Cited by 601Diet, Metabolism, and DiseaseDiabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

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Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats

Kraegen, Edward W, Clark, Peter W, Jenkins, Arthur B, Daley, Eugene A, Chisholm, Donald J, Storlien, Leonard H·1991·Diabetes

DOI 10.2337/diab.40.11.1397

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Abstract

Muscle and hepatic insulin resistance are two major defects of non-insulin-dependent diabetes mellitus. Dietary factors may be important in the etiology of insulin resistance. We studied progressive changes in the development of high-fat–diet–induced insulin resistance in tissues of the adult male Wistar rat. In vivo insulin action was compared 3 days and 3 wk after isocaloric synthetic high-fat or high-starch feeding (59 and 10% cal as fat, respectively). Basal and insulin-stimulated glucose metabolism were assessed in the conscious 5- to 7-h fasted state with the euglycemic clamp (600 pM insulin) with a [3-3H]-glucose infusion. Fat feeding significantly reduced suppressibility of hepatic glucose output by insulin after both 3 days and 3 wk of diet (P < 0.01). However, a significant impairment of insulin-mediated peripheral glucose disposal was only present after 3 wk of diet. Further in vivo [3H]-2-deoxyglucose uptake studies supported this finding and demonstrated adipose but not muscle insulin resistance after 3 days of high-fat feeding. Muscle triglyceride accumulation due to fat feeding was not significant at 3 days but had doubled by 3 wk in red muscle (P < 0.001) compared with starch-fed controls. By 3 wk, high-fat—fed animals had developed significant glucose intolerance. We concludethat fat feeding induces insulin resistance in liver and adipose tissue before skeletal muscle with early metabolic changes favoring an oversupply of energy substrate to skeletal muscle relative to metabolic needs. This may generate later muscle insulin resistance.

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Smith, U. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.3.686s · Cited by 57
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Archer, A. E., Rogers, R. S., Schulze, A. T. V., Wheatley, J. L., Morris, E. M., McCoin, C. S., Thyfault, J. P., & Geiger, P. C. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00073.2018 · Cited by 56
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Background
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Minassian, C., Tarpin, S., & Mithieux, G. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00576-5 · Cited by 53
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Zhang, C., Klett, E. L., & Coleman, R. (2013) · Clinical Lipidology · doi:10.2217/clp.13.67 · Cited by 58
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Shen, M., Kumar, S. P. D. S., & Shi, H. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0007 · Cited by 52
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Background
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Background
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Background
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Morin, C. L., Gayles, E. C., Podolin, D. A., Wei, Y., Xu, M., & Pagliassotti, M. J. (1998) · Endocrinology · doi:10.1210/endo.139.12.6369 · Cited by 46
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Result
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Boon, M. R., Bakker, L. E. H., Haks, M. C., Quinten, E., Schaart, G., van Beek, L., Wang, Y., van Schinkel, L. D., van Harmelen, V., Meinders, A. E., et al. (2014) · Clinical Science · doi:10.1042/cs20140179 · Cited by 45
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Boivin, A., & Deshaies, Y. (1995) · Metabolism · doi:10.1016/0026-0495(95)90072-1 · Cited by 45
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Peng, D., Pan, X., Cui, J., Ren, Y., & Zhang, J. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000356579 · Cited by 45
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Background
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Background
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Cortright, R. N., Muoio, D. M., & Dohm, G. L. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)89660-x · Cited by 44
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Background
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O’Dea, K. (1992) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610080405 · Cited by 44
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Premilovac, D., Bradley, E. A., Ng, H., Richards, S. M., Rattigan, S., & Keske, M. A. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt015 · Cited by 42
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Bessesen, D. H., Rupp, C. L., & Eckel, R. H. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00135.x · Cited by 42
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Samaan, M. C., Marcinko, K., Sikkema, S. R., Fullerton, M. D., Ziafazeli, T., Khan, M. I., & Steinberg, G. R. (2014) · Physiological Reports · doi:10.14814/phy2.12012 · Cited by 44
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Background
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Lark, D. S., Fisher‐Wellman, K. H., & Neufer, P. D. (2012) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2012.20 · Cited by 41
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Fueki, Y., Miida, T., Wardaningsih, E., Ito, M., Nakamura, A., Takahashi, A., Hanyu, O., Tsuda, A., Saitō, H., Hama, H., et al. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.03.027 · Cited by 40
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St‐Pierre, P., Genders, A. J., Keske, M. A., Richards, S. M., & Rattigan, S. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01235.x · Cited by 41
“induce hepatic insulin resistance [15].”
Background
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Arrieta‐Cruz, I., Su, Y., & Juárez, R. G. (2016) · Nutrients · doi:10.3390/nu8020079 · Cited by 43
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Background
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Osei, K., Cottrell, D. A., & Harris, B. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.1.1619033 · Cited by 41
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Jump, D. Β., Clarke, S. D., Thelen, A. P., Liimatta, M. B., Ren, B., & Badin, M. V. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-2670-1_14 · Cited by 39
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Hu, X.-F., Zhang, Q., Zhang, P., et al. (2018) · Fitoterapia · doi:10.1016/j.fitote.2018.02.015 · Cited by 40
Liver mitochondria and insulin resistance.
Vial, G., Dubouchaud, H., & Leverve, X. M. (2010) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2422 · Cited by 42
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Background
Developmental stage modifies diet-induced peripheral insulin resistance in rats
Pagliassotti, M. J., Gayles, E. C., Podolin, D. A., Wei, Y., & Morin, C. L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.1.r66 · Cited by 40
“It also appears that the duration of exposure to either a high-fat (19) or highsucrose (27) diet will influence the tissue distribution of insulin resistance.”
Background
Increased diacylglycerol acyltransferase activity is associated with triglyceride accumulation in tissues of diet-induced insulin-resistant hyperlipidemic hamsters
Casaschi, A., Maiyoh, G. K., Adeli, K., & Theriault, A. (2005) · Metabolism · doi:10.1016/j.metabol.2004.09.016 · Cited by 39
“Rats fed a high-fat diet developed insulin resistance as TG accumulated in the muscle [16].”
Background
Caveats when considering ketogenic diets for the treatment of pyruvate dehydrogenase complex deficiency
Weber, T. A., Antognetti, M. R., & Stacpoole, P. W. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.111817 · Cited by 39
Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue
Boden, G. H., Cheung, P., Salehi, S., Homko, C. J., Loveland-Jones, C. E., Jayarajan, S. N., Stein, T. P., Williams, K. J., Liu, M., Barrero, C. A., et al. (2013) · Diabetes · doi:10.2337/db13-0906 · Cited by 38
Changes in glucose tolerance and leptin responsiveness of rats offered a choice of lard, sucrose, and chow
Harris, R. B. S., & Apolzan, J. W. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00477.2011 · Cited by 42
“Rats fed HFDs also develop insulin resistance (34), but it is unlikely that fat consumption caused insulin insensitivity in the choice rats because HFD rats and chow lard rats had a higher fat intake than choice rats but showed a normal glucose clearance.”
Background
High-Fat Diet-Induced Insulin Resistance in Single Skeletal Muscle Fibers is Fiber Type Selective
Pataky, M. W., Wang, H., Yu, C. S., Arias, E. B., Ploutz-Snyder, R. J., Zheng, X., & Cartee, G. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-12682-z · Cited by 38
“1038/s41598-017-12682-z determined by MHC isoform expression; (4) GLUT4 protein abundance was lower in type IIB fibers from HFD versus LFD rats, but not in whole muscles or in any of the other fiber types; and (5) HFD versus LFD rats differed with regard to abundance of several mitochondrial proteins in type I fibers…”
Acylated ghrelin induces but deacylated ghrelin prevents hepatic steatosis and insulin resistance in lean rats: Effects on DAG/ PKC/JNK pathway
Dallak, M. A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.098 · Cited by 39
The effect of aging on insulin signalling pathway is tissue dependent: Central role of adipose tissue in the insulin resistance of aging
Serrano, R., Villar, M., Gallardo, N., Carrascosa, J. M., Martı́nez, C., & Andrés, A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.11.005 · Cited by 38
“On the other hand, in models of obesity-induced insulin resistance, also associated with hyperinsulinemia, it has been shown that resistance of the liver develops first with the advent of adiposity, and peripheral insulin resistance is a secondary phenomenon (Kim et al., 2003; Kraegen et al., 1991).”
Background
Mechanisms of Insulin Resistance in Hypertensive Rats
Shimamoto, K., & Ura, N. (2006) · Clinical and Experimental Hypertension · doi:10.1080/10641960600851900 · Cited by 39
Saturated-fat diet induces moderate diabetes and severe glomerulosclerosis in hamsters
Popov, D., Simionescu, M., & Shepherd, P. R. (2003) · Diabetologia · doi:10.1007/s00125-003-1185-6 · Cited by 38
Composition of dietary fat affects blood pressure and insulin responses to dietary obesity in the dog.
Truett, A. A., Borne, A., Monteiro, M. P., & West, D. B. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00328.x · Cited by 43
Interaction of exercise and diet on GLUT‐4 protein and gene expression in Type I and Type II rat skeletal muscle
Lee, J. S., Bruce, C. R., Tunstall, R. J., Cameron‐Smith, D., Hügel, H., & Hawley, J. A. (2002) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2002.00963.x · Cited by 38
Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes
Krycer, J. R., Elkington, S. D., Díaz‐Vegas, A., Cooke, K. C., Burchfield, J. G., Fisher‐Wellman, K. H., Cooney, G. J., Fazakerley, D. J., & James, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011695 · Cited by 33
“A small portion of glucose is oxidized (3), and although this does not contribute substantially to respiration, it increases mitochondrial ROS levels (4), eventually leading to insulin resistance (5).”
Background
Enhanced Muscle Mixed and Mitochondrial Protein Synthesis Rates after a High‐fat or High‐sucrose Diet
Chanséaume, E., Giraudet, C., Gryson, C., Walrand, S., Rousset, P., Boirie‌, Y., & Morio, B. (2007) · Obesity · doi:10.1038/oby.2007.582 · Cited by 41
Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway
Li, R., Li, Y., Yang, X., Yu, H., Yu, H., & Li, Y. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03540-2 · Cited by 38
Effect of High-Fat Diet on Body Composition and Hormone Responses to Glucose Tolerance Tests
Brown, J. L., Spicer, M. T., & SPICER, L. J. (2002) · Endocrine · doi:10.1385/endo:19:3:327 · Cited by 37
Protective effect of total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack on diabetic nephropathy in rats
Zou, J., Yu, X., Qu, S., et al. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.11.043 · Cited by 37
Muscle glucose uptake during and after exercise is normal in insulin-resistant rats
Kusunoki, M., Storlien, L. H., MacDessi, J., Oakes, N. D., Kennedy, C., Chisholm, D. J., & Kraegen, E. W. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.2.e167 · Cited by 37
Self-citation
Mice Lacking C1q Are Protected from High Fat Diet-induced Hepatic Insulin Resistance and Impaired Glucose Homeostasis
Hillian, A. D., McMullen, M. R., Sebastian, B. M., Rowchowdhury, S., Kashyap, S. R., Schauer, P. R., Kirwan, J. P., Feldstein, A. E., & Nagy, L. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.465674 · Cited by 35
Vitamin D Deficiency Induces Insulin Resistance and Re‐Supplementation Attenuates Hepatic Glucose Output via the PI3K‐AKT‐FOXO1 Mediated Pathway
Mutt, S. J., Raza, G. S., Mäkinen, M. J., Keinanen-Kiukaanniemi, S. M., Järvelin, M., & Herzig, K. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900728 · Cited by 38
Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP
Faraj, M., & Cianflone, K. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00398.2003 · Cited by 35
“Excess NEFA influx to muscle and liver is associated with lipotoxicity and insulin resistance in mice and human models (9, 10, 31, 32, 47, 60).”
Background
Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats
Foll, C. L., Dunn-Meynell, A. A., & Levin, B. E. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2014 · Cited by 38
Defining lipid mediators of insulin resistance: controversies and challenges
Metcalfe, L. K., Smith, G. C., & Turner, N. A. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0023 · Cited by 35
The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis
Bresciani, N., Demagny, H., Lemos, V., Pontanari, F., Li, X., Sun, Y., Li, H., Perino, A., Auwerx, J. H., & Schoonjans, K. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.05.040 · Cited by 34
Lipid profile and insulin sensitivity in rats fed with high-fat or high-fructose diets
Zaman, M.-Q., Leray, V., Bloc’h, J. L., Thorin, C., Ouguerram, K., & Nguyen, P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004454 · Cited by 34
“IS, as it measures the insulin-mediated glucose uptake under hyperinsulinaemic conditions) compared to the control group, as previously shown in several studies((14,15)).”
Result
Fish-oil supplementation reduces stimulation of plasma glucose fluxes during exercise in untrained males
Delarue, J., Labarthe, F., & Cohen, R. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003964 · Cited by 34
“Dietary fatty acids modulate both hepatic glucose production (HGP) and plasma glucose utilisation in rats and in human subjects fed a high-fat diet (Kraegen et al. 1991; Bisschop et al. 2001).”
Background
Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction
Wu, L. E., Meoli, C. C., Mangiafico, S. P., Fazakerley, D. J., Cogger, V. C., Mohamad, M., Pant, H., Kang, M.-J., Powter, E. E., Burchfield, J. G., et al. (2014) · Diabetes · doi:10.2337/db13-1665 · Cited by 34
Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids
Goff, L. M., Frost, G. S., Hamilton, G., Thomas, E. L., Dhillo, W. S., Dornhorst, A., & Bell, J. D. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002789 · Cited by 34
“Studies in rodents have also shown that high-fat feeding results in a parallel increase in insulin resistance and IMCL storage (Kraegen et al. 1991; Storlien et al. 1991) In addition, it has been found recently that troglitazone, a member of the thiazolidinedione group of insulin-sensitising drugs, reduces IMCL storag…”
Influential
Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis
Kowalski, G. M., Hamley, S., Selathurai, A., Kloehn, J., Souza, D. P. D., O’Callaghan, S., Nijagal, B., Tull, D., McConville, M. J., & Bruce, C. R. (2016) · Scientific Reports · doi:10.1038/srep27541 · Cited by 33
Triacylglycerol accumulation is not primarily affected in myotubes established from type 2 diabetic subjects
Gaster, M., & Beck‐Nielsen, H. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.12.003 · Cited by 33

Authors: Kraegen, E. W., Clark, P. W., Jenkins, A. B., Daley, E. A., Chisholm, D. J., & Storlien, L. H.
Affiliations: Garvan Institute of Medical Research (AU)
ORCID: Clark, Peter W
Jenkins, Arthur B
Chisholm, Donald J
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1991-11-01
Volume: 40
Issue: 11
Pages: 1397-1403
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.40.11.1397
OpenAlex: W2049881486
Cited by: 601
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 7 · 2020: 13 · 2019: 22 · 2018: 18 · 2017: 17 · 2016: 37 · 2015: 22 · 2014: 37 · 2013: 31 · 2012: 27
FWCI: 2.59
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: insulin resistance, high-fat diet, hepatic insulin resistance, skeletal muscle insulin resistance, adipose tissue insulin resistance, hepatic glucose production, impaired glucose tolerance, type 2 diabetes, dietary fat
MeSH terms: Animals, Dietary Fats, Glucose, Insulin, Insulin Resistance, Liver, Male, Muscles, Rats, Inbred Strains, Starch, Triglycerides, Rats

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Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats

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