · Cited by 1
Patients who showed paradoxical increase in HbA1c levels after intensification of diabetes treatment
Koga, M., Saito, H., & Kasayama, S. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.12.001 · Cited by 1
Diabetes Mellitus Selected Aspects of Pathophysiology and Clinical Practice
Porte, D., Halter, J. B., de Haën, C., Palmer, J. P., Asplin, C. M., Graf, R. J., & Pfeifer, M. A. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4187-1_1 · Cited by 1
Medical Monitoring and Diagnosis
Chace, D. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-043848-1.00042-0 · Cited by 1
Vergleich verschiedener Methoden zur Bestimmung glykosylierter Hämoglobine
Schlebusch, H., Sorger, M., & Burisch, H. (1984) · Journal of Molecular Medicine · doi:10.1007/bf01721779 · Cited by 1
REVIEW: High-Performance Ion-Exchange Chromatography of Proteins: The Current Status11This is Journal Paper No. 8930 from the Purdue University Agricultural Experiment Station.
Regnier, F. E. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-335780-9.50006-1 · Cited by 1
Ein Routineverfahren zur chromatographischen HB AI-Bestimmung mittels Mikros�ulentechnik
Gain, T., Henderkott, U., & Bottermann, P. (1981) · Journal of Molecular Medicine · doi:10.1007/bf01476579 · Cited by 1
Editorial
Handelsman, D. J., & Turtle, J. R. (1978) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1978.tb02582.x
Improved column-chromatographic isolation of glycosylated hemoglobin S.
Cirotto, C., Allegrucci, M., Cartechini, M. G., Compagnucci, P., Santeusanio, F., & Bolli, G. B. (1985) · Clinical Chemistry · doi:10.1093/clinchem/31.4.631
“Chromatography on ion-exchange columns is commonly used in estimating the proportion of total hemoglobin (Hb) that is glycosylated ( 1-4 ).”
Background
Hb Alc-Bestimmung mittels Flüssigkeitschromatographie
Topić, E. (1984) · Journal of Laboratory Medicine · doi:10.1515/labm.1984.8.7-8.268
Evaluation ofThreeMinicolumn Procedures forMeasuring Hemoglobin A1
McDonald, J. M., & Ladenson, H. (1982)
Self-citation
ヘモグロビンA1c (HbA1c) 生成反応速度定数を用いた1日平均空腹時血糖値の算定
国香, 清., 板倉光夫, & 亀次郎, 山. (1990) · 糖尿病 · doi:10.11213/tonyobyo1958.33.319
ESTIMATION OF OXIDATIVE STRESS IN TYPE 2 DIABETIC PATIENTS
Ghosh, L. M., Biswas, I. B., & Roy, N. (2017) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2017/387
ヘモグロビンA Ia+b+c の簡易測定法
満夫, 稲., 光重, 西., まり子, 大., 駿一郎, 蔵., & 裕夫, 井. (1979) · 糖尿病 · doi:10.11213/tonyobyo1958.22.811
Correlation of Glycemic Control with Calcium, Inorganic Phosphate, and Alkaline Phosphatase in Type 1 Diabetes Mellitus
Ayinbuomwan, E., & Onovughakpo-Sakpa, E. O. (2022) · Nigerian Journal of Experimental and Clinical Biosciences · doi:10.4103/njecp.njecp_3_22
Luseogliflozin Persistently Lowers Glycemia and Body Weight Over a Period of Two Years in Patients With Type 2 Diabetes
Mori, J.-I., Yamashita, K., & Aizawa, T. (2025) · Cureus · doi:10.7759/cureus.78503
“HbA1c levels were determined using high-performance liquid chromatography [15] with an Arkray HA8181 (Tokyo, Japan).”
Measurement of HbA1c with a new phase function using RBC phase image from a low-cost digital holographic microscopy
Sahu, A. K., Panda, B., Tripathy, A. A., et al. (2025) · Biotechnology Letters · doi:10.1007/s10529-025-03610-7
“However, the method failed to establish a linear relationship between the phase value and the HbA1c; therefore, it failed to replace the present HPLC as the gold standard method (Davis et al. 1978) (Maleska et al. 2017).”
糖尿病者の血糖コントロール及び耐糖能異常の指標としてのGlycosylated Hemoglobin (HbA1) の意義
享, 真., 由夫, 後., & 祐五, 阿. (1979) · 糖尿病 · doi:10.11213/tonyobyo1958.22.1075
Interference Assessment for High‐Performance Liquid Chromatography HbA1c Assays
Zhao, L., Yang, W., Cui, S., Luo, J., Cao, Y., Yan, N., & Wang, H. (2026) · Biomedical Chromatography · doi:10.1002/bmc.70382

Authors: Davis, J. E., Mcdonald, J. M., & Jarett, L.
Affiliations: Washington University in St. Louis (US)
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1978-02-01
Volume: 27
Issue: 2
Pages: 102-107
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.27.2.102
OpenAlex: W2013055957
Cited by: 203
References: 0
Citations by year: 2026: 1 · 2025: 7 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 3
FWCI: 10.47
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
Keywords: HbA1c, HPLC assay, diabetes mellitus, type 1 diabetes, capillary blood samples, sample preparation, small sample volumes, automated assay
MeSH terms: Adolescent, Adult, Age Factors, Child, Child, Preschool, Chromatography, High Pressure Liquid, Diabetes Mellitus, Diabetes Mellitus, Type 1, Glycosides, Hemoglobins, Humans, Middle Aged

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A high‐performance liquid chromatography method for hemoglobin A1c

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks