The DOI matches its Crossref record.
Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats
Abstract
Muscle and hepatic insulin resistance are two major defects of non-insulin-dependent diabetes mellitus. Dietary factors may be important in the etiology of insulin resistance. We studied progressive changes in the development of high-fat–diet–induced insulin resistance in tissues of the adult male Wistar rat. In vivo insulin action was compared 3 days and 3 wk after isocaloric synthetic high-fat or high-starch feeding (59 and 10% cal as fat, respectively). Basal and insulin-stimulated glucose metabolism were assessed in the conscious 5- to 7-h fasted state with the euglycemic clamp (600 pM insulin) with a [3-3H]-glucose infusion. Fat feeding significantly reduced suppressibility of hepatic glucose output by insulin after both 3 days and 3 wk of diet (P < 0.01). However, a significant impairment of insulin-mediated peripheral glucose disposal was only present after 3 wk of diet. Further in vivo [3H]-2-deoxyglucose uptake studies supported this finding and demonstrated adipose but not muscle insulin resistance after 3 days of high-fat feeding. Muscle triglyceride accumulation due to fat feeding was not significant at 3 days but had doubled by 3 wk in red muscle (P < 0.001) compared with starch-fed controls. By 3 wk, high-fat—fed animals had developed significant glucose intolerance. We concludethat fat feeding induces insulin resistance in liver and adipose tissue before skeletal muscle with early metabolic changes favoring an oversupply of energy substrate to skeletal muscle relative to metabolic needs. This may generate later muscle insulin resistance.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Three days of high-fat feeding in rats results specifically in hepatic steatosis and hepatic insulin resistance.”
From Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease (2007) · cites this paper as [13]
Citations
Cited by
Sorted by citations
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis
Farrell, G. C., & Larter, C. Z. (2006) · Hepatology · doi:10.1002/hep.20973 · Cited by 2,428
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322
Insulin action and resistance in obesity and type 2 diabetes
Czech, M. P. (2017) · Nature Medicine · doi:10.1038/nm.4350 · Cited by 1,258
A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat
Reed, M. J., Meszaros, K., Entes, L. J., Claypool, M. D., Pinkett, J. G., Gadbois, T., & Reaven, G. M. (2000) · Metabolism · doi:10.1053/meta.2000.17721 · Cited by 854
Morino, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25151 · Cited by 811
“These data are consistent with those of previous studies in humans (7, 16, 17) and rodents (18, 19), which have suggested that dysregulated intramuscular fatty acid metabolism has an important causative role in insulin resistance and may have a similar role in fat-induced insulin resistance in the…”
REGULATION OF GENE EXPRESSION BY DIETARY FAT
Jump, D. Β., & Clarke, S. D. (1999) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.19.1.63 · Cited by 666
Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance
Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615
Schmitz-Peiffer, C., Craig, D. L., & Biden, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24202 · Cited by 592
The role of fatty acids in insulin resistance
Sears, B., & Perry, M. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0123-1 · Cited by 589
“Once NAFLD is established, the ability of insulin to suppress liver glucose production is diminished without changes in weight, fat mass, or the appearance of any indication of insulin resistance in the skeletal muscle [71].”
BackgroundIncreased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity
Koonen, D. P. Y., Jacobs, R. L., Febbraio, M., Young, M. E., Soltys, C.-L. M., Ong, H., Vance, D. E., & Dyck, J. R. B. (2007) · Diabetes · doi:10.2337/db07-0907 · Cited by 527
“Indeed, elevated levels of plasma fatty acids that are induced by diets rich in fatty acids and the resulting skeletal muscle insulin resistance both contribute to hepatic insulin resistance (5), increased hepatic glucose output (6), hepatic steatosis (4), and increased hepatic triglyceride secretion in VLDLs (7).”
BackgroundInsulin Resistance, Obesity and Lipotoxicity
Yazıcı, D., & Sezer, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_12 · Cited by 525
Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497
Tremblay, F., Brûlé, S., Hee Um, S., Li, Y., Masuda, K., Roden, M., Sun, X. J., Krebs, M., Polakiewicz, R. D., Thomas, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706517104 · Cited by 465
Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430
“In support of findings in animals [7, 19, 21, 23, 24] and humans [25, 30, 31], our data show that an HFD rapidly impairs the ability of insulin to suppress hepatic glucose Fig.”
BackgroundSelf-citationStiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W. P., Kim, Y.-J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308617100 · Cited by 436
Why Visceral Fat is Bad: Mechanisms of the Metabolic Syndrome
Bergman, R. N., Kim, S. P., Catalano, K. J., Hsu, I. R., Chiu, J. D., Kabir, M., Hucking, K., & Ader, M. (2006) · Obesity · doi:10.1038/oby.2006.277 · Cited by 371
Nutrition, hormones, and breast cancer: Is insulin the missing link?
Kaaks, R. (1996) · Cancer Causes & Control · doi:10.1007/bf00051703 · Cited by 354
Dietary fats and insulin action
Storlien, L. H., Baur, L. A., Kriketos, A. D., Pan, D. A., Cooney, G. J., Jenkins, A. B., Calvert, G. D., & Campbell, L. V. (1996) · Diabetologia · doi:10.1007/bf00418533 · Cited by 354
“These studies showed the insulin resistance to occur firstly in the liver within a very short period of time (3 days; [22]) followed by widespread impairment in insulin action in a range of skeletal muscles and in white and brown adipose tissue by 3 weeks.”
BackgroundSelf-citationSkeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise
Corcoran, M. P., Lamon-Fava, S., & Fielding, R. A. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.662 · Cited by 341
“against a high fat diet that induces insulin resistance (9, 181, 182).”
BackgroundAbnormal Lipid and Glucose Metabolism in Obesity: Implications for Nonalcoholic Fatty Liver Disease
Parekh, S., & Anania, F. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.055 · Cited by 344
Mechanisms of Inflammatory Responses in Obese Adipose Tissue
Sun, S., Ji, Y., Kersten, S., & Qi, L. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150623 · Cited by 322
Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes
Sobczak, A. I. S., Blindauer, C. A., & Stewart, A. J. (2019) · Nutrients · doi:10.3390/nu11092022 · Cited by 314
“In non-alcoholic fatty liver disease the ability of the liver to suppress glucose production when present in sufficient quantity is reduced [184].”
BackgroundHigh fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms
Lian, C.-Y., Zhai, Z., Li, Z., & Wang, L. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109199 · Cited by 325
Juárez, R. G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26991 · Cited by 303
“Severe hepatic insulin resistance is indeed among the earliest changes seen with short-term overfeeding (OF) in rats (9, 10).”
BackgroundStyskal, J., Remmen, H. V., Richardson, A. G., & Salmon, A. B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.441 · Cited by 289
“For example, muscle from subjects with T2DM, or from rodent models of diabetes, commonly show reduced insulin-stimulated insulin receptor and IRS-1 phosphorylation and PI-3K activity [4].”
BackgroundPark, S.-Y., Cho, Y.-R., Kim, H.-J., Higashimori, T., Danton, C., Lee, M.-K., Dey, A., Rothermel, B., Kim, Y.-B., Kalinowski, A., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3530 · Cited by 286
“(43) found that insulin resistance develops in liver and adipose tissue before it develops in skeletal muscle during chronic high-fat feeding in Wistar rats.”
BackgroundTargeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
Hagberg, C. E., Mehlem, A., Falkevall, A., Muhl, L., Fam, B. C., Ortsäter, H., Scotney, P. D., Nyqvist, D., Samén, E., Li, L., et al. (2012) · Nature · doi:10.1038/nature11464 · Cited by 290
HOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 295
“By 3 weeks, there is increased lipid in muscle and impaired muscle insulin action (351).”
BackgroundSelf-citationEllis, B. A., Poynten, A., Lowy, A. J., Furler, S. M., Chisholm, D. J., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e554 · Cited by 273
“Rats were randomly assigned to either a high-fat diet for 3 wk as previously described (21), overnight fasting, or insulin stimulation via a euglycemichyperinsulinemic clamp with radioactive tracer administration to assess glucose uptake in vivo (12).”
BackgroundMethodSelf-citationStanhope, K. L., & Havel, P. J. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f2b24a · Cited by 274
Impact of short‐term high‐fat feeding on glucose and insulin metabolism in young healthy men
Brøns, C., Jensen, C. B., Storgaard, H., Hiscock, N. J., White, A., Appel, J. S., Jacobsen, S., Nilsson, E., Larsen, C. M., Astrup, A. V., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169078 · Cited by 278
“Studies of animals have shown that short-term high-fat feeding causes hepatic insulin resistance preceding the subsequent more long-term development of peripheral insulin resistance (Kraegen, 1991; Kim et al. 2003).”
BackgroundFructose induced lipogenesis: from sugar to fat to insulin resistance
Samuel, V. T. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.10.003 · Cited by 271
Kupffer cell activation is a causal factor for hepatic insulin resistance
Lanthier, N., Molendi‐Coste, O., Horsmans, Y., van Rooijen, N., Cani, P. D., & Leclercq, I. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00391.2009 · Cited by 269
“Hepatic insulin resistance refers to inadequate insulin-dependent suppression of hepatic glucose production (HGP) and plays a pivotal role in the development of hyperglycemia and evolution toward type 2 diabetes (17, 30).”
The role of intramuscular lipid in insulin resistance
Hegarty, B. D., Furler, S. M., Ye, J.-M., Cooney, G. J., & Kraegen, E. W. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01162.x · Cited by 258
Self-citationFetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism
Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.023 · Cited by 255
“Hepatic steatosis in rodents develops rapidly in the setting of overnutrition (Kraegen et al., 1991; Stewart et al., 2009; Turner et al., 2013) and occurs at a time point that normally precedes the development of other abnormalities associated with caloric excess, including adipocyte hypertrophy and obesity developmen…”
BackgroundInfluentialCod and soy proteins compared with casein improve glucose tolerance and insulin sensitivity in rats
Lavigne, C., Marette, A., & Jacques, H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.3.e491 · Cited by 252
“Although most studies have examined the role of high-fat (4, 13, 21, 23, 33, 35), lowsoluble fiber (3) or high-sucrose diets (36) in the development of an impaired insulin action, relatively few studies have focused on the impact of dietary proteins.”
BackgroundThe Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
Herman, M. A., & Samuel, V. T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.005 · Cited by 259
“Short-term, high-fat feeding in rodents is associated with steatosis and marked hepatic insulin resistance without peripheral resistance [87, 88].”
Marshall, J. A., Bessesen, D. H., & Hamman, R. F. (1997) · Diabetologia · doi:10.1007/s001250050697 · Cited by 251
“Fasting insulin concentration was used as the response variable in these analyses because it has been shown to be a strong predictor of subsequent development of NIDDM independent of body mass index (BMI) [3, 4] and in subjects with normal glucose tolerance it has been shown to be correlated with whole body glucose up…”
BackgroundInfluentialLeng, S.-H., Lu, F., & Xu, L. (2004) · PubMed · Cited by 237
Muscle Oxidative Capacity Is a Better Predictor of Insulin Sensitivity than Lipid Status
Bruce, C. R., Anderson, M. J., Carey, A. L., Newman, D. G., Bonen, A., Kriketos, A. D., Cooney, G. J., & Hawley, J. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030791 · Cited by 234
Tremblay, F., Lavigne, C., Jacques, H., & Marette, A. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1901 · Cited by 219
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211
Free fatty acids and skeletal muscle insulin resistance
Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 210
Self-citationDelarue, J., Foll, C. L., Corporeau, C., & Lucas, D. (2004) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2004033 · Cited by 205
“Studies from Storlien’s group have demonstrated that the substitution of fish oil (rich in n-3 long chain n-3 fatty acids) for saturated (tallow) or monoinsaturated (olive oil) or polyunsaturated n-6 (safflower oil) high fat diets (60% fat) in rats over 3 weeks completely prevented liver and muscle insulin resistance…”
BackgroundBrain insulin signalling in metabolic homeostasis and disease
Scherer, T., Sakamoto, K., & Buettner, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00498-x · Cited by 205
Effects of dietary fatty acids on insulin sensitivity and secretion
Manco, M., Calvani, M., & Mingrone, G. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00356.x · Cited by 203
Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review
Rahman, M. M., Dhar, P. S., Sumaia, Anika, F., Ahmed, L., Islam, M. R., Sultana, N. A., Cavalu, S. D., Pop, O. L., & Rauf, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113217 · Cited by 225
Kim, S. P., Ellmerer, M., Citters, G. W. V., & Bergman, R. N. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2453 · Cited by 195
“(21) used a diet with very high fat (60%) and a calorie content not generally seen in the human diet.”
MethodExcess body fat in obese and normal-weight subjects
Thomas, E. L., Frost, G. S., Taylor-Robinson, S. D., & Bell, J. D. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422412000054 · Cited by 203
Raubenheimer, P. J., Nyirenda, M., & Walker, B. R. (2006) · Diabetes · doi:10.2337/db06-0097 · Cited by 199
Fatty acid metabolism, energy expenditure and insulin resistance in muscle
Turner, N. A., Cooney, G. J., Kraegen, E. W., & Bruce, C. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0397 · Cited by 206
Self-citationAltered body composition and metabolism in the male offspring of high fat–fed rats
Buckley, A., Keserü, B., BRIODY, J. N., Thompson, M., Ozanne, S. E., & Thompson, C. H. (2005) · Metabolism · doi:10.1016/j.metabol.2004.11.003 · Cited by 186
Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated
Morgan, K., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400458200 · Cited by 192
Ibdah, J. A., Perlegas, P., Zhao, Y., Angdisen, J., Borgerink, H., Shadoan, M. K., Wagner, J. D., Matern, D., Rinaldo, P., & Cline, J. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.001 · Cited by 186
n -3 Polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle
Taouis, M., Dagou, C., Ster, C., Durand, G., Pinault, M., & Delarue, J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00320.2001 · Cited by 184
“This effect of n-3 PUFA could be the result of a prevention of the increased glucose cycle activity, either associated or not with reduced hepatic fatty acid oxidation, which is known to promote gluconeogenesis (12, 17, 21).”
BackgroundŞahin, K., Önderci, M., Tuzcu, M., Üstündağ, B., Çıkım, G., Özercan, İ. H., Sriramoju, V., Juturu, V., & Komorowski, J. R. (2007) · Metabolism · doi:10.1016/j.metabol.2007.04.021 · Cited by 176
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
Deng, X., Chen, L., & Li, N. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01497.x · Cited by 179
“Kraegen et al. ( 16 ) reported that rats fed with high fat diet for 3 days developed hepatic insulin resistance before the development of peripheral insulin resistance, suggesting feeding rats for a short duration would therefore provide an excellent model of NAFLD.”
BackgroundActivation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
Ono, H., Pocai, A., Wang, Y., Sakoda, H., Asano, T., Backer, J., Schwartz, G. J., & Rossetti, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34277 · Cited by 183
The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity
Satoh, A., Stein, L. R., & Imai, S. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_7 · Cited by 175
“Indeed, under diabetogenic HFD conditions (Kraegen et al. 1991; Kubota et al. 1999; Surwit et al. 1988), the activity and/or protein expression of SIRT1 are reduced in several tissues (Deng et al.”
BackgroundWhole body fat: Content and distribution
Thomas, E. L., Fitzpatrick, J. A., Malik, S., Taylor-Robinson, S. D., & Bell, J. D. (2013) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2013.04.001 · Cited by 177
“Elevated IMCL have been observed in diabetes and are inversely related to insulin action [156,157].”
BackgroundHegarty, B. D., Cooney, G. J., Kraegen, E. W., & Furler, S. M. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1477 · Cited by 166
Self-citationUkropcova, B., Sereda, O., de Jonge, L., Bogacka, I., Nguyen, T., Xie, H., Bray, G. A., & Smith, S. R. (2007) · Diabetes · doi:10.2337/db06-0521 · Cited by 165
Diet-regulated production of PDGFcc by macrophages controls energy storage
Cox, N., Crozet, L., Holtman, I. R., Loyher, P.-L., Lazarov, T., White, J. B., Mass, E., Stanley, E. R., Elemento, O., Glass, C. K., et al. (2021) · Science · doi:10.1126/science.abe9383 · Cited by 172
Origins, Biology, and Diseases of Tissue Macrophages
Cox, N., Pokrovskii, M. V., Vicario, R., & Geissmann, F. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-111748 · Cited by 171
Muscular diacylglycerol metabolism and insulin resistance
Timmers, S., Schrauwen, P., & den Bosch, J. D. V. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.12.002 · Cited by 163
“However, an even stronger association has been shown between intramyocellular fat storage and insulin resistance in animals [10,11] and humans [12,13].”
BackgroundKowalski, G. M., & Bruce, C. R. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00165.2014 · Cited by 154
“Yet they also demonstrated that hepatic insulin resistance developed after 3 days of HFD, which occurred prior to the onset of muscle insulin resistance, which is consistent with our findings in mice (171) and that of others in rats (48, 105, 157).”
BackgroundResultInfluentialAntidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats
Zheng, T., Shu, G., Yang, Z., Mo, S., Zhao, Y., & Mei, Z. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.12.025 · Cited by 159
Calvo‐Ochoa, E., Hernández‐Ortega, K., Ferrera, P., Morimoto, S., & Arias, C. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.48 · Cited by 158
Metabolic adaptations to a high-fat diet in endurance cyclists
Goedecke, J. H., Christie, C., Wilson, G., Dennis, S. C., Noakes, T. D., Hopkins, W. G., & Lambert, E. V. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90238-x · Cited by 153
Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content
Neschen, S., Moore, I. K., Regittnig, W., Yu, C. L., Wang, Y., Pypaert, M., Petersen, K. F., & Shulman, G. I. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00414.2001 · Cited by 155
Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
Larter, C. Z., & Farrell, G. C. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.11.030 · Cited by 155
Diet-induced obesity in the rat: A model for gestational diabetes mellitus
Holemans, K., Caluwaerts, S., Poston, L., & Assche, F. A. V. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2003.09.025 · Cited by 154
Choi, S. B., Jang, J. S., & Park, S. (2005) · Endocrinology · doi:10.1210/en.2004-1653 · Cited by 151
Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371807 · Cited by 150
Lavoie, J.-M., & Gauthier, M. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6600-y · Cited by 152
Amylopectin Starch Promotes the Development of Insulin Resistance in Rats
Byrnes, S. E., Brand-Miller, J. C., & Denyer, G. S. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1430 · Cited by 145
Ren, L., Chan, S. M. H., Zeng, X., Laybutt, D. R., Iseli, T. J., Sun, R., Kraegen, E. W., Cooney, G. J., Turner, N. A., & Ye, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030816 · Cited by 143
“As well as being an important site of fatty acid oxidation, the liver is also a major organ for de novo lipogenesis and its insulin sensitivity appears to be more vulnerable to the insult of lipid accumulation compared to muscle [8].”
BackgroundSelf-citationLong-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats
Chalkley, S. M., Hettiarachchi, M., Chisholm, D. J., & Kraegen, E. W. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00173.2001 · Cited by 140
“Previous studies from our institution with shortterm (3 wk-1 mo) high polyunsaturated fat-fed rats showed no metabolically significant hyperglycemia despite the induction of insulin resistance (23, 26, 37).”
BackgroundMethodResultInfluentialSelf-citationShould peripheral CB1 cannabinoid receptors be selectively targeted for therapeutic gain?
Kunos, G., Osei‐Hyiaman, D., Bátkai, S., Sharkey, K. A., & Makriyannis, A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.001 · Cited by 139
“The two most important tissues responsible for dietinduced insulin resistance are the liver and skeletal muscle [53-55], which means that activation of hepatic CB1 receptors likely results in the production/release of a soluble mediator(s) that is involved in inducing insulin resistance in skeletal muscle.”
BackgroundGan, S. K., Kriketos, A. D., Ellis, B. A., Thompson, C. H., Kraegen, E. W., & Chisholm, D. J. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1706 · Cited by 134
Self-citationMuscle Long‐Chain Acyl CoA Esters and Insulin Resistance
Cooney, G. J., Thompson, A. L., Furler, S. M., Ye, J.-M., & Kraegen, E. W. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04276.x · Cited by 131
Self-citationSears, D. D., Miles, P. D. G., Chapman, J., Ofrecio, J. M., Almazan, F., Thapar, D., & Miller, Y. I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007250 · Cited by 135
Ukropec, J., Reseland, J. E., Gašperíková, D., DEMCÁKOVÁ, E., Madsen, L., Berge, R. K., Rustan, A. C., Klimeś, I., Drevon, C. A., & ŠEBÖKOVÁ, E. (2003) · Lipids · doi:10.1007/s11745-006-1156-z · Cited by 136
Insulin action and signalling in fat and muscle from dexamethasone-treated rats
Burén, J., Lai, Y. C., Lundgren, M., Eriksson, J. W., & Jensen, J. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.034 · Cited by 125
Lanthier, N., Molendi‐Coste, O., Cani, P. D., van Rooijen, N., Horsmans, Y., & Leclercq, I. A. (2011) · The FASEB Journal · doi:10.1096/fj.11-189472 · Cited by 138
Induction of Hepatic Glucose-6-Phosphatase Gene Expression by Lipid Infusion
Massillon, D., Barzilai, N., Hawkins, M. A., Prus-Wertheimer, D., & Rossetti, L. (1997) · Diabetes · doi:10.2337/diab.46.1.153 · Cited by 125
“Whether the induction of hepatic Glc-6-Pase expression by glucose (32) and lipids contributes to the increased rate of hepatic glucose production that follows a high-carbohydrate (35) and high-fat diet (34) remains to be delineated.”
BackgroundMechanism of fat-induced hepatic gluconeogenesis: effect of metformin
Song, S., Andrikopoulos, S., Filippis, C., Thorburn, A. W., Khan, D., & Proietto, J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e275 · Cited by 122
“Previous studies have shown that an increase in circulating lipids results in the impaired suppression of hepatic glucose production by insulin (14, 20, 42), although whether this was due to increased gluconeogenesis or glycogenolysis was not known.”
BackgroundKahn, B. B., & Pedersen, O. B. (1993) · Endocrinology · doi:10.1210/endo.132.1.8419118 · Cited by 121
Oakes, N. D., Camilleri, S., Furler, S. M., Chisholm, D. J., & Kraegen, E. W. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90083-4 · Cited by 121
Self-citationKim, Y. I., Lee, F. N., Choi, W. S., Lee, S., & Youn, J. H. (2006) · Diabetes · doi:10.2337/db05-1606 · Cited by 119
“In rats, the development of skeletal muscle insulin resistance took 3 days of high-fat feeding (36,37).”
BackgroundJucker, B. M., Cline, G. W., Barucci, N., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.1.134 · Cited by 119
Developmental Changes in Histone macroH2A1-Mediated Gene Regulation
Changolkar, L. N., Costanzi, C., Leu, N. A., Chen, D., McLaughlin, K. J., & Pehrson, J. R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02334-06 · Cited by 118
“Previous studies of the effects of increased fatty acid delivery on liver insulin resistance have been done on male mice and rats (18, 19, 34), suggesting that the responses of females may be different.”
BackgroundKimura, N. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040503 · Cited by 120
“metabolic syndrome and type II diabetes mellitus (DM) [9].”
BackgroundJoseph, A.-M., Joanisse, D. R., Baillot, R. G., & Hood, D. A. (2011) · Experimental Diabetes Research · doi:10.1155/2012/642038 · Cited by 119
“Specifically, defects in this series of reactions are directly associated with increased levels of plasma and intracellular free fatty acids and alterations in insulin signaling pathways [3, 4].”
BackgroundHoy, A. J., Bruce, C. R., Turpin-Nolan, S. M., Morris, A. J., Febbraio, M. A., & Watt, M. J. (2010) · Endocrinology · doi:10.1210/en.2010-0661 · Cited by 123
Gauthier, M., Favier, R. J. M., & Lavoie, J.-M. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051635 · Cited by 116
“Previous studies have shown that hepatic steatosis can occur as early as after 3 d of high-fat feeding (Kraegen et al. 1991; Samuel et al. 2004).”
Metadata
- Authors
- Kraegen, E. W., Clark, P. W., Jenkins, A. B., Daley, E. A., Chisholm, D. J., & Storlien, L. H.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1991-11-01
- Volume
- 40
- Issue
- 11
- Pages
- 1397-1403
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2049881486
- Cited by
- 601
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 7 · 2020: 13 · 2019: 22 · 2018: 18 · 2017: 17 · 2016: 37 · 2015: 22 · 2014: 37 · 2013: 31 · 2012: 27
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin resistance, high-fat diet, hepatic insulin resistance, skeletal muscle insulin resistance, adipose tissue insulin resistance, hepatic glucose production, impaired glucose tolerance, type 2 diabetes, dietary fat
- MeSH terms
- Animals, Dietary Fats, Glucose, Insulin, Insulin Resistance, Liver, Male, Muscles, Rats, Inbred Strains, Starch, Triglycerides, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
