Cited by 317Pancreatic function and diabetesDiabetes and associated disordersAdrenal Hormones and Disorders

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Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.

Coleman, D L, Leiter, E H, Schwizer, R W·1982·Diabetes

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Abstract

Dehydroepiandrosterone (DHEA), a major adrenal secretory steroid in humans, was therapeutic when fed in a concentration of 0.4% to C57BL/KsJ mice with either non-insulin-dependent or insulin-dependent diabetes. Genetically diabetic (db/db) mice of both sexes develop obesity and a glucose intolerance and hyperglycemia associated with insulin resistance by 2 mo of age, and exhibit beta-cell necrosis and islet atrophy by 4 mo. In contrast, DHEA feeding initiated between 1 and 4 mo of age, while only moderately effective in preventing obesity, did prevent the other pathogenic changes and effected a rapid remission of hyperglycemia, a preservation of beta-cell structure and function, and an increased insulin sensitivity as measured by glucose tolerance tests. DHEA feeding was also therapeutic to normal C57BL/KsJ male mice made diabetic by multiple low doses of streptozotocin (SZ). While DHEA treatments did not block either the direct cytotoxic action of SZ on beta-cells or the development of insulitis, the steroid significantly moderated the severity of the ensuing diabetes (reduced hyperglycemia and water consumption, and increased plasma insulin and numbers of residual, granulated beta-cells.

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Crossref · 10.2337/diab.31.9.830

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Background
7 Diabetes and adrenal disease
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Background
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Background
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Background
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Background
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Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration
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Dehydroepiandrosterone in adrenal insufficiency and ageing
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Background
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Background
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Dehydroepiandrosterone induced alterations in rat liver carbohydrate metabolism
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Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity
Sánchez, J., de Heredia, F. P., Priego, T., Portillo, M. P., Zamora, S., Garaulet, M., & Palou, A. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.10.005 · Cited by 23
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Background
Alternative mechanism for anti-obesity effect of dehydroepiandrosterone: Possible contribution of 11β-hydroxysteroid dehydrogenase type 1 inhibition in rodent adipose tissue
Tagawa, N., Minamitani, E., Yamaguchi, Y., & Kobayashi, Y. (2011) · Steroids · doi:10.1016/j.steroids.2011.09.005 · Cited by 22
“In rodents, a number of studies have also shown that DHEA reduced body weight [12], visceral fat [13], and improved glucose [14] and insulin levels [15].”
Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus
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“On the other hand, DHEA is known to improve the insulin resistance [4] and to increase the insulin secretion frompancreas [36].”
Background
Carbohydrate impairment and insulin secretory abnormalities among Macaca mulatta from Cayo Santiago
Howard, C. F., Kessler, M., & Schwartz, S. M. (1986) · American Journal of Primatology · doi:10.1002/ajp.1350110207 · Cited by 23
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COHEN, H. N., Paterson, K., Wallace, A., Beastall, G. H., Manderson, W. G., & MacCuish, A. C. (1984) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1984.tb00122.x · Cited by 23
Androgen responses to acutely increased endogenous insulin levels in hyperandrogenic and normal cycling women
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Miura, T., Koike, T., & Ishida, T. (2005) · Eisei kagaku · doi:10.1248/jhs.51.708 · Cited by 22
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Imai, K., Koyama, M., Kudo, N., et al. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00159-8 · Cited by 22
C19‐5‐ene Steroids in Nature
Lardy, H. A., Marwah, A. K., & Marwah, P. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71009-8 · Cited by 22
Dehydroepiandrosterone Suppresses Elevated Hepatic Glucose-6-phosphatase mRNA Level in C57BL/KsJ-db/db Mice. Comparison with Troglitazone.
Aoki, K., Kikuchi, T., Mukasa, K., Ito, S., Nakajima, A., SATOH, S., OKAMURA, A., & Sekihara, H. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.799 · Cited by 22
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Haning, R. V., HACKETT, R. J., Boothroid, R. I., & Canick, J. A. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90127-e · Cited by 22
Serum Dehydroepiandrosterone Sulfate and Risk for Type 2 Diabetes in Older Men and Women: The Pro.V.A Study
Veronese, N., Trevisan, C., RUI, M. D., Bolzetta, F., Maggi, S., Zambon, S., Corti, M. C., Baggio, G., Perissinotto, E., Crepaldi, G., et al. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.09.013 · Cited by 21
“An association between low serum DHEAS concentrations and insulin resistance has been demonstrated in several animal studies (5), and an active role for DHEAS in type 2 diabetes is also supported by experimental evidence of DHEAS administration’s improving glucose tolerance and sensitivity in rodents with diabetes (6,…”
Background
Role of first trimester total testosterone in prediction of subsequent gestational diabetes mellitus
Gözükara, Y., Aytan, H., Ertunç, D., Tok, E. C., Demirtürk, F., Şahin, Ş., & Aytan, P. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12525 · Cited by 21
Dehydroepiandrosterone decreases elevated hepatic glucose production in C57BL/KsJ-db/db mice
Aoki, K., Taniguchi, H., Ito, Y., et al. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.031 · Cited by 20
Changes in Serum Sex Hormone Profiles after Short-term Low-dose Administration of Dehydroepiandrosterone (DHEA) to Young and Elderly Persons
Yamada, Y., Sekihara, H., Omura, M., Yanase, T., Takayanagi, R., Mune, T., Yasuda, K., Ishizuka, T., Ueshiba, H., Miyachi, Y., et al. (2007) · Endocrine Journal · doi:10.1507/endocrj.k05-132 · Cited by 20
Dehydroepiandrosterone Protects Muscle Flap Microcirculatory Hemodynamics from Ischemia/Reperfusion Injury
Lohman, R. F., Yowell, R. L., Barton, S., et al. (1997) · doi:10.1097/00005373-199701000-00013 · Cited by 20
“Dehydroepiandrosterone (DHEA) is a naturally occurring, weakly androgenic, catabolic steroid known to have diverse effects when administered in pharmacologic doses.(10-14) It can prevent progressive ischemic damage in burn models by preserving vascular function in thermally injured tissue.”
Background
The effect of long-term DHEA treatment on glucose metabolism, hydrogen peroxide and thioredoxin levels in the skeletal muscle of diabetic rats
Jahn, M. P., Jacob, M., Gomes, L. F., Duarte, R. F., Araújo, A. S. D. R., Belló‐Klein, A., Ribeiro, M. F. M., & Kucharski, L. C. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.015 · Cited by 19
In vivo activation of the constitutive androstane receptor β (CARβ) by treatment with dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEA‐S)
Fujita, A., Furutama, D., Tanaka, T., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03712-2 · Cited by 19
Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) inhibit the apoptosis in human peripheral blood lymphocytes
Takahashi, H., Nakajima, A., & Sekihara, H. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.12.006 · Cited by 19
Altered adrenal and thyroid function in children with insulin-dependent diabetes mellitus
Radetti, G., Paganini, C., Gentili, L., Barbin, F., Pasquino, B., & ZACHMANN, M. (1994) · Acta Diabetologica · doi:10.1007/bf00570367 · Cited by 19
“Dehydroepiandrosterone sulfate (DHEAS), the most abundant, circulating adrenal steroid in the blood, has gained recent interest in view of its beneficial effect on obesity [1], lipids [2], cancer [3], and diabetes in animals [4] and because its administration reduces body fat, total serum cholesterol, and low density…”
Background
Relationships between age, dehydro-epiandrosterone sulphate and plasma glucose in healthy men
Thomas, N. (1999) · Age and Ageing · doi:10.1093/ageing/28.2.217 · Cited by 19
“A therapeutic benefit of DHEA preparations in ameliorating streptozotocininduced diabetes mellitus has been clearly demonstrated in laboratory animals [11].”
Background
The Antiobesity Effect of Dehydroepiandrosterone in Castrated or Noncastrated Obese Zucker Male Rats
Taniguchi, S., Yanase, T., Haji, M., Ishibashi, K., Takayanagi, R., & Nawata, H. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00480.x · Cited by 19
Androgen responses to acutely increased endogenous insulin levels in hyperandrogenic and normal cycling women
Elkind-Hirsch, K. E., Valdés, C. T., McConnell, T. G., & Malinak, L. R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54172-7 · Cited by 19
Adiponectin is involved in the protective effect of DHEA against metabolic risk in aged rats
de Heredia, F. P., Sánchez, J., Priego, T., Nicolás, F., Portillo, M. P., Palou, A., Zamora, S., & Garaulet, M. (2008) · Steroids · doi:10.1016/j.steroids.2008.04.011 · Cited by 18
“The steroid hormone dehydroepiandrosterone (DHEA), esides being precursor for sexual hormones, both androgens nd estrogens [13], is thought to have several positive effects tself, such as cancer prevention [14,15], amelioration of cogitive function [16], and also protection against disturbances elated to the metabolic…”
Effect of dehydroepiandrosterone on mitogen-induced lymphocyte proliferation and cytokine production in young and old F344 rats
Pahlavani, M. A., & Harris, M. D. (1995) · Immunology Letters · doi:10.1016/0165-2478(95)00057-c · Cited by 18
Effects of estradiol and progesterone on diabetes‐associated utero‐ovarian atrophy in C57BL/KsJ (db/db) mutant mice
Garris, D. R. (1989) · The Anatomical Record · doi:10.1002/ar.1092250407 · Cited by 18
Estrogenic stimulation of ovarian follicular maturation in diabetes (db/db) mutant mice: restoration of euglycemia prevents hyperlipidemic cytoatrophy
Garris, D. R. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0967-6 · Cited by 16
“In the present studies, E2-HRx in females has been shown to moderate effectively the diabetes-associated hyperglycemia and to promote a normalization of tissue metabolic and cytoarchitectural indices, whereas pre-testosterone agents are effective in males (Coleman et al. 1982).”
BackgroundMethod
Decreased levels of hepatic epidermal growth factor receptors in obese hyperglycemic rodents.
Blackshear, P. J., Stumpo, D. J., Kennington, E. A., et al. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45361-6 · Cited by 17
Liver composition and lipid metabolism in NZB/W F1 female mice fed dehydroisoandrosterone
Miller, B. C., Ho-Wai, L., Tyler, N. E., et al. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90091-4 · Cited by 17
Dehydroepiandrosterone Feeding and Protein Phosphorylation, Phosphatases, and Lipogenic Enzymes in Mouse Liver
Marrero, M., Prough, R. A., Frenkel, R., et al. (1990) · Experimental Biology and Medicine · doi:10.3181/00379727-193-43010 · Cited by 17
Immunological Properties of Dehydroepiandrosterone, Its Conjugates, and Metabolites
Bradlow, H. L., MURPHY, J., & Byrne, J. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07627.x · Cited by 17
Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia
Garris, D. R., & Garris, B. L. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-1019-y · Cited by 16
“Of particular interest was the promotion of normal pancreatic insulin levels in E2-HRx db/db mutants concurrent with the reestablishment of islet cell cytoarchitecture (Coleman 1985; Coleman et al. 1984, 1982).”
Background
Effects of intensive glycemic control on serum levels of insulin-like growth factor-I and dehydroepiandrosterone sulfate in Type 2 diabetes mellitus.
Kanazawa, I., Yamaguchi, T., & Sugimoto, T. (2012) · PubMed · doi:10.3275/8033 · Cited by 16
Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state
Yamakita, N., Murai, T., Kokubo, Y., Hayashi, M., Akai, A., & Yasuda, K. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01420.x · Cited by 15
“DHEA and DHEA-S have been of increasing interest because of their possible protective roles in diabetes mellitus (Coleman et al., 1982, 1984; Nestler et al., 1989; Nestler, 1995), bone mineral loss (Nawata et al., 1995; Tanaka et al., 1996), arteriosclerosis (Gordon et al., 1988; Bernini et al.,…”
Background
Effect of heat shock treatment on the production of variant testosterone-repressed prostate message-2 (TRPM-2) mRNA in culture cells
Kimura, K., Asami, K., & Yamamoto, M. (1997) · Cell Biochemistry and Function · doi:10.1002/(sici)1099-0844(199712)15:4 · Cited by 26

Authors: Coleman, D. L., Leiter, E. H., & Schwizer, R. W.
Affiliations: Jackson Laboratory (US)
ORCID: Coleman, D L
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1982-09-01
Volume: 31
Issue: 9
Pages: 830-833
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.31.9.830
OpenAlex: W1998106197
Cited by: 317
References: 0
Citations by year: 2026: 1 · 2023: 2 · 2022: 7 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 8
FWCI: 9.70
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: dehydroepiandrosterone, type 2 diabetes, type 1 diabetes, db/db mice, streptozotocin-induced diabetes, insulin resistance, beta-cell function, beta cell necrosis, islet atrophy, hyperglycemia, impaired glucose tolerance, obesity, insulitis, plasma insulin, glucocorticoids
MeSH terms: Animals, Blood Glucose, Dehydroepiandrosterone, Diabetes Mellitus, Experimental, Female, Male, Mice, Inbred C57BL, Pancreas, Mice

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Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.

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