Cited by 317Pancreatic function and diabetesDiabetes and associated disordersAdrenal Hormones and Disorders

The DOI matches its Crossref record.

Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.

Coleman, D L, Leiter, E H, Schwizer, R W·1982·Diabetes

Open this paper in CoChat — free account

Abstract

Dehydroepiandrosterone (DHEA), a major adrenal secretory steroid in humans, was therapeutic when fed in a concentration of 0.4% to C57BL/KsJ mice with either non-insulin-dependent or insulin-dependent diabetes. Genetically diabetic (db/db) mice of both sexes develop obesity and a glucose intolerance and hyperglycemia associated with insulin resistance by 2 mo of age, and exhibit beta-cell necrosis and islet atrophy by 4 mo. In contrast, DHEA feeding initiated between 1 and 4 mo of age, while only moderately effective in preventing obesity, did prevent the other pathogenic changes and effected a rapid remission of hyperglycemia, a preservation of beta-cell structure and function, and an increased insulin sensitivity as measured by glucose tolerance tests. DHEA feeding was also therapeutic to normal C57BL/KsJ male mice made diabetic by multiple low doses of streptozotocin (SZ). While DHEA treatments did not block either the direct cytotoxic action of SZ on beta-cells or the development of insulitis, the steroid significantly moderated the severity of the ensuing diabetes (reduced hyperglycemia and water consumption, and increased plasma insulin and numbers of residual, granulated beta-cells.

Integrity signals

Registry

Crossref · 10.2337/diab.31.9.830

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 201–291 of 291

Cytochrome P-450 mRNAs Are Modulated by Dehydroepiandrosterone, Nafenopin, and Triiodothyronine
Singleton, D., Lei, X.-D., Webb, S. J., Prough, R. A., & Geoghegan, T. E. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15276-2 · Cited by 16
“However, DHEA feeding is associated with a number of beneficial effects that may be distinct from peroxisome proliferation, including antiobesity/antidiabetic effects in mice (Coleman et al., 1982), protection from chemicallyinduced and spontaneous cancer in mice (Schwartz, 1979; Inano et al.”
Effect of dehydroepiandrosterone on hereditary angioedema
Ko�, E., Feh�r, K. G., Feh�r, T., & F�st, G. (1983) · Journal of Molecular Medicine · doi:10.1007/bf01487618 · Cited by 15
“Recent animal experiments have shown that the biological effect of D was related to the immune function [14], and this major adrenal secretory steroid was therapeutic either on noninsulindependent or insulin-dependent diabetes [ 3 ].”
Background
Dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone in male reproductive health: Implications of differential regulation of human Sertoli cells metabolic profile
Dias, T. R., Alves, M. G., Almeida, S., Silva, J., Barros, A., Sousa, M., Silva, B. M., Silvestre, S., & Oliveira, P. F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.06.004 · Cited by 14
An Electrochemical Biosensor Platform for Testing of Dehydroepiandrosterone 3‐Sulfate (DHEA−S) as a Model for Doping Materials
Hanoglu, S. B., Durmus, C., Celikbas, E., Gümüş, Z. P., & Timur, S. (2019) · Electroanalysis · doi:10.1002/elan.201900413 · Cited by 14
Potential Use of Blood Bank Platelet Concentrates to Accelerate Wound Healing of Diabetic Ulcers
Han, S., Kim, D., Jeong, S., et al. (2007) · Annals of Plastic Surgery · doi:10.1097/01.sap.0000258983.25728.0b · Cited by 14
Diabetes (db/db) mutation-induced female reproductive tract hypercytolipidemia: estrogenic restoration of utero-ovarian indices
Garris, D. R., & Garris, B. L. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2004.04.007 · Cited by 14
Effect of dehydroepiandrosterone on lipopolysaccharide-induced interleukin-6 production in DH82 cultured canine macrophage cells
Kim, S.-K., Shin, M.-S., Jung, B., Shim, J., Won, H., Lee, P. R., & Kim, A. (2006) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2006.01.007 · Cited by 14
“, 1977), regulation of blood sugar (Coleman et al., 1982; Laychock and Bauer, 1996), anti-cancer effects (Inano et al.”
Background
6 Hypoglycaemic Agents Which Do Not Release Insulin
Steiner, K., & Lien, E. L. (1987) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(08)70423-5 · Cited by 14
Relationship between type 2 diabetes mellitus and hypothalamic-pituitary-adrenal axis
Felšöci, M., Schroner, Z., Petrovičová, J., & Lazúrová, I. (2010) · Wiener klinische Wochenschrift · doi:10.1007/s00508-010-1497-8 · Cited by 13
Deleterious Effects of Supplementation with Dehydroepiandrosterone Sulphate or Dexamethasone on Rat Insulin-Secreting Cells Under In Vitro Culture Condition
Liu, H., Green, B. D., McClenaghan, N. H., McCluskey, J. T., & Flatt, P. R. (2006) · Bioscience Reports · doi:10.1007/s10540-006-9001-4 · Cited by 13
“Administration of steroids has proven to be beneficial in animal models of type 1 and type 2 diabetes (Coleman et al. 1982, 1984a, b; Coleman 1995).”
Background
Cytoarchitecture of muscle in a genetic model of murine diabetes
Feczko, J. D., & Klueber, K. M. (1988) · American Journal of Anatomy · doi:10.1002/aja.1001820304 · Cited by 13
Dehydroepiandrosterone Alters Zucker Rat Soleus and Cardiac Muscle Lipid Profiles
Abadie, J. M., Malcom, G. T., Porter, J. R., & Svec, F. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020222600811 · Cited by 12
THE MINIPIG AS A MODEL FOR THE STUDY OF AGING IN HUMANS Selective Responses of Hormones Involved in Carbohydrate and Lipid Metabolism in Different Sexes
Johnson, W. (1996) · Cited by 12
Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1−/−, and IRS2−/− male mice fed a high-fat diet
Aoki, K., Tajima, K., Taguri, M., & Terauchi, Y. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.011 · Cited by 12
Effect of a two-month detraining on glucose tolerance and insulin sensitivity in athletes--link to adrenal steroid hormones.
Wang, P.-T., Chiang, I.-T., Lin, C.-Y., Hou, C., Chen, C., Lee, H.-H., Chang, W., & Kuo, C. (2006) · PubMed · Cited by 12
DHEA-PC Slows the Progression of Type 2 Diabetes (Non–Insulin-Dependent Diabetes Mellitus) in the ZDF/Gmi-fa/fa Rat
Byrne, J. J., & Bradlow, H. L. (2001) · Diabetes Technology & Therapeutics · doi:10.1089/152091501300209570 · Cited by 12
“8 Furthermore, DHEA has a protective effect against development of insulin resistance in muscle of rats on high fat diets or accumulated visceral fat.”
Rat Pancreatic Islet and RINm5F Cell Responses to Epiandrosterone, Dehydroepiandrosterone and Interleukin-1β
Laychock, S. G. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00666-7 · Cited by 12
Hyperglycemia Decreases Dehydroepiandrosterone in Japanese Male with Impaired Glucose Tolerance and Low Insulin Response.
Yamauchi, A., Takei, I., Nakamoto, S., et al. (1996) · Endocrine Journal · doi:10.1507/endocrj.43.285 · Cited by 12
“diabetes [9, 10], and atherosclerosis [5, 11].”
Regulation of Cytochromes P450 by DHEA and Its Anticarcinogenic Action
Prough, R. A., LEI, X. ‐., XIAO, G. ‐., et al. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/rp10.1196-annals.1402.auindex_1 · Cited by 12
Estrone Modulates the EGF Receptor in the Liver of db/db Mouse
Chua, B. H. L., Chua, C. C., Zhao, Z.-Y., et al. (1991) · Journal of Receptor Research · doi:10.3109/10799899109064689 · Cited by 11
Steroid sulphates inhibit the rat hepatic microsomal glucose-6-phosphatase system
Scott, H. M., Coughtrie, M. W. H., & Burchell, A. N. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90572-m · Cited by 11
Hypercytolipidemia promotes diabetes (db/db) mutation-associated utero-ovarian involution: counter-regulatory influences of progesterone
Garris, D. R., & Garris, B. L. (2004) · Pathophysiology · doi:10.1016/j.pathophys.2004.02.001 · Cited by 11
“In addition, the utilization of either pre-steroidal or post-cholesterol metabolites has been demonstrated to ameliorate the severity of the expressed-DOS in C57BL/KsJ mice, but not as effectively as ovarian steroid replacement therapy (HRx) [8–12].”
Background
Effects of dehydroepiandrosterone on obesity and glucose‐6‐phosphate dehydrogenase activity in the lethal yellow mouse (strain 129/Sv ‐ Ay/Aw)
Granholm, N. H., Staber, L. D., & Wilkin, P. J. (1987) · Journal of Experimental Zoology · doi:10.1002/jez.1402420109 · Cited by 11
Regional brain glucose uptake in genetically diabetic C57BL/KsJ mice: modulation by the opiate antagonist, Nalmefene
Garris, D. R., & Michel, M. E. (1988) · Brain Research · doi:10.1016/0006-8993(88)91188-2 · Cited by 11
The Effects of Dehydroepiandrosterone on the Rate of Development of Cancer and Autoimmune Processes in Laboratory Rodents
Schwartz, A. G. (1985) · Springer eBooks · doi:10.1007/978-1-4899-2218-2_10 · Cited by 11
Testimony of the correlation between DHEA and bioavailable testosterone using a biochromatographic concept: effect of two salts
André, C., Berthelot, A., Robert, J. F., Thomassin, M., & Guillaume, Y. C. (2003) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(03)00428-x · Cited by 10
C‐Aryl Glucosides with Substituents at the Distal Aryl Ring as Sodium‐Dependent Glucose Cotransporter Inhibitors for the Treatment of Diabetes Mellitus
Wang, X., Li, Y., Yang, B., Li, Z., Huang, W., & Qian, H. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12487 · Cited by 10
“1 mmol/L or higher were considered to be diabetic and were used in the experiment (23).”
Method
IMMUNOPATHOLOGICAL INFLUENCE OF THE Ay, db, ob AND nu GENES PLACED ON THE INBRED NOD BACKGROUND AS MURINE MODELS FOR HUMAN TYPE I DIABETES
Nishimura, M., & Miyamoto, H. (1987) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.1987.tb00372.x · Cited by 10
Dehydroepiandrosterone (DHEA) stimulates glucose uptake in rat adipocytes: activation of phospholipase D
Ishizawa, M., Ishizuka, T., Kajita, K., et al. (2001) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00444-4 · Cited by 10
The Minipig as a Model for the Study of Aging in Humans
Bhathena, S. J., Berlin, E., & Johnson, W. (1996) · Springer eBooks · doi:10.1007/978-1-4615-5885-9_12 · Cited by 9
Screening of novel synthetic derivatives of dehydroepiandrosterone for antivirals against flaviviruses infections
Imran, M., Zhang, L., Zheng, B., Zhao, Z., Zhou, D., Wan, S., Chen, Z., Duan, H., Li, Q., Liu, X., et al. (2022) · Virologica Sinica · doi:10.1016/j.virs.2022.01.007 · Cited by 9
“These analogs have been used in various studies as a therapeutic agent (Coleman et al., 1982).”
Dehydroepiandrosterone: Biological Effects and Clinical Significance
Gaby, A. R. (1996) · Cited by 9
The influence of DHEA on serum lipids, insulin and sex hormone levels in rabbits with induced hypercholesterolemia
Bednarek-Tupikowska, G., Milewicz, A., Kosowska, B., Bohdanowicz-Pawlak, A., & Ściborski, R. (1995) · Gynecological Endocrinology · doi:10.3109/09513599509160187 · Cited by 9
The role for long-term use of dehydroepiandrosterone in adrenal insufficiency
Bennett, G., Cussen, L., & O’Reilly, M. (2022) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000728 · Cited by 8
“The effect of DHEA on glucose homeostasis is not fully understood, but it appears to have an impact on insulin sensitivity and insulin secretion in animal studies [44].”
Background
Reversion of aging-related DHEAS decline in mouse plasma alleviates aging-related glucose tolerance impairment by potentiation of glucose-stimulated insulin secretion of acute phase
Ma, J., Yue, J., Huang, R., Liao, Y., Li, S., & Liu, W. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.134 · Cited by 8
Immunological consequences of inhibiting dehydroepiandrosterone (DHEA) sulfatase in vivo
Foulkes, R., Shaw, S., & SUITTERS, A. J. (1997) · Springer eBooks · doi:10.1007/978-1-4471-0931-0_6 · Cited by 8
Cytosolic phenol and steroid sulphotransferase activities are decreased in a sex-dependent manner in streptozotocin-induced diabetic rats
Coughtrie, M. W. H., Pears, J. S., Jones, A. L., et al. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90252-g · Cited by 8
The stabilizing effect of dehydroepiandrosterone on clinical parameters of metabolic syndrome in patients with schizophrenia treated with olanzapine - a randomized, double-blind trial.
Holka-Pokorska, J., Radzio, R., Jarema, M., et al. (2015) · Psychiatria Polska · doi:10.12740/pp/30180 · Cited by 7
Dehydroepiandrosterone-induced changes in mitochondrial proteins contribute to phenotypic alterations in hepatoma cells
Cheng, M., Chi, L., Wu, P., & Ho, H. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.08.005 · Cited by 7
Intranasal Administration of Adrenocorticotropin-(1-24) Stimulates Adrenocortical Hormone Secretion
Hiroi, N., Ichijo, T., Ueshiba, H., & Miyachi, Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8399 · Cited by 7
Thyroid Hormone and Dehydroepiandrosterone Permit Gluconeogenic Hormone Responses in Hepatocytes
Kneer, N. M., & Lardy, H. A. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1668 · Cited by 7
Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia and inflammation by the dehydroepiandrosterone analog 16α-fluoro-5-androsten-17-one and its reversal by NADPH liposomes
Schwartz, A. G., & Pashko, L. L. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00423-2 · Cited by 7
UHPLC-MS/MS-Based Metabolomics and Clinical Phenotypes Analysis Reveal Broad-Scale Perturbations in Early Pregnancy Related to Gestational Diabetes Mellitus
Hu, T., An, Z., Li, H., Liu, Y.-P., Xia, L., Qiu, L., Yao, A., Ma, L., & Liu, L. (2022) · Disease Markers · doi:10.1155/2022/4231031 · Cited by 6
“Besides the regulation of lipid metabolism, dehydroepiandrosterone was also proved to decrease hyperglycemia and increase insulin sensitivity [38, 39].”
Background
The role of androgens in hormone replacement therapy
Johnson, C., & Berman, J. R. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.11.1815 · Cited by 6
“The reduction in the formation of DHEAS (up to 95%) by the adrenals during ageing results in a dramatic reduction in the formation of androgens and oestrogens in the peripheral target tissues, a situation that has been suggested to be associated with agerelated diseases, such as insulin resistance [17], cardiovascular…”
Background
Dehydroepiandrosterone-enhanced dual specificity protein phosphatase (DDSP) prevents diet-induced and genetic obesity
Watanabe, T., Ashida, K., Goto, K., Nawata, H., Takayanagi, R., Yanase, T., & Nomura, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.10.131 · Cited by 6
Synthesis, characterization and in silico screening of potential biological activity of 17α-ethynyl-3β, 17β, 19-trihydroxyandrost-5-en acetylated derivatives
Ochoa, M. E., Farfán, N., Labra‐Vázquez, P., Soto‐Castro, D., & Santillan, R. L. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.129167 · Cited by 6
Dehydroepiandrosterone therapeutics: Acetylation of DHA in mouse liver
Casey, M. L., Shackleton, C. H. L., & MacDonald, P. C. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90087-8 · Cited by 6
Obesity and dehydroepiandrosterone/dehydroepiandrosterone sulfate relationships in lean, obese, and meat-type cross-bred boars: responses to porcine growth hormone
Wise, T., Klindt, J., & BUONOMO, F. C. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628365 · Cited by 6
DHEA : célèbre et méconnue
Schlienger, J.-L., Perrin, A., & Goichot, B. (2002) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(02)00591-x · Cited by 6
Climacteric obesity: from genesis to clinic
Milewicz, A., & Jędrzejuk, D. (2006) · Gynecological Endocrinology · doi:10.1080/09513590500453775 · Cited by 5
[Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease--preliminary study].
Rabijewski, M., & Zgliczyński, W. (2005) · PubMed · Cited by 5
Correlation of dehydroepiandrosterone with diabetic nephropathy and its clinical value in early detection
Ma, Y., Wang, Q., Chen, Y., Su, J.-P., Gao, Q., Fan, Y., Feng, J., Liu, M. R., & He, Q. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13862 · Cited by 4
Transgenic Mouse Models of Disease: Altering Adipose Tissue Function in Vivo
Ross, S. R., Graves, R. A., Choy, L., et al. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb24835.x · Cited by 4
CHANGES IN mRNA LEVELS OF INTRACELLULAR FATTY ACID METABOLISM REGULATORS IN HUMAN HEPATOMA HepG2 CELLS FOLLOWING THEIR TREATMENT WITH NON-ESTERIFIED FATTY ACIDS AND DEHYDROEPIANDROSTERONE
Rypka, M., Červenková, K., Uherková, L., Poczatková, H., Bogdanová, K., & Veselý, J. (2005) · Biomedical Papers · doi:10.5507/bp.2005.034 · Cited by 4
Dehydroepiandrosterone metabolism in the female rhesus monkey: Oral versus intravenous administration
Longcope, C., & Tast, J. (1996) · Steroids · doi:10.1016/0039-128x(95)00168-p · Cited by 4
Hypercytolipidemia-Induced Nuclear Lipoapoptosis: Cytochemical Analysis and Integrated Review of Hypogonadal, Diabetes-Obesity Syndrome-Induced Female Reproductive Axis Disruption
Garris, D. R., Novikova, L., Garris, B. L., & Lau, Y.-S. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.198 · Cited by 4
Preparation and characterization of steroid and umbelliferone-based hetero-bifunctional poly(ε-caprolactone)s for potential drug delivery systems: antimicrobial and anticancer activities
Erdağı, S. İ., & Isik, S. (2022) · Journal of Polymer Research · doi:10.1007/s10965-022-03059-6 · Cited by 3
“Studies show that levels of DHEA decreases with advancing age, for most cases beginning from one’s twenties [10].”
Background
Low serum dehydroepiandrosterone is associated with diabetic dyslipidemia risk in males with type 2 diabetes
Chen, S., Li, S., Zhang, X., Fan, Y., & Liu, M. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1272797 · Cited by 3
Intravaginal DHEA, by a strictly local action, exerts beneficial effects on both vaginal atrophy symptoms and sexual dysfunction
Labrie, F. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.064 · Cited by 3
“This marked reduction in the secretion of DHEA by the adrenals during aging (39) results in a parallel fall in the formation of androgens and estrogens in peripheral target tissues, a situation believed to be associated with a series of medical problems of menopause, namely, among others, insulin resistance (40), fat…”
Background
Analysis: Potential Therapeutic Use of Dehydroepiandrosterone and Structural Analogs
Schwartz, A. G., & Pashko, L. L. (2001) · Diabetes Technology & Therapeutics · doi:10.1089/152091501300209589 · Cited by 3
Effects of Dehydroepiandrosterone (DHEA) on Ubiquinone and Catalase in the Livers of Male F-344 Rats
Khan, S. A. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1301 · Cited by 3
[Dehydroepiandrosterone therapy in men with angiographically verified coronary heart disease: the effects on plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) and fibrinogen plasma concentrations].
Rabijewski, M., & Zgliczyński, W. (2007) · PubMed · Cited by 3
Age-related differences in the regulation of dehydroepiandrosterone sulfate levels in peripheral blood plasma of monkeys
Goncharova, N. D. (1993) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf00785482 · Cited by 3
Dehydroepiandrosterone sulfate does not prevent spontaneous and iodine-induced lymphocytic thyroiditis and diabetes mellitus in the BB/Wor rat
Alex, S., Braverman, L. E., Fang, S.-L., Norvell, B., Robinson, S., Franz, C., & Longcope, C. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1380719 · Cited by 3
“atrophy ( 8 ). DHEAS was shown to be as effective as DHEA at a dose of 0.1% in the diet.”
MethodInfluential
Molecular cloning of full-length cDNA encoding delta-9 desaturase through PCR strategies and its genomic organization and expression in grass carp (Ctenopharyngodon idella)
Chang, B., Hsieh, S., & Kuo, C.-M. (2001) · Molecular Reproduction and Development · doi:10.1002/1098-2795(200103)58:3 · Cited by 28
IMPACT OF DEHYDROEPIANDROSTERONE IN PREVENTION OF PARACETAMOL INDUCED NEPHROTOXICITY IN RATS
Elkarib (2014) · Current Research in Medicine · doi:10.3844/amjsp.2014.16.27 · Cited by 2
Anti-Obesity Effects of Androgens, Dehydroepiandrosterone (DHEA) and Testosterone
Kajita, K., Mori, I., Yamauchi, M., Ikeda, T., Morita, H., & Ishizuka, T. (2015) · InTech eBooks · doi:10.5772/59604 · Cited by 2
“, demonstrated that administration of DHEA reduces blood glucose level in db/ db mice [46].”
Background
The Riddle of Adrenarche
Auchus, R. J. (2004) · The Endocrinologist · doi:10.1097/01.ten.0000146265.52916.23 · Cited by 1
Effect Of Some Herbal Medicine On Some biochemical paramcters In Diabetic Rats
Helal, E. G. E., & Abbas, M. A. (2006) · The Egyptian Journal of Hospital Medicine · doi:10.12816/ejhm.2006.18032 · Cited by 1
“Agents which sequester counterregulatory hormones such as growth hormone or binding protiens agents which increase thermogenesis by enhancing glucose utilization through futile cycling (Coleman et al., 1982).”
Background
Sucrose dependence on the human serum albumin–dehydroepiandrosterone binding
André, C., Robert, J. F., Thomassin, M., & Guillaume, Y. C. (2004) · Analytica Chimica Acta · doi:10.1016/j.aca.2003.11.011 · Cited by 1
Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs
Schwartz, A. G., & Pashko, L. L. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-767-3_19 · Cited by 1
Accelerated Conversion of Dehydroepiandrosterone Sulfate to Estrogen in a Patient with Crow-Fukase Syndrome and Diabetes Mellitus
Mano, T., Mori, K., Sawai, Y., Oda, N., Tugawa, T., Nakano, I., Watanabe, F., Hamada, M., Nakai, A., Yamamoto, H., et al. (1999) · Endocrine Research · doi:10.1080/07435809909066154 · Cited by 1
Vitamin A, Dehydroepiandrosterone (DHEA) and 5’ Nucleotidase: Regulatory Factors in Tumor Growth
Regelson, W. (1985) · Cancer Investigation · doi:10.3109/07357908509039801 · Cited by 1
Effect of Dehydroepiandrosterone on Lipemia, Glucose Tolerance, Insulinemia, Insulin Binding to Erythrocytes in SHR/N-cp Lean Rats of Koletsky Type
Golda, V., & Hilgertová, J. (1997) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2020.40 · Cited by 1
Effect of Dehydroepiandrosterone on Insulin Sensitivity and Adipocyte Growth in Otsuka Long-Evans Tokushima-Fatty Rats
Ishizuka, T., Kajita, K., Fujioka, K., Hanamoto, T., Ikeda, T., Mori, I., Yamauchi, M., Okada, H., Usui, T., Takahashi, N. K., et al. (2011) · InTech eBooks · doi:10.5772/22973
“Meanwhile, administration of DHEA has been reported to improve obesity (19), diabetes (20), and cancer (21) in animal studies.”
Background
DHEA and Impaired Glucose Tolerance Clinical and Basic Study
Ueshiba, H. (2012) · InTech eBooks · doi:10.5772/26677
Desidroepiandrosterona (DHEA) e envelhecimento: mecanismos celulares do efeito potencializador sobre a secreção de insulina.
Almeida, F. N. (2012) · doi:10.11606/t.42.2012.tde-17042013-095205
“Entretanto a alimentação suplementada com DHEA-S induziu uma preservação da estrutura e função das células B em camundongos diabéticos (Coleman et al., 1982; Giroix et al., 1997).”
Background
Cytoarchitecture of diabetic myopathy during the pathogenesis of the disease: Fast versus slow muscle
Klueber, K. M., & Porta, D. J. (1994) · Clinical Anatomy · doi:10.1002/ca.980070606
Supplement. Anti-apoptotic effect of dehydroepiandrosterone and its role in an aging society.
Yamada, Y., Nakajima, A., & Sekihara, H. (2004) · Internal medicine · doi:10.2169/internalmedicine.43.158
Antidiabetic characteristics of dehydroepiandrosterone in animal and human studies
Cleary, M. P. (1996) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4112-6_20
Symposium 1. Hormone and longevity. Additional speech. Apoptosis inhibitory effect of Dehydroepiandrosterone (DHEA) and role in longevity.
佳彦, 山., Nakajima, J., & Sekihara, H. (2003) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.92.1705
A SENSIBILIDADE À INSULINA E SECREÇÃO EM ILHOTAS
Ratas, I. D. (2011)
CASTRAÇÃO, DIETA HIPERLIPÍDICA E DHEA: EFEITOS SOBRE A SENSIBILIDADE À INSULINA E SECREÇÃO EM ILHOTAS
Ratas, I. D. (2011)
Aus der Medizinischen Klinik und Poliklinik I der
München, L.-M.-U., & Steinbeck, G. (2002)
Alternative Therapy: Dehydroepiandrosterone for Menopausal Hormone Replacement
Dudley, P. S., & Buster, J. E. (2007) · Elsevier eBooks · doi:10.1016/b978-012369443-0/50071-5
男性高齢者の Dehydroepiandrosterone sulfate(DHEAS) と Pulse wave velocity(PWV) により評価した動脈硬化進展の関連 : 端野・壮瞥町研究
磯部, 健., 斎藤, 重., 高木, 覚., 竹内, 宏., 千葉, 雄., 加藤, 伸., 藤原, 禎., 中村, 陽., & 島本, 和. (2005) · 日本循環器病予防学会誌 · doi:10.11381/jjcdp2001.40.116
Identify a novel cuproptosis-related prognostic signature and build its ceRNA net and candidate medicine active ingredients in Pancreatic cancerPreprint
Huang, Q., Li, G., Han, J., & Chang, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2534581/v1
Healing effect of decellularized human placenta and gelatin hydrogel on diabetic wound in animal model
Afraz, E. S., Sahraee, S., Varnamkhasti, A. G., & Mani, H. (2022) · Journal of Biological Studies · doi:10.62400/jbs.v5i3.7085
Association between serum dehydroepiandrosterone sulfate and type 2 diabetes in US adults with adiposity as a mediator
Wu, M., Hu, X., Chen, L., Zeng, Z., & Chen, L. L. (2026) · Medicine · doi:10.1097/md.0000000000048280
THE ROLE OF STEROID SULFATASE IN ENERGY HOMEOSTASIS AND INFLAMMATION
Jiang, M. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Aging of Adrenal Cortex and Ovary
Lipsett, M. B. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5047-7_5 · Cited by 1

Authors: Coleman, D. L., Leiter, E. H., & Schwizer, R. W.
Affiliations: Jackson Laboratory (US)
ORCID: Coleman, D L
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1982-09-01
Volume: 31
Issue: 9
Pages: 830-833
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.31.9.830
OpenAlex: W1998106197
Cited by: 317
References: 0
Citations by year: 2026: 1 · 2023: 2 · 2022: 7 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 8
FWCI: 9.70
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: dehydroepiandrosterone, type 2 diabetes, type 1 diabetes, db/db mice, streptozotocin-induced diabetes, insulin resistance, beta-cell function, beta cell necrosis, islet atrophy, hyperglycemia, impaired glucose tolerance, obesity, insulitis, plasma insulin, glucocorticoids
MeSH terms: Animals, Blood Glucose, Dehydroepiandrosterone, Diabetes Mellitus, Experimental, Female, Male, Mice, Inbred C57BL, Pancreas, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks