The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Abstract
In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate with reduced skeletal muscle and whole body insulin action. The aim of this study was to test this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age 28 ± 1 years). Insulin sensitivity at physiological (M) and supraphysiological (MZ) insulin levels was assessed by the euglycemic clamp. Lipid and carbohydrate oxidation were determined by indirect calorimetry before and during insulin administration. mTG was determined in vastus lateralis muscles obtained by percutaneous biopsy. Percentage of body fat (mean 29 ± 1%, range 14–44%) was measured by underwater weighing. In simple regressions, negative relationships were found between mTG (mean 5.4 ± 0.3 μmol/g, range 1.3–1.9 μmol/g) and log10M (r = −0.53, P ≤ 0.001), MZ (r = −0.44, P = 0.006), and nonoxidative glucose disposal (r = −0.48 and −0.47 at physiological and supraphysiological insulin levels, respectively, both P = 0.005) but not glucose or lipid oxidation. mTG was not related to any measure of adiposity. In multiple regressions, measures of insulin resistance (log10M, MZ, log10[fasting insulin]) were significantly related to mTG independent of all measures of obesity (percentage of body fat, BMI, waist-to-thigh ratio). In turn, all measures of obesity were related to the insulin resistance measures independent of mTG. The obesity measures and mTG accounted for similar proportions of the variance in insulin resistance in these relationships. The results suggest that in this human population, as in animal models, skeletal muscle insulin sensitivity is strongly influenced by local supplies of triglycerides, as well as by remote depots and circulating lipids. The mechanism(s) underlying the relationship between mTG and insulin action on skeletal muscle glycogen synthesis may be central to an understanding of insulin resistance.
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In the citing paper
“Muscle biopsy studies [53, 54] have demonstrated increased triglyceride content in skeletal muscle of obese NGT subjects compared to lean individuals and an inverse relationship between muscle insulin sensitivity and the intramuscular triglyceride content.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [53]
In the citing paper
“The mechanism via which obesity causes insulin resistance in skeletal muscle is related to the accumulation of fat in the myocytes.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [53]
In the citing paper
“These lipids interfere with insulin signaling and represent one of the key aspects that could contribute to insulin resistance in situations of high-fat feeding or lipid infusion (Pan et al, 1997; Krssak et al, 1999; Goodpaster et al, 2000).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Pan et al, 1997
In the citing paper
“For instance, IMCL levels were increased in first-level relatives of T2DM patients and associated with impaired insulin-stimulated glucose uptake in muscle (Pan et al, 1997).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Pan et al, 1997
Citations
Cites
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967
Self-citationRole of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition
Reaven, G. M. (1993) · Annual Review of Medicine · doi:10.1146/annurev.me.44.020193.001005 · Cited by 908
Keys, A. B., & Brožek, J. (1953) · Physiological Reviews · doi:10.1152/physrev.1953.33.3.245 · Cited by 855
What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes
McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657
Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats
Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S. (1987) · Science · doi:10.1126/science.3303333 · Cited by 648
Self-citationMuscle triglyceride utilization during exercise: effect of training
Hurley, B. F., Nemeth, P. M., Martin, W. H., Hagberg, J. M., Dalsky, G. P., & Holloszy, J. O. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.2.562 · Cited by 522
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Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Simental‐Mendía, L. E., Rodríguez‐Morán, M., & Guerrero‐Romero, F. (2008) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0034 · Cited by 2,581
Guerrero‐Romero, F., Simental‐Mendía, L. E., González-Ortíz, M., Martínez‐Abundis, E., Ramos-Zavala, M. G., Hernández‐González, S. O., Jacques-Camarena, O., & Rodríguez‐Morán, M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0288 · Cited by 2,379
Metadata
- Authors
- Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H.
- Affiliations
- University of Wollongong (AU)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Royal Prince Alfred Hospital (AU)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1997-06-01
- Volume
- 46
- Issue
- 6
- Pages
- 983-988
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2134604231
- Cited by
- 1,179
- References
- 37
- Citations by year
- 2026: 2 · 2025: 17 · 2024: 14 · 2023: 26 · 2022: 23 · 2021: 28 · 2020: 25 · 2019: 32 · 2018: 31 · 2017: 42 · 2016: 36 · 2015: 47 · 2014: 44 · 2013: 28 · 2012: 56
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Figshare (submittedVersion)
- Funders
- Diabetes Australia Research Trust
- Diabetes Australia
- Grains Research and Development Corporation
- Juvenile Diabetes Research Foundation Australia
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin resistance, skeletal muscle insulin sensitivity, nonoxidative glucose disposal, lipid oxidation, glucose oxidation, obesity, adiposity, Pima Indians, vastus lateralis, euglycemic clamp
- MeSH terms
- Adult, Arizona, Biopsy, Body Composition, Body Constitution, Humans, Indians, North American, Insulin, Male, Obesity, Regression Analysis, Triglycerides, Glucose Clamp Technique, Muscle, Skeletal
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