Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: Study in vasopressin-deficient Brattleboro rats
Open accessAbstract
Diabetic nephropathy represents a major complication of diabetes mellitus (DM), and the origin of this complication is poorly understood. Vasopressin (VP), which is elevated in type I and type II DM, has been shown to increase glomerular filtration rate in normal rats and to contribute to progression of chronic renal failure in 5/6 nephrectomized rats. The present study was thus designed to evaluate whether VP contributes to the renal disorders of DM. Renal function was compared in Brattleboro rats with diabetes insipidus (DI) lacking VP and in normal Long-Evans (LE) rats, with or without streptozotocin-induced DM. Blood and urine were collected after 2 and 4 weeks of DM, and creatinine clearance, urinary glucose and albumin excretion, and kidney weight were measured. Plasma glucose increased 3-fold in DM rats of both strains, but glucose excretion was ≈40% lower in DI-DM than in LE-DM, suggesting less intense metabolic disorders. Creatinine clearance increased significantly in LE-DM ( P < 0.01) but failed to increase in DI-DM. Urinary albumin excretion more than doubled in LE-DM but rose by only 34% in DI-DM rats ( P < 0.05). Kidney hypertrophy was also less intense in DI-DM than in LE-DM ( P < 0.001). These results suggest that VP plays a critical role in diabetic hyperfiltration and albuminuria induced by DM. This hormone thus seems to be an additional risk factor for diabetic nephropathy and, thus, a potential target for prevention and/or therapeutic intervention.
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VP increases glomerular filtration rate.
“VP increases glomerular filtration rate [41,42]”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [42]
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- Authors
- Bardoux, P., Martin, H., Ahloulay, M., Schmitt, F., Bouby, N., Trinh-Trang-Tan, M.-M., & Bankir, L.
- Affiliations
- Hôpital Necker-Enfants Malades (FR)
- Institut National de la Santé et de la Recherche Médicale, Unité 367, 17, Rue du Fer à Moulin 75005 Paris, France; and Institut National de la Santé et de la Recherche Médicale, Unité 90, and Laboratoire de Biochimie A, Hôpital Necker-Enfants Malades, 75743 Paris Cedex 15, France
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1999-08-31
- Volume
- 96
- Issue
- 18
- Pages
- 10397-10402
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC17899
- OpenAlex
- W2106269091
- Cited by
- 138
- References
- 54
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- vasopressin, diabetic nephropathy, diabetes mellitus, hyperfiltration, albuminuria, renal hypertrophy, Brattleboro rats, diabetes insipidus, streptozotocin-induced diabetes, glomerular filtration rate, creatinine clearance, urinary albumin excretion, kidney weight
- MeSH terms
- Albuminuria, Animals, Creatinine, Diabetes Insipidus, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Glomerular Filtration Rate, Glycosuria, Hypertrophy, Kidney, Kidney Failure, Chronic, Male, Nephrectomy, Organ Size, Rats, Brattleboro, Vasopressins, Rats, Long-Evans, Rats
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