Vasopressin in Rats With Genetic and Streptozocin-Induced Diabetes
Abstract
Rats were administered streptozocin (STZ; 50 or 75 mg/kg i.v., tail vein) or vehicle. Approximately 2 wk later, venous and arterial catheters were implanted for subsequent (24 h later) vasopressin, electrolyte, and hemodynamic measurements. STZ-induced diabetic (STZ-D) rats demonstrated a dose-dependent increase in the plasma glucose concentration, plasma osmolality, and plasma vasopressin concentration. Mean arterial blood pressure (MABP) was unchanged, but heart rate was reduced. Diabetes-prone BB rats, maintained on or withdrawn from insulin treatment for 24–48 h, and diabetes-resistant rats were instrumented and studied as above. Spontaneous-diabetes–prone rats demonstrated increases in plasma glucose concentration and plasma osmolality similar to STZ-D rats but had significantly greater plasma vasopressin concentrations. The significant decrease in MABP observed in these animals probably contributed to the enhanced vasopressin response. We conclude that both osmotic and cardiovascular parameters play important roles in vasopressin secretion in diabetic rats.
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Plasma vasopressin is increased in patients with type 1 or type 2 diabetes and in animal models of diabetes.
“Although it has been known for several decades that plasma vasopressin (VP) is increased in patients with type 1 or with type 2 diabetes mellitus [1] and in animal models of diabetes [2,3]”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [2]
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- Authors
- Brooks, D. P., Nutting, D. F., Crofton, J. T., & Share, L.
- Affiliations
- Department of Physiology and Biophysics, University of Tennessee Memphis, Tennessee
- ORCID
- Brooks, David P
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1989-01-01
- Volume
- 38
- Issue
- 1
- Pages
- 54-57
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2007764235
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 19209, HL12990)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- vasopressin, streptozotocin-induced diabetes, BB rat, diabetes-prone rats, plasma osmolality, plasma glucose, blood pressure, heart rate, insulin therapy, osmoregulation, cardiovascular regulation
- MeSH terms
- Animals, Blood Glucose, Blood Pressure, Diabetes Mellitus, Experimental, Male, Osmolar Concentration, Rats, Inbred Strains, Vasopressins, Rats
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