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Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1
Abstract
An assay was developed to detect the cytotoxic effects of cytokines on rat pancreatic islet cells in monolayer culture. Cell lysis was detected by a 51Cr-release assay after 4 days of incubation with various cytokines. When tested alone, murine (rat and mouse) interferon-γ (mIFN-γ) produced a small dose-dependent lysis of islet cells; human IFN-γ, mouse IFN-α/β, interleukins 1 and 2 (IL-1 and IL-2), tumor necrosis factor (TNF), and lymphotoxin (LT) were inactive. When added together, the following combinations of cytokines showed synergistic cytotoxic effects: TNF (or LT) plus IL-1, TNF (or LT) plus mIFN-γ, and IL-1 plus mIFN-γ. These results indicate that the cytokine products of mononuclear cells of the immune system, IFN-γ, TNF, LT, and IL-1 have strong synergistic cytotoxic effects on islet cells and therefore may act as direct chemical mediators of islet β-cell destruction in type I (insulin-dependent) diabetes.
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Citations
Cites
Pathologic anatomy of the pancreas in juvenile diabetes mellitus
Gepts, W. (1965) · Diabetes · doi:10.2337/diab.14.10.619 · Cited by 1,345
Cited by
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Wong, G. H. W., & Goeddel, D. V. (1988) · Science · doi:10.1126/science.3263703 · Cited by 914
IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family
Dinarello, C. A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70518-x · Cited by 819
Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat
Castano, L., & Eisenbarth, G. S. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.003243 · Cited by 644
T Helper Cell Subsets in Insulin-Dependent Diabetes
Katz, J. D., Benoist, C., & Mathis, D. (1995) · Science · doi:10.1126/science.7761837 · Cited by 593
Host response to tissue engineered devices
Babensee, J. E., Anderson, J. M., McIntire, L. V., & Mikos, A. G. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00023-4 · Cited by 585
Metadata
- Authors
- Pukel, C., Baquerizo, H., & Rabinovitch, A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1988-01-01
- Volume
- 37
- Issue
- 1
- Pages
- 133-136
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2099354064
- Cited by
- 290
- References
- 1
- FWCI
- 17.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pukel, C., Baquerizo, H., & Rabinovitch, A. (1988). Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1. Diabetes. https://doi.org/10.2337/diab.37.1.133
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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