Reduced risk of IDDM among breast-fed children. The Colorado IDDM Registry
Abstract
The hypothesis that breast-feeding can provide protection against the development of insulindependent diabetes mellitus (IDDM) and would, therefore, be less common among subjects with IDDM was tested with a retrospective design. Cases (n = 268) were selected from the Colorado IDDM Registry and the Barbara Davis Center for Childhood Diabetes (Denver, CO). Two control groups were recruited, one from physicians' practices throughout Colorado (n = 291) and the second through random-digit dialing from the Denver area (n = 188). Cases were less likely to have been breast-fed than controls after adjustment for birth year, maternal age, maternal education, family income, race, and sex [adjusted odds ratio (OR) = 0.70; 95% confidence interval (Cl) = 0.50–0.97]. This finding was consistent for both control groups and by birth-year intervals. A greater decrease in risk of IDDM was seen among subjects who had been breast-fed to an older age (for breast-feeding duration of ≥12 mo, adjusted OR = 0.54, 95% Cl = 0.27–1.08). The amount of IDDM that might be explained by breast-feeding habits (population percentage attributable risk) ranged from 2 to 26%, varying according to the breast-feeding prevalence reported in other studies. Replication of this work in different populations, controlled for the strong secular trends in breast-feeding habits, is critical before the hypothesis of protection is accepted.
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Evidence on whether early introduction of cow's milk or protective effects of breast milk contribute to childhood type 1 diabetes is equivocal and may depend on genetic susceptibility.
“Evidence regarding early introduction of cow’s milk (or protective effects of breast milk consumption) in infants contributing to the development of childhood T1D is equivocal73–76 and may depend on genetic susceptibility77.”
From Epidemiology of type 1 diabetes (2010) · cites this paper as [75]
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- Authors
- Mayer, E. J., Hamman, R. F., Gay, E. C., Lezotte, D. C., Savitz, D. A., & Klingensmith, G. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1988-12-01
- Volume
- 37
- Issue
- 12
- Pages
- 1625-1632
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2006426218
- Cited by
- 169
- References
- 0
- Citations by year
- 2024: 1 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am030747-03)
- Topics
- Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- breastfeeding, type 1 diabetes, pediatric diabetes, diabetes risk factors, breastfeeding duration, population attributable risk
- MeSH terms
- Breast Feeding, Colorado, Diabetes Mellitus, Type 1, Female, Humans, Infant, Male, Milk, Human, Registries, Retrospective Studies, Risk Factors
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