Cited by 317Pancreatic function and diabetesDiabetes and associated disordersAdrenal Hormones and Disorders

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Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.

Coleman, D L, Leiter, E H, Schwizer, R W·1982·Diabetes

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Abstract

Dehydroepiandrosterone (DHEA), a major adrenal secretory steroid in humans, was therapeutic when fed in a concentration of 0.4% to C57BL/KsJ mice with either non-insulin-dependent or insulin-dependent diabetes. Genetically diabetic (db/db) mice of both sexes develop obesity and a glucose intolerance and hyperglycemia associated with insulin resistance by 2 mo of age, and exhibit beta-cell necrosis and islet atrophy by 4 mo. In contrast, DHEA feeding initiated between 1 and 4 mo of age, while only moderately effective in preventing obesity, did prevent the other pathogenic changes and effected a rapid remission of hyperglycemia, a preservation of beta-cell structure and function, and an increased insulin sensitivity as measured by glucose tolerance tests. DHEA feeding was also therapeutic to normal C57BL/KsJ male mice made diabetic by multiple low doses of streptozotocin (SZ). While DHEA treatments did not block either the direct cytotoxic action of SZ on beta-cells or the development of insulitis, the steroid significantly moderated the severity of the ensuing diabetes (reduced hyperglycemia and water consumption, and increased plasma insulin and numbers of residual, granulated beta-cells.

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DHEA Treatment Reduces Fat Accumulation and Protects Against Insulin Resistance in Male Rats
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Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia
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“Previous studies in animal have documented therapeutic effects of DHEA in mice used as a model of diabetes [7].”
Background
The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo
Campbell, C. S. G., Caperuto, L. C., Hirata, A. E., ARAUJO, E. P. D., Velloso, L. A., Saad, M. J. A., & Carvalho, C. R. D. O. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.06.017 · Cited by 50
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Androgenic and estrogenic metabolites in serum of mice fed dehydroepiandrosterone: Relationship to antihyperglycemic effects
Leiter, E. H., Beamer, W. G., Coleman, D. L., & Longcope, C. (1987) · Metabolism · doi:10.1016/0026-0495(87)90095-3 · Cited by 50
Self-citation
Metabolism of DHEA by Cytochromes P450 in Rat and Human Liver Microsomal Fractions
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DHEA administration and exercise training improves insulin resistance in obese rats
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“Moreover, several reports demonstrated that shortterm (2 weeks) DHEA administration induced an acute decrease in blood glucose levels in mice [8,9], reduced serum insulin levels in older rats [2,10,11], and enhanced the activities of enzyme related to hepatic glucose metabolismin diet-induced or Zucker obese rats [12,…”
Background
Effect of Dehydroepiandrosterone (DHEA) on Diabetes Mellitus and Obesity
Aoki, K., & Terauchi, Y. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.01.008 · Cited by 49

Authors: Coleman, D. L., Leiter, E. H., & Schwizer, R. W.
Affiliations: Jackson Laboratory (US)
ORCID: Coleman, D L
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1982-09-01
Volume: 31
Issue: 9
Pages: 830-833
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.31.9.830
OpenAlex: W1998106197
Cited by: 317
References: 0
Citations by year: 2026: 1 · 2023: 2 · 2022: 7 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 8
FWCI: 9.70
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: dehydroepiandrosterone, type 2 diabetes, type 1 diabetes, db/db mice, streptozotocin-induced diabetes, insulin resistance, beta-cell function, beta cell necrosis, islet atrophy, hyperglycemia, impaired glucose tolerance, obesity, insulitis, plasma insulin, glucocorticoids
MeSH terms: Animals, Blood Glucose, Dehydroepiandrosterone, Diabetes Mellitus, Experimental, Female, Male, Mice, Inbred C57BL, Pancreas, Mice

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Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.

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