Sleep-associated fall in glucose disposal and hepatic glucose output in normal humans. Putative signaling mechanism linking peripheral and hepatic events
Abstract
Values reported for basal hepatic glucose production and glucose utilization do not reflect metabolic changes occurring during sleep. To determine the effect of sleep with its associated lowered metabolic rate and thermogenesis on glucose kinetics and gluconeogenic substrate availability, 11 normal volunteers underwent an overnight study in which [3-3H]glucose was infused. Despite decreased insulin secretion, a fall in hepatic glucose output was observed with sleep that was synchronous with a reduction in glucose utilization and lipolysis (decreased plasma glycerol and free fatty acids). When activity was increased, these parameters rose toward previously reported basal levels. Prevention of sleep in 6 additional subjects attenuated the fall in glucose utilization and production as well as the fall in glycerol and free fatty acids despite similar insulin and counterregulatory hormone profiles. We suggest that sleep-associated metabolic changes produce a peripheral signal(s) that modulates hepatic glucose production in humans.
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During sleep, glucose levels remain stable or fall only minimally in spite of fasting, mostly because of decreased energy needs.
“During sleep glucose levels remain stable or fall only minimally in spite of fasting, mostly because of decreased energy needs.44”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [44]
During the first part of the night, when most slow wave sleep occurs, glucose production is diminished.
“During the first part of the night, when most slow wave sleep (SWS) occurs, glucose production is diminished44 (Fig. 2).”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [44]
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- Authors
- Clore, J. N., Nestler, J. E., & Blackard, W. G.
- Affiliations
- Virginia Commonwealth University Medical Center (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1989-03-01
- Volume
- 38
- Issue
- 3
- Pages
- 285-290
- ISSN
- 0012-1797 (ISSN-L)
- OpenAlex
- W2116656512
- Cited by
- 62
- References
- 0
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 4 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2013: 2 · 2012: 3
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK18903)
- National Center for Research Resources (RR 00065)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep, hepatic glucose production, glucose utilization, glucose kinetics, gluconeogenesis, lipolysis, glycerol, free fatty acids, insulin secretion, counterregulatory hormones, thermogenesis, metabolic rate
- MeSH terms
- Adult, Alanine, Blood Glucose, Body Temperature, C-Peptide, Fatty Acids, Nonesterified, Female, Glucagon, Glucose, Glycerol, Humans, Insulin, Lactates, Liver, Male, Sleep, Growth Hormone
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