The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Low plasma leptin levels contribute to diabetic hyperphagia in rats.
Abstract
The adipocyte hormone leptin reduces food intake in normal animals. During uncontrolled type 1 diabetes, plasma leptin levels fall, whereas food intake increases. To test the hypothesis that low leptin levels contribute to diabetic hyperphagia, we investigated the effect on food intake of replacement of leptin at basal plasma concentrations for 7 days in Long-Evans rats with uncontrolled diabetes induced by streptozotocin (STZ). One group of STZ diabetic rats received saline (STZ + Sal) (n = 11), while the other group (STZ + Lep) (n = 15) received a subcutaneous infusion of recombinant rat leptin (100 microg x kg(-1) x day(-1)) via osmotic minipumps. A nondiabetic control group (Con) (n = 11) received saline only. In the STZ + Sal group, plasma leptin levels decreased by 75% (P < 0.05) from 2.4+/-0.5 on the day before STZ/citrate buffer vehicle (Veh) injection (day 0) to 0.6+/-0.2 ng/ml on day 7. In contrast, plasma leptin levels on days 3-7 were comparable to pretreatment values in both the STZ + Lep group (day 0: 2.6+/-0.4 vs. day 7: 2.5+/-0.3 ng/ml, NS) and the Con group (day 0: 3.8+/-0.4 vs. day 7: 2.9+/-1.0 ng/ml, NS). In the STZ + Sal group, daily food intake increased gradually to values 43% above basal by day 7 (day 0: 24+/-2 to day 7: 33+/-3 g, P < 0.05), whereas food intake did not increase in either the STZ + Lep group (day 0: 24+/-1 vs. day 7: 21+/-2 g, NS), or the Con group (day 0: 23+/-1 vs. day 7: 23+/-2 g). Plasma glucose levels exceeded nondiabetic control values (7.7+/-0.2 mmol/l) in both diabetic groups, but were lower in the STZ + Lep group (17.2+/-1.8 mmol/l) than in the STZ + Sal group (24.3+/-1.1 mmol/l, P < 0.05). To determine if sensitivity to leptin-induced anorexia was affected by STZ treatment, a second experiment was performed in which the effect of intracerebroventricular leptin injection (at doses of 0.35, 1.0, or 3.5 microg) on food intake was measured 10 days after STZ or Veh treatment. Leptin suppressed both 4- and 24-h food intake in the two groups to an equal extent at every dose (by 15, 22, and 35%, respectively). These findings support the hypothesis that the effect of uncontrolled diabetes to lower leptin levels contributes to diabetic hyperphagia and that this effect is not due to altered leptin sensitivity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“reduction in the plasma level of both leptin and insulin is implicated in the pathogenesis of diabetic hyperphagia in rats treated with streptozotocin (STZ) (173)”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [173]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012
Insulin in the Brain: A Hormonal Regulator of Energy Balance*
Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C., & Porte, D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-3-387 · Cited by 808
Self-citationInhibition of hypothalamic neuropeptide Y gene expression by insulin.
Schwartz, M. W., Sipols, A. J., Marks, J. L., Sanacora, G., White, J. D., Scheurink, A., Kahn, S. E., Baskin, D. G., Woods, S. C., & Figlewicz, D. P. (1992) · Endocrinology · doi:10.1210/endo.130.6.1597158 · Cited by 555
Self-citationHavel, P. J., Kasim-karakas, S., Mueller, W. M., Johnson, P. R., Gingerich, R. L., & Stern, J. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954050 · Cited by 412
Self-citationEffect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels
Weigle, D. S. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.561 · Cited by 287
Dubuc, G. R., Phinney, S. D., Stern, J. S., & Havel, P. J. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90055-5 · Cited by 217
Self-citationKinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.
Schwartz, M. W., Sipols, A. J., Kahn, S. E., Lattemann, D. F., Taborsky, G. J., Bergman, R. N., Woods, S. C., & Porte, D. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.3.e378 · Cited by 191
Self-citationThe Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus
Jacob, R. J., Dziura, J. D., Medwick, M. B., Leone, P., Caprio, S., During, M. J., Shulman, G. I., & Sherwin, R. (1997) · Diabetes · doi:10.2337/diab.46.1.150 · Cited by 134
Cited by
Sorted by citations
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationNeuroendocrine control of food intake
Valassi, E., Scacchi, M., & Cavagnini, F. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.06.004 · Cited by 649
Havel, P. J. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s143 · Cited by 628
Self-citationHavel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575
Self-citationHavel, P. J. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122601102 · Cited by 486
Self-citationNiswender, K. D., & Schwartz, M. W. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00105-x · Cited by 428
Self-citationGenetics and Pathophysiology of Human Obesity
Cummings, D. E., & Schwartz, M. W. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152403 · Cited by 375
Self-citationLeptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338
“Moreover, we recently found that continuous infusion of leptin directly into the brain normalizes blood glucose levels in STZinduced diabetic rats via a mechanism that cannot be explained by reduced food intake, increased urinary glucose losses, or a recovery of pancreatic beta-cells.”
BackgroundInfluentialSelf-citationHavel, P. J. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000410 · Cited by 330
Self-citationPancreatic signals controlling food intake; insulin, glucagon and amylin
Woods, S. C., Lutz, T. A., Geary, N., & Langhans, W. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1858 · Cited by 301
Self-citationInsulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
Niswender, K. D., Baskin, D. G., & Schwartz, M. W. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.07.009 · Cited by 267
Self-citationAssessment of Feeding Behavior in Laboratory Mice
Ellacott, K. L. J., Morton, G. J., Woods, S. C., Tso, P., & Schwartz, M. W. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.06.001 · Cited by 254
Self-citationLeptin and Insulin Action in the Central Nervous System
Porte, D., Baskin, D. G., & Schwartz, M. W. (2002) · Nutrition Reviews · doi:10.1301/002966402320634797 · Cited by 229
Self-citationLeptin—Much More Than a Satiety Signal
Harris, R. B. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.45 · Cited by 222
The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box
Williams, G., Harrold, J. A., & Cutler, D. J. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000434 · Cited by 220
German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169
Self-citationLeptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
German, J. P., Wisse, B. E., Thaler, J. P., Oh-I, S., Sarruf, D. A., Ogimoto, K., Kaiyala, K. J., Fischer, J. D., Matsen, M. E., Taborsky, G. J., et al. (2010) · Diabetes · doi:10.2337/db09-1918 · Cited by 159
Self-citationVickers, M. H., Reddy, S., Ikenasio, B., & Breier, B. H. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700323 · Cited by 151
The role of leptin in glucose homeostasis
Denroche, H. C., Huynh, F. K., & Kieffer, T. J. (2012) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2012.00203.x · Cited by 153
Leptin reverses sucrose-conditioned place preference in food-restricted rats
Figlewicz, D. P., HIGGINS, M., Ng-Evans, S., & Havel, P. J. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00486-3 · Cited by 132
Self-citationDenroche, H. C., Levi, J., Wideman, R. D., Sequeira, R. M., Huynh, F. K., Covey, S. D., & Kieffer, T. J. (2011) · Diabetes · doi:10.2337/db10-0958 · Cited by 126
Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin
McMinn, J. E., Sindelar, D. K., Havel, P. J., & Schwartz, M. W. (2000) · Endocrinology · doi:10.1210/endo.141.12.7815 · Cited by 129
Self-citationCentral leptin increases insulin sensitivity in streptozotocin-induced diabetic rats
Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00489.2001 · Cited by 124
Takada, J., Machado, M. A., Peres, S. B., Brito, L. C., Borges‐Silva, C. N., da Costa, C. E. M., Fonseca‐Alaniz, M. H., Andreotti, S., & Lima, F. B. (2007) · Metabolism · doi:10.1016/j.metabol.2006.05.021 · Cited by 106
NamKoong, C., Kim, M., Jang, P., Han, S. M., Park, H. S., Koh, E. H., Lee, W. J., Kim, J. Y., Park, I. S., Park, J. Y., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.1.63 · Cited by 106
Obesity: molecular bases of a multifactorial problem
Palou, A., Serra, F. A., Bonet, M. L., & Picó, C. (2000) · European Journal of Nutrition · doi:10.1007/s003940070017 · Cited by 99
True, C. A., Kirigiti, M. A., Kievit, P., Grove, K. L., & Smith, M. S. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02144.x · Cited by 93
Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression
Makimura, H., Mizuno, T. M., Isoda, F., Beasley, J., Silverstein, J. H., & Mobbs, C. V. (2003) · BMC Physiology · doi:10.1186/1472-6793-3-5 · Cited by 94
Perry, R. J., Resch, J. M., Douglass, A. M., Madara, J. C., Rabin-Court, A., Kucukdereli, H., Wu, C., Song, J. D., Lowell, B. B., & Shulman, G. I. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901795116 · Cited by 95
Diabetes-induced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin
Barber, M., Kasturi, B. S., Austin, M. E., Patel, K. P., MohanKumar, S. M. J., & MohanKumar, P. S. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04091-x · Cited by 85
van de Pol, I., Flik, G., & Gorissen, M. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00036 · Cited by 86
Meek, T. H., Wisse, B. E., Thaler, J. P., Guyenet, S. J., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2013) · Diabetes · doi:10.2337/db12-0837 · Cited by 80
Self-citationLiu, Y., Nakagawa, Y., Wang, Y., Li, R., Li, X., Ohzeki, T., & Friedman, T. C. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1409 · Cited by 80
Effect of Uncontrolled Diabetes on Plasma Ghrelin Concentrations and Ghrelin-Induced Feeding
Gelling, R. W., Overduin, J., Morrison, C. D., Morton, G. J., Frayo, R. S., Cummings, D. E., & Schwartz, M. W. (2004) · Endocrinology · doi:10.1210/en.2004-0605 · Cited by 78
Self-citationAppetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity
Gan, H., Cerbone, M., & Dattani, M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad033 · Cited by 75
Leptin treatment prevents type I diabetic marrow adiposity but not bone loss in mice
Motyl, K. J., & McCabe, L. R. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21608 · Cited by 63
Lechuga-Sancho, A. M., Arroba, A. I., Frago, L. M., García-Cáceres, C., de Célix, A. D.-R., Argente, J., & Chowen, J. A. (2006) · Endocrinology · doi:10.1210/en.2006-0766 · Cited by 64
Skeletal muscle as a therapeutic target for delaying type 1 diabetic complications
Coleman, S. K. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i17.1323 · Cited by 67
T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
Rani, J., Mittal, I., Pramanik, A., Singh, N., Dube, N., Sharma, S., Puniya, B. L., Raghunandanan, M. V., Mobeen, A., & Ramachandran, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-07238-0 · Cited by 60
The Hepatic Vagus Mediates Fat-Induced Inhibition of Diabetic Hyperphagia
la Fleur, S. E., Ji, H. L., Manalo, S. L., Friedman, M. I., & Dallman, M. F. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2321 · Cited by 62
Marques, T. M., Patterson, E., Wall, R., O’Sullivan, Ó., Fitzgerald, G. F., Cotter, P. D., Dinan, T. G., Cryan, J. F., Ross, R. P., & Stanton, C. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0154 · Cited by 59
Mechanisms regulating leptin production: implications for control of energy balance
Havel, P. J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.305 · Cited by 60
Self-citationRole of Endogenous Ghrelin in the Hyperphagia of Mice with Streptozotocin-Induced Diabetes
Dong, J., Peeters, T. L., Smet, B., Moechars, D., Delporte, C., Berghe, P. V., Coulie, B. J., Tang, M., & Depoortere, I. (2006) · Endocrinology · doi:10.1210/en.2005-1335 · Cited by 57
Verhulst, P., Smet, B. D., Saels, I. Y., Thijs, T., Donck, L. V., Moechars, D., Peeters, T. L., & Depoortere, I. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.044 · Cited by 54
Regulation of energy homeostasis by peripheral signals
Woods, S. C., Benoit, S. C., Clegg, D. J., & Seeley, R. J. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.08.004 · Cited by 56
Self-citationMeek, T. H., Matsen, M. E., Dorfman, M. D., Guyenet, S. J., Damian, V. M., Hồng, N. T., Taborsky, G. J., & Morton, G. J. (2013) · Endocrinology · doi:10.1210/en.2013-1328 · Cited by 51
Leptin as an adjunct of insulin therapy in insulin-deficient diabetes
Miyanaga, F., Ogawa, Y., Ebihara, K., Hidaka, S., Tanaka, T., Hayashi, S., Masuzaki, H., & Nakao, K. (2003) · Diabetologia · doi:10.1007/s00125-003-1193-6 · Cited by 52
Kim, E., Sohn, S., Lee, M., Jung, J., Kineman, R. D., & Park, S. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06501 · Cited by 51
Leptin, diabetes, and the brain
Morton, G. J., & Meek, T. H. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105568 · Cited by 47
Morton, G. J., Meek, T. H., Matsen, M. E., & Schwartz, M. W. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82723 · Cited by 41
Self-citationRole of lipoic acid on insulin resistance and leptin in experimentally diabetic rats
Kandeil, M. A., Amin, K. A., Hassanin, K. M. A., Ali, K. M., & Mohammed, E. T. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2009.09.007 · Cited by 40
Surwit, R. S., Edwards, C. L., Murthy, S., & Petro, A. E. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1203 · Cited by 39
R�os, S., Garcı́a-Rocha, M., Calbó, J., & Guinovart, J. J. (2011) · Diabetologia · doi:10.1007/s00125-011-2238-x · Cited by 39
Leptin, 20years of searching for glucose homeostasis
Fernández-Formoso, G., Perez‐Sieira, S., González-Touceda, D., Diéguez, C., & Tovar, S. A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.02.008 · Cited by 39
Leptina: o diálogo entre adipócitos e neurônios
Negrão, A. B., & Licinio, J. (2000) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302000000300004 · Cited by 39
Enhanced carbohydrate craving in patients with poorly controlled Type 2 diabetes mellitus
Yu, J. H., Shin, M. S., Kim, D. J., Lee, J. R., Yoon, S., Kim, S. G., Koh, E. H., Lee, W. J., Park, J.-Y., & Kim, M. ‐. (2013) · Diabetic Medicine · doi:10.1111/dme.12209 · Cited by 35
Effects of high glucose on caveolin-1 and insulin signaling in 3T3-L1 adipocytes
Palacios-Ortega, S., Varela-Guruceaga, M., Martínez, J. A., de Miguel, C., & Milagro, F. I. (2015) · Adipocyte · doi:10.1080/21623945.2015.1122856 · Cited by 35
Antidepressant-like effect of leptin in streptozotocin-induced diabetic mice
Hirano, S., Miyata, S., & Kamei, J. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.003 · Cited by 33
The Endocannabinoid System: Mechanisms Behind Metabolic Homeostasis and Imbalance
Woods, S. C. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.11.013 · Cited by 34
Self-citationKratzsch, J., Knerr, I., Galler, A., Kapellen, T. M., Raile, K., Körner, A., Thiery, J., Dötsch, J., & Kiess, W. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02261 · Cited by 34
Meek, T. H., Dorfman, M. D., Matsen, M. E., Fischer, J. D., Cubelo, A., Kumar, M. R., Taborsky, G. J., & Morton, G. J. (2015) · Diabetes · doi:10.2337/db14-1562 · Cited by 31
Neuroactive steroids and diabetic complications in the nervous system
Giatti, S., Mastrangelo, R., D’Antonio, M., Pesaresi, M., Romano, S., Diviccaro, S., Caruso, D., Mitro, N., & Melcangi, R. C. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.006 · Cited by 32
Effects of leptin on oxidative stress in healthy and Streptozotocin-induced diabetic rats
Gülen, Ş., & Dinçer, S. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9426-5 · Cited by 31
Maekawa, F., Fujiwara, K., Kohno, D., Kuramochi, M., Kurita, H., & Yada, T. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01470.x · Cited by 29
Moreira, T. J., Malec, E., Östenson, C.-G., Efendić, S., & Liljequist, S. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.034 · Cited by 29
Yang, R., & Newgard, C. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213112200 · Cited by 28
Kim, G. H., Szabo, A., King, E. M., Ayala, J., Ayala, J. E., & Altarejos, J. Y. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.12.006 · Cited by 24
Remor, A. P., da Silva, R. A., Matos, F., Glaser, V., Martins, R. D. P., Ghisoni, K., Scheffer, D. D. L., Andia, D. C., Portinho, D., de Souza, A. P., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1175-9 · Cited by 24
Leptin downregulates ghrelin levels in streptozotocin-induced diabetic mice
Tsubone, T., Masaki, T., Katsuragi, I., Tanaka, K., Kakuma, T., & Yoshimatsu, H. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00773.2004 · Cited by 24
Agouti-related protein is a mediator of diabetic hyperphagia
Qu, S.-Y., Yang, Y.-K., Li, J.-Y., Zeng, Q., & Gantz, I. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00230-5 · Cited by 24
Akirav, E. M., Chan, O. T. M., Inouye, K., Riddell, M. C., Matthews, S. G., & Vranić, M. (2004) · Metabolism · doi:10.1016/j.metabol.2004.06.024 · Cited by 23
Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats
Iwata, K., Kinoshita, M., Yamada, S., Imamura, T., Uenoyama, Y., Tsukamura, H., & Maeda, K.-I. (2011) · The Journal of Physiological Sciences · doi:10.1007/s12576-010-0127-6 · Cited by 22
Matsen, M. E., Thaler, J. P., Wisse, B. E., Guyenet, S. J., Meek, T. H., Ogimoto, K., Cubelo, A., Fischer, J. D., Kaiyala, K. J., Schwartz, M. W., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2012 · Cited by 21
Self-citationRole of serotonergic mechanisms in leptin-induced suppression of milk intake in mice
Yamada, J., Sugimoto, Y., Hirose, H., & Kajiwara, Y. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00772-9 · Cited by 21
Burgos‐Ramos, E., González‐Rodríguez, Á., Canelles, S., Baquedano, E., Frago, L. M., Revuelta‐Cervantes, J., Gómez‐Ambrosi, J., Frühbeck, G., Chowen, J. A., Argente, J., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1278 · Cited by 20
Effects of Obesity and Diabetes on Sperm Cell Proteomics in Rats
Carvalho, M. G., Silva, K. M., Aristizábal, V. H. V., Ortiz, P. E. O., Paranzini, C. S., Melchert, A., Amaro, J. L., & de Souza, F. F. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c01044 · Cited by 19
Dietary Synergies in Appetite Control: Distal Gastrointestinal Tract
Woods, S. C. (2006) · Obesity · doi:10.1038/oby.2006.301 · Cited by 15
Self-citationA reappraisal on the ability of leptin to induce fever
Steiner, A. A., Krall, C. M., & Liu, E. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.018 · Cited by 13
Medina, E. A., Erickson, K. L., Stanhope, K. L., & Havel, P. J. (2002) · Metabolism · doi:10.1053/meta.2002.34699 · Cited by 14
Self-citationMera, T., Fujihara, H., Saito, J., Kawasaki, M., Hashimoto, H., Saito, T., Shibata, M., Onaka, T., Tanaka, Y., Oka, T., et al. (2007) · Peptides · doi:10.1016/j.peptides.2007.06.023 · Cited by 11
Effects of Selected Minerals on Leptin Secretion in Streptozotocin-lnduced Hyperglycemic Mice
Chen, M.-D., Yang, V. C., Alexander, P. S., Lin, P., & Song, Y.-M. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600905 · Cited by 10
Wang, J., Wernette, C. M., Judd, R. L., Huggins, K. W., & White, B. D. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0135 · Cited by 8
Szilvássy, Z., Németh, J., Kovacs, P. L., Paragh, G., Sári, R. Z., Vı́gh, L., & Peitl, B. (2011) · Metabolism · doi:10.1016/j.metabol.2011.10.010 · Cited by 8
Adiponectina: el tejido adiposo más allá de la reserva inerte de energía
Reyes, C. A. D. (2007) · Revista de Endocrinología y Nutrición · Cited by 7
Effects of free access to sugar solutions on the control of energy intake
Zhao, C., & Castonguay, T. W. (2016) · Food Reviews International · doi:10.1080/87559129.2016.1149863 · Cited by 7
Xu, Y., & Tong, Q. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.027 · Cited by 7
Meek, T. H., Matsen, M. E., Faber, C. L., Samstag, C. L., Damian, V. M., Hồng, N. T., Scarlett, J. M., Flak, J. N., Myers, M. G., & Morton, G. J. (2018) · Endocrinology · doi:10.1210/en.2017-03199 · Cited by 7
Ambivalent Food Craving and Psychobiological Characteristics in Individuals With Weight Suppression
Lee, M., & Lee, J.-H. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.619025 · Cited by 6
Wakshlag, J. J., Streeter, R. M., Struble, A. M., Mann, S., Bauer, J. E., Nydam, D. V., Todhunter, R. J., Castelhano, M. G., & Cummings, B. P. (2015) · Veterinary Medicine Research and Reports · doi:10.2147/vmrr.s60478 · Cited by 6
Regulation of Glucose Metabolism in the Liver
Newgard, C. B. (2004) · doi:10.1002/0470862092.d0303 · Cited by 6
Rat Model of Type 2 Diabetes Mellitus Recapitulates Human Disease in the Anterior Segment of the Eye
Wang, C. L., Skeie, J. M., Allamargot, C., Goldstein, A. S., Nishimura, D. Y., Huffman, J. M., Aldrich, B. T., Schmidt, G. A., Teixeira, L. B. C., Kuehn, M. H., et al. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.02.004 · Cited by 5
Balancing Hepatic Glucose Disposal and Production
Yang, R. S., & Newgard, C. B. (2004) · KARGER eBooks · doi:10.1159/000079031 · Cited by 4
Madhkhoor, S. R., & Ibrahim, I. R. (2016) · International Journal of Advanced Research · doi:10.21474/ijar01/102 · Cited by 3
Annuzzi, G., Giacco, R., Patti, L., Bozzetto, L., Viscovo, D., & Rivellese, A. A. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.01.009 · Cited by 3
Hormonal mediation of energy homeostasis in obesity, diabetes and related disorders
Woods, S. C., & Seeley, R. J. (2005) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2005.08.004 · Cited by 3
Self-citationWren, A., & Bloom, S. R. (2002) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200204000-00004 · Cited by 3
Sonoda, S., Yoshimura, M., Ueno, H., Nishimura, H., Nishimura, K., Tanaka, K., Motojima, Y., Saito, R., Maruyama, T., Hashimoto, H., et al. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.03.003 · Cited by 3
An unexpected role for the brain in the pathogenesis of diabetic ketoacidosis
Mirzadeh, Z., Morton, G. J., Hirsch, I. B., & Schwartz, M. W. (2025) · Journal of Clinical Investigation · doi:10.1172/jci196357 · Cited by 2
Self-citationMetabolic Signals in the Control of Food Intake
Woods, S. C. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48643-1_10 · Cited by 3
Self-citationSayed, H. Y. I. A., Abdelglil, M. I., Mohamed, H. R. H., Baiomy, A. A. A., & Mohamed, A. S. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103423 · Cited by 1
Metadata
- Authors
- Sindelar, D. K., Havel, P. J., Seeley, R. J., Wilkinson, C. W., Woods, S. C., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1999-06-01
- Volume
- 48
- Issue
- 6
- Pages
- 1275-1280
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2130115423
- Cited by
- 119
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-52989-01, DK 50129, R01DK052989, R01DK050129)
- National Institute of Neurological Disorders and Stroke (NS-32273)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, type 1 diabetes, streptozotocin-induced diabetes, dietary intake, plasma leptin, Long-Evans rats, plasma glucose, leptin resistance, adipokines, insulin resistance, leptin receptor, leptin signaling
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Experimental, Hyperphagia, Insulin, Male, Obesity, Proteins, Rats, Long-Evans, Leptin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
