Cited by 203Diabetes Management and ResearchAdvanced Glycation End Products researchAnalytical Chemistry and Chromatography

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A high‐performance liquid chromatography method for hemoglobin A1c

Davis, J E, Mcdonald, Jay M, Jarett, Leonard·1978·Diabetes

DOI 10.2337/diab.27.2.102

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Abstract

Hemoglobin A1c (HbA1c) is a glycosylated derivative of hemoglobin and is one of a family of derivatives whose concentrations are elevated in patients with diabetes mellitus. Published methods for the measurement of HbA1c are relatively tedious and require modest amounts of blood. A high-performance liquid chromatographic (HPLC) method for the determination of HbA1c is presented. The method is rapid (20 minutes), precise (coefficient of variation of 5-10 per cent), uses small amounts of sample (3 microliter.), can be automated. A sample preparation technique using filtration was developed that shortened and simplified preparation of venous blood and allowed use of capillary samples. HbA1c was measured by this method in three age-stratified groups of controls and a group of insulin-requiring juvenile diabetics. There was clear separation of HbA1c values between all normals (5.9 +/- 1.3, 5.6 +/- 0.7, 7.1 +/- 0.9 per cent) and the diabetics (12.1 +/- 2.4 per cent). Use of this method can facilitate large-scale clinical investigations and permit biochemical investigations of the metabolism and formation of hemoglobin A1c where small sample sizes are necessary.

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Method
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Retinopathy in African Americans and Whites With Insulin-Dependent Diabetes Mellitus
Arfken, C. L. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420220097011 · Cited by 28
A double-blinded, randomized, placebo-controlled study evaluating the impact of dates vinegar consumption on blood biochemical and hematological parameters in patients with type 2 diabetes
Ali, Z., Ma, H., Wali, A., Ayim, I., Rashid, M. T., & Younas, S. (2019) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v17i12.23 · Cited by 27
“, Torrance, CA, USA), photodiode-array detector Jasco MD-915 (Tokyo, Japan) and an Agilent UV- detector model 1100, was used to analyze folate and HbA1c concentrations [19,20].”
Method
Multiple chemiluminescence immunoassay detection of the concentration ratio of glycosylated hemoglobin A1c to total hemoglobin in whole blood samples
Zhao, H., Qiu, X., Su, E., et al. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.339379 · Cited by 27
Methods for the Analysis of Glycated Haemoglobins: What is Being Measured?
John, W. G., Bullock, D. G., & MacKenzie, F. (1992) · Diabetic Medicine · doi:10.1111/j.1464-5491.1992.tb01708.x · Cited by 27
A semi-automated method for the determination of glycosylated haemoglobin
Ross, I. S., & Gibson, P. F. (1979) · Clinica Chimica Acta · doi:10.1016/0009-8981(79)90165-7 · Cited by 27
Nutrient intakes; biochemical and risk indices associated with Type 2 diabetes and glycosylated haemoglobin, in the British National Diet and Nutrition Survey of people aged 65 years and over
Bates, C. J., Lean, M. E. J., Mansoor, M. A., et al. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01228.x · Cited by 26
Recent Advances in Glycosylated Hemoglobin Measurements
Goldstein, D. E., Wiedmeyer, H.-M., England, J. D., Little, R. R., Parker, K. M., & Simon, M. (1984) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368409165782 · Cited by 26
Separation and Characterization of the Molecular Species of Thrombomodulin in the Plasma of Diabetic Patients
Uehara, S., Gotoh, K., & Handa, H. (2001) · Thrombosis Research · doi:10.1016/s0049-3848(01)00358-9 · Cited by 24
Chromatographic and colorimetric detection of glycosylated hemoglobins: A comparative analysis of two different methods
Saibene, V., Brembilla, L., Bertoletti, A., Bolognani, L., & Pozza, G. (1979) · Clinica Chimica Acta · doi:10.1016/0009-8981(79)90089-5 · Cited by 24
Defective glucose counterregulation limits intensive therapy of diabetes mellitus
Santiago, J. V., White, N. H., Skor, D. A., Levandoski, L. A., Bier, D. M., & Cryer, P. E. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.2.e215 · Cited by 24
Nonenzymatic Glycosylation of Proteins in Vitro and in Vivo
Thorpe, S. R., & Baynes, J. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-356103-9.50012-9 · Cited by 24
Influence of SGLT2 Inhibitor Treatment on Urine Antioxidant Status in Type 2 Diabetic Patients: A Pilot Study
Nabrdalik-Leśniak, D., Nabrdalik, K., Sedlaczek, K., Główczyński, P., Kwiendacz, H., Sawczyn, T., Hajzler, W., Drożdż, K., Hendel, M., Irlik, K., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5593589 · Cited by 22
“HbA1c was measured with the HLPC (high-performance liquid chromatography) method [25], creatinine was measured with Jaffe’s colorimetric assay [26] (Cobas Integra 800, Roche Diagnostics®), and eGFR was calculated according to CKDEPI formula [27].”
Method
Effects of dietary cholesterol on plasma lipoproteins and their subclasses in IDDM patients
Romanò, G., Tilly-Kiesi, M., Patti, L., Taskinen, M., Pacioni, D., Cassader, M., Riccardi, G., & Rivellese, A. A. (1998) · Diabetologia · doi:10.1007/s001250050889 · Cited by 22
“HbA 1c was measured by a high pressure liquid chromatography [ 27 ].”
Method
Plasma Lipids in Patients With Type I Diabetes Mellitus
Semenkovich, C. F. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390010069006 · Cited by 22
Association of ANK1 variants with new-onset type 2 diabetes in a Han Chinese population from northeast China
Sun, L., Zhang, X., Wang, T., et al. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4866 · Cited by 20
“HbA1c levels were measured using high-performance liquid chromatography as previous described (20).”
Method
Quantitative assessment of urinary protein and enzyme excretion—a diagnostic programme for the detection of renal involvement in type I diabetes mellitus
Kordonouri, O., Jörres, A., Muller, C. R., et al. (1992) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519209088381 · Cited by 21
Comparison of hemoglobin A1c and hemoglobin A1 in diabetic patients
James, T., Davis, J. E., McDonald, J. M., Santiago, J. V., & Ladenson, J. H. (1981) · Clinical Biochemistry · doi:10.1016/0009-9120(81)90135-1 · Cited by 20
Self-citation

Authors: Davis, J. E., Mcdonald, J. M., & Jarett, L.
Affiliations: Washington University in St. Louis (US)
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1978-02-01
Volume: 27
Issue: 2
Pages: 102-107
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.27.2.102
OpenAlex: W2013055957
Cited by: 203
References: 0
Citations by year: 2026: 1 · 2025: 7 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 3
FWCI: 10.47
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
Keywords: HbA1c, HPLC assay, diabetes mellitus, type 1 diabetes, capillary blood samples, sample preparation, small sample volumes, automated assay
MeSH terms: Adolescent, Adult, Age Factors, Child, Child, Preschool, Chromatography, High Pressure Liquid, Diabetes Mellitus, Diabetes Mellitus, Type 1, Glycosides, Hemoglobins, Humans, Middle Aged

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A high‐performance liquid chromatography method for hemoglobin A1c

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